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Protein

DNA polymerase gamma

Gene

MIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the replication of mitochondrial DNA.

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
Present with 377 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3'-5' exonuclease activity Source: SGD
  • DNA binding Source: UniProtKB-KW
  • DNA-directed DNA polymerase activity Source: SGD

GO - Biological processi

  • mitochondrial DNA catabolic process Source: SGD
  • mitochondrial DNA replication Source: SGD
  • mitochondrial genome maintenance Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication
LigandMagnesium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33807-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase gamma (EC:2.7.7.7)
Alternative name(s):
Mitochondrial DNA polymerase catalytic subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIP1
Ordered Locus Names:YOR330C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005857 MIP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001012781 – 1254DNA polymerase gammaAdd BLAST1254

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15801

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15801

PRoteomics IDEntifications database

More...
PRIDEi
P15801

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15801

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34715, 159 interactors

Protein interaction database and analysis system

More...
IntActi
P15801, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YOR330C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15801

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000176668

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15801

KEGG Orthology (KO)

More...
KOi
K02332

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKWYKDL

Database of Orthologous Groups

More...
OrthoDBi
EOG092C03LT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR012337 RNaseH-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10267 PTHR10267, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00476 DNA_pol_A, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000797 DNA_pol_mt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00867 DNAPOLG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00482 POLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKLMVRSEC MLRMVRRRPL RVQFCARWFS TKKNTAEAPR INPVGIQYLG
60 70 80 90 100
ESLQRQVFGS CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP
110 120 130 140 150
LPPLQGRSLD EHFQKIGRFN SEPYKSFCED KFTEMVARPA EWLRKPGWVK
160 170 180 190 200
YVPGMAPVEV AYPDEELVVF DVETLYNVSD YPTLATALSS TAWYLWCSPF
210 220 230 240 250
ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF RDSKAFFLDT
260 270 280 290 300
QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS
310 320 330 340 350
ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA
360 370 380 390 400
TSQVFDEIFP VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL
410 420 430 440 450
YQQSKVQIES KIVQIIKDIV LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK
460 470 480 490 500
GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI TIKSRIIPIL FKLSWENSPV
510 520 530 540 550
IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT HNLGLQCTGV
560 570 580 590 600
LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY
610 620 630 640 650
WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM
660 670 680 690 700
GTITRRAVEN AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW
710 720 730 740 750
IASLVGDSIF NVHGGTAIGW MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI
760 770 780 790 800
FNYGRIYGAG AKFASQLLKR FNPSLTDEET KKIANKLYEN TKGKTKRSKL
810 820 830 840 850
FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM KKNLRANSFL
860 870 880 890 900
PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE
910 920 930 940 950
KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV
960 970 980 990 1000
NMDCITPSNK TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY
1010 1020 1030 1040 1050
REPVFEEYNK SYTPEFLKYF LAMQVQSDKR DVNRLEDEYL RECTSKEYAR
1060 1070 1080 1090 1100
DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN FLDGTKNAKA DQRIRLPVNM
1110 1120 1130 1140 1150
PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT RKKNTTPMER
1160 1170 1180 1190 1200
KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS
1210 1220 1230 1240 1250
NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI

SREY
Length:1,254
Mass (Da):143,502
Last modified:October 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80EE686E8EA9F2EC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA99652 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8S → F in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti35T → A in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti222I → V in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti357E → K in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti540 – 541TH → MN in AAA17543 (PubMed:2684980).Curated2
Sequence conflicti616S → N in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti661A → T in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti978S → P in AAA17543 (PubMed:2684980).Curated1
Sequence conflicti986N → S in AAA17543 (PubMed:2684980).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05117 Unassigned DNA Translation: AAA17543.1
Z49821 Genomic DNA Translation: CAA89977.1
Z75238 Genomic DNA Translation: CAA99652.1 Different initiation.
U42227 Genomic DNA Translation: AAA85442.1
BK006948 Genomic DNA Translation: DAA11093.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S62062 A32686

NCBI Reference Sequences

More...
RefSeqi
NP_014975.2, NM_001183750.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR330C_mRNA; YOR330C_mRNA; YOR330C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR330C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05117 Unassigned DNA Translation: AAA17543.1
Z49821 Genomic DNA Translation: CAA89977.1
Z75238 Genomic DNA Translation: CAA99652.1 Different initiation.
U42227 Genomic DNA Translation: AAA85442.1
BK006948 Genomic DNA Translation: DAA11093.1
PIRiS62062 A32686
RefSeqiNP_014975.2, NM_001183750.1

3D structure databases

ProteinModelPortaliP15801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34715, 159 interactors
IntActiP15801, 3 interactors
STRINGi4932.YOR330C

PTM databases

iPTMnetiP15801

Proteomic databases

MaxQBiP15801
PaxDbiP15801
PRIDEiP15801

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR330C_mRNA; YOR330C_mRNA; YOR330C
GeneIDi854508
KEGGisce:YOR330C

Organism-specific databases

SGDiS000005857 MIP1

Phylogenomic databases

GeneTreeiENSGT00390000000453
HOGENOMiHOG000176668
InParanoidiP15801
KOiK02332
OMAiPKWYKDL
OrthoDBiEOG092C03LT

Enzyme and pathway databases

BioCyciYEAST:G3O-33807-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P15801

Family and domain databases

InterProiView protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR002297 DNA-dir_DNA_pol_A_mt
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR012337 RNaseH-like_sf
PANTHERiPTHR10267 PTHR10267, 1 hit
PfamiView protein in Pfam
PF00476 DNA_pol_A, 1 hit
PIRSFiPIRSF000797 DNA_pol_mt, 1 hit
PRINTSiPR00867 DNAPOLG
SMARTiView protein in SMART
SM00482 POLAc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOG_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15801
Secondary accession number(s): D6W327, Q08785
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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