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Entry version 130 (07 Apr 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Laminin subunit beta-2

Gene

Lamb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-3000157, Laminin interactions
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin chain B3
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lamb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
2988, Lamb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Add BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707036 – 1801Laminin subunit beta-2Add BLAST1766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi288 ↔ 313PROSITE-ProRule annotation
Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi327 ↔ 347PROSITE-ProRule annotation
Disulfide bondi350 ↔ 359PROSITE-ProRule annotation
Disulfide bondi352 ↔ 377PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi392 ↔ 410PROSITE-ProRule annotation
Disulfide bondi413 ↔ 426PROSITE-ProRule annotation
Disulfide bondi415 ↔ 441PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi455 ↔ 470PROSITE-ProRule annotation
Disulfide bondi473 ↔ 487PROSITE-ProRule annotation
Disulfide bondi475 ↔ 494PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi508 ↔ 522PROSITE-ProRule annotation
Disulfide bondi525 ↔ 537PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi786 ↔ 798PROSITE-ProRule annotation
Disulfide bondi788 ↔ 805PROSITE-ProRule annotation
Disulfide bondi807 ↔ 816PROSITE-ProRule annotation
Disulfide bondi819 ↔ 831PROSITE-ProRule annotation
Disulfide bondi834 ↔ 846PROSITE-ProRule annotation
Disulfide bondi836 ↔ 853PROSITE-ProRule annotation
Disulfide bondi855 ↔ 864PROSITE-ProRule annotation
Disulfide bondi867 ↔ 877PROSITE-ProRule annotation
Disulfide bondi880 ↔ 889PROSITE-ProRule annotation
Disulfide bondi882 ↔ 896PROSITE-ProRule annotation
Disulfide bondi899 ↔ 908PROSITE-ProRule annotation
Disulfide bondi911 ↔ 927PROSITE-ProRule annotation
Disulfide bondi930 ↔ 946PROSITE-ProRule annotation
Disulfide bondi932 ↔ 957PROSITE-ProRule annotation
Disulfide bondi959 ↔ 968PROSITE-ProRule annotation
Disulfide bondi971 ↔ 986PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1003PROSITE-ProRule annotation
Disulfide bondi991 ↔ 1010PROSITE-ProRule annotation
Disulfide bondi1013 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1025 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1041 ↔ 1061PROSITE-ProRule annotation
Disulfide bondi1043 ↔ 1068PROSITE-ProRule annotation
Disulfide bondi1070 ↔ 1079PROSITE-ProRule annotation
Disulfide bondi1082 ↔ 1095PROSITE-ProRule annotation
Glycosylationi1088N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi1098 ↔ 1110PROSITE-ProRule annotation
Disulfide bondi1100 ↔ 1117PROSITE-ProRule annotation
Disulfide bondi1119 ↔ 1128PROSITE-ProRule annotation
Disulfide bondi1131 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1148 ↔ 1165PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1176PROSITE-ProRule annotation
Disulfide bondi1179 ↔ 1190PROSITE-ProRule annotation
Disulfide bondi1193InterchainCurated
Disulfide bondi1196InterchainCurated
Glycosylationi1252N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1351N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi1502N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1535PhosphoserineBy similarity1
Disulfide bondi1800InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15800

PRoteomics IDEntifications database

More...
PRIDEi
P15800

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P15800, 7 sites, 11 N-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15800

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15800

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes (major component). S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000065052

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15800

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 285Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini286 – 349Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini350 – 412Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini413 – 472Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini473 – 524Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST52
Domaini525 – 555Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini564 – 780Laminin IV type BPROSITE-ProRule annotationAdd BLAST217
Domaini786 – 833Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini834 – 879Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini880 – 929Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini930 – 988Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini989 – 1040Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1041 – 1097Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini1098 – 1145Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1146 – 1192Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1193 – 1412Domain IIAdd BLAST220
Regioni1413 – 1445Domain alphaAdd BLAST33
Regioni1446 – 1801Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1259 – 1306Sequence analysisAdd BLAST48
Coiled coili1475 – 1529Sequence analysisAdd BLAST55
Coiled coili1576 – 1793Sequence analysisAdd BLAST218

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15800

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15800

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 10 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P15800-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWASGKPGR GRQGQPVPWE LRLGLLLSVL AATLAQVPSL DVPGCSRGSC
60 70 80 90 100
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF
110 120 130 140 150
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH
160 170 180 190 200
LIMTFKTFRP AAMLVERSAD FGRTWRVYRY FSYDCGADFP GIPLAPPRRW
210 220 230 240 250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV
260 270 280 290 300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG
310 320 330 340 350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC
360 370 380 390 400
ECNGHSHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE LCRPFFYRDP
410 420 430 440 450
TKDMRDPAAC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT
460 470 480 490 500
RCQQCRDGFF GLSASNPRGC QRCQCNSRGT VPGGTPCDSS SGTCFCKRLV
510 520 530 540 550
TGDGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCPCRPHM
560 570 580 590 600
IGRRCEQVQP GYFRPFLDHL TWEAEGAHGQ VLEVVERLVT NRETPSWTGV
610 620 630 640 650
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELVVQRPGP
660 670 680 690 700
VSAHSPCGHV LPRDDRIQGM LHPNTRVLVF PRPVCLEPGL SYKLKLKLTG
710 720 730 740 750
TGGRAHPETP YSGSGILIDS LVLQPHVLML EMFSGGDAAA LERRTTFERY
760 770 780 790 800
RCHEEGLMPS KTPLSEACVP LLISASSLVY NGALPCQCDP QGSLSSECNP
810 820 830 840 850
HGGQCRCKPG VVGRRCDACA TGYYGFGPAG CQACQCSPDG ALSALCEGTS
860 870 880 890 900
GQCLCRTGAF GLRCDHCQRG QWGFPNCRPC VCNGRADECD AHTGACLGCR
910 920 930 940 950
DYTGGEHCER CIAGFHGDPR LPYGGQCRPC PCPEGPGSQR HFATSCHRDG
960 970 980 990 1000
YSQQIVCHCR AGYTGLRCEA CAPGHFGDPS KPGGRCQLCE CSGNIDPTDP
1010 1020 1030 1040 1050
GACDPHTGQC LRCLHHTEGP HCGHCKPGFH GQAARQSCHR CTCNLLGTDP
1060 1070 1080 1090 1100
QRCPSTDLCH CDPSTGQCPC LPHVQGLSCD RCAPNFWNFT SGRGCQPCAC
1110 1120 1130 1140 1150
HPSRARGPTC NEFTGQCHCH AGFGGRTCSE CQELHWGDPG LQCRACDCDP
1160 1170 1180 1190 1200
RGIDKPQCHR STGHCSCRPG VSGVRCDQCA RGFSGVFPAC HPCHACFGDW
1210 1220 1230 1240 1250
DRVVQDLAAR TRRLEQWAQE LQQTGVLGAF ESSFLNLQGK LGMVQAIVAA
1260 1270 1280 1290 1300
RNTSAASTAK LVEATEGLRH EIGKTTERLT QLEAELTDVQ DENFNANHAL
1310 1320 1330 1340 1350
SGLERDGLAL NLTLRQLDQH LDILKHSNFL GAYDSIRHAH SQSTEAERRA
1360 1370 1380 1390 1400
NASTFAIPSP VSNSADTRRR AEVLMGAQRE NFNRQHLANQ QALGRLSTHT
1410 1420 1430 1440 1450
HTLSLTGVNE LVCGAPGDAP CATSPCGGAG CRDEDGQPRC GGLGCSGAAA
1460 1470 1480 1490 1500
TADLALGRAR HTQAELQRAL VEGGGILSRV SETRRQAEEA QQRAQAALDK
1510 1520 1530 1540 1550
ANASRGQVEQ ANQELRELIQ NVKDFLSQEG ADPDSIEMVA TRVLDISIPA
1560 1570 1580 1590 1600
SPEQIQRLAS EIAERVRSLA DVDTILAHTM GDVRRAEQLL QDAQRARSRA
1610 1620 1630 1640 1650
EGERQKAETV QAALEEAQRA QGAAQGAIRG AVVDTKNTEQ TLQQVQERMA
1660 1670 1680 1690 1700
GTEQSLNSAS ERARQLHALL EALKLKRAGN SLAASTAEET AGSAQSRARE
1710 1720 1730 1740 1750
AEKQLREQVG DQYQTVRALA ERKAEGVLAA QARAEQLRDE ARGLLQAAQD
1760 1770 1780 1790 1800
KLQRLQELEG TYEENERELE VKAAQLDGLE ARMRSVLQAI NLQVQIYNTC

Q
Length:1,801
Mass (Da):196,474
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97AEF32F8F31FA75
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R6K0M0R6K0_RAT
Laminin subunit beta-2
Lamb2 rCG_25327
1,801Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5M7W9Q5M7W9_RAT
Lamb2 protein
Lamb2
1,593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X16563 mRNA Translation: CAA34561.1

Protein sequence database of the Protein Information Resource

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PIRi
S03539, MMRTS

NCBI Reference Sequences

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RefSeqi
NP_037106.1, NM_012974.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
25473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25473

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16563 mRNA Translation: CAA34561.1
PIRiS03539, MMRTS
RefSeqiNP_037106.1, NM_012974.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LF2X-ray1.85A/B523-833[»]
SMRiP15800
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065052

PTM databases

GlyGeniP15800, 7 sites, 11 N-linked glycans (4 sites)
iPTMnetiP15800
PhosphoSitePlusiP15800

Proteomic databases

PaxDbiP15800
PRIDEiP15800

Genome annotation databases

GeneIDi25473
KEGGirno:25473

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3913
RGDi2988, Lamb2

Phylogenomic databases

eggNOGiKOG0994, Eukaryota
InParanoidiP15800
PhylomeDBiP15800

Enzyme and pathway databases

ReactomeiR-RNO-3000157, Laminin interactions
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8874081, MET activates PTK2 signaling
R-RNO-8957275, Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P15800

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 10 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 12 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15800
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 7, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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