UniProtKB - P15800 (LAMB2_RAT)
Laminin subunit beta-2
Lamb2
Functioni
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
GO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
- integrin binding Source: RGD
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- astrocyte development Source: RGD
- axon extension involved in regeneration Source: RGD
- axon guidance Source: RGD
- basement membrane assembly Source: GO_Central
- cell migration Source: GO_Central
- cell morphogenesis involved in differentiation Source: RGD
- metanephric glomerular basement membrane development Source: RGD
- metanephric glomerular visceral epithelial cell development Source: RGD
- neuromuscular junction development Source: RGD
- neuron projection development Source: RGD
- retina development in camera-type eye Source: RGD
- Schwann cell development Source: RGD
- substrate adhesion-dependent cell spreading Source: GO_Central
- synapse organization Source: RGD
- tissue development Source: GO_Central
- visual perception Source: RGD
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-RNO-3000157, Laminin interactions R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8874081, MET activates PTK2 signaling R-RNO-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Laminin subunit beta-2Alternative name(s): Laminin chain B3 Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta Short name: S-LAM beta |
Gene namesi | Name:Lamb2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2988, Lamb2 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- synaptic cleft Source: RGD
Other locations
- basement membrane Source: RGD
- laminin complex Source: RGD
- laminin-3 complex Source: RGD
- neuromuscular junction Source: RGD
- synapse Source: RGD
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Add BLAST | 35 | |
ChainiPRO_0000017070 | 36 – 1801 | Laminin subunit beta-2Add BLAST | 1766 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 286 ↔ 295 | PROSITE-ProRule annotation | ||
Disulfide bondi | 288 ↔ 313 | PROSITE-ProRule annotation | ||
Disulfide bondi | 315 ↔ 324 | PROSITE-ProRule annotation | ||
Disulfide bondi | 327 ↔ 347 | PROSITE-ProRule annotation | ||
Disulfide bondi | 350 ↔ 359 | PROSITE-ProRule annotation | ||
Disulfide bondi | 352 ↔ 377 | PROSITE-ProRule annotation | ||
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 380 ↔ 389 | PROSITE-ProRule annotation | ||
Disulfide bondi | 392 ↔ 410 | PROSITE-ProRule annotation | ||
Disulfide bondi | 413 ↔ 426 | PROSITE-ProRule annotation | ||
Disulfide bondi | 415 ↔ 441 | PROSITE-ProRule annotation | ||
Disulfide bondi | 443 ↔ 452 | PROSITE-ProRule annotation | ||
Disulfide bondi | 455 ↔ 470 | PROSITE-ProRule annotation | ||
Disulfide bondi | 473 ↔ 487 | PROSITE-ProRule annotation | ||
Disulfide bondi | 475 ↔ 494 | PROSITE-ProRule annotation | ||
Disulfide bondi | 496 ↔ 505 | PROSITE-ProRule annotation | ||
Disulfide bondi | 508 ↔ 522 | PROSITE-ProRule annotation | ||
Disulfide bondi | 525 ↔ 537 | PROSITE-ProRule annotation | ||
Disulfide bondi | 527 ↔ 544 | PROSITE-ProRule annotation | ||
Disulfide bondi | 546 ↔ 555 | PROSITE-ProRule annotation | ||
Disulfide bondi | 786 ↔ 798 | PROSITE-ProRule annotation | ||
Disulfide bondi | 788 ↔ 805 | PROSITE-ProRule annotation | ||
Disulfide bondi | 807 ↔ 816 | PROSITE-ProRule annotation | ||
Disulfide bondi | 819 ↔ 831 | PROSITE-ProRule annotation | ||
Disulfide bondi | 834 ↔ 846 | PROSITE-ProRule annotation | ||
Disulfide bondi | 836 ↔ 853 | PROSITE-ProRule annotation | ||
Disulfide bondi | 855 ↔ 864 | PROSITE-ProRule annotation | ||
Disulfide bondi | 867 ↔ 877 | PROSITE-ProRule annotation | ||
Disulfide bondi | 880 ↔ 889 | PROSITE-ProRule annotation | ||
Disulfide bondi | 882 ↔ 896 | PROSITE-ProRule annotation | ||
Disulfide bondi | 899 ↔ 908 | PROSITE-ProRule annotation | ||
Disulfide bondi | 911 ↔ 927 | PROSITE-ProRule annotation | ||
Disulfide bondi | 930 ↔ 946 | PROSITE-ProRule annotation | ||
Disulfide bondi | 932 ↔ 957 | PROSITE-ProRule annotation | ||
Disulfide bondi | 959 ↔ 968 | PROSITE-ProRule annotation | ||
Disulfide bondi | 971 ↔ 986 | PROSITE-ProRule annotation | ||
Disulfide bondi | 989 ↔ 1003 | PROSITE-ProRule annotation | ||
Disulfide bondi | 991 ↔ 1010 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1013 ↔ 1022 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1025 ↔ 1038 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1041 ↔ 1061 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1043 ↔ 1068 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1070 ↔ 1079 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1082 ↔ 1095 | PROSITE-ProRule annotation | ||
Glycosylationi | 1088 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Disulfide bondi | 1098 ↔ 1110 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1100 ↔ 1117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1119 ↔ 1128 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1131 ↔ 1143 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1146 ↔ 1158 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1148 ↔ 1165 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1167 ↔ 1176 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1179 ↔ 1190 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1193 | InterchainCurated | ||
Disulfide bondi | 1196 | InterchainCurated | ||
Glycosylationi | 1252 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1351 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 1502 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1535 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 1800 | InterchainCurated |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P15800 |
PRIDEi | P15800 |
PTM databases
GlyGeni | P15800, 7 sites, 11 N-linked glycans (4 sites) |
iPTMneti | P15800 |
PhosphoSitePlusi | P15800 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).
GO - Molecular functioni
- integrin binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065052 |
Structurei
Secondary structure
3D structure databases
SMRi | P15800 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 285 | Laminin N-terminalPROSITE-ProRule annotationAdd BLAST | 240 | |
Domaini | 286 – 349 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 350 – 412 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 413 – 472 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 473 – 524 | Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 525 – 555 | Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 564 – 780 | Laminin IV type BPROSITE-ProRule annotationAdd BLAST | 217 | |
Domaini | 786 – 833 | Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 834 – 879 | Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 880 – 929 | Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 930 – 988 | Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 989 – 1040 | Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 1041 – 1097 | Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 1098 – 1145 | Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 1146 – 1192 | Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1193 – 1412 | Domain IIAdd BLAST | 220 | |
Regioni | 1413 – 1445 | Domain alphaAdd BLAST | 33 | |
Regioni | 1446 – 1801 | Domain IAdd BLAST | 356 | |
Regioni | 1684 – 1703 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1259 – 1306 | Sequence analysisAdd BLAST | 48 | |
Coiled coili | 1475 – 1529 | Sequence analysisAdd BLAST | 55 | |
Coiled coili | 1576 – 1793 | Sequence analysisAdd BLAST | 218 |
Domaini
Keywords - Domaini
Coiled coil, Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0994, Eukaryota |
InParanoidi | P15800 |
PhylomeDBi | P15800 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 13 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR013015, Laminin_IV_B IPR008211, Laminin_N IPR002049, LE_dom |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 13 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 10 hits SM00180, EGF_Lam, 13 hits SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 10 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 12 hits PS50027, EGF_LAM_2, 13 hits PS51116, LAMININ_IVB, 1 hit PS51117, LAMININ_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEWASGKPGR GRQGQPVPWE LRLGLLLSVL AATLAQVPSL DVPGCSRGSC
60 70 80 90 100
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF
110 120 130 140 150
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH
160 170 180 190 200
LIMTFKTFRP AAMLVERSAD FGRTWRVYRY FSYDCGADFP GIPLAPPRRW
210 220 230 240 250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV
260 270 280 290 300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG
310 320 330 340 350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC
360 370 380 390 400
ECNGHSHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE LCRPFFYRDP
410 420 430 440 450
TKDMRDPAAC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT
460 470 480 490 500
RCQQCRDGFF GLSASNPRGC QRCQCNSRGT VPGGTPCDSS SGTCFCKRLV
510 520 530 540 550
TGDGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCPCRPHM
560 570 580 590 600
IGRRCEQVQP GYFRPFLDHL TWEAEGAHGQ VLEVVERLVT NRETPSWTGV
610 620 630 640 650
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELVVQRPGP
660 670 680 690 700
VSAHSPCGHV LPRDDRIQGM LHPNTRVLVF PRPVCLEPGL SYKLKLKLTG
710 720 730 740 750
TGGRAHPETP YSGSGILIDS LVLQPHVLML EMFSGGDAAA LERRTTFERY
760 770 780 790 800
RCHEEGLMPS KTPLSEACVP LLISASSLVY NGALPCQCDP QGSLSSECNP
810 820 830 840 850
HGGQCRCKPG VVGRRCDACA TGYYGFGPAG CQACQCSPDG ALSALCEGTS
860 870 880 890 900
GQCLCRTGAF GLRCDHCQRG QWGFPNCRPC VCNGRADECD AHTGACLGCR
910 920 930 940 950
DYTGGEHCER CIAGFHGDPR LPYGGQCRPC PCPEGPGSQR HFATSCHRDG
960 970 980 990 1000
YSQQIVCHCR AGYTGLRCEA CAPGHFGDPS KPGGRCQLCE CSGNIDPTDP
1010 1020 1030 1040 1050
GACDPHTGQC LRCLHHTEGP HCGHCKPGFH GQAARQSCHR CTCNLLGTDP
1060 1070 1080 1090 1100
QRCPSTDLCH CDPSTGQCPC LPHVQGLSCD RCAPNFWNFT SGRGCQPCAC
1110 1120 1130 1140 1150
HPSRARGPTC NEFTGQCHCH AGFGGRTCSE CQELHWGDPG LQCRACDCDP
1160 1170 1180 1190 1200
RGIDKPQCHR STGHCSCRPG VSGVRCDQCA RGFSGVFPAC HPCHACFGDW
1210 1220 1230 1240 1250
DRVVQDLAAR TRRLEQWAQE LQQTGVLGAF ESSFLNLQGK LGMVQAIVAA
1260 1270 1280 1290 1300
RNTSAASTAK LVEATEGLRH EIGKTTERLT QLEAELTDVQ DENFNANHAL
1310 1320 1330 1340 1350
SGLERDGLAL NLTLRQLDQH LDILKHSNFL GAYDSIRHAH SQSTEAERRA
1360 1370 1380 1390 1400
NASTFAIPSP VSNSADTRRR AEVLMGAQRE NFNRQHLANQ QALGRLSTHT
1410 1420 1430 1440 1450
HTLSLTGVNE LVCGAPGDAP CATSPCGGAG CRDEDGQPRC GGLGCSGAAA
1460 1470 1480 1490 1500
TADLALGRAR HTQAELQRAL VEGGGILSRV SETRRQAEEA QQRAQAALDK
1510 1520 1530 1540 1550
ANASRGQVEQ ANQELRELIQ NVKDFLSQEG ADPDSIEMVA TRVLDISIPA
1560 1570 1580 1590 1600
SPEQIQRLAS EIAERVRSLA DVDTILAHTM GDVRRAEQLL QDAQRARSRA
1610 1620 1630 1640 1650
EGERQKAETV QAALEEAQRA QGAAQGAIRG AVVDTKNTEQ TLQQVQERMA
1660 1670 1680 1690 1700
GTEQSLNSAS ERARQLHALL EALKLKRAGN SLAASTAEET AGSAQSRARE
1710 1720 1730 1740 1750
AEKQLREQVG DQYQTVRALA ERKAEGVLAA QARAEQLRDE ARGLLQAAQD
1760 1770 1780 1790 1800
KLQRLQELEG TYEENERELE VKAAQLDGLE ARMRSVLQAI NLQVQIYNTC
Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R6K0 | M0R6K0_RAT | Laminin subunit beta-2 | Lamb2 rCG_25327 | 1,801 | Annotation score: | ||
Q5M7W9 | Q5M7W9_RAT | Lamb2 protein | Lamb2 | 1,593 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16563 mRNA Translation: CAA34561.1 |
PIRi | S03539, MMRTS |
RefSeqi | NP_037106.1, NM_012974.1 |
Genome annotation databases
GeneIDi | 25473 |
KEGGi | rno:25473 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16563 mRNA Translation: CAA34561.1 |
PIRi | S03539, MMRTS |
RefSeqi | NP_037106.1, NM_012974.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5LF2 | X-ray | 1.85 | A/B | 523-833 | [»] | |
SMRi | P15800 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065052 |
PTM databases
GlyGeni | P15800, 7 sites, 11 N-linked glycans (4 sites) |
iPTMneti | P15800 |
PhosphoSitePlusi | P15800 |
Proteomic databases
PaxDbi | P15800 |
PRIDEi | P15800 |
Genome annotation databases
GeneIDi | 25473 |
KEGGi | rno:25473 |
Organism-specific databases
CTDi | 3913 |
RGDi | 2988, Lamb2 |
Phylogenomic databases
eggNOGi | KOG0994, Eukaryota |
InParanoidi | P15800 |
PhylomeDBi | P15800 |
Enzyme and pathway databases
Reactomei | R-RNO-3000157, Laminin interactions R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8874081, MET activates PTK2 signaling R-RNO-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
PROi | PR:P15800 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 13 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR013015, Laminin_IV_B IPR008211, Laminin_N IPR002049, LE_dom |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 13 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 10 hits SM00180, EGF_Lam, 13 hits SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 10 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 12 hits PS50027, EGF_LAM_2, 13 hits PS51116, LAMININ_IVB, 1 hit PS51117, LAMININ_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMB2_RAT | |
Accessioni | P15800Primary (citable) accession number: P15800 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references