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Protein

Envelope small membrane protein

Gene

E

Organism
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.UniRule annotation

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope small membrane proteinUniRule annotation
Short name:
E proteinUniRule annotation
Short name:
sM proteinUniRule annotation
Gene namesi
Name:EUniRule annotation
Synonyms:sM
ORF Names:5b
OrganismiBovine coronavirus (strain Mebus) (BCoV) (BCV)
Taxonomic identifieri11132 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000007554 Componenti: Genome

Subcellular locationi

  • Host Golgi apparatus membrane UniRule annotation; Single-pass type III membrane protein UniRule annotation
  • Note: The cytoplasmic tail functions as a Golgi complex-targeting signal.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18Virion surfaceUniRule annotationAdd BLAST18
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21
Topological domaini40 – 80IntravirionUniRule annotationAdd BLAST41

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060861 – 84Envelope small membrane proteinAdd BLAST84

Interactioni

Subunit structurei

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the betacoronaviruses E protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001NY

Family and domain databases

HAMAPiMF_04204 BETA_CORONA_E, 1 hit
InterProiView protein in InterPro
IPR003873 NS3/E
PfamiView protein in Pfam
PF02723 NS3_envE, 1 hit

Sequencei

Sequence statusi: Complete.

P15779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMADAYFAD TVWYVGQIIF IVAICLLVII VVVAFLATFK LCIQLCGMCN
60 70 80
TLGLSPSIYV FNRGRQFYEF YNDVKPPVLD VDDV
Length:84
Mass (Da):9,542
Last modified:April 1, 1990 - v1
Checksum:i49D0797F6D44DC10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00735 Genomic RNA Translation: AAA42914.1
PIRiD46346

Similar proteinsi

Entry informationi

Entry nameiVEMP_CVBM
AccessioniPrimary (citable) accession number: P15779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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