PHKG2

Functionⁱ

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).By similarity1 Publication

Catalytic activityⁱ

2 ATP + phosphorylase b = 2 ADP + phosphorylase a.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	53	ATPPROSITE-ProRule annotation		1
Active siteⁱ	153	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	30 – 38	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW
enzyme binding Source: Ensembl
phosphorylase kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 10487978
protein serine/threonine kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 10487978
tau-protein kinase activity
Source: UniProtKB
Traceable author statementⁱ
- 8999860

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 8896567
glycogen biosynthetic process Source: InterPro
glycogen metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8896567
intracellular signal transduction Source: GO_Central
peptidyl-serine phosphorylation Source: GO_Central
peptidyl-threonine phosphorylation Source: GO_Central
positive regulation of glycogen catabolic process
Source: UniProtKB
Traceable author statementⁱ
- 10487978
protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 2948189

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Carbohydrate metabolism, Glycogen metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS08155-MONOMER
BRENDAⁱ	2.7.11.19 2681
Reactomeⁱ	R-HSA-70221 Glycogen breakdown (glycogenolysis)
SignaLinkⁱ	P15735

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (EC:2.7.11.19) Short name: PHK-gamma-LT Short name: PHK-gamma-T Alternative name(s): PSK-C3 Phosphorylase kinase subunit gamma-2
Gene namesⁱ	Name:PHKG2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156873.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8931 PHKG2
MIMⁱ	172471 gene
neXtProtⁱ	NX_P15735

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Glycogen storage disease 9C (GSD9C)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA metabolic disorder manifesting in infancy with hepatomegaly, growth retardation, hypotonia, liver dysfunction, and elevated plasma aminotransferases and lipids. These symptoms improve with age in most cases; however, some patients may develop hepatic fibrosis or cirrhosis.

Keywords - Diseaseⁱ

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5261
GeneReviewsⁱ	PHKG2
MalaCards human disease database More...MalaCardsⁱ	PHKG2
MIMⁱ	613027 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000156873
Orphanetⁱ	264580 Glycogen storage disease due to liver phosphorylase kinase deficiency
PharmGKBⁱ	PA33272

Chemistry databases

ChEMBLⁱ	CHEMBL2349
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2147

Polymorphism and mutation databases

BioMutaⁱ	PHKG2
DMDMⁱ	125536

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086512	1 – 406	Phosphorylase b kinase gamma catalytic chain, liver/testis isoformAdd BLAST		406

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	345	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P15735
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15735
PaxDbⁱ	P15735
PeptideAtlas More...PeptideAtlasⁱ	P15735
PRIDEⁱ	P15735
ProteomicsDBⁱ	53208 53209 [P15735-2]

PTM databases

iPTMnetⁱ	P15735
PhosphoSitePlusⁱ	P15735

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000156873 Expressed in 165 organ(s), highest expression level in right testis
CleanExⁱ	HS_PHKG2
ExpressionAtlasⁱ	P15735 baseline and differential
Genevisibleⁱ	P15735 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065618 HPA068751

HPAⁱ

HPA065618
HPA068751

Interactionⁱ

Subunit structureⁱ

Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PHKA2	P46019	4	EBI-1383819,EBI-1642846

With

Entry

#Exp.

IntAct

Notes

PHKA2

P46019

4

EBI-1383819,EBI-1642846

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111279, 59 interactors
IntActⁱ	P15735, 34 interactors
STRINGⁱ	9606.ENSP00000455607

Chemistry databases

BindingDBⁱ

P15735

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	13 – 23	Combined sources	11
Beta strandⁱ	24 – 32	Combined sources	9
Beta strandⁱ	34 – 43	Combined sources	10
Turnⁱ	44 – 46	Combined sources	3
Beta strandⁱ	49 – 56	Combined sources	8
Helixⁱ	64 – 84	Combined sources	21
Beta strandⁱ	93 – 107	Combined sources	15
Helixⁱ	115 – 122	Combined sources	8
Helixⁱ	127 – 146	Combined sources	20
Helixⁱ	156 – 158	Combined sources	3
Beta strandⁱ	159 – 161	Combined sources	3
Beta strandⁱ	167 – 169	Combined sources	3
Helixⁱ	191 – 193	Combined sources	3
Helixⁱ	196 – 201	Combined sources	6
Helixⁱ	214 – 228	Combined sources	15
Helixⁱ	238 – 247	Combined sources	10
Helixⁱ	254 – 257	Combined sources	4
Beta strandⁱ	258 – 260	Combined sources	3
Helixⁱ	262 – 271	Combined sources	10
Turnⁱ	276 – 278	Combined sources	3
Helixⁱ	282 – 287	Combined sources	6
Helixⁱ	289 – 291	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P15735
SMRⁱ	P15735
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 291	Protein kinasePROSITE-ProRule annotationAdd BLAST		268

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	306 – 330	Calmodulin-binding (domain-N)By similarityAdd BLAST		25
Regionⁱ	346 – 370	Calmodulin-binding (domain-C)By similarityAdd BLAST		25

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0599 Eukaryota ENOG410Y7VX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129744
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG106193
InParanoidⁱ	P15735
KEGG Orthology (KO) More...KOⁱ	K00871
PhylomeDBⁱ	P15735
TreeFamⁱ	TF320349

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR002291 Phosph_kin_gamma IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR01049 PHOSPHBKNASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P15735-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGHEF 
        60         70         80         90        100
AVKIMEVTAE RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS 
       110        120        130        140        150
SFMFLVFDLM RKGELFDYLT EKVALSEKET RSIMRSLLEA VSFLHANNIV 
       160        170        180        190        200
HRDLKPENIL LDDNMQIRLS DFGFSCHLEP GEKLRELCGT PGYLAPEILK 
       210        220        230        240        250
CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL MLRMIMEGQY 
       260        270        280        290        300
QFSSPEWDDR SSTVKDLISR LLQVDPEARL TAEQALQHPF FERCEGSQPW 
       310        320        330        340        350
NLTPRQRFRV AVWTVLAAGR VALSTHRVRP LTKNALLRDP YALRSVRHLI 
       360        370        380        390        400
DNCAFRLYGH WVKKGEQQNR AALFQHRPPG PFPIMGPEEE GDSAAITEDE 

AVLVLG

Length:406

Mass (Da):46,442

Last modified:April 1, 1990 - v1

Checksum:ⁱE991CFF2D3D70F60

GO

Isoform 2 (identifier: P15735-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
362-374: VKKGEQQNRAALF → IRKQWIGKLMACV
375-406: Missing.

« Hide

        10         20         30         40         50
MTLDVGPEDE LPDWAAAKEF YQKYDPKDVI GRGVSSVVRR CVHRATGHEF 
        60         70         80         90        100
AVKIMEVTAE RLSPEQLEEV REATRRETHI LRQVAGHPHI ITLIDSYESS 
       110        120        130        140        150
SFMFLVFDLM RKGELFDYLT EKVALSEKET RSIMRSLLEA VSFLHANNIV 
       160        170        180        190        200
HRDLKPENIL LDDNMQIRLS DFGFSCHLEP GEKLRELCGT PGYLAPEILK 
       210        220        230        240        250
CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL MLRMIMEGQY 
       260        270        280        290        300
QFSSPEWDDR SSTVKDLISR LLQVDPEARL TAEQALQHPF FERCEGSQPW 
       310        320        330        340        350
NLTPRQRFRV AVWTVLAAGR VALSTHRVRP LTKNALLRDP YALRSVRHLI 
       360        370 
DNCAFRLYGH WIRKQWIGKL MACV

Show »

Length:374

Mass (Da):43,158

Checksum:ⁱD0E2416820A68AA7

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KNN3	J3KNN3_HUMAN	Phosphorylase b kinase gamma cataly... Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2	410	Annotation score:
H3BP07	H3BP07_HUMAN	Phosphorylase b kinase gamma cataly... Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2	254	Annotation score:
H3BTW6	H3BTW6_HUMAN	Phosphorylase b kinase gamma cataly... Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2	266	Annotation score:
H3BTI9	H3BTI9_HUMAN	Phosphorylase b kinase gamma cataly... Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2	80	Annotation score:
H3BN16	H3BN16_HUMAN	Phosphorylase b kinase gamma cataly... Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2	87	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	146	A → P in AAA36518 (PubMed:2948189).Curated	1
Sequence conflictⁱ	176	C → S in AAA36518 (PubMed:2948189).Curated	1
Sequence conflictⁱ	179	E → D in AAA36518 (PubMed:2948189).Curated	1
Sequence conflictⁱ	212 – 214	KEV → LVD in AAA36518 (PubMed:2948189).Curated	3
Sequence conflictⁱ	221	V → E in AAA36518 (PubMed:2948189).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_009517	106	V → E in GSD9C. 1 PublicationCorresponds to variant dbSNP:rs137853589EnsemblClinVar.	1
Natural variantⁱVAR_020854	157	E → K in GSD9C. 1 PublicationCorresponds to variant dbSNP:rs752961445Ensembl.	1
Natural variantⁱVAR_009518	189	G → E in GSD9C. 1 PublicationCorresponds to variant dbSNP:rs137853588EnsemblClinVar.	1
Natural variantⁱVAR_020855	215	D → N in GSD9C. 1 PublicationCorresponds to variant dbSNP:rs767427889Ensembl.	1
Natural variantⁱVAR_051658	247	E → G. Corresponds to variant dbSNP:rs34006569Ensembl.	1
Natural variantⁱVAR_040996	317	A → T1 PublicationCorresponds to variant dbSNP:rs759992249Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041858	362 – 374	VKKGE…RAALF → IRKQWIGKLMACV in isoform 2. 1 PublicationAdd BLAST		13
Alternative sequenceⁱVSP_041859	375 – 406	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31606 mRNA Translation: AAA36442.1 Y11950, Y11951 Genomic DNA Translation: CAA72694.1 AK289492 mRNA Translation: BAF82181.1 AK293551 mRNA Translation: BAG57028.1 AC106886 Genomic DNA No translation available. BC002541 mRNA Translation: AAH02541.1 M14503 mRNA Translation: AAA36518.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10690.1 [P15735-1] CCDS54002.1 [P15735-2]
PIRⁱ	A40069 KIHUCT
NCBI Reference Sequences More...RefSeqⁱ	NP_000285.1, NM_000294.2 [P15735-1] NP_001165903.1, NM_001172432.1 [P15735-2]
UniGeneⁱ	Hs.65735

Genome annotation databases

Ensemblⁱ	ENST00000424889; ENSP00000388571; ENSG00000156873 [P15735-2] ENST00000563588; ENSP00000455607; ENSG00000156873 [P15735-1]
GeneIDⁱ	5261
KEGGⁱ	hsa:5261
UCSC genome browser More...UCSCⁱ	uc021tgo.3 human [P15735-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P15735	Phosphorylase kinase, gamma 2 (Testis) variant (Fragment)		HUMAN		272	UniRef100_P15735
PHKG2 isoform 7 (Fragment)		PANTR		266
Phosphorylase kinase, gamma 2 (Testis), isoform CRA_a		HUMAN		297
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Fragment)		HUMAN		266

Protein	Similar proteins		Species	Score	Length	Source
P15735	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		BOVIN		406	UniRef90_P15735
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		MOUSE		406
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		RAT		406
Phosphorylase kinase, gamma 2 (Testis) variant (Fragment)		HUMAN		272
PHKG2 isoform 7 (Fragment)		PANTR		266
+147
P15735-2	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform isoform 1		HETGA		432	UniRef90_P15735-2
PHKG2 isoform 3		PANTR		374
Uncharacterized protein		PANPA		374
Uncharacterized protein		NOMLE		374
Uncharacterized protein		MANLE		374
+11

Protein	Similar proteins		Species	Score	Length	Source
P15735	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		BOVIN		406	UniRef50_P15735
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		RAT		406
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform		MOUSE		406
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform		HUMAN		387
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	)	RABIT		387
+337

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M31606 mRNA Translation: AAA36442.1 Y11950, Y11951 Genomic DNA Translation: CAA72694.1 AK289492 mRNA Translation: BAF82181.1 AK293551 mRNA Translation: BAG57028.1 AC106886 Genomic DNA No translation available. BC002541 mRNA Translation: AAH02541.1 M14503 mRNA Translation: AAA36518.1
CCDSⁱ	CCDS10690.1 [P15735-1] CCDS54002.1 [P15735-2]
PIRⁱ	A40069 KIHUCT
RefSeqⁱ	NP_000285.1, NM_000294.2 [P15735-1] NP_001165903.1, NM_001172432.1 [P15735-2]
UniGeneⁱ	Hs.65735

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Y7J	X-ray	2.50	A/B/C/D	6-293	[»]
ProteinModelPortalⁱ	P15735
SMRⁱ	P15735
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111279, 59 interactors
IntActⁱ	P15735, 34 interactors
STRINGⁱ	9606.ENSP00000455607

Chemistry databases

BindingDBⁱ	P15735
ChEMBLⁱ	CHEMBL2349
GuidetoPHARMACOLOGYⁱ	2147

PTM databases

iPTMnetⁱ	P15735
PhosphoSitePlusⁱ	P15735

Polymorphism and mutation databases

BioMutaⁱ	PHKG2
DMDMⁱ	125536

Proteomic databases

EPDⁱ	P15735
MaxQBⁱ	P15735
PaxDbⁱ	P15735
PeptideAtlasⁱ	P15735
PRIDEⁱ	P15735
ProteomicsDBⁱ	53208 53209 [P15735-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5261
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000424889; ENSP00000388571; ENSG00000156873 [P15735-2] ENST00000563588; ENSP00000455607; ENSG00000156873 [P15735-1]
GeneIDⁱ	5261
KEGGⁱ	hsa:5261
UCSCⁱ	uc021tgo.3 human [P15735-1]

Organism-specific databases

CTDⁱ	5261
DisGeNETⁱ	5261
EuPathDBⁱ	HostDB:ENSG00000156873.15
GeneCardsⁱ	PHKG2
GeneReviewsⁱ	PHKG2
HGNCⁱ	HGNC:8931 PHKG2
HPAⁱ	HPA065618 HPA068751
MalaCardsⁱ	PHKG2
MIMⁱ	172471 gene 613027 phenotype
neXtProtⁱ	NX_P15735
OpenTargetsⁱ	ENSG00000156873
Orphanetⁱ	264580 Glycogen storage disease due to liver phosphorylase kinase deficiency
PharmGKBⁱ	PA33272
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0599 Eukaryota ENOG410Y7VX LUCA
GeneTreeⁱ	ENSGT00840000129744
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG106193
InParanoidⁱ	P15735
KOⁱ	K00871
PhylomeDBⁱ	P15735
TreeFamⁱ	TF320349

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS08155-MONOMER
BRENDAⁱ	2.7.11.19 2681
Reactomeⁱ	R-HSA-70221 Glycogen breakdown (glycogenolysis)
SignaLinkⁱ	P15735

Miscellaneous databases

ChiTaRSⁱ	PHKG2 human
GeneWikiⁱ	PHKG2
GenomeRNAiⁱ	5261
Protein Ontology More...PROⁱ	PR:P15735
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000156873 Expressed in 165 organ(s), highest expression level in right testis
CleanExⁱ	HS_PHKG2
ExpressionAtlasⁱ	P15735 baseline and differential
Genevisibleⁱ	P15735 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR002291 Phosph_kin_gamma IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PRINTSⁱ	PR01049 PHOSPHBKNASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PHKG2_HUMAN
Accessionⁱ	P15735Primary (citable) accession number: P15735 Secondary accession number(s): A8K0C7 , B4DEB7, E9PEU3, P11800
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	September 12, 2018
	This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P15735 (PHKG2_HUMAN)

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Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ