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UniProtKB - P15705 (STI1_YEAST)
Protein
Heat shock protein STI1
Gene
STI1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May play a role in mediating the heat shock response of some HSP70 genes. It is required for optimal growth of yeast cells at both low and high temperature.
Miscellaneous
Present with 67600 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- ATPase inhibitor activity Source: SGD
- Hsp70 protein binding Source: SGD
- Hsp90 protein binding Source: SGD
- mRNA binding Source: SGD
GO - Biological processi
- protein folding Source: SGD
- protein localization Source: SGD
- protein targeting to mitochondrion Source: SGD
Keywordsi
Biological process | Stress response |
Enzyme and pathway databases
Reactomei | R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-SCE-9696273, RND1 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein STI1 |
Gene namesi | Name:STI1 Ordered Locus Names:YOR027W ORF Names:OR26.17 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005553, STI1 |
VEuPathDBi | FungiDB:YOR027W |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106341 | 1 – 589 | Heat shock protein STI1Add BLAST | 589 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Cross-linki | 168 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 227 | PhosphoserineCombined sources | 1 | |
Cross-linki | 384 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P15705 |
PaxDbi | P15705 |
PRIDEi | P15705 |
2D gel databases
SWISS-2DPAGEi | P15705 |
PTM databases
iPTMneti | P15705 |
Expressioni
Inductioni
By heat shock and canavanine.
Interactioni
Subunit structurei
Part of a larger complex that includes HSP70, HSP90, and immunophilins.
Binary interactionsi
P15705
With | #Exp. | IntAct |
---|---|---|
HSC82 [P15108] | 3 | EBI-18418,EBI-8666 |
HSP82 [P02829] | 18 | EBI-18418,EBI-8659 |
GO - Molecular functioni
- Hsp70 protein binding Source: SGD
- Hsp90 protein binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34430, 323 interactors |
DIPi | DIP-2329N |
IntActi | P15705, 31 interactors |
MINTi | P15705 |
STRINGi | 4932.YOR027W |
Miscellaneous databases
RNActi | P15705, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P15705 |
SMRi | P15705 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 5 – 38 | TPR 1Add BLAST | 34 | |
Repeati | 40 – 73 | TPR 2Add BLAST | 34 | |
Repeati | 74 – 107 | TPR 3Add BLAST | 34 | |
Domaini | 138 – 177 | STI1 1Add BLAST | 40 | |
Repeati | 262 – 295 | TPR 4Add BLAST | 34 | |
Repeati | 297 – 328 | TPR 5Add BLAST | 32 | |
Repeati | 336 – 369 | TPR 6Add BLAST | 34 | |
Repeati | 396 – 429 | TPR 7Add BLAST | 34 | |
Repeati | 430 – 463 | TPR 8Add BLAST | 34 | |
Repeati | 465 – 492 | TPR 9Add BLAST | 28 | |
Domaini | 537 – 576 | STI1 2Add BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 199 – 265 | DisorderedSequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 213 – 228 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000170181 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | P15705 |
OMAi | EDPRGYS |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
IDEALi | IID50201 |
InterProi | View protein in InterPro IPR041243, STI1 IPR045248, Sti1-like IPR006636, STI1_HS-bd IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
PANTHERi | PTHR22904, PTHR22904, 1 hit |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF00515, TPR_1, 2 hits PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 4 hits |
i Sequence
Sequence statusi: Complete.
P15705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTADEYKQ QGNAAFTAKD YDKAIELFTK AIEVSETPNH VLYSNRSACY
60 70 80 90 100
TSLKKFSDAL NDANECVKIN PSWSKGYNRL GAAHLGLGDL DEAESNYKKA
110 120 130 140 150
LELDASNKAA KEGLDQVHRT QQARQAQPDL GLTQLFADPN LIENLKKNPK
160 170 180 190 200
TSEMMKDPQL VAKLIGYKQN PQAIGQDLFT DPRLMTIMAT LMGVDLNMDD
210 220 230 240 250
INQSNSMPKE PETSKSTEQK KDAEPQSDST TSKENSSKAP QKEESKESEP
260 270 280 290 300
MEVDEDDSKI EADKEKAEGN KFYKARQFDE AIEHYNKAWE LHKDITYLNN
310 320 330 340 350
RAAAEYEKGE YETAISTLND AVEQGREMRA DYKVISKSFA RIGNAYHKLG
360 370 380 390 400
DLKKTIEYYQ KSLTEHRTAD ILTKLRNAEK ELKKAEAEAY VNPEKAEEAR
410 420 430 440 450
LEGKEYFTKS DWPNAVKAYT EMIKRAPEDA RGYSNRAAAL AKLMSFPEAI
460 470 480 490 500
ADCNKAIEKD PNFVRAYIRK ATAQIAVKEY ASALETLDAA RTKDAEVNNG
510 520 530 540 550
SSAREIDQLY YKASQQRFQP GTSNETPEET YQRAMKDPEV AAIMQDPVMQ
560 570 580
SILQQAQQNP AALQEHMKNP EVFKKIQTLI AAGIIRTGR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28486 Genomic DNA Translation: AAA35121.1 X87331 Genomic DNA Translation: CAA60743.1 Z74935 Genomic DNA Translation: CAA99217.1 BK006948 Genomic DNA Translation: DAA10809.1 |
PIRi | A32567 |
RefSeqi | NP_014670.1, NM_001183446.1 |
Genome annotation databases
EnsemblFungii | YOR027W_mRNA; YOR027W; YOR027W |
GeneIDi | 854192 |
KEGGi | sce:YOR027W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28486 Genomic DNA Translation: AAA35121.1 X87331 Genomic DNA Translation: CAA60743.1 Z74935 Genomic DNA Translation: CAA99217.1 BK006948 Genomic DNA Translation: DAA10809.1 |
PIRi | A32567 |
RefSeqi | NP_014670.1, NM_001183446.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LLV | NMR | - | A | 127-197 | [»] | |
2LLW | NMR | - | A | 519-589 | [»] | |
3UPV | X-ray | 1.60 | A | 395-518 | [»] | |
3UQ3 | X-ray | 2.60 | A | 262-515 | [»] | |
BMRBi | P15705 | |||||
SMRi | P15705 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34430, 323 interactors |
DIPi | DIP-2329N |
IntActi | P15705, 31 interactors |
MINTi | P15705 |
STRINGi | 4932.YOR027W |
PTM databases
iPTMneti | P15705 |
2D gel databases
SWISS-2DPAGEi | P15705 |
Proteomic databases
MaxQBi | P15705 |
PaxDbi | P15705 |
PRIDEi | P15705 |
Genome annotation databases
EnsemblFungii | YOR027W_mRNA; YOR027W; YOR027W |
GeneIDi | 854192 |
KEGGi | sce:YOR027W |
Organism-specific databases
SGDi | S000005553, STI1 |
VEuPathDBi | FungiDB:YOR027W |
Phylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000170181 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | P15705 |
OMAi | EDPRGYS |
Enzyme and pathway databases
Reactomei | R-SCE-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-SCE-9696273, RND1 GTPase cycle |
Miscellaneous databases
PROi | PR:P15705 |
RNActi | P15705, protein |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
IDEALi | IID50201 |
InterProi | View protein in InterPro IPR041243, STI1 IPR045248, Sti1-like IPR006636, STI1_HS-bd IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
PANTHERi | PTHR22904, PTHR22904, 1 hit |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF00515, TPR_1, 2 hits PF13181, TPR_8, 2 hits |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | STI1_YEAST | |
Accessioni | P15705Primary (citable) accession number: P15705 Secondary accession number(s): D6W293 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 212 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references