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UniProtKB - P15699 (AMDR_EMENI)
Protein
Acetamidase regulatory protein
Gene
amdR
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Positively regulates the expression of 5 genes involved in the catabolism of certain amides (amdS), omega amino acids (gatA and gabA), and lactams (lamA and lamB) in the presence of omega amino acid inducers.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 20 – 50 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Acetamidase regulatory protein |
Gene namesi | Name:amdR Synonyms:intA ORF Names:AN4035 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114936 | 1 – 798 | Acetamidase regulatory proteinAdd BLAST | 798 |
Structurei
3D structure databases
AlphaFoldDBi | P15699 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 96 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 115 – 172 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 632 – 714 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 119 – 151 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 639 – 677 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 686 – 714 | Polar residuesSequence analysisAdd BLAST | 29 |
Phylogenomic databases
eggNOGi | ENOG502SIAM, Eukaryota |
HOGENOMi | CLU_006329_4_0_1 |
InParanoidi | P15699 |
OrthoDBi | 917119at2759 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P15699-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSTAHPTNL APSGNGSAAC VHCHRRKVRC DARLVGLPCS NCRSAGKTDC
60 70 80 90 100
QIHEKKKKLA VRSILDPVPI RCRPPNPEEA PKPISSLSPS SEPPNAFTTA
110 120 130 140 150
LRAVQSDITA PSGVANRVAH IRSRSSQYDT KGTRSNNNSG NNTQYQNVLP
160 170 180 190 200
EPDSPPYSRP AASDPSEGES RADIEKRLVN LIDGEASDSR AIQRGVRAIY
210 220 230 240 250
VGHELSNMSF LIRQQRDTGD DVYHFAGNEI PRRQLRTGHD QLLMDALTLP
260 270 280 290 300
EPALADELVH AYFAQVNPGY PIVEEELFMS QYRNRDPADA PPILLLQTIL
310 320 330 340 350
LVGAHVTRPK SERDTLKDIF FRRAKWLFDN RIERNRDILV QAALLLTWHS
360 370 380 390 400
DLADDDVSAN AHYWIGIAAR IATGLGMHRN PVCSRFVPRD RRMWRRLWYI
410 420 430 440 450
LVQFDVMVSL SYGRPQALNL EDSDVSPLTF SDFEGCGARV QADFVIHFSE
460 470 480 490 500
LCTMISYIVR ERFGLRISAE RRKAALLEAD EALANWSLRL PDRLRLRASD
510 520 530 540 550
MDPWSAMLHL TYNNFLILLH RPHPRASAYS DDYGPHDAEI CSAAAGVIAS
560 570 580 590 600
IFEELRIHDR LKQVWYSGVH TLFTAMIQVR VELRFSNPVL AINALRRFDS
610 620 630 640 650
ASYSLRELAQ YWSHASTILR LFEESRRLQE DLRTTTSDRP RRFSNLSNNS
660 670 680 690 700
TNSPASQQKN TSGIPHLANI NSSDATPPSA PSIPPLQPSS QLSYEVPTTE
710 720 730 740 750
SAHHNPRSQP TLSAHTHTYT TQPFDTWIPS NNLTPMDTVD NSREMLDWRQ
760 770 780 790
LFSFTDLEGP VLPSTMEGIT ELEDEWRQIY WQETPMSDLL QDGGWMHG
Sequence cautioni
The sequence AAA33294 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CBF74839 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA59506 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 563 – 564 | QV → LL in EAA59506 (PubMed:2188110).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31517 Genomic DNA Translation: AAA33294.1 Sequence problems. AACD01000065 Genomic DNA Translation: EAA59506.1 Sequence problems. BN001302 Genomic DNA Translation: CBF74839.1 Sequence problems. |
PIRi | A36332 |
RefSeqi | XP_661639.1, XM_656547.1 |
Genome annotation databases
EnsemblFungii | EAA59506; EAA59506; AN4035.2 |
GeneIDi | 2873450 |
KEGGi | ani:AN4035.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31517 Genomic DNA Translation: AAA33294.1 Sequence problems. AACD01000065 Genomic DNA Translation: EAA59506.1 Sequence problems. BN001302 Genomic DNA Translation: CBF74839.1 Sequence problems. |
PIRi | A36332 |
RefSeqi | XP_661639.1, XM_656547.1 |
3D structure databases
AlphaFoldDBi | P15699 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00004647 |
Genome annotation databases
EnsemblFungii | EAA59506; EAA59506; AN4035.2 |
GeneIDi | 2873450 |
KEGGi | ani:AN4035.2 |
Phylogenomic databases
eggNOGi | ENOG502SIAM, Eukaryota |
HOGENOMi | CLU_006329_4_0_1 |
InParanoidi | P15699 |
OrthoDBi | 917119at2759 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AMDR_EMENI | |
Accessioni | P15699Primary (citable) accession number: P15699 Secondary accession number(s): C8V5M9, Q5B5Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | May 26, 2009 | |
Last modified: | May 25, 2022 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |