UniProtKB - P15692 (VEGFA_HUMAN)
Vascular endothelial growth factor A
VEGFA
Functioni
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).
By similarity4 PublicationsGO - Molecular functioni
- chemoattractant activity Source: UniProtKB
- cytokine activity Source: BHF-UCL
- extracellular matrix binding Source: BHF-UCL
- fibronectin binding Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- heparin binding Source: UniProtKB
- identical protein binding Source: IntAct
- neuropilin binding Source: BHF-UCL
- platelet-derived growth factor receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
- vascular endothelial growth factor receptor 1 binding Source: BHF-UCL
- vascular endothelial growth factor receptor 2 binding Source: UniProtKB
- vascular endothelial growth factor receptor binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: BHF-UCL
- angiogenesis Source: UniProtKB
- artery morphogenesis Source: BHF-UCL
- basophil chemotaxis Source: UniProtKB
- branching involved in blood vessel morphogenesis Source: BHF-UCL
- camera-type eye morphogenesis Source: BHF-UCL
- cardiac muscle cell development Source: BHF-UCL
- cardiac vascular smooth muscle cell development Source: BHF-UCL
- cell maturation Source: BHF-UCL
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- cellular response to hypoxia Source: MGI
- cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
- cellular stress response to acid chemical Source: BHF-UCL
- commissural neuron axon guidance Source: BHF-UCL
- coronary artery morphogenesis Source: BHF-UCL
- coronary vein morphogenesis Source: BHF-UCL
- dopaminergic neuron differentiation Source: BHF-UCL
- endothelial cell chemotaxis Source: BHF-UCL
- epithelial cell differentiation Source: BHF-UCL
- eye photoreceptor cell development Source: BHF-UCL
- heart morphogenesis Source: BHF-UCL
- induction of positive chemotaxis Source: UniProtKB
- in utero embryonic development Source: BHF-UCL
- kidney development Source: BHF-UCL
- lactation Source: BHF-UCL
- lung development Source: BHF-UCL
- lymph vessel morphogenesis Source: BHF-UCL
- macrophage differentiation Source: DFLAT
- mammary gland alveolus development Source: BHF-UCL
- mesoderm development Source: BHF-UCL
- monocyte differentiation Source: DFLAT
- motor neuron migration Source: UniProtKB
- negative regulation of adherens junction organization Source: ARUK-UCL
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of blood-brain barrier permeability Source: ARUK-UCL
- negative regulation of cell-cell adhesion mediated by cadherin Source: ARUK-UCL
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of establishment of endothelial barrier Source: ARUK-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- nervous system development Source: UniProtKB
- outflow tract morphogenesis Source: BHF-UCL
- ovarian follicle development Source: BHF-UCL
- positive chemotaxis Source: BHF-UCL
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of axon extension involved in axon guidance Source: BHF-UCL
- positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: ARUK-UCL
- positive regulation of branching involved in ureteric bud morphogenesis Source: BHF-UCL
- positive regulation of cell adhesion Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
- positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of cellular component movement Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of CREB transcription factor activity Source: BHF-UCL
- positive regulation of DNA biosynthetic process Source: UniProtKB
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of endothelial cell migration Source: BHF-UCL
- positive regulation of endothelial cell proliferation Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: BHF-UCL
- positive regulation of epithelial tube formation Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of focal adhesion assembly Source: UniProtKB
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of histone deacetylase activity Source: BHF-UCL
- positive regulation of leukocyte migration Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of mast cell chemotaxis Source: UniProtKB
- positive regulation of neuroblast proliferation Source: BHF-UCL
- positive regulation of p38MAPK cascade Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine autophosphorylation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of phosphorylation Source: BHF-UCL
- positive regulation of positive chemotaxis Source: BHF-UCL
- positive regulation of protein autophosphorylation Source: BHF-UCL
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of protein kinase B signaling Source: BHF-UCL
- positive regulation of protein kinase C signaling Source: BHF-UCL
- positive regulation of protein kinase D signaling Source: BHF-UCL
- positive regulation of protein localization to early endosome Source: BHF-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of receptor internalization Source: BHF-UCL
- positive regulation of retinal ganglion cell axon guidance Source: BHF-UCL
- positive regulation of sprouting angiogenesis Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: BHF-UCL
- positive regulation of trophoblast cell migration Source: BHF-UCL
- positive regulation of vascular permeability Source: ARUK-UCL
- post-embryonic camera-type eye development Source: BHF-UCL
- primitive erythrocyte differentiation Source: BHF-UCL
- regulation of cell shape Source: BHF-UCL
- regulation of nitric oxide mediated signal transduction Source: MGI
- regulation of retinal ganglion cell axon guidance Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- response to hypoxia Source: UniProtKB
- sprouting angiogenesis Source: GO_Central
- surfactant homeostasis Source: BHF-UCL
- tube formation Source: UniProtKB
- vascular endothelial growth factor receptor-2 signaling pathway Source: BHF-UCL
- vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
- vascular endothelial growth factor signaling pathway Source: UniProtKB
- vascular wound healing Source: BHF-UCL
- vasculogenesis Source: UniProtKB
- VEGF-activated neuropilin signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, Growth factor, Heparin-binding, Mitogen |
Biological process | Angiogenesis, Differentiation |
Enzyme and pathway databases
PathwayCommonsi | P15692 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1234158, Regulation of gene expression by Hypoxia-inducible Factor R-HSA-194138, Signaling by VEGF R-HSA-194313, VEGF ligand-receptor interactions R-HSA-195399, VEGF binds to VEGFR leading to receptor dimerization R-HSA-4420097, VEGFA-VEGFR2 Pathway [P15692-4] R-HSA-5218921, VEGFR2 mediated cell proliferation [P15692-4] R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-9679191, Potential therapeutics for SARS [P15692-4] |
SignaLinki | P15692 |
SIGNORi | P15692 |
Protein family/group databases
MoonDBi | P15692, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular endothelial growth factor AShort name: VEGF-A Alternative name(s): Vascular permeability factor Short name: VPF |
Gene namesi | Name:VEGFA Synonyms:VEGF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12680, VEGFA |
MIMi | 192240, gene |
neXtProti | NX_P15692 |
VEuPathDBi | HostDB:ENSG00000112715 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Note: VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Other locations
- adherens junction Source: ARUK-UCL
- cell surface Source: BHF-UCL
- cytoplasm Source: UniProtKB
- extracellular matrix Source: UniProtKB
- membrane Source: InterPro
- platelet alpha granule lumen Source: Reactome
- secretory granule Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Microvascular complications of diabetes 1 (MVCD1)1 Publication
Organism-specific databases
DisGeNETi | 7422 |
MalaCardsi | VEGFA |
MIMi | 603933, phenotype |
OpenTargetsi | ENSG00000112715 |
PharmGKBi | PA37302 |
Miscellaneous databases
Pharosi | P15692, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1783 |
DrugBanki | DB05434, ABT-510 DB08885, Aflibercept DB00112, Bevacizumab DB06642, Bevasiranib DB14864, Brolucizumab DB01136, Carvedilol DB09301, Chondroitin sulfate DB06779, Dalteparin DB05932, Denibulin DB15303, Faricimab DB10772, Foreskin keratinocyte (neonatal) DB01120, Gliclazide DB01017, Minocycline DB04895, Pegaptanib DB03088, Pidolic acid DB01270, Ranibizumab DB05969, SNS-032 DB05294, Vandetanib DB05890, Veglin |
DrugCentrali | P15692 |
Genetic variation databases
BioMutai | VEGFA |
DMDMi | 17380528 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 2 PublicationsAdd BLAST | 26 | |
ChainiPRO_0000023386 | 27 – 232 | Vascular endothelial growth factor AAdd BLAST | 206 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 52 ↔ 94 | |||
Disulfide bondi | 77 | Interchain | ||
Disulfide bondi | 83 ↔ 128 | |||
Disulfide bondi | 86 | Interchain | ||
Disulfide bondi | 87 ↔ 130 | |||
Glycosylationi | 101 | N-linked (GlcNAc...) asparagine | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P15692 |
MassIVEi | P15692 |
PaxDbi | P15692 |
PeptideAtlasi | P15692 |
PRIDEi | P15692 |
ProteomicsDBi | 34350 34645 34652 34682 35749 40743 53195 [P15692-1] 53196 [P15692-10] 53197 [P15692-11] 53198 [P15692-12] 53199 [P15692-13] 53200 [P15692-14] 53201 [P15692-2] 53202 [P15692-3] 53203 [P15692-4] 53204 [P15692-5] 53205 [P15692-6] 53206 [P15692-8] 53207 [P15692-9] |
PTM databases
GlyGeni | P15692, 1 site |
iPTMneti | P15692 |
PhosphoSitePlusi | P15692 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000112715, Expressed in left lobe of thyroid gland and 240 other tissues |
ExpressionAtlasi | P15692, baseline and differential |
Genevisiblei | P15692, HS |
Organism-specific databases
HPAi | ENSG00000112715, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P15692
With | #Exp. | IntAct |
---|---|---|
FLT1 [P17948] | 4 | EBI-1026643,EBI-1026718 |
KDR [P35968] | 6 | EBI-1026643,EBI-1005487 |
NRP1 [O14786] | 4 | EBI-1026643,EBI-1187100 |
itself | 10 | EBI-1026643,EBI-1026643 |
VEGFA - isoform VEGF165 [P15692-4]
With | #Exp. | IntAct |
---|---|---|
FLT1 [P17948] | 3 | EBI-1026691,EBI-1026718 |
KDR [P35968] | 8 | EBI-1026691,EBI-1005487 |
NRP1 - isoform 2 [O14786-2] | 4 | EBI-1026691,EBI-6285281 |
itself | 5 | EBI-1026691,EBI-1026691 |
Isoform L-VEGF121 [P15692-12]
GO - Molecular functioni
- chemoattractant activity Source: UniProtKB
- cytokine activity Source: BHF-UCL
- fibronectin binding Source: BHF-UCL
- growth factor activity Source: BHF-UCL
- identical protein binding Source: IntAct
- neuropilin binding Source: BHF-UCL
- platelet-derived growth factor receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- receptor ligand activity Source: BHF-UCL
- vascular endothelial growth factor receptor 1 binding Source: BHF-UCL
- vascular endothelial growth factor receptor 2 binding Source: UniProtKB
- vascular endothelial growth factor receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113265, 62 interactors |
ComplexPortali | CPX-1977, Vascular endothelial growth factor A complex |
CORUMi | P15692 |
DIPi | DIP-5740N |
IntActi | P15692, 24 interactors |
MINTi | P15692 |
STRINGi | 9606.ENSP00000478570 |
Chemistry databases
BindingDBi | P15692 |
Miscellaneous databases
RNActi | P15692, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P15692 |
BMRBi | P15692 |
SMRi | P15692 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15692 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 161 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 145 – 161 | Basic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QVI8, Eukaryota |
GeneTreei | ENSGT00940000157284 |
HOGENOMi | CLU_042996_3_0_1 |
InParanoidi | P15692 |
OMAi | NCAERRK |
PhylomeDBi | P15692 |
Family and domain databases
CDDi | cd00135, PDGF, 1 hit |
Gene3Di | 2.10.160.10, 1 hit 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR023581, PD_growth_factor_CS IPR000072, PDGF/VEGF_dom IPR027928, VEGF_C IPR036841, VEGF_C_sf |
Pfami | View protein in Pfam PF00341, PDGF, 1 hit PF14554, VEGF_C, 1 hit |
SMARTi | View protein in SMART SM00141, PDGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit SSF57593, SSF57593, 1 hit |
PROSITEi | View protein in PROSITE PS00249, PDGF_1, 1 hit PS50278, PDGF_2, 1 hit |
s (17+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 17 produced by isoformsialternative promoter usage, alternative splicing and alternative initiation. AlignAdd to basketThis entry has 17 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGGQNHHEV VKFMDVYQRS
60 70 80 90 100
YCHPIETLVD IFQEYPDEIE YIFKPSCVPL MRCGGCCNDE GLECVPTEES
110 120 130 140 150
NITMQIMRIK PHQGQHIGEM SFLQHNKCEC RPKKDRARQE KKSVRGKGKG
160 170 180 190 200
QKRKRKKSRY KSWSVYVGAR CCLMPWSLPG PHPCGPCSER RKHLFVQDPQ
210 220 230
TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR
The sequence of this isoform differs from the canonical sequence as follows:
166-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
160-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
141-141: K → N
142-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
141-141: K → N
142-182: Missing.
215-215: A → M
216-232: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
166-226: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
141-141: K → N
142-182: Missing.
227-232: CDKPRR → SLTRKD
The sequence of this isoform differs from the canonical sequence as follows:
142-226: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
132-226: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
141-141: K → N
142-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
142-226: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
166-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
141-182: KKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPH → N
227-232: CDKPRR → SLTRKD
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
160-182: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
141-182: KKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPH → N
215-215: A → M
216-232: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTDRQTDTAP...AGPGRASETM
132-226: Missing.
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPA4 | J3KPA4_HUMAN | Vascular endothelial growth factor ... | VEGFA | 412 | Annotation score: | ||
A0A0A0MSI7 | A0A0A0MSI7_HUMAN | Vascular endothelial growth factor ... | VEGFA | 389 | Annotation score: | ||
A0A0A0MSH5 | A0A0A0MSH5_HUMAN | Vascular endothelial growth factor ... | VEGFA | 395 | Annotation score: | ||
H3BLW8 | H3BLW8_HUMAN | Vascular endothelial growth factor ... | VEGFA | 371 | Annotation score: | ||
A0A0A0MSH7 | A0A0A0MSH7_HUMAN | Vascular endothelial growth factor ... | VEGFA | 354 | Annotation score: | ||
A0A0A0MTB2 | A0A0A0MTB2_HUMAN | Vascular endothelial growth factor ... | VEGFA | 371 | Annotation score: | ||
A0A5F9ZH41 | A0A5F9ZH41_HUMAN | Vascular endothelial growth factor ... | VEGFA | 393 | Annotation score: | ||
A2A2V4 | A2A2V4_HUMAN | Vascular endothelial growth factor ... | VEGFA | 163 | Annotation score: | ||
H0YBI8 | H0YBI8_HUMAN | Vascular endothelial growth factor ... | VEGFA | 111 | Annotation score: | ||
H0YBZ0 | H0YBZ0_HUMAN | Vascular endothelial growth factor ... | VEGFA | 323 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 87 | C → S in AAC63143 (PubMed:9450968).Curated | 1 | |
Sequence conflicti | 210 | D → H in AAC63143 (PubMed:9450968).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038745 | 1 | M → MTDRQTDTAPSPSYHLLPGR RRTVDAAASRGQGPEPAPGG GVEGVGARGVALKLFVQLLG CSRFGGAVVRAGEAEPSGAA RSASSGREEPQPEEGEEEEE KEEERGPQWRLGARKPGSWT GEAAVCADSAPAARAPQALA RASGRGGRVARRGAEESGPP HSPSRRGSASRAGPGRASET M in isoform L-VEGF165, isoform L-VEGF121, isoform L-VEGF189, isoform L-VEGF206, isoform 15, isoform 16, isoform 17 and isoform 18. 1 Publication | 1 | |
Alternative sequenceiVSP_026781 | 132 – 226 | Missing in isoform VEGF111 and isoform 18. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_054111 | 141 – 182 | KKSVR…LPGPH → N in isoform 15 and isoform 17. CuratedAdd BLAST | 42 | |
Alternative sequenceiVSP_004618 | 141 | K → N in isoform VEGF148, isoform VEGF165, isoform VEGF165B and isoform L-VEGF165. 10 Publications | 1 | |
Alternative sequenceiVSP_004620 | 142 – 226 | Missing in isoform VEGF121 and isoform L-VEGF121. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_004619 | 142 – 182 | Missing in isoform VEGF148, isoform VEGF165, isoform VEGF165B and isoform L-VEGF165. 10 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_004621 | 160 – 182 | Missing in isoform VEGF183 and isoform 16. 2 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_004623 | 166 – 226 | Missing in isoform VEGF145. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_004622 | 166 – 182 | Missing in isoform VEGF189 and isoform L-VEGF189. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_004624 | 215 | A → M in isoform VEGF148 and isoform 17. 1 Publication | 1 | |
Alternative sequenceiVSP_004625 | 216 – 232 | Missing in isoform VEGF148 and isoform 17. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_014783 | 227 – 232 | CDKPRR → SLTRKD in isoform VEGF165B and isoform 15. 1 Publication | 6 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative initiation, Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia VEGF entry |
SeattleSNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BJ1 | X-ray | 2.40 | V/W | 34-135 | [»] | |
1CZ8 | X-ray | 2.40 | V/W | 40-133 | [»] | |
1FLT | X-ray | 1.70 | V/W | 38-135 | [»] | |
1KAT | NMR | - | V/W | 37-135 | [»] | |
1KMX | NMR | - | A | 183-232 | [»] | |
1MJV | X-ray | 2.10 | A/B | 40-134 | [»] | |
1MKG | X-ray | 2.50 | A/B/C/D | 40-134 | [»] | |
1MKK | X-ray | 1.32 | A/B | 40-134 | [»] | |
1QTY | X-ray | 2.70 | R/S/V/W | 34-135 | [»] | |
1TZH | X-ray | 2.60 | V/W | 34-135 | [»] | |
1TZI | X-ray | 2.80 | V | 34-135 | [»] | |
1VGH | NMR | - | A | 180-232 | [»] | |
1VPF | X-ray | 2.50 | A/B/C/D | 34-135 | [»] | |
1VPP | X-ray | 1.90 | V/W | 34-135 | [»] | |
2FJG | X-ray | 2.80 | V/W | 34-135 | [»] | |
2FJH | X-ray | 3.10 | V/W | 34-135 | [»] | |
2QR0 | X-ray | 3.50 | C/D/I/J/O/P/U/V | 39-135 | [»] | |
2VGH | NMR | - | A | 182-232 | [»] | |
2VPF | X-ray | 1.93 | A/B/C/D/E/F/G/H | 34-135 | [»] | |
3BDY | X-ray | 2.60 | V | 34-135 | [»] | |
3P9W | X-ray | 2.41 | A/C/E/G | 35-138 | [»] | |
3QTK | X-ray | 1.85 | A/B/C/D/E/F | 34-135 | [»] | |
3S1B | X-ray | 2.90 | V | 38-133 | [»] | |
3S1K | X-ray | 2.55 | V/W | 34-135 | [»] | |
3V2A | X-ray | 3.20 | A | 27-140 | [»] | |
4DEQ | X-ray | 2.65 | A/B | 183-232 | [»] | |
4GLN | X-ray | 1.60 | E/F | 34-135 | [»] | |
4GLS | X-ray | 1.60 | E/F | 34-135 | [»] | |
4KZN | X-ray | 1.71 | A | 39-135 | [»] | |
4QAF | X-ray | 1.80 | C/D | 34-135 | [»] | |
4WPB | X-ray | 3.11 | A/B | 34-135 | [»] | |
4ZFF | X-ray | 2.75 | C/D | 37-135 | [»] | |
5DN2 | X-ray | 1.95 | E/F/G | 205-232 | [»] | |
5FV1 | X-ray | 2.70 | V/W | 27-136 | [»] | |
5FV2 | X-ray | 3.45 | V/W/X | 27-136 | [»] | |
5HHC | X-ray | 2.10 | A/B | 34-135 | [»] | |
5HHD | X-ray | 2.10 | A/B | 34-135 | [»] | |
5O4E | X-ray | 2.15 | E/F | 39-134 | [»] | |
5T89 | X-ray | 4.00 | V/W | 27-155 | [»] | |
6BFT | X-ray | 2.55 | C/G | 36-135 | [»] | |
6D3O | X-ray | 3.10 | A/B | 34-135 | [»] | |
6T9D | X-ray | 2.90 | CCC/DDD | 27-141 | [»] | |
6V7K | X-ray | 2.50 | A/B | 34-135 | [»] | |
6Z13 | X-ray | 1.80 | V/W | 39-133 | [»] | |
6Z3F | X-ray | 2.10 | V/W | 39-133 | [»] | |
6ZBR | X-ray | 1.60 | V/W | 39-133 | [»] | |
6ZCD | X-ray | 1.80 | V/W | 39-133 | [»] | |
6ZFL | X-ray | 1.60 | V/W | 39-133 | [»] | |
7KEZ | X-ray | 2.31 | V | 27-136 | [»] | |
7KF0 | X-ray | 2.32 | C/V | 27-136 | [»] | |
7KF1 | X-ray | 2.45 | C/F/J/V | 27-136 | [»] | |
7LL8 | X-ray | 2.31 | A/B | 34-135 | [»] | |
7LL9 | X-ray | 2.90 | A/B/E/F | 34-135 | [»] | |
AlphaFoldDBi | P15692 | |||||
BMRBi | P15692 | |||||
SMRi | P15692 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113265, 62 interactors |
ComplexPortali | CPX-1977, Vascular endothelial growth factor A complex |
CORUMi | P15692 |
DIPi | DIP-5740N |
IntActi | P15692, 24 interactors |
MINTi | P15692 |
STRINGi | 9606.ENSP00000478570 |
Chemistry databases
BindingDBi | P15692 |
ChEMBLi | CHEMBL1783 |
DrugBanki | DB05434, ABT-510 DB08885, Aflibercept DB00112, Bevacizumab DB06642, Bevasiranib DB14864, Brolucizumab DB01136, Carvedilol DB09301, Chondroitin sulfate DB06779, Dalteparin DB05932, Denibulin DB15303, Faricimab DB10772, Foreskin keratinocyte (neonatal) DB01120, Gliclazide DB01017, Minocycline DB04895, Pegaptanib DB03088, Pidolic acid DB01270, Ranibizumab DB05969, SNS-032 DB05294, Vandetanib DB05890, Veglin |
DrugCentrali | P15692 |
Protein family/group databases
MoonDBi | P15692, Predicted |
PTM databases
GlyGeni | P15692, 1 site |
iPTMneti | P15692 |
PhosphoSitePlusi | P15692 |
Genetic variation databases
BioMutai | VEGFA |
DMDMi | 17380528 |
Proteomic databases
jPOSTi | P15692 |
MassIVEi | P15692 |
PaxDbi | P15692 |
PeptideAtlasi | P15692 |
PRIDEi | P15692 |
ProteomicsDBi | 34350 34645 34652 34682 35749 40743 53195 [P15692-1] 53196 [P15692-10] 53197 [P15692-11] 53198 [P15692-12] 53199 [P15692-13] 53200 [P15692-14] 53201 [P15692-2] 53202 [P15692-3] 53203 [P15692-4] 53204 [P15692-5] 53205 [P15692-6] 53206 [P15692-8] 53207 [P15692-9] |
Protocols and materials databases
ABCDi | P15692, 25 sequenced antibodies |
Antibodypediai | 3956, 2774 antibodies from 55 providers |
CPTCi | P15692, 1 antibody |
DNASUi | 7422 |
Genome annotation databases
Organism-specific databases
CTDi | 7422 |
DisGeNETi | 7422 |
GeneCardsi | VEGFA |
HGNCi | HGNC:12680, VEGFA |
HPAi | ENSG00000112715, Low tissue specificity |
MalaCardsi | VEGFA |
MIMi | 192240, gene 603933, phenotype |
neXtProti | NX_P15692 |
OpenTargetsi | ENSG00000112715 |
PharmGKBi | PA37302 |
VEuPathDBi | HostDB:ENSG00000112715 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVI8, Eukaryota |
GeneTreei | ENSGT00940000157284 |
HOGENOMi | CLU_042996_3_0_1 |
InParanoidi | P15692 |
OMAi | NCAERRK |
PhylomeDBi | P15692 |
Enzyme and pathway databases
PathwayCommonsi | P15692 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-1234158, Regulation of gene expression by Hypoxia-inducible Factor R-HSA-194138, Signaling by VEGF R-HSA-194313, VEGF ligand-receptor interactions R-HSA-195399, VEGF binds to VEGFR leading to receptor dimerization R-HSA-4420097, VEGFA-VEGFR2 Pathway [P15692-4] R-HSA-5218921, VEGFR2 mediated cell proliferation [P15692-4] R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-9679191, Potential therapeutics for SARS [P15692-4] |
SignaLinki | P15692 |
SIGNORi | P15692 |
Miscellaneous databases
BioGRID-ORCSi | 7422, 13 hits in 1082 CRISPR screens |
ChiTaRSi | VEGFA, human |
EvolutionaryTracei | P15692 |
GeneWikii | Vascular_endothelial_growth_factor_A |
GenomeRNAii | 7422 |
Pharosi | P15692, Tclin |
PROi | PR:P15692 |
RNActi | P15692, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112715, Expressed in left lobe of thyroid gland and 240 other tissues |
ExpressionAtlasi | P15692, baseline and differential |
Genevisiblei | P15692, HS |
Family and domain databases
CDDi | cd00135, PDGF, 1 hit |
Gene3Di | 2.10.160.10, 1 hit 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR023581, PD_growth_factor_CS IPR000072, PDGF/VEGF_dom IPR027928, VEGF_C IPR036841, VEGF_C_sf |
Pfami | View protein in Pfam PF00341, PDGF, 1 hit PF14554, VEGF_C, 1 hit |
SMARTi | View protein in SMART SM00141, PDGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit SSF57593, SSF57593, 1 hit |
PROSITEi | View protein in PROSITE PS00249, PDGF_1, 1 hit PS50278, PDGF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VEGFA_HUMAN | |
Accessioni | P15692Primary (citable) accession number: P15692 Secondary accession number(s): B5BU86 Q9UL23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | November 16, 2001 | |
Last modified: | May 25, 2022 | |
This is version 258 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families