UniProtKB - P15656 (FGF5_MOUSE)
Fibroblast growth factor 5
Fgf5
Functioni
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: MGI
- growth factor activity Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- cell population proliferation Source: MGI
- fibroblast growth factor receptor signaling pathway Source: MGI
- glial cell differentiation Source: MGI
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: MGI
- positive regulation of gene expression Source: GO_Central
- positive regulation of protein phosphorylation Source: GO_Central
- regulation of cell migration Source: GO_Central
- signal transduction involved in regulation of gene expression Source: MGI
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-190372, FGFR3c ligand binding and activation R-MMU-190373, FGFR1c ligand binding and activation R-MMU-190375, FGFR2c ligand binding and activation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654687, Downstream signaling of activated FGFR1 R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5658623, FGFRL1 modulation of FGFR1 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 5Short name: FGF-5 Alternative name(s): Heparin-binding growth factor 5 Short name: HBGF-5 |
Gene namesi | Name:Fgf5 Synonyms:Fgf-5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95519, Fgf5 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000008959 | 21 – 264 | Fibroblast growth factor 5Add BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P15656 |
PRIDEi | P15656 |
ProteomicsDBi | 271751 [P15656-1] 271752 [P15656-2] |
PTM databases
GlyGeni | P15656, 1 site |
iPTMneti | P15656 |
PhosphoSitePlusi | P15656 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029337, Expressed in embryo and 102 other tissues |
Genevisiblei | P15656, MM |
Interactioni
Subunit structurei
Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
By similarityGO - Molecular functioni
- fibroblast growth factor receptor binding Source: MGI
- growth factor activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031280 |
Miscellaneous databases
RNActi | P15656, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 59 | Poly-Ser | 7 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000158449 |
HOGENOMi | CLU_081609_7_0_1 |
InParanoidi | P15656 |
OMAi | EWFVALN |
OrthoDBi | 1157770at2759 |
PhylomeDBi | P15656 |
TreeFami | TF317805 |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028240, FGF5 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF23, PTHR11486:SF23, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLSLLFLIF CSHLIHSAWA HGEKRLTPEG QPAPPRNPGD SSGSRGRSSA
60 70 80 90 100
TFSSSSASSP VAASPGSQGS GSEHSSFQWS PSGRRTGSLY CRVGIGFHLQ
110 120 130 140 150
IYPDGKVNGS HEASVLSILE IFAVSQGIVG IRGVFSNKFL AMSKKGKLHA
160 170 180 190 200
SAKFTDDCKF RERFQENSYN TYASAIHRTE KTGREWYVAL NKRGKAKRGC
210 220 230 240 250
SPRVKPQHVS THFLPRFKQS EQPELSFTVT VPEKKKPPVK PKVPLSQPRR
260
SPSPVKYRLK FRFG
The sequence of this isoform differs from the canonical sequence as follows:
118-121: ILEI → QIYG
122-264: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001520 | 118 – 121 | ILEI → QIYG in isoform Short. 1 Publication | 4 | |
Alternative sequenceiVSP_001521 | 122 – 264 | Missing in isoform Short. 1 PublicationAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30643 mRNA Translation: AAA96698.1 M37823, M37821, M37822 Genomic DNA Translation: AAB02660.1 M37821 Genomic DNA Translation: AAB02659.1 Sequence problems. AB016516 mRNA Translation: BAA33737.1 AK028694 mRNA Translation: BAC26069.1 AK028894 mRNA Translation: BAC26179.1 BC071227 mRNA Translation: AAH71227.1 |
CCDSi | CCDS19455.1 [P15656-1] CCDS80344.1 [P15656-2] |
PIRi | A36207 B36207 |
RefSeqi | NP_001264197.1, NM_001277268.1 [P15656-2] NP_034333.1, NM_010203.5 [P15656-1] |
Genome annotation databases
Ensembli | ENSMUST00000031280; ENSMUSP00000031280; ENSMUSG00000029337 [P15656-1] ENSMUST00000200059; ENSMUSP00000142420; ENSMUSG00000029337 [P15656-2] |
GeneIDi | 14176 |
KEGGi | mmu:14176 |
UCSCi | uc008ygc.2, mouse [P15656-1] uc008ygd.2, mouse [P15656-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30643 mRNA Translation: AAA96698.1 M37823, M37821, M37822 Genomic DNA Translation: AAB02660.1 M37821 Genomic DNA Translation: AAB02659.1 Sequence problems. AB016516 mRNA Translation: BAA33737.1 AK028694 mRNA Translation: BAC26069.1 AK028894 mRNA Translation: BAC26179.1 BC071227 mRNA Translation: AAH71227.1 |
CCDSi | CCDS19455.1 [P15656-1] CCDS80344.1 [P15656-2] |
PIRi | A36207 B36207 |
RefSeqi | NP_001264197.1, NM_001277268.1 [P15656-2] NP_034333.1, NM_010203.5 [P15656-1] |
3D structure databases
SMRi | P15656 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031280 |
PTM databases
GlyGeni | P15656, 1 site |
iPTMneti | P15656 |
PhosphoSitePlusi | P15656 |
Proteomic databases
PaxDbi | P15656 |
PRIDEi | P15656 |
ProteomicsDBi | 271751 [P15656-1] 271752 [P15656-2] |
Protocols and materials databases
Antibodypediai | 4148, 290 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000031280; ENSMUSP00000031280; ENSMUSG00000029337 [P15656-1] ENSMUST00000200059; ENSMUSP00000142420; ENSMUSG00000029337 [P15656-2] |
GeneIDi | 14176 |
KEGGi | mmu:14176 |
UCSCi | uc008ygc.2, mouse [P15656-1] uc008ygd.2, mouse [P15656-2] |
Organism-specific databases
CTDi | 2250 |
MGIi | MGI:95519, Fgf5 |
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000158449 |
HOGENOMi | CLU_081609_7_0_1 |
InParanoidi | P15656 |
OMAi | EWFVALN |
OrthoDBi | 1157770at2759 |
PhylomeDBi | P15656 |
TreeFami | TF317805 |
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-190372, FGFR3c ligand binding and activation R-MMU-190373, FGFR1c ligand binding and activation R-MMU-190375, FGFR2c ligand binding and activation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654687, Downstream signaling of activated FGFR1 R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5658623, FGFRL1 modulation of FGFR1 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
BioGRID-ORCSi | 14176, 0 hits in 52 CRISPR screens |
ChiTaRSi | Fgf5, mouse |
PROi | PR:P15656 |
RNActi | P15656, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029337, Expressed in embryo and 102 other tissues |
Genevisiblei | P15656, MM |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028240, FGF5 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF23, PTHR11486:SF23, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF5_MOUSE | |
Accessioni | P15656Primary (citable) accession number: P15656 Secondary accession number(s): O88825 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families