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Entry version 182 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

FRS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 5440 molecules/cell in log phase SD medium.1 Publication

Caution

Was originally erroneously assigned as an alpha subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32214-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRS1
Ordered Locus Names:YLR060W
ORF Names:L2165
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004050, FRS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLR060W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001270232 – 595Phenylalanine--tRNA ligase beta subunitAdd BLAST594

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15624

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15624

PRoteomics IDEntifications database

More...
PRIDEi
P15624

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P15624

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15624

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer of two alpha and two beta subunits.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31335, 233 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1738, Phenylalanyl-tRNA synthetase complex

Database of interacting proteins

More...
DIPi
DIP-6746N

Protein interaction database and analysis system

More...
IntActi
P15624, 6 interactors

Molecular INTeraction database

More...
MINTi
P15624

STRING: functional protein association networks

More...
STRINGi
4932.YLR060W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P15624, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15624

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 370B5PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni86 – 90CCA binding of tRNASequence analysis5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2472, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020279_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15624

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPGRCAN

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00769, PheRS_beta_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR004531, Phe-tRNA-synth_IIc_bsu_arc_euk
IPR020825, Phe-tRNA_synthase-like_B3/B4
IPR041616, PheRS_beta_core
IPR040659, PhetRS_B1
IPR005147, tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF18262, PhetRS_B1, 1 hit
PF17759, tRNA_synthFbeta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955, SSF46955, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00471, pheT_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483, B5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTVSVNKQQ LFDLLGKNYT SQEFDELCFE FGMEMDEDTT EEALKTGEEP
60 70 80 90 100
ELKLDISANR YDLLCIEGIS QSLNEYLERK ERPDYKLSKP TTKLIIDKST
110 120 130 140 150
EQIRPFATAA VLRNIKLNEK SYASFIALQD KLHANLCRNR SLVAMGTHDL
160 170 180 190 200
DSIEGPFHYR ALPPKDIKFV PLNQTQEFTG DKLIEFYKSP EQKNNIGRYV
210 220 230 240 250
HIIEDSPVFP VIMDSKDRVC SLPPLINSEH SKISVNTRNI LIDITATDKT
260 270 280 290 300
KAEIVLNILT TMFSRYCDEP FTVEPVEIVS EHNGQSRLAP NFNDRIMDVS
310 320 330 340 350
IKYINSCLGL DQSADEIAHC LKKMSLHAVQ SKEDKDILHV DIPVTRPDIL
360 370 380 390 400
HACDIMEDAA VGYGFNNLPK GEKLSNANFI AKPLPINKVS DIFRVASSQA
410 420 430 440 450
TWVEVLPLTL CSHDENFKFL RQSDNGDLAV KLANPKTLEY QVVRTTLLPG
460 470 480 490 500
ILKTVKENRK HSLPIKVFET GDVVFKDDKL ERKAYNERHW AAIYVGKNSG
510 520 530 540 550
FEIIQGLLGK IMQTFRTEWI ADYGAAASGR GYWIEEDDSV KTYFPGRGAK
560 570 580 590
VMFRSKEGAE PKQIGHLGVL HPEVMMNFDV PFAASFVEVN AEVFL
Length:595
Mass (Da):67,365
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68DA23E49644F801
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35151 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18N → D AA sequence (PubMed:3049607).Curated1
Sequence conflicti426G → D in AAA35151 (PubMed:3049607).Curated1
Sequence conflicti544F → L in AAT92797 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03964 Genomic DNA Translation: AAA35151.1 Different initiation.
X94607 Genomic DNA Translation: CAA64307.1
Z73232 Genomic DNA Translation: CAA97591.1
AY692778 Genomic DNA Translation: AAT92797.1
BK006945 Genomic DNA Translation: DAA09378.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61634, YFBYBC

NCBI Reference Sequences

More...
RefSeqi
NP_013161.1, NM_001181947.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR060W_mRNA; YLR060W; YLR060W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR060W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03964 Genomic DNA Translation: AAA35151.1 Different initiation.
X94607 Genomic DNA Translation: CAA64307.1
Z73232 Genomic DNA Translation: CAA97591.1
AY692778 Genomic DNA Translation: AAT92797.1
BK006945 Genomic DNA Translation: DAA09378.1
PIRiS61634, YFBYBC
RefSeqiNP_013161.1, NM_001181947.1

3D structure databases

SMRiP15624
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi31335, 233 interactors
ComplexPortaliCPX-1738, Phenylalanyl-tRNA synthetase complex
DIPiDIP-6746N
IntActiP15624, 6 interactors
MINTiP15624
STRINGi4932.YLR060W

PTM databases

CarbonylDBiP15624
iPTMnetiP15624

Proteomic databases

MaxQBiP15624
PaxDbiP15624
PRIDEiP15624

Genome annotation databases

EnsemblFungiiYLR060W_mRNA; YLR060W; YLR060W
GeneIDi850749
KEGGisce:YLR060W

Organism-specific databases

SGDiS000004050, FRS1
VEuPathDBiFungiDB:YLR060W

Phylogenomic databases

eggNOGiKOG2472, Eukaryota
GeneTreeiENSGT00530000063489
HOGENOMiCLU_020279_2_0_1
InParanoidiP15624
OMAiFPGRCAN

Enzyme and pathway databases

BioCyciYEAST:G3O-32214-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P15624
RNActiP15624, protein

Family and domain databases

CDDicd00769, PheRS_beta_core, 1 hit
Gene3Di3.50.40.10, 1 hit
InterProiView protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR009061, DNA-bd_dom_put_sf
IPR004531, Phe-tRNA-synth_IIc_bsu_arc_euk
IPR020825, Phe-tRNA_synthase-like_B3/B4
IPR041616, PheRS_beta_core
IPR040659, PhetRS_B1
IPR005147, tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483, B3_4, 1 hit
PF03484, B5, 1 hit
PF18262, PhetRS_B1, 1 hit
PF17759, tRNA_synthFbeta, 1 hit
SMARTiView protein in SMART
SM00873, B3_4, 1 hit
SM00874, B5, 1 hit
SUPFAMiSSF46955, SSF46955, 2 hits
TIGRFAMsiTIGR00471, pheT_arch, 1 hit
PROSITEiView protein in PROSITE
PS51483, B5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYFB_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15624
Secondary accession number(s): D6VY62, E9P8X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  4. SIMILARITY comments
    Index of protein domains and families
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