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Protein

Zinc finger protein 250

Gene

ZNF250

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 250
Alternative name(s):
Zinc finger protein 647
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF250
Synonyms:ZNF647
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196150.13

Human Gene Nomenclature Database

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HGNCi
HGNC:13044 ZNF250

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15622

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000196150

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37622

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF250

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474831 – 560Zinc finger protein 250Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15622

MaxQB - The MaxQuant DataBase

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MaxQBi
P15622

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P15622

PeptideAtlas

More...
PeptideAtlasi
P15622

PRoteomics IDEntifications database

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PRIDEi
P15622

ProteomicsDB human proteome resource

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ProteomicsDBi
53193
53194 [P15622-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
P15622

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P15622

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15622

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196150 Expressed in 154 organ(s), highest expression level in right ovary

CleanEx database of gene expression profiles

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CleanExi
HS_ZNF250

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15622 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15622 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020853

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121830, 54 interactors

Protein interaction database and analysis system

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IntActi
P15622, 110 interactors

Molecular INTeraction database

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MINTi
P15622

STRING: functional protein association networks

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STRINGi
9606.ENSP00000292579

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P15622

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15622

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 93KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri479 – 501C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri507 – 529C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri535 – 557C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15622

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVICQLE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15622

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15622-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAARLLPVP AGPQPLSFQA KLTFEDVAVL LSQDEWDRLC PAQRGLYRNV
60 70 80 90 100
MMETYGNVVS LGLPGSKPDI ISQLERGEDP WVLDRKGAKK SQGLWSDYSD
110 120 130 140 150
NLKYDHTTAC TQQDSLSCPW ECETKGESQN TDLSPKPLIS EQTVILGKTP
160 170 180 190 200
LGRIDQENNE TKQSFCLSPN SVDHREVQVL SQSMPLTPHQ AVPSGERPYM
210 220 230 240 250
CVECGKCFGR SSHLLQHQRI HTGEKPYVCS VCGKAFSQSS VLSKHRRIHT
260 270 280 290 300
GEKPYECNEC GKAFRVSSDL AQHHKIHTGE KPHECLECRK AFTQLSHLIQ
310 320 330 340 350
HQRIHTGERP YVCPLCGKAF NHSTVLRSHQ RVHTGEKPHR CNECGKTFSV
360 370 380 390 400
KRTLLQHQRI HTGEKPYTCS ECGKAFSDRS VLIQHHNVHT GEKPYECSEC
410 420 430 440 450
GKTFSHRSTL MNHERIHTEE KPYACYECGK AFVQHSHLIQ HQRVHTGEKP
460 470 480 490 500
YVCGECGHAF SARRSLIQHE RIHTGEKPFQ CTECGKAFSL KATLIVHLRT
510 520 530 540 550
HTGEKPYECN SCGKAFSQYS VLIQHQRIHT GEKPYECGEC GRAFNQHGHL
560
IQHQKVHRKL
Length:560
Mass (Da):63,468
Last modified:July 19, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i800170E1875D988C
GO
Isoform 2 (identifier: P15622-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: Missing.
     366-477: Missing.

Show »
Length:443
Mass (Da):50,022
Checksum:i5C51169876D5BBF5
GO
Isoform 3 (identifier: P15622-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: Missing.

Note: No experimental confirmation available.
Show »
Length:555
Mass (Da):62,895
Checksum:i28038298ED50A5B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RA56F6RA56_HUMAN
Zinc finger protein 250
ZNF250
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL28E9PL28_HUMAN
Zinc finger protein 250
ZNF250
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQX5E9PQX5_HUMAN
Zinc finger protein 250
ZNF250
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3B7J8Q3B7J8_HUMAN
ZNF250 protein
ZNF250
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPG5E9PPG5_HUMAN
Zinc finger protein 250
ZNF250
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKP2E9PKP2_HUMAN
Zinc finger protein 250
ZNF250
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJU7E9PJU7_HUMAN
Zinc finger protein 250
ZNF250
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA34358 differs from that shown. Reason: Frameshift at positions 458 and 488.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti515 – 521AFSQYSV → PSASTQL (Ref. 6) Curated7
Sequence conflicti542R → G (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01103915 – 19Missing in isoform 2 and isoform 3. 2 Publications5
Alternative sequenceiVSP_011040366 – 477Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK095705 mRNA Translation: BAC04614.1
AB208810 mRNA Translation: BAD92047.1 Different initiation.
AF235103 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82029.1
CH471162 Genomic DNA Translation: EAW82030.1
BC017091 mRNA Translation: AAH17091.2
X16282 mRNA Translation: CAA34358.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34972.1 [P15622-1]
CCDS55282.1 [P15622-3]

Protein sequence database of the Protein Information Resource

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PIRi
S06781

NCBI Reference Sequences

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RefSeqi
NP_001103159.1, NM_001109689.3 [P15622-3]
NP_066405.1, NM_021061.4 [P15622-1]
XP_005272384.1, XM_005272327.1
XP_005272385.1, XM_005272328.3
XP_006716675.1, XM_006716612.3
XP_006716676.1, XM_006716613.3
XP_011515511.1, XM_011517209.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.532277
Hs.733851

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000292579; ENSP00000292579; ENSG00000196150 [P15622-1]
ENST00000417550; ENSP00000393442; ENSG00000196150 [P15622-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58500

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:58500

UCSC genome browser

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UCSCi
uc003zeq.4 human [P15622-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095705 mRNA Translation: BAC04614.1
AB208810 mRNA Translation: BAD92047.1 Different initiation.
AF235103 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82029.1
CH471162 Genomic DNA Translation: EAW82030.1
BC017091 mRNA Translation: AAH17091.2
X16282 mRNA Translation: CAA34358.1 Frameshift.
CCDSiCCDS34972.1 [P15622-1]
CCDS55282.1 [P15622-3]
PIRiS06781
RefSeqiNP_001103159.1, NM_001109689.3 [P15622-3]
NP_066405.1, NM_021061.4 [P15622-1]
XP_005272384.1, XM_005272327.1
XP_005272385.1, XM_005272328.3
XP_006716675.1, XM_006716612.3
XP_006716676.1, XM_006716613.3
XP_011515511.1, XM_011517209.1
UniGeneiHs.532277
Hs.733851

3D structure databases

ProteinModelPortaliP15622
SMRiP15622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121830, 54 interactors
IntActiP15622, 110 interactors
MINTiP15622
STRINGi9606.ENSP00000292579

PTM databases

iPTMnetiP15622
PhosphoSitePlusiP15622

Polymorphism and mutation databases

BioMutaiZNF250
DMDMi50403721

2D gel databases

REPRODUCTION-2DPAGEiP15622

Proteomic databases

jPOSTiP15622
MaxQBiP15622
PaxDbiP15622
PeptideAtlasiP15622
PRIDEiP15622
ProteomicsDBi53193
53194 [P15622-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292579; ENSP00000292579; ENSG00000196150 [P15622-1]
ENST00000417550; ENSP00000393442; ENSG00000196150 [P15622-3]
GeneIDi58500
KEGGihsa:58500
UCSCiuc003zeq.4 human [P15622-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58500
EuPathDBiHostDB:ENSG00000196150.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF250
HGNCiHGNC:13044 ZNF250
HPAiHPA020853
neXtProtiNX_P15622
OpenTargetsiENSG00000196150
PharmGKBiPA37622

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162306
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP15622
KOiK09228
OMAiNVICQLE
OrthoDBi1318335at2759
PhylomeDBiP15622
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF250 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58500

Protein Ontology

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PROi
PR:P15622

Gene expression databases

BgeeiENSG00000196150 Expressed in 154 organ(s), highest expression level in right ovary
CleanExiHS_ZNF250
ExpressionAtlasiP15622 baseline and differential
GenevisibleiP15622 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN250_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15622
Secondary accession number(s): D3DWP1
, Q59HE9, Q8N942, Q96AH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 19, 2004
Last modified: January 16, 2019
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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