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Protein

Zinc finger protein 44

Gene

ZNF44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri524 – 546C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 44
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 2
Short name:
GIOT-2
Zinc finger protein 55
Zinc finger protein 58
Zinc finger protein KOX7
Gene namesi
Name:ZNF44
Synonyms:GIOT2, KOX7, ZNF55, ZNF58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197857.13
HGNCiHGNC:13110 ZNF44
MIMi194542 gene
neXtProtiNX_P15621

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51710
OpenTargetsiENSG00000197857
PharmGKBiPA37685

Polymorphism and mutation databases

BioMutaiZNF44
DMDMi215274197

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473771 – 663Zinc finger protein 44Add BLAST663

Proteomic databases

MaxQBiP15621
PaxDbiP15621
PeptideAtlasiP15621
PRIDEiP15621
ProteomicsDBi53190
53191 [P15621-2]
53192 [P15621-3]

PTM databases

iPTMnetiP15621
PhosphoSitePlusiP15621

Expressioni

Gene expression databases

BgeeiENSG00000197857 Expressed in 234 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF44
ExpressionAtlasiP15621 baseline and differential
GenevisibleiP15621 HS

Organism-specific databases

HPAiHPA003146

Interactioni

Protein-protein interaction databases

BioGridi119691, 4 interactors
IntActiP15621, 1 interactor
STRINGi9606.ENSP00000348419

Structurei

3D structure databases

ProteinModelPortaliP15621
SMRiP15621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 138KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri524 – 546C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP15621
KOiK09228
OMAiPYTHKQC
OrthoDBiEOG091G02KC
PhylomeDBiP15621
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD
60 70 80 90 100
SVAFEDVAVN FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI
110 120 130 140 150
DDQHQNLRRN PRCDVVERFG KSKDGSQCGE TLSQIRNSIV NKNTPARVDA
160 170 180 190 200
CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE CHEYAEKSYT HKQCGKGLSY
210 220 230 240 250
RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG GDGPYKCELC
260 270 280 290 300
GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP
310 320 330 340 350
YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI
360 370 380 390 400
HTGEKPYTCK QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA
410 420 430 440 450
RIHEGTHTLE KPYECKQCGK LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF
460 470 480 490 500
DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT SSSLRKHETT HTGEQPYKCK
510 520 530 540 550
CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC RHERTHSEEK
560 570 580 590 600
SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER
610 620 630 640 650
THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS
660
FNRHKRTHWK DIL
Length:663
Mass (Da):76,524
Last modified:November 25, 2008 - v3
Checksum:i6B66F4715A972432
GO
Isoform 2 (identifier: P15621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-49: Q → M
     638-663: Missing.

Show »
Length:589
Mass (Da):68,089
Checksum:iCDEA5A84ACE31162
GO
Isoform 3 (identifier: P15621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-663: Missing.

Show »
Length:637
Mass (Da):73,462
Checksum:i6A73DE76DBA740AA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7T7F8W7T7_HUMAN
Zinc finger protein 44
ZNF44
615Annotation score:
M0R160M0R160_HUMAN
Zinc finger protein 44 (KOX 7), iso...
ZNF44 hCG_2002471
154Annotation score:
E2QRP2E2QRP2_HUMAN
Zinc finger protein 44
ZNF44
64Annotation score:

Sequence cautioni

The sequence CAA34357 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389I → R in BAA86988 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04742592G → A. Corresponds to variant dbSNP:rs11882046Ensembl.1
Natural variantiVAR_047426212T → A1 PublicationCorresponds to variant dbSNP:rs11879168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357571 – 48Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_03575849Q → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_035759638 – 663Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021642 mRNA Translation: BAA86988.1
AK297528 mRNA Translation: BAG59931.1
AC012618 Genomic DNA No translation available.
BC136502 mRNA Translation: AAI36503.1
X16281 mRNA Translation: CAA34357.1 Frameshift.
X52338 mRNA Translation: CAA36564.1
CCDSiCCDS54223.1 [P15621-1]
PIRiD56409 S06779
RefSeqiNP_001157748.1, NM_001164276.1 [P15621-1]
UniGeneiHs.296731

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857 [P15621-1]
ENST00000393337; ENSP00000377008; ENSG00000197857 [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857 [P15621-2]
GeneIDi51710
KEGGihsa:51710
UCSCiuc010xmj.3 human [P15621-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021642 mRNA Translation: BAA86988.1
AK297528 mRNA Translation: BAG59931.1
AC012618 Genomic DNA No translation available.
BC136502 mRNA Translation: AAI36503.1
X16281 mRNA Translation: CAA34357.1 Frameshift.
X52338 mRNA Translation: CAA36564.1
CCDSiCCDS54223.1 [P15621-1]
PIRiD56409 S06779
RefSeqiNP_001157748.1, NM_001164276.1 [P15621-1]
UniGeneiHs.296731

3D structure databases

ProteinModelPortaliP15621
SMRiP15621
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119691, 4 interactors
IntActiP15621, 1 interactor
STRINGi9606.ENSP00000348419

PTM databases

iPTMnetiP15621
PhosphoSitePlusiP15621

Polymorphism and mutation databases

BioMutaiZNF44
DMDMi215274197

Proteomic databases

MaxQBiP15621
PaxDbiP15621
PeptideAtlasiP15621
PRIDEiP15621
ProteomicsDBi53190
53191 [P15621-2]
53192 [P15621-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857 [P15621-1]
ENST00000393337; ENSP00000377008; ENSG00000197857 [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857 [P15621-2]
GeneIDi51710
KEGGihsa:51710
UCSCiuc010xmj.3 human [P15621-1]

Organism-specific databases

CTDi51710
DisGeNETi51710
EuPathDBiHostDB:ENSG00000197857.13
GeneCardsiZNF44
HGNCiHGNC:13110 ZNF44
HPAiHPA003146
MIMi194542 gene
neXtProtiNX_P15621
OpenTargetsiENSG00000197857
PharmGKBiPA37685
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP15621
KOiK09228
OMAiPYTHKQC
OrthoDBiEOG091G02KC
PhylomeDBiP15621
TreeFamiTF338854

Miscellaneous databases

ChiTaRSiZNF44 human
GeneWikiiZNF44
GenomeRNAii51710
PROiPR:P15621
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197857 Expressed in 234 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF44
ExpressionAtlasiP15621 baseline and differential
GenevisibleiP15621 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF44_HUMAN
AccessioniPrimary (citable) accession number: P15621
Secondary accession number(s): B4DML9
, B9EGJ5, B9ZVM2, P17018, Q9ULZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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