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Entry version 189 (22 Apr 2020)
Sequence version 3 (25 Nov 2008)
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Protein

Zinc finger protein 44

Gene

ZNF44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri189 – 211C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri524 – 546C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 44
Alternative name(s):
Gonadotropin-inducible ovary transcription repressor 2
Short name:
GIOT-2
Zinc finger protein 55
Zinc finger protein 58
Zinc finger protein KOX7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF44
Synonyms:GIOT2, KOX7, ZNF55, ZNF58
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13110 ZNF44

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194542 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15621

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51710

Open Targets

More...
OpenTargetsi
ENSG00000197857

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37685

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P15621 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF44

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473771 – 663Zinc finger protein 44Add BLAST663

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15621

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P15621

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15621

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15621

PeptideAtlas

More...
PeptideAtlasi
P15621

PRoteomics IDEntifications database

More...
PRIDEi
P15621

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53190 [P15621-1]
53191 [P15621-2]
53192 [P15621-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15621

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197857 Expressed in amniotic fluid and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15621 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15621 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197857 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119691, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P15621, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348419

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P15621 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15621

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 138KRABPROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri245 – 267C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri273 – 295C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri301 – 323C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 518C2H2-type 12PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri524 – 546C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15621

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCQEHER

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15621

TreeFam database of animal gene trees

More...
TreeFami
TF338854

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALCYGTFWG YPKMLEAANL MEGLVDIGPW VTLPRGQPEV LEWGLPKDQD
60 70 80 90 100
SVAFEDVAVN FTHEEWALLG PSQKNLYRDV MRETIRNLNC IGMKWENQNI
110 120 130 140 150
DDQHQNLRRN PRCDVVERFG KSKDGSQCGE TLSQIRNSIV NKNTPARVDA
160 170 180 190 200
CGSSVNGEVI MGHSSLNCYI RVDTGHKHRE CHEYAEKSYT HKQCGKGLSY
210 220 230 240 250
RHSFQTCERP HTGKKPYDCK ECGKTFSSPG NLRRHMVVKG GDGPYKCELC
260 270 280 290 300
GKAFFWPSLL RMHERTHTGE KPYECKQCSK AFPVYSSYLR HEKIHTGEKP
310 320 330 340 350
YECKQCSKAF PDYSSYLRHE RTHTGEKPYK CKQCGKAFSV SGSLRVHERI
360 370 380 390 400
HTGEKPYTCK QCGKAFCHLG SFQRHMIMHS GDGPHKCKIC GKGFDFPGSA
410 420 430 440 450
RIHEGTHTLE KPYECKQCGK LLSHRSSFRR HMMAHTGDGP HKCTVCGKAF
460 470 480 490 500
DSPSVFQRHE RTHTGEKPYE CKQCGKAFRT SSSLRKHETT HTGEQPYKCK
510 520 530 540 550
CGKAFSDLFS FQSHETTHSE EEPYECKECG KAFSSFKYFC RHERTHSEEK
560 570 580 590 600
SYECQICGKA FSRFSYLKTH ERTHTAEKPY ECKQCRKAFF WPSFLLRHER
610 620 630 640 650
THTGERPYEC KHCGKAFSRS SFCREHERTH TGEKPYECKE CGKAFSSLSS
660
FNRHKRTHWK DIL
Length:663
Mass (Da):76,524
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B66F4715A972432
GO
Isoform 2 (identifier: P15621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-49: Q → M
     638-663: Missing.

Show »
Length:589
Mass (Da):68,089
Checksum:iCDEA5A84ACE31162
GO
Isoform 3 (identifier: P15621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     638-663: Missing.

Show »
Length:637
Mass (Da):73,462
Checksum:i6A73DE76DBA740AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7T7F8W7T7_HUMAN
Zinc finger protein 44
ZNF44
615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R160M0R160_HUMAN
Zinc finger protein 44
ZNF44 hCG_2002471
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QRP2E2QRP2_HUMAN
Zinc finger protein 44
ZNF44
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA34357 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389I → R in BAA86988 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04742592G → A. Corresponds to variant dbSNP:rs11882046Ensembl.1
Natural variantiVAR_047426212T → A1 PublicationCorresponds to variant dbSNP:rs11879168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357571 – 48Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_03575849Q → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_035759638 – 663Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB021642 mRNA Translation: BAA86988.1
AK297528 mRNA Translation: BAG59931.1
AC012618 Genomic DNA No translation available.
BC136502 mRNA Translation: AAI36503.1
X16281 mRNA Translation: CAA34357.1 Frameshift.
X52338 mRNA Translation: CAA36564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS54223.1 [P15621-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
D56409 S06779

NCBI Reference Sequences

More...
RefSeqi
NP_001157748.1, NM_001164276.1 [P15621-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356109; ENSP00000348419; ENSG00000197857 [P15621-1]
ENST00000393337; ENSP00000377008; ENSG00000197857 [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857 [P15621-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51710

UCSC genome browser

More...
UCSCi
uc010xmj.3 human [P15621-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021642 mRNA Translation: BAA86988.1
AK297528 mRNA Translation: BAG59931.1
AC012618 Genomic DNA No translation available.
BC136502 mRNA Translation: AAI36503.1
X16281 mRNA Translation: CAA34357.1 Frameshift.
X52338 mRNA Translation: CAA36564.1
CCDSiCCDS54223.1 [P15621-1]
PIRiD56409 S06779
RefSeqiNP_001157748.1, NM_001164276.1 [P15621-1]

3D structure databases

SMRiP15621
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119691, 5 interactors
IntActiP15621, 2 interactors
STRINGi9606.ENSP00000348419

PTM databases

iPTMnetiP15621
PhosphoSitePlusiP15621

Polymorphism and mutation databases

BioMutaiZNF44
DMDMi215274197

Proteomic databases

jPOSTiP15621
MassIVEiP15621
MaxQBiP15621
PaxDbiP15621
PeptideAtlasiP15621
PRIDEiP15621
ProteomicsDBi53190 [P15621-1]
53191 [P15621-2]
53192 [P15621-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
835 104 antibodies

Genome annotation databases

EnsembliENST00000356109; ENSP00000348419; ENSG00000197857 [P15621-1]
ENST00000393337; ENSP00000377008; ENSG00000197857 [P15621-3]
ENST00000397742; ENSP00000380850; ENSG00000197857 [P15621-2]
GeneIDi51710
KEGGihsa:51710
UCSCiuc010xmj.3 human [P15621-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51710
DisGeNETi51710

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF44
HGNCiHGNC:13110 ZNF44
HPAiENSG00000197857 Low tissue specificity
MIMi194542 gene
neXtProtiNX_P15621
OpenTargetsiENSG00000197857
PharmGKBiPA37685

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000182755
HOGENOMiCLU_002678_44_3_1
InParanoidiP15621
KOiK09228
OMAiFCQEHER
OrthoDBi1318335at2759
PhylomeDBiP15621
TreeFamiTF338854

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF44 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF44

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51710
PharosiP15621 Tbio

Protein Ontology

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PROi
PR:P15621
RNActiP15621 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197857 Expressed in amniotic fluid and 233 other tissues
ExpressionAtlasiP15621 baseline and differential
GenevisibleiP15621 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF44_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15621
Secondary accession number(s): B4DML9
, B9EGJ5, B9ZVM2, P17018, Q9ULZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: April 22, 2020
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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