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Entry version 205 (05 Jun 2019)
Sequence version 1 (01 Apr 1990)
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Protein

NAD(P)H dehydrogenase [quinone] 1

Gene

NQO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Miscellaneous

Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dicoumarol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei12FAD3 Publications1
Binding sitei67FAD3 Publications1
Binding sitei156FAD3 Publications1
Binding sitei201FAD3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 19FAD3 Publications2
Nucleotide bindingi104 – 107FAD3 Publications4
Nucleotide bindingi148 – 151FAD3 Publications4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS11566-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.6.5.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P15559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)
Alternative name(s):
Azoreductase
DT-diaphorase
Short name:
DTD
Menadione reductase
NAD(P)H:quinone oxidoreductase 1
Phylloquinone reductase
Quinone reductase 1
Short name:
QR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NQO1
Synonyms:DIA4, NMOR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2874 NQO1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
125860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15559

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1728

Open Targets

More...
OpenTargetsi
ENSG00000181019

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31744

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3623

Drug and drug target database

More...
DrugBanki
DB00958 Carboplatin
DB02633 Cibacron Blue
DB00515 Cisplatin
DB00266 Dicoumarol
DB00997 Doxorubicin
DB01927 Duroquinone
DB03147 Flavin adenine dinucleotide
DB00170 Menadione
DB00526 Oxaliplatin
DB00163 Vitamin E

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NQO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000716221 – 274NAD(P)H dehydrogenase [quinone] 1Add BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P15559

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15559

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15559

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15559

PeptideAtlas

More...
PeptideAtlasi
P15559

PRoteomics IDEntifications database

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PRIDEi
P15559

ProteomicsDB human proteome resource

More...
ProteomicsDBi
12688 [P15559-2]
53187
53188 [P15559-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P15559-1 [P15559-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15559

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15559

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15559

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By dioxin (PubMed:1657151). By oxidative stress (PubMed:21636573).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000181019 Expressed in 220 organ(s), highest expression level in endometrium epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15559 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15559 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012421
HPA007308

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:10543876, PubMed:10706635, PubMed:11735396, PubMed:11587640, PubMed:16700548). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (PubMed:21636573).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108072, 30 interactors

Database of interacting proteins

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DIPi
DIP-24210N

Protein interaction database and analysis system

More...
IntActi
P15559, 5 interactors

Molecular INTeraction database

More...
MINTi
P15559

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319788

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15559

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15559

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15559

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni126 – 128Substrate binding3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKWF Eukaryota
COG2249 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000149970

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15559

KEGG Orthology (KO)

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KOi
K00355

Identification of Orthologs from Complete Genome Data

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OMAi
LFPIHHG

Database of Orthologous Groups

More...
OrthoDBi
1394543at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15559

TreeFam database of animal gene trees

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TreeFami
TF300296

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003680 Flavodoxin_fold
IPR029039 Flavoprotein-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02525 Flavodoxin_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52218 SSF52218, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI
60 70 80 90 100
ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF
110 120 130 140 150
QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG
160 170 180 190 200
GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA
210 220 230 240 250
RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK
260 270
KFGLSVGHHL GKSIPTDNQI KARK
Length:274
Mass (Da):30,868
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4010462AD00F3FE
GO
Isoform 2 (identifier: P15559-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-173: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):27,295
Checksum:i63EF4B34E6394793
GO
Isoform 3 (identifier: P15559-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-139: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,365
Checksum:i8BF801EAD71D02AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNV2H3BNV2_HUMAN
NAD(P)H dehydrogenase [quinone] 1
NQO1 hCG_28204
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DLR8B4DLR8_HUMAN
NAD(P)H dehydrogenase [quinone] 1
NQO1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRK3H3BRK3_HUMAN
NAD(P)H dehydrogenase [quinone] 1
NQO1
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252F → S in BAG60289 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 30864±6 Da from positions 2 - 274. Determined by ESI. 1 Publication

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016170139R → W. Corresponds to variant dbSNP:rs1131341Ensembl.1
Natural variantiVAR_008384187P → S Lack of activity. 4 PublicationsCorresponds to variant dbSNP:rs1800566EnsemblClinVar.1
Natural variantiVAR_050220269Q → H. Corresponds to variant dbSNP:rs34447156Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044446102 – 139Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_042716140 – 173Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03934 mRNA Translation: AAA59940.1
M81600
, M81596, M81597, M81598, M81599 Genomic DNA Translation: AAB60701.1
AY281093 Genomic DNA Translation: AAP20940.1 Sequence problems.
AK297979 mRNA Translation: BAG60289.1
AK312368 mRNA Translation: BAG35286.1
AK316246 mRNA Translation: BAH14617.1
AC092115 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83283.1
CH471092 Genomic DNA Translation: EAW83284.1
BC007659 mRNA Translation: AAH07659.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10883.1 [P15559-1]
CCDS32471.1 [P15559-3]
CCDS32472.1 [P15559-2]

Protein sequence database of the Protein Information Resource

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PIRi
A41135 A30879

NCBI Reference Sequences

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RefSeqi
NP_000894.1, NM_000903.2 [P15559-1]
NP_001020604.1, NM_001025433.1 [P15559-2]
NP_001020605.1, NM_001025434.1 [P15559-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000320623; ENSP00000319788; ENSG00000181019 [P15559-1]
ENST00000379046; ENSP00000368334; ENSG00000181019 [P15559-3]
ENST00000379047; ENSP00000368335; ENSG00000181019 [P15559-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1728

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1728

UCSC genome browser

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UCSCi
uc002exp.5 human [P15559-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03934 mRNA Translation: AAA59940.1
M81600
, M81596, M81597, M81598, M81599 Genomic DNA Translation: AAB60701.1
AY281093 Genomic DNA Translation: AAP20940.1 Sequence problems.
AK297979 mRNA Translation: BAG60289.1
AK312368 mRNA Translation: BAG35286.1
AK316246 mRNA Translation: BAH14617.1
AC092115 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83283.1
CH471092 Genomic DNA Translation: EAW83284.1
BC007659 mRNA Translation: AAH07659.1
CCDSiCCDS10883.1 [P15559-1]
CCDS32471.1 [P15559-3]
CCDS32472.1 [P15559-2]
PIRiA41135 A30879
RefSeqiNP_000894.1, NM_000903.2 [P15559-1]
NP_001020604.1, NM_001025433.1 [P15559-2]
NP_001020605.1, NM_001025434.1 [P15559-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4AX-ray1.70A/B/C/D2-274[»]
1DXOX-ray2.50A/B/C/D2-274[»]
1GG5X-ray2.50A/B/C/D2-274[»]
1H66X-ray2.00A/B/C/D3-274[»]
1H69X-ray1.86A/B/C/D3-274[»]
1KBOX-ray2.30A/B/C/D2-274[»]
1KBQX-ray1.80A/B/C/D2-274[»]
1QBGX-ray2.30A/B/C/D4-274[»]
2F1OX-ray2.75A/B/C/D/E/F/G/H2-274[»]
3JSXX-ray2.45A/B/C/D/E/F/G/H2-274[»]
4CETX-ray2.20A1-274[»]
4CF6X-ray2.69A/B1-274[»]
5A4KX-ray2.09A/B/C/D1-274[»]
5EA2X-ray2.01A/C/E/G1-273[»]
5EAIX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L/M/N1-274[»]
5FUQX-ray2.04A/B1-274[»]
6FY4X-ray2.76A/B/C/D1-274[»]
SMRiP15559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108072, 30 interactors
DIPiDIP-24210N
IntActiP15559, 5 interactors
MINTiP15559
STRINGi9606.ENSP00000319788

Chemistry databases

BindingDBiP15559
ChEMBLiCHEMBL3623
DrugBankiDB00958 Carboplatin
DB02633 Cibacron Blue
DB00515 Cisplatin
DB00266 Dicoumarol
DB00997 Doxorubicin
DB01927 Duroquinone
DB03147 Flavin adenine dinucleotide
DB00170 Menadione
DB00526 Oxaliplatin
DB00163 Vitamin E

PTM databases

iPTMnetiP15559
PhosphoSitePlusiP15559
SwissPalmiP15559

Polymorphism and mutation databases

BioMutaiNQO1
DMDMi118607

Proteomic databases

EPDiP15559
jPOSTiP15559
MaxQBiP15559
PaxDbiP15559
PeptideAtlasiP15559
PRIDEiP15559
ProteomicsDBi12688 [P15559-2]
53187
53188 [P15559-2]
TopDownProteomicsiP15559-1 [P15559-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1728
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320623; ENSP00000319788; ENSG00000181019 [P15559-1]
ENST00000379046; ENSP00000368334; ENSG00000181019 [P15559-3]
ENST00000379047; ENSP00000368335; ENSG00000181019 [P15559-2]
GeneIDi1728
KEGGihsa:1728
UCSCiuc002exp.5 human [P15559-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1728
DisGeNETi1728

GeneCards: human genes, protein and diseases

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GeneCardsi
NQO1
HGNCiHGNC:2874 NQO1
HPAiCAB012421
HPA007308
MIMi125860 gene
neXtProtiNX_P15559
OpenTargetsiENSG00000181019
PharmGKBiPA31744

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKWF Eukaryota
COG2249 LUCA
GeneTreeiENSGT00940000159150
HOGENOMiHOG000149970
InParanoidiP15559
KOiK00355
OMAiLFPIHHG
OrthoDBi1394543at2759
PhylomeDBiP15559
TreeFamiTF300296

Enzyme and pathway databases

BioCyciMetaCyc:HS11566-MONOMER
BRENDAi1.6.5.2 2681
ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)
SIGNORiP15559

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NQO1 human
EvolutionaryTraceiP15559

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NAD(P)H_dehydrogenase_(quinone_1)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1728

Protein Ontology

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PROi
PR:P15559

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181019 Expressed in 220 organ(s), highest expression level in endometrium epithelium
ExpressionAtlasiP15559 baseline and differential
GenevisibleiP15559 HS

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR003680 Flavodoxin_fold
IPR029039 Flavoprotein-like_sf
PfamiView protein in Pfam
PF02525 Flavodoxin_2, 1 hit
SUPFAMiSSF52218 SSF52218, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNQO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15559
Secondary accession number(s): B2R5Y9
, B4DNM7, B7ZAD1, Q86UK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 5, 2019
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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