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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161Copper ACurated1
Metal bindingi196Copper ACurated1
Metal bindingi200Copper ACurated1
Metal bindingi204Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25Mitochondrial intermembraneSequence analysisAdd BLAST25
Transmembranei26 – 47HelicalSequence analysisAdd BLAST22
Topological domaini48 – 62Mitochondrial matrixSequence analysisAdd BLAST15
Transmembranei63 – 84HelicalSequence analysisAdd BLAST22
Topological domaini85 – 229Mitochondrial intermembraneSequence analysisAdd BLAST145

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836971 – 229Cytochrome c oxidase subunit 2Add BLAST229

Proteomic databases

PRIDEiP15545

Structurei

3D structure databases

ProteinModelPortaliP15545
SMRiP15545
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP15545
KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P15545-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTWAQFGLQ DASSPLMEEL TYFHDYALIV LTLITILVFY GLVSLLVSSN
60 70 80 90 100
TNRFFFEGQE LETIWTVIPA LILILIALPS LQLLYLMDEV NDPFLTIKAF
110 120 130 140 150
GHQWYWSYEY TDFNDLEFDS YMVPTSDVSF GNPRLLEVDN RLVLPMQNPI
160 170 180 190 200
RVLVSSADVL HSWAVPSLGT KMDAVPGRLN QTTFFAARTG VFYGQCSEIC
210 220
GANHSFMPIV IESVPFNTFE NWVTQYLEE
Length:229
Mass (Da):26,111
Last modified:April 1, 1990 - v1
Checksum:iFF5C6BBF46EED403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12631 Genomic DNA Translation: CAA31155.1
PIRiS01503
RefSeqiNP_006969.1, NC_001453.1

Genome annotation databases

GeneIDi2652720
KEGGispu:2652720

Similar proteinsi

Entry informationi

Entry nameiCOX2_STRPU
AccessioniPrimary (citable) accession number: P15545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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