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Protein

Cytochrome P450 11B2, mitochondrial

Gene

Cyp11b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms corticosterone from 11-deoxycorticosterone.

Catalytic activityi

A steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11-beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O.By similarity
Corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi447Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 11B2, mitochondrial
Alternative name(s):
Aldosterone synthase
CYPXIB2
Cytochrome P450C11
Steroid 11-beta-hydroxylase (EC:1.14.15.4, EC:1.14.15.5)
Gene namesi
Name:Cyp11b2
Synonyms:Cyp11b-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88584 Cyp11b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3621020

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionAdd BLAST24
ChainiPRO_000000360025 – 500Cytochrome P450 11B2, mitochondrialAdd BLAST476

Proteomic databases

MaxQBiP15539
PaxDbiP15539
PRIDEiP15539

PTM databases

PhosphoSitePlusiP15539

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131503

Chemistry databases

BindingDBiP15539

Structurei

3D structure databases

ProteinModelPortaliP15539
SMRiP15539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
HOGENOMiHOG000013161
HOVERGENiHBG051098
InParanoidiP15539
KOiK00497
PhylomeDBiP15539

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002399 Cyt_P450_mitochondrial
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00408 MITP450
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P15539-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRVTADVW LARPWQCLHR TRALGTTATL APKTLQPFEA IPQYSRNKWL
60 70 80 90 100
KMIQILREQG QENLHLEMHQ VFRELGPIFR HSVGKTQIVS VMLPEDAEKL
110 120 130 140 150
HQVESMLPRR MHLEPWVAHR ELRGLRRGVF LLNGPEWRLN RLRLNRNVLS
160 170 180 190 200
PKAVQKFVPM VDMVARDFLE TLKEKVLQNA RGSLTMDVQQ SLFNYTIEAS
210 220 230 240 250
NFALFGERLG LLGHDLSPGS LKFIHALHSM FKSTSQLLFL PKSLTRWTST
260 270 280 290 300
RVWKEHFDAW DVISEYANRC IWKVHQELRL GSSQTYSGIV AELISQGSLP
310 320 330 340 350
LDAIKANSME LTAGSVDTTA IPLVMTLFEL ARNPDVQKAL RQESLAAEAS
360 370 380 390 400
IAANPQKAMS DLPLLRAALK ETLRLYPVGG FLERILSSDL VLQNYHVPAG
410 420 430 440 450
TLVLLYLYSM GRNPAVFPRP ERYMPQRWLE RKRSFQHLAF GFGVRQCLGR
460 470 480 490 500
RLAEVEMMLL LHHILKTFQV ETLRQEDVQM AYRFVLMPSS SPVLTFRPVS
Length:500
Mass (Da):57,373
Last modified:July 27, 2011 - v3
Checksum:iDCAFFF3EF2663195
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWE4G3UWE4_MOUSE
Cytochrome P450 11B2, mitochondrial
Cyp11b2 mCG_2779
502Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491S → E in AAB21517 (PubMed:1686470).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S85260 Genomic DNA Translation: AAB21517.2
BC116908 mRNA Translation: AAI16909.1
BC119321 mRNA Translation: AAI19322.1
J04451 Genomic DNA Translation: AAA50299.1
PIRiA41552
RefSeqiNP_034121.3, NM_009991.3
UniGeneiMm.377079

Genome annotation databases

GeneIDi13072
KEGGimmu:13072

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S85260 Genomic DNA Translation: AAB21517.2
BC116908 mRNA Translation: AAI16909.1
BC119321 mRNA Translation: AAI19322.1
J04451 Genomic DNA Translation: AAA50299.1
PIRiA41552
RefSeqiNP_034121.3, NM_009991.3
UniGeneiMm.377079

3D structure databases

ProteinModelPortaliP15539
SMRiP15539
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131503

Chemistry databases

BindingDBiP15539
ChEMBLiCHEMBL3621020

PTM databases

PhosphoSitePlusiP15539

Proteomic databases

MaxQBiP15539
PaxDbiP15539
PRIDEiP15539

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13072
KEGGimmu:13072

Organism-specific databases

CTDi1585
MGIiMGI:88584 Cyp11b2

Phylogenomic databases

eggNOGiKOG0159 Eukaryota
COG2124 LUCA
HOGENOMiHOG000013161
HOVERGENiHBG051098
InParanoidiP15539
KOiK00497
PhylomeDBiP15539

Miscellaneous databases

PROiPR:P15539
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002399 Cyt_P450_mitochondrial
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00408 MITP450
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC11B2_MOUSE
AccessioniPrimary (citable) accession number: P15539
Secondary accession number(s): Q14AB5, Q64661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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