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Entry version 222 (03 Jul 2019)
Sequence version 1 (01 Apr 1990)
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Protein

Nucleoside diphosphate kinase A

Gene

NME1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.3 Publications

Miscellaneous

The role of this protein in tumor development and progression is uncertain. This protein is found in reduced amount in some tumor cells of high metastatic potential. However, increased NME1 levels correlate with aggressive tumor features in neuroblastoma. May have distinct if not opposite roles in different tumors.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits the endonuclease activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei12ATP1
Binding sitei60ATP1
Binding sitei88ATP1
Binding sitei94ATP1
Binding sitei105ATP1
Binding sitei115ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei118Pros-phosphohistidine intermediate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processDifferentiation, Endocytosis, Neurogenesis, Nucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000011052-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.4.6 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-499943 Interconversion of nucleotide di- and triphosphates

SIGNOR Signaling Network Open Resource

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SIGNORi
P15531

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate kinase A (EC:2.7.4.6)
Short name:
NDK A
Short name:
NDP kinase A
Alternative name(s):
Granzyme A-activated DNase
Short name:
GAAD
Metastasis inhibition factor nm23
NM23-H1
Tumor metastatic process-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NME1
Synonyms:NDPKA, NM23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7849 NME1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
156490 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15531

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60F → W: No loss of activity or substrate binding. 1 Publication1
Mutagenesisi96P → S: Increased motility of carcinoma cells. 1 Publication1
Mutagenesisi118H → F: Loss of serine/threonine kinase activity. Some loss of motility of carcinoma cells. 2 Publications1
Mutagenesisi118H → G: Loss of activity. 2 Publications1
Mutagenesisi120S → A: Limited increase in motility of carcinoma cells. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4830

MalaCards human disease database

More...
MalaCardsi
NME1

Open Targets

More...
OpenTargetsi
ENSG00000239672

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA249

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2159

Drug and drug target database

More...
DrugBanki
DB03491 2'-Deoxyguanosine-5'-Diphosphate
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB00718 Adefovir Dipivoxil
DB02607 Adenosine Phosphonoacetic Acid
DB04068 Fudp
DB04315 Guanosine-5'-Diphosphate
DB00709 Lamivudine
DB02345 Selenocysteine
DB00300 Tenofovir
DB03103 Thymidine-5'- Diphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NME1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001371141 – 152Nucleoside diphosphate kinase AAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P15531

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15531

MaxQB - The MaxQuant DataBase

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MaxQBi
P15531

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P15531

PeptideAtlas

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PeptideAtlasi
P15531

PRoteomics IDEntifications database

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PRIDEi
P15531

ProteomicsDB human proteome resource

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ProteomicsDBi
53183
53184 [P15531-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P15531-1 [P15531-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P15531

USC-OGP 2-DE database

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OGPi
P15531

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P15531

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15531

SwissPalm database of S-palmitoylation events

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SwissPalmi
P15531

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239672 Expressed in 111 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15531 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15531 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB040571
HPA008467
HPA041113

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6).

Interacts with PRUNE1.

Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, interacts directly with SET.

Also interacts with TREX1, but only following translocation to the nucleus.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110894, 80 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P15531

Database of interacting proteins

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DIPi
DIP-39164N

Protein interaction database and analysis system

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IntActi
P15531, 35 interactors

Molecular INTeraction database

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MINTi
P15531

STRING: functional protein association networks

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STRINGi
9606.ENSP00000337060

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15531

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15531

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0888 Eukaryota
COG0105 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000224564

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15531

KEGG Orthology (KO)

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KOi
K00940

Identification of Orthologs from Complete Genome Data

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OMAi
KIVAMKM

Database of Orthologous Groups

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OrthoDBi
1334716at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15531

TreeFam database of animal gene trees

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TreeFami
TF106373

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.141, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00451 NDP_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00334 NDK, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01243 NUCDPKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00562 NDK, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54919 SSF54919, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00469 NDP_KINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15531-1) [UniParc]FASTAAdd to basket
Also known as: NM23-H1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE
60 70 80 90 100
HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK
110 120 130 140 150
PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI

YE
Length:152
Mass (Da):17,149
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAE9C0DF63CB70A1
GO
Isoform 2 (identifier: P15531-2) [UniParc]FASTAAdd to basket
Also known as: NM23-H1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVLLSTLGIVFQGEGPPISSCDTGTM

Show »
Length:177
Mass (Da):19,654
Checksum:iDEA9961E992D0378
GO
Isoform 3 (identifier: P22392-2) [UniParc]FASTAAdd to basket
Also known as: NM23-LV
The sequence of this isoform can be found in the external entry P22392.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces an NME1-NME2 fusion protein.
Length:267
Mass (Da):30,137
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERL0E7ERL0_HUMAN
Nucleoside diphosphate kinase A
NME1
139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHP0E5RHP0_HUMAN
Nucleoside diphosphate kinase A
NME1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K028C9K028_HUMAN
Nucleoside diphosphate kinase A
NME1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35621 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004625120S → G in a neuroblastoma sample; increased motility of carcinoma cells. 1 PublicationCorresponds to variant dbSNP:rs121917887Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367071M → MVLLSTLGIVFQGEGPPISS CDTGTM in isoform 2. 1 Publication1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X17620 mRNA Translation: CAA35621.1 Different initiation.
X73066 mRNA Translation: CAA51527.1
X75598 Genomic DNA Translation: CAA53270.1
AF487339 mRNA Translation: AAO85436.1
AK291105 mRNA Translation: BAF83794.1
CR542104 mRNA Translation: CAG46901.1
CR542115 mRNA Translation: CAG46912.1
AC005839 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94568.1
BC000293 mRNA Translation: AAH00293.1
BC018994 mRNA Translation: AAH18994.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11578.1 [P15531-2]
CCDS11579.1 [P15531-1]

Protein sequence database of the Protein Information Resource

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PIRi
A33386

NCBI Reference Sequences

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RefSeqi
NP_000260.1, NM_000269.2 [P15531-1]
NP_937818.1, NM_198175.1 [P15531-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000013034; ENSP00000013034; ENSG00000239672 [P15531-2]
ENST00000336097; ENSP00000337060; ENSG00000239672 [P15531-2]
ENST00000393196; ENSP00000376892; ENSG00000239672 [P15531-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4830

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4830

UCSC genome browser

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UCSCi
uc002ith.3 human [P15531-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17620 mRNA Translation: CAA35621.1 Different initiation.
X73066 mRNA Translation: CAA51527.1
X75598 Genomic DNA Translation: CAA53270.1
AF487339 mRNA Translation: AAO85436.1
AK291105 mRNA Translation: BAF83794.1
CR542104 mRNA Translation: CAG46901.1
CR542115 mRNA Translation: CAG46912.1
AC005839 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94568.1
BC000293 mRNA Translation: AAH00293.1
BC018994 mRNA Translation: AAH18994.1
CCDSiCCDS11578.1 [P15531-2]
CCDS11579.1 [P15531-1]
PIRiA33386
RefSeqiNP_000260.1, NM_000269.2 [P15531-1]
NP_937818.1, NM_198175.1 [P15531-2]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JXVX-ray2.20A/B/C/D/E/F1-152[»]
1UCNX-ray2.00A/B/C1-152[»]
2HVDX-ray2.15A/B/C1-152[»]
2HVEX-ray2.40A/B/C1-152[»]
3L7UX-ray2.10A/B/C1-152[»]
4ENOX-ray2.80A/B1-152[»]
5UI4X-ray2.75A/B/C/D/E/F1-152[»]
SMRiP15531
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110894, 80 interactors
CORUMiP15531
DIPiDIP-39164N
IntActiP15531, 35 interactors
MINTiP15531
STRINGi9606.ENSP00000337060

Chemistry databases

ChEMBLiCHEMBL2159
DrugBankiDB03491 2'-Deoxyguanosine-5'-Diphosphate
DB02181 2'-Deoxyguanosine-5'-Triphosphate
DB04542 3'-Azido-3'-Deoxythymidine-5'-Diphosphate
DB04366 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
DB00718 Adefovir Dipivoxil
DB02607 Adenosine Phosphonoacetic Acid
DB04068 Fudp
DB04315 Guanosine-5'-Diphosphate
DB00709 Lamivudine
DB02345 Selenocysteine
DB00300 Tenofovir
DB03103 Thymidine-5'- Diphosphate

PTM databases

iPTMnetiP15531
PhosphoSitePlusiP15531
SwissPalmiP15531

Polymorphism and mutation databases

BioMutaiNME1
DMDMi127981

2D gel databases

DOSAC-COBS-2DPAGEiP15531
OGPiP15531

Proteomic databases

EPDiP15531
jPOSTiP15531
MaxQBiP15531
PaxDbiP15531
PeptideAtlasiP15531
PRIDEiP15531
ProteomicsDBi53183
53184 [P15531-2]
TopDownProteomicsiP15531-1 [P15531-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4830
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000013034; ENSP00000013034; ENSG00000239672 [P15531-2]
ENST00000336097; ENSP00000337060; ENSG00000239672 [P15531-2]
ENST00000393196; ENSP00000376892; ENSG00000239672 [P15531-1]
GeneIDi4830
KEGGihsa:4830
UCSCiuc002ith.3 human [P15531-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4830
DisGeNETi4830

GeneCards: human genes, protein and diseases

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GeneCardsi
NME1
HGNCiHGNC:7849 NME1
HPAiCAB040571
HPA008467
HPA041113
MalaCardsiNME1
MIMi156490 gene
neXtProtiNX_P15531
OpenTargetsiENSG00000239672
PharmGKBiPA249

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00940000162213
HOGENOMiHOG000224564
InParanoidiP15531
KOiK00940
OMAiKIVAMKM
OrthoDBi1334716at2759
PhylomeDBiP15531
TreeFamiTF106373

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000011052-MONOMER
BRENDAi2.7.4.6 2681
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
SIGNORiP15531

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NME1 human
EvolutionaryTraceiP15531

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NME1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4830

Protein Ontology

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PROi
PR:P15531

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000239672 Expressed in 111 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP15531 baseline and differential
GenevisibleiP15531 HS

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDKA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15531
Secondary accession number(s): Q6FGK3, Q86XQ2, Q9UDJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 3, 2019
This is version 222 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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