UniProtKB - P15530 (CD79B_MOUSE)
B-cell antigen receptor complex-associated protein beta chain
Cd79b
Functioni
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
4 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- B cell differentiation Source: GO_Central
- B cell receptor signaling pathway Source: MGI
- response to bacterium Source: MGI
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-5690714, CD22 mediated BCR regulation R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell antigen receptor complex-associated protein beta chainAlternative name(s): B-cell-specific glycoprotein B29 Ig-beta Immunoglobulin-associated B29 protein CD_antigen: CD79b |
Gene namesi | Name:Cd79b Synonyms:Igb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96431, Cd79b |
VEuPathDBi | HostDB:ENSMUSG00000040592 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein 3 Publications
Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- B cell receptor complex Source: MGI
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 158 | ExtracellularSequence analysisAdd BLAST | 133 | |
Transmembranei | 159 – 180 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 181 – 228 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Add BLAST | 25 | |
ChainiPRO_0000014561 | 26 – 228 | B-cell antigen receptor complex-associated protein beta chainAdd BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 124 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 65 ↔ 120 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 135 | Interchain (with C-113 in alpha chain)PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 195 | Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 206 | Phosphotyrosine; by SRC-type Tyr-kinasesPROSITE-ProRule annotation1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P15530 |
PRIDEi | P15530 |
ProteomicsDBi | 280028 |
PTM databases
GlyGeni | P15530, 3 sites |
iPTMneti | P15530 |
PhosphoSitePlusi | P15530 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000040592, Expressed in bone marrow and 138 other tissues |
ExpressionAtlasi | P15530, baseline and differential |
Genevisiblei | P15530, MM |
Interactioni
Subunit structurei
Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains.
Interacts with LYN.
4 PublicationsBinary interactionsi
P15530
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15869050,EBI-15869050 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 200546, 3 interactors |
DIPi | DIP-59498N |
ELMi | P15530 |
STRINGi | 10090.ENSMUSP00000048239 |
Miscellaneous databases
RNActi | P15530, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P15530 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15530 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 132 | Ig-like V-typeAdd BLAST | 92 | |
Domaini | 184 – 212 | ITAMPROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S7X8, Eukaryota |
GeneTreei | ENSGT00940000154363 |
InParanoidi | P15530 |
OMAi | YRGCGTE |
OrthoDBi | 1234092at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR039695, CD79a/CD79b IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR14334, PTHR14334, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MATLVLSSMP CHWLLFLLLL FSGEPVPAMT SSDLPLNFQG SPCSQIWQHP
60 70 80 90 100
RFAAKKRSSM VKFHCYTNHS GALTWFRKRG SQQPQELVSE EGRIVQTQNG
110 120 130 140 150
SVYTLTIQNI QYEDNGIYFC KQKCDSANHN VTDSCGTELL VLGFSTLDQL
160 170 180 190 200
KRRNTLKDGI ILIQTLLIIL FIIVPIFLLL DKDDGKAGME EDHTYEGLNI
210 220
DQTATYEDIV TLRTGEVKWS VGEHPGQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1ARJ9 | B1ARJ9_MOUSE | B-cell antigen receptor complex-ass... | Cd79b | 288 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03857 mRNA Translation: AAA37274.1 AK143573 mRNA Translation: BAE25444.1 CT010358 mRNA Translation: CAJ18566.1 BC012226 mRNA Translation: AAH12226.1 AF002279 Genomic DNA Translation: AAB93965.1 |
CCDSi | CCDS48960.1 |
PIRi | B60228 |
RefSeqi | NP_001300868.1, NM_001313939.1 NP_032365.1, NM_008339.3 |
Genome annotation databases
Ensembli | ENSMUST00000167143; ENSMUSP00000129029; ENSMUSG00000040592 |
GeneIDi | 15985 |
KEGGi | mmu:15985 |
UCSCi | uc007lyt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03857 mRNA Translation: AAA37274.1 AK143573 mRNA Translation: BAE25444.1 CT010358 mRNA Translation: CAJ18566.1 BC012226 mRNA Translation: AAH12226.1 AF002279 Genomic DNA Translation: AAB93965.1 |
CCDSi | CCDS48960.1 |
PIRi | B60228 |
RefSeqi | NP_001300868.1, NM_001313939.1 NP_032365.1, NM_008339.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KHO | X-ray | 3.11 | A/B | 27-159 | [»] | |
3KHQ | X-ray | 1.70 | A | 27-159 | [»] | |
SMRi | P15530 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200546, 3 interactors |
DIPi | DIP-59498N |
ELMi | P15530 |
STRINGi | 10090.ENSMUSP00000048239 |
PTM databases
GlyGeni | P15530, 3 sites |
iPTMneti | P15530 |
PhosphoSitePlusi | P15530 |
Proteomic databases
PaxDbi | P15530 |
PRIDEi | P15530 |
ProteomicsDBi | 280028 |
Protocols and materials databases
ABCDi | P15530, 2 sequenced antibodies |
Antibodypediai | 2218, 1048 antibodies from 42 providers |
DNASUi | 15985 |
Genome annotation databases
Ensembli | ENSMUST00000167143; ENSMUSP00000129029; ENSMUSG00000040592 |
GeneIDi | 15985 |
KEGGi | mmu:15985 |
UCSCi | uc007lyt.2, mouse |
Organism-specific databases
CTDi | 974 |
MGIi | MGI:96431, Cd79b |
VEuPathDBi | HostDB:ENSMUSG00000040592 |
Phylogenomic databases
eggNOGi | ENOG502S7X8, Eukaryota |
GeneTreei | ENSGT00940000154363 |
InParanoidi | P15530 |
OMAi | YRGCGTE |
OrthoDBi | 1234092at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-5690714, CD22 mediated BCR regulation R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
BioGRID-ORCSi | 15985, 3 hits in 64 CRISPR screens |
ChiTaRSi | Cd79b, mouse |
EvolutionaryTracei | P15530 |
PROi | PR:P15530 |
RNActi | P15530, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040592, Expressed in bone marrow and 138 other tissues |
ExpressionAtlasi | P15530, baseline and differential |
Genevisiblei | P15530, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR039695, CD79a/CD79b IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003110, Phos_immunorcpt_sig_ITAM |
PANTHERi | PTHR14334, PTHR14334, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF02189, ITAM, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00077, ITAM, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51055, ITAM_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD79B_MOUSE | |
Accessioni | P15530Primary (citable) accession number: P15530 Secondary accession number(s): Q4FJP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references