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UniProtKB - P15516 (HIS3_HUMAN)

Entry version 175 (07 Apr 2021)
Sequence version 2 (01 Feb 1991)
Previous versions | rss
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Protein

Histatin-3

Gene

HTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.2 Publications

Miscellaneous

The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei32Important for candidacidal activity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi34Zinc1
Sitei41Important for candidacidal activity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
Biological processBiomineralization
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P15516

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6803157, Antimicrobial peptides

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.79.1.1, the channel-forming histatin antimicrobial peptide (histatin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histatin-3
Alternative name(s):
Basic histidine-rich protein
Short name:
Hst
Histidine-rich protein 3
PB
Cleaved into the following 26 chains:
Histatin-3
His3-(20-44)-peptide
Short name:
His3 20/44
Alternative name(s):
His3-(1-25)-peptide
Short name:
His3 1/25
Histatin-3 1/25
Histatin-6
His3-(20-43)-peptide
Short name:
His3 20/43
Alternative name(s):
His3-(1-24)-peptide
Short name:
His3 1/24
Histatin-3 1/24
Histatin-5
His3-(20-32)-peptide
Short name:
His3 20/32
Alternative name(s):
His3-(1-13)-peptide
Short name:
His3 1/13
Histatin-3 1/13
His3-(20-31)-peptide
Short name:
His3 20/31
Alternative name(s):
His3-(1-12)-peptide
Short name:
His3 1/12
Histatin-3 1/12
His3-(20-30)-peptide
Short name:
His3 20/30
Alternative name(s):
His3-(1-11)-peptide
Short name:
His3 1/11
Histatin-3 1/11
His3-(24-32)-peptide
Short name:
His3 24/32
Alternative name(s):
His3-(5-13)-peptide
Short name:
His3 5/13
Histatin-3 5/13
His3-(24-31)-peptide
Short name:
His3 24/31
Alternative name(s):
His3-(5-12)-peptide
Short name:
His3 5/12
Histatin-11
Histatin-3 5/12
His3-(24-30)-peptide
Short name:
His3 24/30
Alternative name(s):
His3-(5-11)-peptide
Short name:
His3 5/11
Histatin-12
Histatin-3 5/11
His3-(25-32)-peptide
Short name:
His3 25/32
Alternative name(s):
His3-(6-13)-peptide
Short name:
His3 6/13
Histatin-3 6/13
His3-(25-30)-peptide
Short name:
His3 25/30
Alternative name(s):
His3-(6-11)-peptide
Short name:
His3 6/11
Histatin-3 6/11
His3-(26-32)-peptide
Short name:
His3 26/32
Alternative name(s):
His3-(7-13)-peptide
Short name:
His3 7/13
Histatin-3 7/13
His3-(26-31)-peptide
Short name:
His3 26/31
Alternative name(s):
His3-(7-12)-peptide
Short name:
His3 7/12
Histatin-3 7/12
His3-(26-30)-peptide
Short name:
His3 26/30
Alternative name(s):
His3-(7-11)-peptide
Short name:
His3 7/11
Histatin-3 7/11
His3-(31-51)-peptide
Short name:
His3 31/51
Alternative name(s):
His3-(12-32)-peptide
Short name:
His3 12/32
Histatin-3 12/32
Histatin-4
His3-(31-44)-peptide
Short name:
His3 31/44
Alternative name(s):
His3-(12-25)-peptide
Short name:
His3 12/25
Histatin-3 12/25
Histatin-9
His3-(31-43)-peptide
Short name:
His3 31/43
Alternative name(s):
His3-(12-24)-peptide
Short name:
His3 12/24
Histatin-3 12/24
Histatin-7
His3-(32-44)-peptide
Short name:
His3 32/44
Alternative name(s):
His3-(13-25)-peptide
Short name:
His3 13/25
Histatin-10
Histatin-3 13/25
His3-(32-43)-peptide
Short name:
His3 32-43
Alternative name(s):
His3-(13-24)-peptide
Short name:
His3 13/24
Histatin-3 13/24
Histatin-8
His3-(33-44)-peptide
Short name:
His3 33/44
Alternative name(s):
His3-(14-25)-peptide
Short name:
His3 14/25
Histatin-3 14/25
His3-(33-43)-peptide
Short name:
His3 33/43
Alternative name(s):
His3-(14-24)-peptide
Short name:
His3 14/24
Histatin-3 14/24
His3-(34-44)-peptide
Short name:
His3 34/44
Alternative name(s):
His3-(15-25)-peptide
Short name:
His3 15/25
Histatin-3 15/25
His3-(34-43)-peptide
Short name:
His3 34/43
Alternative name(s):
His3-(15-24)-peptide
Short name:
His3 15/24
Histatin-3 15/24
His3-(45-51)-peptide
Short name:
His3 45/51
Alternative name(s):
His3-(26-32)-peptide
Short name:
His3 26/32
Histatin-3 26/32
His3-(47-51)-peptide
Short name:
His3 47/51
Alternative name(s):
His3-(28-32)-peptide
Short name:
His3 28/32
Histatin-3 28/32
His3-(48-51)-peptide
Short name:
His3 48/51
Alternative name(s):
His3-(29-32)-peptide
Short name:
His3 29/32
Histatin-3 29/32
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTN3
Synonyms:HIS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5284, HTN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142702, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P15516

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000205649.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31R → I: No effect on candidacidal activity of His3-(20-43)-peptide. 1 Publication1
Mutagenesisi32K → T or E: 3-fold reduction in candidacidal activity of His3-(20-43)-peptide. 1 Publication1
Mutagenesisi36K → N: No effect on candidacidal activity of His3-(20-43)-peptide. 1 Publication1
Mutagenesisi38H → P: No effect on candidacidal activity of His3-(20-43)-peptide. 1 Publication1
Mutagenesisi40H → L or R: No effect on candidacidal activity of His3-(20-43)-peptide. 1 Publication1
Mutagenesisi41R → G: 10-fold reduction in candidacidal activity of His3-(20-43)-peptide; when associated with E-32. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3347

Open Targets

More...OpenTargetsi		ENSG00000205649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29547

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P15516, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTN3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 193 PublicationsAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002141820 – 51Histatin-3Add BLAST32
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002141920 – 44His3-(20-44)-peptideAdd BLAST25
PeptideiPRO_000002142020 – 43His3-(20-43)-peptideAdd BLAST24
PeptideiPRO_000002142120 – 32His3-(20-32)-peptideAdd BLAST13
PeptideiPRO_000002142220 – 31His3-(20-31)-peptideAdd BLAST12
PeptideiPRO_000002142320 – 30His3-(20-30)-peptideAdd BLAST11
PeptideiPRO_000002142424 – 32His3-(24-32)-peptide9
PeptideiPRO_000002142524 – 31His3-(24-31)-peptide8
PeptideiPRO_000002142624 – 30His3-(24-30)-peptide7
PeptideiPRO_000002142725 – 32His3-(25-32)-peptide8
PeptideiPRO_000002142825 – 30His3-(25-30)-peptide6
PeptideiPRO_000002142926 – 32His3-(26-32)-peptide7
PeptideiPRO_000002143026 – 31His3-(26-31)-peptide6
PeptideiPRO_000002143126 – 30His3-(26-30)-peptide5
PeptideiPRO_000002143231 – 51His3-(31-51)-peptideAdd BLAST21
PeptideiPRO_000002143331 – 44His3-(31-44)-peptideAdd BLAST14
PeptideiPRO_000002143431 – 43His3-(31-43)-peptideAdd BLAST13
PeptideiPRO_000002143532 – 44His3-(32-44)-peptideAdd BLAST13
PeptideiPRO_000002143632 – 43His3-(32-43)-peptideAdd BLAST12
PeptideiPRO_000002143733 – 44His3-(33-44)-peptideAdd BLAST12
PeptideiPRO_000002143833 – 43His3-(33-43)-peptideAdd BLAST11
PeptideiPRO_000002143934 – 44His3-(34-44)-peptideAdd BLAST11
PeptideiPRO_000002144034 – 43His3-(34-43)-peptide10
PeptideiPRO_000002144145 – 51His3-(45-51)-peptide7
PeptideiPRO_000002144247 – 51His3-(47-51)-peptide5
PeptideiPRO_000002144348 – 51His3-(48-51)-peptide4

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

24 proteolytic products are found in saliva.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Not sulfated1 Publication1
Sitei47Not sulfated1 Publication1
Sitei49Not sulfated1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P15516

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15516

PeptideAtlas

More...PeptideAtlasi		P15516

PRoteomics IDEntifications database

More...PRIDEi		P15516

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53166

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000205649, Expressed in saliva-secreting gland and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P15516, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P15516, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000205649, Tissue enriched (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109579, 32 interactors

Protein interaction database and analysis system

More...IntActi		P15516, 4 interactors

Molecular INTeraction database

More...MINTi		P15516

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000432561

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P15516, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histatin/statherin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TEIC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164572

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15516

Identification of Orthologs from Complete Genome Data

More...OMAi		DSHEEKH

Database of Orthologous Groups

More...OrthoDBi		1623335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15516

TreeFam database of animal gene trees

More...TreeFami		TF341637

Family and domain databases

Database of protein disorder

More...DisProti		DP02206

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030774, Histatin-3
IPR030773, Histatin/statherin

The PANTHER Classification System

More...PANTHERi		PTHR15057, PTHR15057, 1 hit
PTHR15057:SF1, PTHR15057:SF1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P15516-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFFVFALIL ALMLSMTGAD SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD 

N
Length:51
Mass (Da):6,149
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFCCB4B32083FD65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RAH8X6RAH8_HUMAN
Histatin-3
HTN3
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are two alleles of HTN3, HIS21 (shown here) and HIS22 that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00528841R → Q in histatin-3-2; loss of the proteolytic cleavage site. 1 PublicationCorresponds to variant dbSNP:rs1136511EnsemblClinVar.1
Natural variantiVAR_00528947 – 51Missing in histatin-3-2. 1 PublicationCorresponds to variant dbSNP:rs17147990Ensembl.5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M26665 mRNA Translation: AAA58646.1
M18372 mRNA Translation: AAA51830.1
L05514, L05513 Genomic DNA Translation: AAA02746.1
BC009791 mRNA Translation: AAH09791.1
BC095438 mRNA Translation: AAH95438.1
S74382 Genomic DNA Translation: AAB32411.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33999.1

Protein sequence database of the Protein Information Resource

More...PIRi		B32541

NCBI Reference Sequences

More...RefSeqi		NP_000191.1, NM_000200.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000530128; ENSP00000432561; ENSG00000205649
ENST00000635585; ENSP00000489520; ENSG00000282967
ENST00000672568; ENSP00000500810; ENSG00000282967
ENST00000673563; ENSP00000500623; ENSG00000205649
ENST00000677679; ENSP00000504141; ENSG00000282967

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3347

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3347

UCSC genome browser

More...UCSCi		uc003hew.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26665 mRNA Translation: AAA58646.1
M18372 mRNA Translation: AAA51830.1
L05514, L05513 Genomic DNA Translation: AAA02746.1
BC009791 mRNA Translation: AAH09791.1
BC095438 mRNA Translation: AAH95438.1
S74382 Genomic DNA Translation: AAB32411.1
CCDSiCCDS33999.1
PIRiB32541
RefSeqiNP_000191.1, NM_000200.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109579, 32 interactors
IntActiP15516, 4 interactors
MINTiP15516
STRINGi9606.ENSP00000432561

Protein family/group databases

TCDBi1.C.79.1.1, the channel-forming histatin antimicrobial peptide (histatin) family

Genetic variation databases

BioMutaiHTN3

Proteomic databases

MassIVEiP15516
PaxDbiP15516
PeptideAtlasiP15516
PRIDEiP15516
ProteomicsDBi53166

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24280, 11 antibodies

The DNASU plasmid repository

More...DNASUi		3347

Genome annotation databases

EnsembliENST00000530128; ENSP00000432561; ENSG00000205649
ENST00000635585; ENSP00000489520; ENSG00000282967
ENST00000672568; ENSP00000500810; ENSG00000282967
ENST00000673563; ENSP00000500623; ENSG00000205649
ENST00000677679; ENSP00000504141; ENSG00000282967
GeneIDi3347
KEGGihsa:3347
UCSCiuc003hew.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3347
DisGeNETi3347

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTN3
HGNCiHGNC:5284, HTN3
HPAiENSG00000205649, Tissue enriched (salivary)
MIMi142702, gene
neXtProtiNX_P15516
OpenTargetsiENSG00000205649
PharmGKBiPA29547
VEuPathDBiHostDB:ENSG00000205649.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TEIC, Eukaryota
GeneTreeiENSGT00940000164572
InParanoidiP15516
OMAiDSHEEKH
OrthoDBi1623335at2759
PhylomeDBiP15516
TreeFamiTF341637

Enzyme and pathway databases

PathwayCommonsiP15516
ReactomeiR-HSA-6803157, Antimicrobial peptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3347, 0 hits in 456 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HTN3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HTN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3347
PharosiP15516, Tbio

Protein Ontology

More...PROi		PR:P15516
RNActiP15516, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000205649, Expressed in saliva-secreting gland and 67 other tissues
ExpressionAtlasiP15516, baseline and differential
GenevisibleiP15516, HS

Family and domain databases

DisProtiDP02206
InterProiView protein in InterPro
IPR030774, Histatin-3
IPR030773, Histatin/statherin
PANTHERiPTHR15057, PTHR15057, 1 hit
PTHR15057:SF1, PTHR15057:SF1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIS3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15516
Secondary accession number(s): Q16243, Q502Z1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1991
Last modified: April 7, 2021
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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