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Entry version 68 (02 Jun 2021)
Sequence version 2 (26 Sep 2001)
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Protein

Myomodulin neuropeptides 1

Gene

MYOMOD1

Organism
Aplysia californica (California sea hare)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exogenous application of myomodulins potentiates ARC muscle contraction.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myomodulin neuropeptides 1
Cleaved into the following 7 chains:
Myomodulin-A
Short name:
MM-A
Alternative name(s):
Neuron B16 peptide
PMSMLRL-amide
Myomodulin-B
Short name:
MM-B
Short name:
MMb
Alternative name(s):
GSYRMMRL-amide
Myomodulin-D
Short name:
MM-D
Short name:
MMd
Alternative name(s):
GLSMLRL-amide
Myomodulin-F
Short name:
MM-F
Short name:
MMf
Alternative name(s):
SLNMLRL-amide
Myomodulin-G
Short name:
MM-G
Short name:
MMg
Alternative name(s):
TLSMLRL-amide
Myomodulin-H
Short name:
MM-H
Short name:
MMh
Alternative name(s):
GLHMLRL-amide
Myomodulin-I
Short name:
MM-I
Short name:
MMi
Alternative name(s):
SLSMLRL-amide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYOMOD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAplysia californica (California sea hare)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6500 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiidaAplysioideaAplysiidaeAplysia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000183719 – 50Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000000183853 – 60Myomodulin-B1 Publication8
PeptideiPRO_000000183963 – 69Myomodulin-H1 Publication7
PropeptideiPRO_000000184073 – 190Sequence analysisAdd BLAST118
PeptideiPRO_0000001841193 – 199Myomodulin-I1 Publication7
PeptideiPRO_0000001842203 – 209Myomodulin-D1 Publication7
PropeptideiPRO_0000001843213 – 237Sequence analysisAdd BLAST25
PeptideiPRO_0000001844240 – 246Myomodulin-G1 Publication7
PeptideiPRO_0000001845250 – 256Myomodulin-A1 Publication7
PeptideiPRO_0000001846260 – 266Myomodulin-A1 Publication7
PeptideiPRO_0000001847270 – 276Myomodulin-A1 Publication7
PeptideiPRO_0000001848280 – 286Myomodulin-A1 Publication7
PeptideiPRO_0000001849290 – 296Myomodulin-A1 Publication7
PeptideiPRO_0000001850300 – 306Myomodulin-A1 Publication7
PeptideiPRO_0000001851310 – 316Myomodulin-A1 Publication7
PeptideiPRO_0000001852320 – 326Myomodulin-A1 Publication7
PeptideiPRO_0000001853330 – 336Myomodulin-A1 Publication7
PeptideiPRO_0000001854340 – 346Myomodulin-A1 Publication7
PropeptideiPRO_0000001855350 – 355Sequence analysis6
PeptideiPRO_0000001856358 – 364Myomodulin-F1 Publication7
PropeptideiPRO_0000001857368 – 370Sequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60Leucine amide1
Modified residuei69Leucine amide1 Publication1
Modified residuei199Leucine amide1 Publication1
Modified residuei209Leucine amide1 Publication1
Modified residuei246Leucine amide1 Publication1
Modified residuei256Leucine amide1 Publication1
Modified residuei266Leucine amide1 Publication1
Modified residuei276Leucine amide1 Publication1
Modified residuei286Leucine amide1 Publication1
Modified residuei296Leucine amide1 Publication1
Modified residuei306Leucine amide1 Publication1
Modified residuei316Leucine amide1 Publication1
Modified residuei326Leucine amide1 Publication1
Modified residuei336Leucine amide1 Publication1
Modified residuei346Leucine amide1 Publication1
Modified residuei364Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all ganglia of the CNS, but only in a subset of neurons including L10 in the abdominal ganglion and B16 in the buccal ganglion.3 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 52DisorderedSequence analysisAdd BLAST25
Regioni210 – 230DisorderedSequence analysisAdd BLAST21
Regioni344 – 370DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 43Polar residuesSequence analysisAdd BLAST16
Compositional biasi344 – 362Basic and acidic residuesSequence analysisAdd BLAST19

Keywords - Domaini

Repeat, Signal

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15513-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVYMLLPLA VFASLTYQGA CEETAAAQTS SDASTSSASS EHAENELSRA
60 70 80 90 100
KRGSYRMMRL GRGLHMLRLG KRGGPVEPES EENLETLLNL LQGYYSDVPE
110 120 130 140 150
YPSEFDDTDL AYPYEEYDAP AHPRYRRSTP PTDGVVAPDV LQKGSSEFED
160 170 180 190 200
FGDSQLDESD EGYYGYDPEN YLYGDFEDYL EPEEGGLGEE KRSLSMLRLG
210 220 230 240 250
KRGLSMLRLG KREGEEGDEM DKKQDESLND DFENDDIKRT LSMLRLGKRP
260 270 280 290 300
MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP
310 320 330 340 350
MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRD
360 370
DDEKEKKSLN MSRLGKRSTQ
Length:370
Mass (Da):42,254
Last modified:September 26, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A792085939C88CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti231D → A in AAB27697 (PubMed:8340812).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti362S → L1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L01421 mRNA Translation: AAA27758.1
S55210 mRNA Translation: AAB25131.1
S55211 mRNA Translation: AAB25132.1
S64300 mRNA Translation: AAB27697.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28340

NCBI Reference Sequences

More...
RefSeqi
NP_001191423.1, NM_001204494.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100533334

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01421 mRNA Translation: AAA27758.1
S55210 mRNA Translation: AAB25131.1
S55211 mRNA Translation: AAB25132.1
S64300 mRNA Translation: AAB27697.1
PIRiA28340
RefSeqiNP_001191423.1, NM_001204494.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100533334

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100533334

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOM1_APLCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15513
Secondary accession number(s): Q07974, Q27916
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 26, 2001
Last modified: June 2, 2021
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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