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Entry version 152 (12 Aug 2020)
Sequence version 4 (23 Jan 2007)
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Protein

Spectrin beta chain, erythrocytic

Gene

Sptb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Miscellaneous

This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-445095, Interaction between L1 and Ankyrins
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-6807878, COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chain, erythrocytic
Alternative name(s):
Beta-I spectrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sptb
Synonyms:Spnb-1, Spnb1, Sptb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98387, Sptb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734601 – 2128Spectrin beta chain, erythrocyticAdd BLAST2128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineCombined sources1
Modified residuei104PhosphothreonineBy similarity1
Modified residuei1289PhosphoserineCombined sources1
Modified residuei2034PhosphoserineBy similarity1
Modified residuei2064PhosphothreonineBy similarity1
Modified residuei2072PhosphothreonineCombined sources1
Modified residuei2101PhosphothreonineBy similarity1
Modified residuei2105PhosphoserineBy similarity1
Modified residuei2108PhosphoserineBy similarity1
Modified residuei2114PhosphoserineBy similarity1
Modified residuei2116PhosphoserineBy similarity1
Modified residuei2119PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15508

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15508

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15508

PeptideAtlas

More...
PeptideAtlasi
P15508

PRoteomics IDEntifications database

More...
PRIDEi
P15508

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15508

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of nonhomologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P15508, 5 interactors

Molecular INTeraction database

More...
MINTi
P15508

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021458

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P15508, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15508

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 158Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati303 – 411Spectrin 1Sequence analysisAdd BLAST109
Repeati416 – 517Spectrin 2Sequence analysisAdd BLAST102
Repeati521 – 627Spectrin 3Sequence analysisAdd BLAST107
Repeati630 – 733Spectrin 4Sequence analysisAdd BLAST104
Repeati736 – 838Spectrin 5Sequence analysisAdd BLAST103
Repeati845 – 942Spectrin 6Sequence analysisAdd BLAST98
Repeati950 – 1050Spectrin 7Sequence analysisAdd BLAST101
Repeati1054 – 1157Spectrin 8Sequence analysisAdd BLAST104
Repeati1162 – 1250Spectrin 9Sequence analysisAdd BLAST89
Repeati1267 – 1368Spectrin 10Sequence analysisAdd BLAST102
Repeati1381 – 1455Spectrin 11Sequence analysisAdd BLAST75
Repeati1473 – 1574Spectrin 12Sequence analysisAdd BLAST102
Repeati1576 – 1680Spectrin 13Sequence analysisAdd BLAST105
Repeati1682 – 1784Spectrin 14Sequence analysisAdd BLAST103
Repeati1789 – 1890Spectrin 15Sequence analysisAdd BLAST102
Repeati1897 – 1997Spectrin 16Sequence analysisAdd BLAST101
Repeati2004 – 2064Spectrin 17Sequence analysisAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 275Actin-bindingAdd BLAST274

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0517, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15508

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297, Spectrin_beta_subunit, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P15508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSATEFENV GNQPPFSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD
60 70 80 90 100
EREVVQKKTF TKWVNSHLAR VSCRISDLYK DLRDGRMLIK LLEVLSGEML
110 120 130 140 150
PRPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI
160 170 180 190 200
WTIILRFQIQ DIVVQTQEGR EQRSAKDALL LWCQMKTAGY PHVNVTNFTS
210 220 230 240 250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFDV AERQLGIIPL
260 270 280 290 300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET
310 320 330 340 350
EKMIEKYSGL ASDLLTWIEQ TISVLNSRKF ANSLSGVQQQ LQAFSTYRTV
360 370 380 390 400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE
410 420 430 440 450
EAEYQRELAL RSELIRQEFD RKAAMRETWL NENQRLVTQD NFGYDLAAVE
460 470 480 490 500
AAKKKHEAIE TDTAAYEERV KALEDLAQEL EKENYHDQKR IIARKDNILR
510 520 530 540 550
LWSYLQELLR SRRQRLEATL ALQKLFQDML HSIDWMDEIK AHILSAEFGK
560 570 580 590 600
HLLEVEDLLQ KHKLMEADIA IQGDKVKAIT AATLQFAEGK GYQPCDPQVI
610 620 630 640 650
QDRVSHLEQC FSELSNMAAG RKAQLEQSKR LWKFFWEMDE AESWIKEKEQ
660 670 680 690 700
IYSSLDYGKD LTSVLILQRK HKAFEDELRG LDAHLKQIFQ EADDMVAQKQ
710 720 730 740 750
FGHPQIETRV KEVSAQWDHL KELAAFRKKD LQDAENFFQF QGDADDLKAW
760 770 780 790 800
LQDAHRLLSG EDVGQDEGAT RALGKKHKEF LEELEESRGV MEHLEHQAQG
810 820 830 840 850
FPEEFRDSPD VTNRLQALRK LYQQVLTQAE LRGHKLQEAL DLYTVFGESD
860 870 880 890 900
ACELWMTEKG KWLDQMDIPN TLEDLEVVQH RFDILDQEMK TLMAQIDGVN
910 920 930 940 950
LAANNLVESG HPRSGEVKQY QDRLNKRWQA FQAVVSEQRE AVDSALRVNN
960 970 980 990 1000
YCVDCEETSK WIMDKTKVVE STKDLGQDLA GVIAIQRKLS GLERDVLAIR
1010 1020 1030 1040 1050
DRVSALERES QYLMESHPEQ KEDIGQRQAD VEKLWKGLQD ALQGQELSLG
1060 1070 1080 1090 1100
EASKLQAFLQ DLDDFKAWLS MAQKAVASED MPESLPEAEQ LLQQHAAIKE
1110 1120 1130 1140 1150
EIDAHRDDYH RVKASGEKVI EGQTDPDYQL LGQRLEGLDT DWDALRRMWE
1160 1170 1180 1190 1200
SRGNTLTQCL GFQEFQKDAK QAEAILSNQE YTLAHLEPPD SLAAAEAGIR
1210 1220 1230 1240 1250
KFEDFLVSME NNRDKILSPV DSGNKLVAEG NLYSNKIMEK VQLIEDRHKK
1260 1270 1280 1290 1300
NNEKAQEATV LLKDNLELQN FLQNCKELTL WINDKLLTSP DVSYDEARNL
1310 1320 1330 1340 1350
HNKWMKHQAF MAELASHQGW LENIDAEGRQ LMAEKPQFKD VVSERLEALH
1360 1370 1380 1390 1400
KLWEELQSTA KAKAEQLSAA RSSDLRLQTH ADLNKWIGAM EDQLRSDDLG
1410 1420 1430 1440 1450
KDLTTVNRML AKLKRVEEQV NLRKEELEEL FADAPSLGAE AGDTDMSIEK
1460 1470 1480 1490 1500
RFLDLLEPLG RRKKQLELSK AKLQISRDLE DETLWVEERL PLAQSADYGT
1510 1520 1530 1540 1550
NLQTVQLFMK KNQTLQNEIL GHAPRVEDVL RRGQELVKAA EIDCQDIEER
1560 1570 1580 1590 1600
LGHLQSSWDT LREAAAGRLQ RLRDAHEAQQ YYLDAGEAEA WISEQELYVF
1610 1620 1630 1640 1650
SDEPPKDEEG AIVMLKRHLR QQRTVEEYGR NIKQLAGRAQ SLLSAGHPEG
1660 1670 1680 1690 1700
EQIIRLQGQV DKQYAGLKDM AEERRRRLEN MYHLFQLKRE ADDLEQWITE
1710 1720 1730 1740 1750
KEMVASSQEM GQDFDHVTML RDKFRDFARE TGAIGQERVD NVTIIERLID
1760 1770 1780 1790 1800
AGHSEAATIA EWKDGLNDMW ADLLELIDTR MQLLAASYDL HRYFYTGTEI
1810 1820 1830 1840 1850
LGLIDEKHRE LPEDVGLDAS TAESFHRVHT AFERELHLLG VQVQQFQDVA
1860 1870 1880 1890 1900
TRLQTAYAGE KADAIQSKEQ EVSAAWQALL DACAGRRAQL VDTADKFRFF
1910 1920 1930 1940 1950
SMVRDLLSWM ESIIRQIETQ ERPRDVSSVE LLLKYHQGIK AEINTRAKNF
1960 1970 1980 1990 2000
STCLELGESL LQRQHQASDE IREKLQQVIS RRQEMNDKWE ARSDRLHMLL
2010 2020 2030 2040 2050
EVCQFSRDAS VAEAWLIAQE PYLASRDFGH TVDSVEKLIK RHEAFEKSTA
2060 2070 2080 2090 2100
SWAERFAALE KPTTLELKER QTPERPTEEP GPQEEEGETA GEAPQVHHAA
2110 2120
TERTSPVSFM SRLSSSWESL LPEPAHPF
Length:2,128
Mass (Da):245,250
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10E576111106DFE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UGX2Q3UGX2_MOUSE
Spectrin beta chain
Sptb Spnb1
2,329Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q397E9Q397_MOUSE
Spectrin beta chain
Sptb Spnb1
2,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S66283 mRNA Translation: AAB28600.1
M18641 mRNA Translation: AAA40126.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45929

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66283 mRNA Translation: AAB28600.1
M18641 mRNA Translation: AAA40126.1
PIRiA45929

3D structure databases

SMRiP15508
ModBaseiSearch...

Protein-protein interaction databases

IntActiP15508, 5 interactors
MINTiP15508
STRINGi10090.ENSMUSP00000021458

PTM databases

iPTMnetiP15508
PhosphoSitePlusiP15508

Proteomic databases

jPOSTiP15508
MaxQBiP15508
PaxDbiP15508
PeptideAtlasiP15508
PRIDEiP15508

Organism-specific databases

MGIiMGI:98387, Sptb

Phylogenomic databases

eggNOGiKOG0517, Eukaryota
InParanoidiP15508

Enzyme and pathway databases

ReactomeiR-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-445095, Interaction between L1 and Ankyrins
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-6807878, COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sptb, mouse

Protein Ontology

More...
PROi
PR:P15508
RNActiP15508, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR016343, Spectrin_bsu
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 17 hits
PIRSFiPIRSF002297, Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 17 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15508
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 152 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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