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Protein

Elastin

Gene

ELN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: ProtInc
  • aortic valve morphogenesis Source: BHF-UCL
  • blood circulation Source: ProtInc
  • cell proliferation Source: ProtInc
  • extracellular matrix organization Source: Reactome
  • outflow tract morphogenesis Source: BHF-UCL
  • respiratory gaseous exchange Source: ProtInc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres

SIGNOR Signaling Network Open Resource

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SIGNORi
P15502

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elastin
Alternative name(s):
Tropoelastin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000049540.16

Human Gene Nomenclature Database

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HGNCi
HGNC:3327 ELN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
130160 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15502

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cutis laxa, autosomal dominant, 1 (ADCL1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema.
See also OMIM:123700
Supravalvular aortic stenosis (SVAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCongenital narrowing of the ascending aorta which can occur sporadically, as an autosomal dominant condition, or as one component of Williams-Beuren syndrome.
See also OMIM:185500
ELN is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of ELN may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:8812460).1 Publication

Keywords - Diseasei

Williams-Beuren syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
2006

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ELN

MalaCards human disease database

More...
MalaCardsi
ELN
MIMi123700 phenotype
185500 phenotype

Open Targets

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OpenTargetsi
ENSG00000049540

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90348 Autosomal dominant cutis laxa
91387 Familial thoracic aortic aneurysm and aortic dissection
3193 Supravalvular aortic stenosis
904 Williams syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27757

Protein family/group databases

Allergome; a platform for allergen knowledge

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Allergomei
11040 Hom s Elastin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3713712

Drug and drug target database

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DrugBanki
DB00533 Rofecoxib

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ELN

Domain mapping of disease mutations (DMDM)

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DMDMi
306526276

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26By similarityAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002116327 – 786ElastinAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34Hydroxyproline1 Publication1
Modified residuei65Hydroxyproline; partial1 Publication1
Modified residuei67Hydroxyproline; partial1 Publication1
Modified residuei88Hydroxyproline; partial1 Publication1
Modified residuei104AllysineBy similarity1
Modified residuei107AllysineBy similarity1
Modified residuei1164-hydroxyproline; partial1 Publication1
Modified residuei156Hydroxyproline; partial1 Publication1
Modified residuei167Hydroxyproline; partial1 Publication1
Modified residuei170Hydroxyproline; partial1 Publication1
Modified residuei177Hydroxyproline; partial1 Publication1
Modified residuei1904-hydroxyproline; partial2 Publications1
Modified residuei241AllysineBy similarity1
Modified residuei261AllysineBy similarity1
Modified residuei265AllysineBy similarity1
Modified residuei2834-hydroxyproline; partial1 Publication1
Modified residuei2864-hydroxyproline; partial2 Publications1
Modified residuei290Hydroxyproline; partial1 Publication1
Modified residuei312AllysineBy similarity1
Modified residuei315AllysineBy similarity1
Modified residuei3274-hydroxyproline; partial1 Publication1
Modified residuei3424-hydroxyproline; partial1 Publication1
Modified residuei3474-hydroxyproline; partial1 Publication1
Modified residuei352Hydroxyproline; partial1 Publication1
Modified residuei355Hydroxyproline; partial1 Publication1
Modified residuei3604-hydroxyproline; partial1 Publication1
Modified residuei375AllysineBy similarity1
Modified residuei379AllysineBy similarity1
Modified residuei382AllysineBy similarity1
Modified residuei4154-hydroxyproline; partial1 Publication1
Modified residuei421Hydroxyproline; partial1 Publication1
Modified residuei4274-hydroxyproline; partial2 Publications1
Modified residuei448AllysineBy similarity1
Modified residuei451AllysineBy similarity1
Modified residuei465Hydroxyproline; partial1 Publication1
Modified residuei4814-hydroxyproline; partial1 Publication1
Modified residuei492AllysineBy similarity1
Modified residuei496AllysineBy similarity1
Modified residuei522Hydroxyproline; partial1 Publication1
Modified residuei550Hydroxyproline; partial1 Publication1
Modified residuei558AllysineBy similarity1
Modified residuei562AllysineBy similarity1
Modified residuei566AllysineBy similarity1
Modified residuei5804-hydroxyproline; partial2 Publications1
Modified residuei5894-hydroxyproline1 Publication1
Modified residuei5984-hydroxyproline1 Publication1
Modified residuei6074-hydroxyproline; partial1 Publication1
Modified residuei646Hydroxyproline; partial1 Publication1
Modified residuei653AllysineBy similarity1
Modified residuei656AllysineBy similarity1
Modified residuei6774-hydroxyproline; partial2 Publications1
Modified residuei693AllysineBy similarity1
Modified residuei697AllysineBy similarity1
Modified residuei735AllysineBy similarity1
Modified residuei738AllysineBy similarity1
Modified residuei769Hydroxyproline; partial1 Publication1
Modified residuei772Hydroxyproline; partial1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi776 ↔ 781By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P15502

PeptideAtlas

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PeptideAtlasi
P15502

PRoteomics IDEntifications database

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PRIDEi
P15502

ProteomicsDB human proteome resource

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ProteomicsDBi
53144
53145 [P15502-1]
53146 [P15502-10]
53147 [P15502-11]
53148 [P15502-12]
53149 [P15502-13]
53150 [P15502-2]
53151 [P15502-4]
53152 [P15502-5]
53153 [P15502-6]
53154 [P15502-7]
53155 [P15502-8]
53156 [P15502-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15502

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P15502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000049540 Expressed in 181 organ(s), highest expression level in thoracic aorta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15502 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15502 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010750
HPA018111
HPA056941

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Interacts with FBLN5 (PubMed:15790312, PubMed:17035250). Interacts with FBN1 (PubMed:15790312). Forms a ternary complex with FBN1 and FBLN2 or FBLN5 (PubMed:17255108). Interacts with MFAP4 in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108321, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P15502

Protein interaction database and analysis system

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IntActi
P15502, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252034

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P15502

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi97 – 102Poly-Ala6
Compositional biasi236 – 742Ala-richAdd BLAST507

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the elastin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZT8 Eukaryota
ENOG4111817 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111510

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15502

KEGG Orthology (KO)

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KOi
K14211

TreeFam database of animal gene trees

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TreeFami
TF338594

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003979 Tropoelastin

The PANTHER Classification System

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PANTHERi
PTHR24018 PTHR24018, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01500 TROPOELASTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 13 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P15502-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLTAAAPR PGVLLLLLSI LHPSRPGGVP GAIPGGVPGG VFYPGAGLGA
60 70 80 90 100
LGGGALGPGG KPLKPVPGGL AGAGLGAGLG AFPAVTFPGA LVPGGVADAA
110 120 130 140 150
AAYKAAKAGA GLGGVPGVGG LGVSAGAVVP QPGAGVKPGK VPGVGLPGVY
160 170 180 190 200
PGGVLPGARF PGVGVLPGVP TGAGVKPKAP GVGGAFAGIP GVGPFGGPQP
210 220 230 240 250
GVPLGYPIKA PKLPGGYGLP YTTGKLPYGY GPGGVAGAAG KAGYPTGTGV
260 270 280 290 300
GPQAAAAAAA KAAAKFGAGA AGVLPGVGGA GVPGVPGAIP GIGGIAGVGT
310 320 330 340 350
PAAAAAAAAA AKAAKYGAAA GLVPGGPGFG PGVVGVPGAG VPGVGVPGAG
360 370 380 390 400
IPVVPGAGIP GAAVPGVVSP EAAAKAAAKA AKYGARPGVG VGGIPTYGVG
410 420 430 440 450
AGGFPGFGVG VGGIPGVAGV PGVGGVPGVG GVPGVGISPE AQAAAAAKAA
460 470 480 490 500
KYGAAGAGVL GGLVPGAPGA VPGVPGTGGV PGVGTPAAAA AKAAAKAAQF
510 520 530 540 550
GLVPGVGVAP GVGVAPGVGV APGVGLAPGV GVAPGVGVAP GVGVAPGIGP
560 570 580 590 600
GGVAAAAKSA AKVAAKAQLR AAAGLGAGIP GLGVGVGVPG LGVGAGVPGL
610 620 630 640 650
GVGAGVPGFG AGADEGVRRS LSPELREGDP SSSQHLPSTP SSPRVPGALA
660 670 680 690 700
AAKAAKYGAA VPGVLGGLGA LGGVGIPGGV VGAGPAAAAA AAKAAAKAAQ
710 720 730 740 750
FGLVGAAGLG GLGVGGLGVP GVGGLGGIPP AAAAKAAKYG AAGLGGVLGG
760 770 780
AGQFPLGGVA ARPGFGLSPI FPGGACLGKA CGRKRK
Length:786
Mass (Da):68,398
Last modified:July 18, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A128EC9EA2CC29F
GO
Isoform 1 (identifier: P15502-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.
     500-500: F → FALLNLA
     612-644: Missing.

Show »
Length:730
Mass (Da):63,230
Checksum:iB38B11526A0CB52D
GO
Isoform 2 (identifier: P15502-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.
     612-644: Missing.

Show »
Length:724
Mass (Da):62,634
Checksum:i0A7E4424F9EC0F78
GO
Isoform 4 (identifier: P15502-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-481: Missing.

Show »
Length:757
Mass (Da):66,106
Checksum:i2B24F955D8360738
GO
Isoform 5 (identifier: P15502-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AAPSVP
     453-481: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.
Show »
Length:711
Mass (Da):61,605
Checksum:i151A0A4E089B3A5C
GO
Isoform 6 (identifier: P15502-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Show »
Length:687
Mass (Da):59,500
Checksum:i86446D90C8E2664F
GO
Isoform 7 (identifier: P15502-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-54: Missing.
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):58,789
Checksum:iC5082D1C00A310BA
GO
Isoform 8 (identifier: P15502-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-228: Missing.
     453-500: Missing.
     555-570: AAAKSAAKVAAKAQLR → G
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):56,551
Checksum:i5DAFC55566AB809B
GO
Isoform 9 (identifier: P15502-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-500: F → FALLNLA

Note: No experimental confirmation available.
Show »
Length:792
Mass (Da):68,993
Checksum:i7A7B61760A54B712
GO
Isoform 10 (identifier: P15502-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-500: F → FALLNLA
     612-644: Missing.

Note: No experimental confirmation available.
Show »
Length:759
Mass (Da):65,522
Checksum:i8283EA3092BB83F3
GO
Isoform 11 (identifier: P15502-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-180: Missing.
     215-228: Missing.
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Note: No experimental confirmation available.
Show »
Length:570
Mass (Da):48,897
Checksum:i6C9128F3D079D9B0
GO
Isoform 12 (identifier: P15502-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AAPSVP
     453-500: Missing.
     612-644: Missing.
     740-757: Missing.

Show »
Length:692
Mass (Da):59,951
Checksum:i65D038D48352C5E9
GO
Isoform 13 (identifier: P15502-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     453-500: Missing.
     612-644: Missing.

Show »
Length:705
Mass (Da):60,980
Checksum:i78F444C823E5F8B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAH6F8WAH6_HUMAN
Elastin
ELN
786Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENM0E7ENM0_HUMAN
Elastin
ELN
706Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EN65E7EN65_HUMAN
Elastin
ELN
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KRT8B3KRT8_HUMAN
Elastin (Supravalvular aortic steno...
ELN hCG_18037
617Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E950G5E950_HUMAN
Elastin (Supravalvular aortic steno...
ELN hCG_18037
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V0G6G3V0G6_HUMAN
Elastin
ELN hCG_18037
700Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWS8E7EWS8_HUMAN
Elastin
ELN
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP82E7EP82_HUMAN
Elastin
ELN
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETP7E7ETP7_HUMAN
Elastin
ELN
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENW7E7ENW7_HUMAN
Elastin
ELN
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD98065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti317G → E in CAD97910 (PubMed:17974005).Curated1
Sequence conflicti553V → I in BAC85506 (PubMed:14702039).Curated1
Sequence conflicti691A → T in CAD98065 (PubMed:17974005).Curated1
Sequence conflicti773G → D in CAD97910 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072395211P → S Found as homozygous mutation in a patient with autosomal recessive cutis laxa also carrying a mutation in FBLN5; unknown pathological significance. 1 Publication1
Natural variantiVAR_020882422G → S7 PublicationsCorresponds to variant dbSNP:rs2071307EnsemblClinVar.1
Natural variantiVAR_056869610G → R2 PublicationsCorresponds to variant dbSNP:rs17855988Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01247945 – 54Missing in isoform 7. 1 Publication10
Alternative sequenceiVSP_01248078 – 180Missing in isoform 11. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_012481125A → AAPSVP in isoform 5 and isoform 12. 2 Publications1
Alternative sequenceiVSP_012482215 – 228Missing in isoform 8 and isoform 11. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_012483453 – 500Missing in isoform 6, isoform 7, isoform 8, isoform 11, isoform 12 and isoform 13. 4 PublicationsAdd BLAST48
Alternative sequenceiVSP_012484453 – 481Missing in isoform 1, isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_012485500F → FALLNLA in isoform 1, isoform 9 and isoform 10. 1 Publication1
Alternative sequenceiVSP_012486555 – 570AAAKS…KAQLR → G in isoform 8. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_012487612 – 644Missing in isoform 1, isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10, isoform 11, isoform 12 and isoform 13. 6 PublicationsAdd BLAST33
Alternative sequenceiVSP_012488740 – 757Missing in isoform 5, isoform 6, isoform 7, isoform 8, isoform 11 and isoform 12. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17282
, M16983, M17265, M17266, M17267, M17268, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17281 Genomic DNA Translation: AAC98393.1
M17282
, M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA Translation: AAC98394.1
M17282
, M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17274, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA Translation: AAC98395.1
M36860 mRNA Translation: AAA52382.1
AK095990 mRNA Translation: BAG53188.1
AK122731 mRNA Translation: BAC85506.1
BX537939 mRNA Translation: CAD97910.1
BX538199 mRNA Translation: CAD98065.1 Different initiation.
AK225659 mRNA No translation available.
AC005056 Genomic DNA Translation: AAS07435.1
CH471200 Genomic DNA Translation: EAW69627.1
BC065566 mRNA Translation: AAH65566.1
X15603 Genomic DNA Translation: CAA33627.1
U93037
, U93034, U93035, U93036 Genomic DNA Translation: AAB65620.1
U93037
, U93034, U93035, U93036 Genomic DNA Translation: AAB65621.1
M24782 mRNA Translation: AAA53190.1
U63721 Genomic DNA Translation: AAC13884.1
U62292 Genomic DNA Translation: AAB17544.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43598.1 [P15502-5]
CCDS43599.1 [P15502-7]
CCDS47611.1 [P15502-12]
CCDS47612.1 [P15502-13]
CCDS5562.2 [P15502-2]
CCDS64673.1 [P15502-1]
CCDS64675.1 [P15502-8]
CCDS75616.1 [P15502-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A32707 EAHU

NCBI Reference Sequences

More...
RefSeqi
NP_000492.2, NM_000501.3 [P15502-2]
NP_001075221.1, NM_001081752.2 [P15502-7]
NP_001075222.1, NM_001081753.2 [P15502-12]
NP_001075223.1, NM_001081754.2 [P15502-5]
NP_001075224.1, NM_001081755.2 [P15502-13]
NP_001265844.1, NM_001278915.1 [P15502-1]
NP_001265845.1, NM_001278916.1 [P15502-8]
NP_001265868.1, NM_001278939.1 [P15502-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.647061

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252034; ENSP00000252034; ENSG00000049540 [P15502-2]
ENST00000320399; ENSP00000313565; ENSG00000049540 [P15502-4]
ENST00000357036; ENSP00000349540; ENSG00000049540 [P15502-5]
ENST00000358929; ENSP00000351807; ENSG00000049540 [P15502-3]
ENST00000380553; ENSP00000369926; ENSG00000049540 [P15502-11]
ENST00000380562; ENSP00000369936; ENSG00000049540 [P15502-1]
ENST00000380575; ENSP00000369949; ENSG00000049540 [P15502-7]
ENST00000380576; ENSP00000369950; ENSG00000049540 [P15502-13]
ENST00000380584; ENSP00000369958; ENSG00000049540 [P15502-8]
ENST00000429192; ENSP00000391129; ENSG00000049540 [P15502-12]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2006

UCSC genome browser

More...
UCSCi
uc003tzn.5 human [P15502-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Elastin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17282
, M16983, M17265, M17266, M17267, M17268, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17281 Genomic DNA Translation: AAC98393.1
M17282
, M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA Translation: AAC98394.1
M17282
, M16983, M17265, M17266, M17267, M17268, M17270, M17271, M17272, M17273, M17274, M17275, M17276, M17277, M17278, M17279, M17280, M17281 Genomic DNA Translation: AAC98395.1
M36860 mRNA Translation: AAA52382.1
AK095990 mRNA Translation: BAG53188.1
AK122731 mRNA Translation: BAC85506.1
BX537939 mRNA Translation: CAD97910.1
BX538199 mRNA Translation: CAD98065.1 Different initiation.
AK225659 mRNA No translation available.
AC005056 Genomic DNA Translation: AAS07435.1
CH471200 Genomic DNA Translation: EAW69627.1
BC065566 mRNA Translation: AAH65566.1
X15603 Genomic DNA Translation: CAA33627.1
U93037
, U93034, U93035, U93036 Genomic DNA Translation: AAB65620.1
U93037
, U93034, U93035, U93036 Genomic DNA Translation: AAB65621.1
M24782 mRNA Translation: AAA53190.1
U63721 Genomic DNA Translation: AAC13884.1
U62292 Genomic DNA Translation: AAB17544.1
CCDSiCCDS43598.1 [P15502-5]
CCDS43599.1 [P15502-7]
CCDS47611.1 [P15502-12]
CCDS47612.1 [P15502-13]
CCDS5562.2 [P15502-2]
CCDS64673.1 [P15502-1]
CCDS64675.1 [P15502-8]
CCDS75616.1 [P15502-3]
PIRiA32707 EAHU
RefSeqiNP_000492.2, NM_000501.3 [P15502-2]
NP_001075221.1, NM_001081752.2 [P15502-7]
NP_001075222.1, NM_001081753.2 [P15502-12]
NP_001075223.1, NM_001081754.2 [P15502-5]
NP_001075224.1, NM_001081755.2 [P15502-13]
NP_001265844.1, NM_001278915.1 [P15502-1]
NP_001265845.1, NM_001278916.1 [P15502-8]
NP_001265868.1, NM_001278939.1 [P15502-3]
UniGeneiHs.647061

3D structure databases

ProteinModelPortaliP15502
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108321, 14 interactors
CORUMiP15502
IntActiP15502, 11 interactors
STRINGi9606.ENSP00000252034

Chemistry databases

ChEMBLiCHEMBL3713712
DrugBankiDB00533 Rofecoxib

Protein family/group databases

Allergomei11040 Hom s Elastin

PTM databases

iPTMnetiP15502
PhosphoSitePlusiP15502

Polymorphism and mutation databases

BioMutaiELN
DMDMi306526276

Proteomic databases

PaxDbiP15502
PeptideAtlasiP15502
PRIDEiP15502
ProteomicsDBi53144
53145 [P15502-1]
53146 [P15502-10]
53147 [P15502-11]
53148 [P15502-12]
53149 [P15502-13]
53150 [P15502-2]
53151 [P15502-4]
53152 [P15502-5]
53153 [P15502-6]
53154 [P15502-7]
53155 [P15502-8]
53156 [P15502-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252034; ENSP00000252034; ENSG00000049540 [P15502-2]
ENST00000320399; ENSP00000313565; ENSG00000049540 [P15502-4]
ENST00000357036; ENSP00000349540; ENSG00000049540 [P15502-5]
ENST00000358929; ENSP00000351807; ENSG00000049540 [P15502-3]
ENST00000380553; ENSP00000369926; ENSG00000049540 [P15502-11]
ENST00000380562; ENSP00000369936; ENSG00000049540 [P15502-1]
ENST00000380575; ENSP00000369949; ENSG00000049540 [P15502-7]
ENST00000380576; ENSP00000369950; ENSG00000049540 [P15502-13]
ENST00000380584; ENSP00000369958; ENSG00000049540 [P15502-8]
ENST00000429192; ENSP00000391129; ENSG00000049540 [P15502-12]
GeneIDi2006
KEGGihsa:2006
UCSCiuc003tzn.5 human [P15502-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2006
DisGeNETi2006
EuPathDBiHostDB:ENSG00000049540.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ELN
GeneReviewsiELN

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0006761
HGNCiHGNC:3327 ELN
HPAiCAB010750
HPA018111
HPA056941
MalaCardsiELN
MIMi123700 phenotype
130160 gene
185500 phenotype
neXtProtiNX_P15502
OpenTargetsiENSG00000049540
Orphaneti90348 Autosomal dominant cutis laxa
91387 Familial thoracic aortic aneurysm and aortic dissection
3193 Supravalvular aortic stenosis
904 Williams syndrome
PharmGKBiPA27757

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZT8 Eukaryota
ENOG4111817 LUCA
GeneTreeiENSGT00730000111510
InParanoidiP15502
KOiK14211
TreeFamiTF338594

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres
SIGNORiP15502

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ELN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Elastin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2006
PMAP-CutDBiP15502

Protein Ontology

More...
PROi
PR:P15502

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000049540 Expressed in 181 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiP15502 baseline and differential
GenevisibleiP15502 HS

Family and domain databases

InterProiView protein in InterPro
IPR003979 Tropoelastin
PANTHERiPTHR24018 PTHR24018, 2 hits
PRINTSiPR01500 TROPOELASTIN

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15502
Secondary accession number(s): B3KTS6
, O15336, O15337, Q14233, Q14234, Q14235, Q14238, Q6P0L4, Q6ZWJ6, Q75MU5, Q7Z316, Q7Z3F5, Q9UMF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 18, 2018
Last modified: December 5, 2018
This is version 196 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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