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Protein

Peripherin-2

Gene

Prph2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: GO_Central
  • retina development in camera-type eye Source: MGI
  • visual perception Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin-2
Alternative name(s):
Retinal degeneration slow protein
Gene namesi
Name:Prph2
Synonyms:Rds
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:102791 Prph2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 61LumenalSequence analysisAdd BLAST18
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 99CytoplasmicSequence analysisAdd BLAST19
Transmembranei100 – 123HelicalSequence analysisAdd BLAST24
Topological domaini124 – 264LumenalSequence analysisAdd BLAST141
Transmembranei265 – 290HelicalSequence analysisAdd BLAST26
Topological domaini291 – 346CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Responsible for retinal degeneration slow (Rds) (PubMed:8530028).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681061 – 346Peripherin-2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15499
PRIDEiP15499

PTM databases

PhosphoSitePlusiP15499

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiENSMUSG00000023978 Expressed in 10 organ(s), highest expression level in retina
CleanExiMM_PRPH2
ExpressionAtlasiP15499 baseline and differential
GenevisibleiP15499 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a ROM1 homodimer. Other proteins could associate with this complex in rods. Interacts with MREG.1 Publication

Protein-protein interaction databases

BioGridi202399, 1 interactor
STRINGi10090.ENSMUSP00000024773

Structurei

3D structure databases

ProteinModelPortaliP15499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 346Interaction with MREG1 Publication6

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000016192
HOGENOMiHOG000026780
HOVERGENiHBG004964
InParanoidiP15499
KOiK17343
OMAiGKICYDS
OrthoDBiEOG091G0956
PhylomeDBiP15499
TreeFamiTF331684

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000830 Peripherin/rom-1
IPR018498 Peripherin/rom-1_CS
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00218 PERIPHERNRDS
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00930 RDS_ROM1, 1 hit

Sequencei

Sequence statusi: Complete.

P15499-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLKVKFDQ KKRVKLAQGL WLMNWLSVLA GIVLFSLGLF LKIELRKRSE
60 70 80 90 100
VMNNSESHFV PNSLIGVGVL SCVFNSLAGK ICYDALDPAK YAKWKPWLKP
110 120 130 140 150
YLAVCIFFNV ILFLVALCCF LLRGSLESTL AYGLKNGMKY YRDTDTPGRC
160 170 180 190 200
FMKKTIDMLQ IEFKCCGNNG FRDWFEIQWI SNRYLDFSSK EVKDRIKSNV
210 220 230 240 250
DGRYLVDGVP FSCCNPSSPR PCIQYQLTNN SAHYSYDHQT EELNLWLRGC
260 270 280 290 300
RAALLNYYSS LMNSMGVVTL LVWLFEVSIT AGLRYLHTAL ESVSNPEDPE
310 320 330 340
CESEGWLLEK SVPETWKAFL ESFKKLGKSN QVEAEGADAG PAPEAG
Length:346
Mass (Da):39,260
Last modified:April 1, 1990 - v1
Checksum:iF9B80C14F2867BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA Translation: CAA32878.1
BC028958 mRNA Translation: AAH28958.1
BC085266 mRNA Translation: AAH85266.1
L42167 Genomic DNA Translation: AAC37674.1
CCDSiCCDS28844.1
PIRiS03347
RefSeqiNP_032964.1, NM_008938.1
UniGeneiMm.291370

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978
GeneIDi19133
KEGGimmu:19133
UCSCiuc008cun.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14770 mRNA Translation: CAA32878.1
BC028958 mRNA Translation: AAH28958.1
BC085266 mRNA Translation: AAH85266.1
L42167 Genomic DNA Translation: AAC37674.1
CCDSiCCDS28844.1
PIRiS03347
RefSeqiNP_032964.1, NM_008938.1
UniGeneiMm.291370

3D structure databases

ProteinModelPortaliP15499
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202399, 1 interactor
STRINGi10090.ENSMUSP00000024773

PTM databases

PhosphoSitePlusiP15499

Proteomic databases

PaxDbiP15499
PRIDEiP15499

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024773; ENSMUSP00000024773; ENSMUSG00000023978
GeneIDi19133
KEGGimmu:19133
UCSCiuc008cun.1 mouse

Organism-specific databases

CTDi5961
MGIiMGI:102791 Prph2

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000016192
HOGENOMiHOG000026780
HOVERGENiHBG004964
InParanoidiP15499
KOiK17343
OMAiGKICYDS
OrthoDBiEOG091G0956
PhylomeDBiP15499
TreeFamiTF331684

Miscellaneous databases

ChiTaRSiPrph2 mouse
PROiPR:P15499
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023978 Expressed in 10 organ(s), highest expression level in retina
CleanExiMM_PRPH2
ExpressionAtlasiP15499 baseline and differential
GenevisibleiP15499 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000830 Peripherin/rom-1
IPR018498 Peripherin/rom-1_CS
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00218 PERIPHERNRDS
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00930 RDS_ROM1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRPH2_MOUSE
AccessioniPrimary (citable) accession number: P15499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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