UniProtKB - P15497 (APOA1_BOVIN)
Apolipoprotein A-I
APOA1
Functioni
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
GO - Molecular functioni
- amyloid-beta binding Source: Ensembl
- apolipoprotein A-I receptor binding Source: Ensembl
- chemorepellent activity Source: Ensembl
- cholesterol binding Source: GO_Central
- cholesterol transfer activity Source: Ensembl
- enzyme binding Source: Ensembl
- heat shock protein binding Source: Ensembl
- high-density lipoprotein particle binding Source: Ensembl
- high-density lipoprotein particle receptor binding Source: GO_Central
- identical protein binding Source: Ensembl
- phosphatidylcholine binding Source: GO_Central
- phosphatidylcholine-sterol O-acyltransferase activator activity Source: GO_Central
- phospholipid binding Source: GO_Central
GO - Biological processi
- adrenal gland development Source: Ensembl
- blood vessel endothelial cell migration Source: Ensembl
- cholesterol biosynthetic process Source: GO_Central
- cholesterol efflux Source: GO_Central
- cholesterol homeostasis Source: GO_Central
- cholesterol import Source: Ensembl
- endothelial cell proliferation Source: Ensembl
- glucocorticoid metabolic process Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Ensembl
- high-density lipoprotein particle assembly Source: GO_Central
- high-density lipoprotein particle remodeling Source: Ensembl
- integrin-mediated signaling pathway Source: Ensembl
- lipid storage Source: Ensembl
- lipoprotein biosynthetic process Source: Ensembl
- lipoprotein metabolic process Source: GO_Central
- negative regulation of cell adhesion molecule production Source: Ensembl
- negative regulation of cytokine production involved in immune response Source: Ensembl
- negative regulation of heterotypic cell-cell adhesion Source: Ensembl
- negative regulation of hydrolase activity Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of interleukin-1 beta production Source: Ensembl
- negative regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
- negative regulation of very-low-density lipoprotein particle remodeling Source: Ensembl
- peptidyl-methionine modification Source: UniProtKB
- phosphatidylcholine biosynthetic process Source: Ensembl
- phosphatidylcholine metabolic process Source: GO_Central
- phospholipid efflux Source: GO_Central
- phospholipid homeostasis Source: Ensembl
- positive regulation of cholesterol efflux Source: UniProtKB
- positive regulation of cholesterol esterification Source: GO_Central
- positive regulation of fatty acid biosynthetic process Source: GO_Central
- positive regulation of lipid biosynthetic process Source: GO_Central
- positive regulation of lipoprotein lipase activity Source: GO_Central
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of phospholipid efflux Source: UniProtKB
- positive regulation of Rho protein signal transduction Source: Ensembl
- positive regulation of stress fiber assembly Source: Ensembl
- positive regulation of substrate adhesion-dependent cell spreading Source: Ensembl
- positive regulation of triglyceride catabolic process Source: GO_Central
- protein oxidation Source: UniProtKB
- protein stabilization Source: UniProtKB
- regulation of Cdc42 protein signal transduction Source: Ensembl
- regulation of intestinal cholesterol absorption Source: GO_Central
- regulation of protein phosphorylation Source: Ensembl
- reverse cholesterol transport Source: GO_Central
- triglyceride homeostasis Source: GO_Central
- very-low-density lipoprotein particle remodeling Source: GO_Central
- vitamin transport Source: Ensembl
Keywordsi
Biological process | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Apolipoprotein A-IShort name: Apo-AI Short name: ApoA-I Alternative name(s): Apolipoprotein A1 Cleaved into the following 2 chains: |
Gene namesi | Name:APOA1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000002258 |
VGNCi | VGNC:26022, APOA1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- chylomicron Source: GO_Central
- high-density lipoprotein particle Source: GO_Central
- spherical high-density lipoprotein particle Source: Ensembl
- very-low-density lipoprotein particle Source: Ensembl
Other locations
- endocytic vesicle Source: Ensembl
Keywords - Cellular componenti
HDL, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000425319 | 19 – 265 | Proapolipoprotein A-IAdd BLAST | 247 | |
ChainiPRO_0000001935 | 25 – 265 | Apolipoprotein A-IAdd BLAST | 241 | |
ChainiPRO_0000416571 | 25 – 264 | Truncated apolipoprotein A-IBy similarityAdd BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 109 | Methionine sulfoxideBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Lipoprotein, Oxidation, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P15497 |
PeptideAtlasi | P15497 |
PRIDEi | P15497 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSBTAG00000002258, Expressed in diaphragm and 93 other tissues |
ExpressionAtlasi | P15497, baseline and differential |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with APOA1BP and CLU.
Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin.
Interacts with NDRG1.
Interacts with SCGB3A2 (By similarity).
Interacts with NAXE and YJEFN3 (By similarity).
By similarityGO - Molecular functioni
- apolipoprotein A-I receptor binding Source: Ensembl
- chemorepellent activity Source: Ensembl
- enzyme binding Source: Ensembl
- heat shock protein binding Source: Ensembl
- high-density lipoprotein particle receptor binding Source: GO_Central
- identical protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | P15497, 1 interactor |
STRINGi | 9913.ENSBTAP00000002914 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 67 – 88 | 1Add BLAST | 22 | |
Repeati | 89 – 110 | 2Add BLAST | 22 | |
Repeati | 111 – 121 | 3; half-lengthAdd BLAST | 11 | |
Repeati | 122 – 143 | 4Add BLAST | 22 | |
Repeati | 144 – 165 | 5Add BLAST | 22 | |
Repeati | 166 – 187 | 6Add BLAST | 22 | |
Repeati | 188 – 209 | 7Add BLAST | 22 | |
Repeati | 210 – 230 | 8Add BLAST | 21 | |
Repeati | 231 – 241 | 9; half-lengthAdd BLAST | 11 | |
Repeati | 242 – 265 | 10Add BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 265 | 10 X approximate tandem repeatsAdd BLAST | 199 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502S1XQ, Eukaryota |
GeneTreei | ENSGT00950000182929 |
HOGENOMi | CLU_058447_1_0_1 |
InParanoidi | P15497 |
OMAi | KEVREMW |
OrthoDBi | 1553412at2759 |
TreeFami | TF334458 |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MKAVVLTLAV LFLTGSQARH FWQQDDPQSS WDRVKDFATV YVEAIKDSGR
60 70 80 90 100
DYVAQFEASA LGKQLNLKLL DNWDTLASTL SKVREQLGPV TQEFWDNLEK
110 120 130 140 150
ETASLRQEMH KDLEEVKQKV QPYLDEFQKK WHEEVEIYRQ KVAPLGEEFR
160 170 180 190 200
EGARQKVQEL QDKLSPLAQE LRDRARAHVE TLRQQLAPYS DDLRQRLTAR
210 220 230 240 250
LEALKEGGGS LAEYHAKASE QLKALGEKAK PVLEDLRQGL LPVLESLKVS
260
ILAAIDEASK KLNAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MJJ4 | A0A3Q1MJJ4_BOVIN | Apolipoprotein A-I | APOA1 | 250 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 – 186 | QL → HV in AAA30381 (PubMed:2117227).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35870 mRNA Translation: AAA30381.1 BC102941 mRNA Translation: AAI02942.1 BC140619 mRNA Translation: AAI40620.1 |
PIRi | I45853, A56858 |
RefSeqi | NP_776667.2, NM_174242.3 |
Genome annotation databases
Ensembli | ENSBTAT00000002914; ENSBTAP00000002914; ENSBTAG00000002258 |
GeneIDi | 281631 |
KEGGi | bta:281631 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35870 mRNA Translation: AAA30381.1 BC102941 mRNA Translation: AAI02942.1 BC140619 mRNA Translation: AAI40620.1 |
PIRi | I45853, A56858 |
RefSeqi | NP_776667.2, NM_174242.3 |
3D structure databases
SMRi | P15497 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P15497, 1 interactor |
STRINGi | 9913.ENSBTAP00000002914 |
Proteomic databases
PaxDbi | P15497 |
PeptideAtlasi | P15497 |
PRIDEi | P15497 |
Genome annotation databases
Ensembli | ENSBTAT00000002914; ENSBTAP00000002914; ENSBTAG00000002258 |
GeneIDi | 281631 |
KEGGi | bta:281631 |
Organism-specific databases
CTDi | 335 |
VEuPathDBi | HostDB:ENSBTAG00000002258 |
VGNCi | VGNC:26022, APOA1 |
Phylogenomic databases
eggNOGi | ENOG502S1XQ, Eukaryota |
GeneTreei | ENSGT00950000182929 |
HOGENOMi | CLU_058447_1_0_1 |
InParanoidi | P15497 |
OMAi | KEVREMW |
OrthoDBi | 1553412at2759 |
TreeFami | TF334458 |
Gene expression databases
Bgeei | ENSBTAG00000002258, Expressed in diaphragm and 93 other tissues |
ExpressionAtlasi | P15497, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000074, ApoA_E |
Pfami | View protein in Pfam PF01442, Apolipoprotein, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APOA1_BOVIN | |
Accessioni | P15497Primary (citable) accession number: P15497 Secondary accession number(s): A5D7M9, Q3SZD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | May 1, 1992 | |
Last modified: | September 29, 2021 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families