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Protein

Mu-conotoxin GS

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mu-conotoxins block voltage-gated sodium channels (Nav). No effect was observed upon injections into mice and goldfish (25 µg).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-conotoxin GS
Short name:
CGS
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServeri1268 conotoxin-GS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448781 – 34Mu-conotoxin GSAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 141 Publication
Disulfide bondi9 ↔ 191 Publication
Modified residuei104-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi13 ↔ 271 Publication
Modified residuei324-carboxyglutamate1 Publication1

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP15472
SMRiP15472
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15472

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012629 Conotoxin_TVIIAGS
PfamiView protein in Pfam
PF08094 Toxin_24, 1 hit

Sequencei

Sequence statusi: Complete.

P15472-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
ACSGRGSRCP PQCCMGLRCG RGNPQKCIGA HEDV
Length:34
Mass (Da):3,548
Last modified:April 1, 1990 - v1
Checksum:i16614FD96DB1A78C
GO

Sequence databases

PIRiA31043

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA31043

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG7NMR-A1-34[»]
ProteinModelPortaliP15472
SMRiP15472
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1268 conotoxin-GS

Miscellaneous databases

EvolutionaryTraceiP15472

Family and domain databases

InterProiView protein in InterPro
IPR012629 Conotoxin_TVIIAGS
PfamiView protein in Pfam
PF08094 Toxin_24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU6GS_CONGE
AccessioniPrimary (citable) accession number: P15472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 10, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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