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UniProtKB - P15428 (PGDH_HUMAN)

Entry version 197 (16 Oct 2019)
Sequence version 1 (01 Apr 1990)
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Protein

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene

HPGD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.4 µM for prostaglandin E21 Publication
  2. KM=38 µM for NAD1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei91NAD; via carbonyl oxygen1 Publication1
    Binding sitei138SubstrateCurated1
    Binding sitei148SubstrateCurated1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei151Proton acceptor1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 20NAD1 Publication9
    Nucleotide bindingi36 – 37NAD1 Publication2
    Nucleotide bindingi63 – 65NAD1 Publication3
    Nucleotide bindingi151 – 155NAD1 Publication5
    Nucleotide bindingi186 – 188NAD1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processFatty acid metabolism, Lipid metabolism, Prostaglandin metabolism
    LigandNAD

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.1.1.141 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2142700 Synthesis of Lipoxins (LX)
    R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    R-HSA-9018676 Biosynthesis of D-series resolvins
    R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P15428

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P15428

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000000732

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    15-hydroxyprostaglandin dehydrogenase [NAD(+)] (EC:1.1.1.141)
    Short name:
    15-PGDH
    Alternative name(s):
    Prostaglandin dehydrogenase 1
    Short chain dehydrogenase/reductase family 36C member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HPGD
    Synonyms:PGDH1, SDR36C1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:5154 HPGD

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		601688 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P15428

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
    Related information in OMIM
    Cranioosteoarthropathy (COA)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046209140A → P in COA; inactive. 1 PublicationCorresponds to variant dbSNP:rs121434480EnsemblClinVar.1
    Isolated congenital nail clubbing (ICNC)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_060792193S → P in ICNC. 1 PublicationCorresponds to variant dbSNP:rs121434481EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi148Q → A: Loss of activity. 1 Publication1
    Mutagenesisi148Q → E, H or N: Reduced affinity for NAD and prostaglandin E2. 1 Publication1
    Mutagenesisi151Y → A: Loss of activity. 1 Publication1

    Keywords - Diseasei

    Disease mutation, Tumor suppressor

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		3248

    MalaCards human disease database

    More...    MalaCardsi    		HPGD
    MIMi119900 phenotype
    259100 phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000164120

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		1525 Cranio-osteoarthropathy
    217059 Isolated congenital digital clubbing
    2796 Pachydermoperiostosis

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA29424

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P15428

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL1293255

    Drug and drug target database

    More...    DrugBanki    		DB00157 NADH

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		1384

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		HPGD

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		129889

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000547441 – 26615-hydroxyprostaglandin dehydrogenase [NAD(+)]Add BLAST266

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P15428

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P15428

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P15428

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P15428

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P15428

    PeptideAtlas

    More...    PeptideAtlasi    		P15428

    PRoteomics IDEntifications database

    More...    PRIDEi    		P15428

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		18546
    48016
    5156
    53141 [P15428-1]
    53142 [P15428-2]

    2D gel databases

    Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

    More...    SWISS-2DPAGEi    		P15428

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P15428

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P15428

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in colon epithelium (at protein level).1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000164120 Expressed in 175 organ(s), highest expression level in metanephros

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P15428 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P15428 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA004919
    HPA005679

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		109485, 1 interactor

    Protein interaction database and analysis system

    More...    IntActi    		P15428, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000296522

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P15428

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1266
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P15428

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P15428

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG4169 Eukaryota
    COG1028 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000154593

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000070121

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P15428

    KEGG Orthology (KO)

    More...    KOi    		K00069

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		PLEMKPQ

    Database of Orthologous Groups

    More...    OrthoDBi    		896005at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P15428

    TreeFam database of animal gene trees

    More...    TreeFami    		TF324093

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00106 adh_short, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00081 GDHRDH
    PR00080 SDRFAMILY

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51735 SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P15428-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD 
            60         70         80         90        100
    EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW 
           110        120        130        140        150
    EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV 
           160        170        180        190        200
    YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM 
           210        220        230        240        250
    GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG AIMKITTSKG 
           260 
    IHFQDYDTTP FQAKTQ
    Length:266
    Mass (Da):28,977
    Last modified:April 1, 1990 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB860D2DE80E49514
    GO
    Isoform 2 (identifier: P15428-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         167-266: LAANLMNSGV...DTTPFQAKTQ → PTIDCQWIDNTH

    Show »
    Length:178
    Mass (Da):19,284
    Checksum:i685B577B3CA27EE3
    GO
    Isoform 3 (identifier: P15428-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-121: Missing.

    Show »
    Length:145
    Mass (Da):15,696
    Checksum:i7113DD63B7540112
    GO
    Isoform 4 (identifier: P15428-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         140-143: AGLM → AAHH
         144-266: Missing.

    Show »
    Length:143
    Mass (Da):15,534
    Checksum:i67C9DD0CC7E3366C
    GO
    Isoform 5 (identifier: P15428-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-140: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:198
    Mass (Da):21,526
    Checksum:i1D571F22D8738F64
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    D6RA66D6RA66_HUMAN
    15-hydroxyprostaglandin dehydrogena...
    HPGD
    		97Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RA83D6RA83_HUMAN
    15-hydroxyprostaglandin dehydrogena...
    HPGD
    		99Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PBZ2E9PBZ2_HUMAN
    15-hydroxyprostaglandin dehydrogena...
    HPGD
    		176Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PD69E9PD69_HUMAN
    15-hydroxyprostaglandin dehydrogena...
    HPGD
    		87Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RHF8D6RHF8_HUMAN
    15-hydroxyprostaglandin dehydrogena...
    HPGD
    		37Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50D → H in AAA89175 (PubMed:1697582).Curated1
    Sequence conflicti50D → H in AAA89174 (PubMed:1697582).Curated1
    Sequence conflicti97E → K in CAA57843 (PubMed:7557451).Curated1
    Sequence conflicti219I → V in BAG61916 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_046209140A → P in COA; inactive. 1 PublicationCorresponds to variant dbSNP:rs121434480EnsemblClinVar.1
    Natural variantiVAR_060792193S → P in ICNC. 1 PublicationCorresponds to variant dbSNP:rs121434481EnsemblClinVar.1
    Natural variantiVAR_006972217Y → C. Corresponds to variant dbSNP:rs140209262Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451061 – 121Missing in isoform 3. 1 PublicationAdd BLAST121
    Alternative sequenceiVSP_04557973 – 140Missing in isoform 5. 1 PublicationAdd BLAST68
    Alternative sequenceiVSP_045107140 – 143AGLM → AAHH in isoform 4. 1 Publication4
    Alternative sequenceiVSP_045108144 – 266Missing in isoform 4. 1 PublicationAdd BLAST123
    Alternative sequenceiVSP_043032167 – 266LAANL…QAKTQ → PTIDCQWIDNTH in isoform 2. 2 PublicationsAdd BLAST100

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		L76465 mRNA Translation: AAA89175.1
    J05594 mRNA Translation: AAA89174.1
    X82460 mRNA Translation: CAA57843.1
    U63296 mRNA Translation: AAB53034.1
    AK296642 mRNA Translation: BAH12408.1
    AK300125 mRNA Translation: BAG61916.1
    AK300524 mRNA Translation: BAG62236.1
    AK300940 mRNA Translation: BAG62569.1
    AK314624 mRNA Translation: BAG37190.1
    DQ903072 Genomic DNA Translation: ABI75347.1
    AC096751 Genomic DNA No translation available.
    CH471056 Genomic DNA Translation: EAX04734.1
    CH471056 Genomic DNA Translation: EAX04735.1
    CH471056 Genomic DNA Translation: EAX04736.1
    CH471056 Genomic DNA Translation: EAX04737.1
    BC018986 mRNA Translation: AAH18986.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS3821.1 [P15428-1]
    CCDS54821.1 [P15428-2]
    CCDS58933.1 [P15428-3]
    CCDS58934.1 [P15428-5]
    CCDS58935.1 [P15428-4]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A35802

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000851.2, NM_000860.5 [P15428-1]
    NP_001139288.1, NM_001145816.2 [P15428-2]
    NP_001243230.1, NM_001256301.1 [P15428-3]
    NP_001243234.1, NM_001256305.1 [P15428-4]
    NP_001243235.1, NM_001256306.1 [P15428-5]
    NP_001243236.1, NM_001256307.1 [P15428-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000296521; ENSP00000296521; ENSG00000164120 [P15428-2]
    ENST00000296522; ENSP00000296522; ENSG00000164120 [P15428-1]
    ENST00000422112; ENSP00000398720; ENSG00000164120 [P15428-5]
    ENST00000510901; ENSP00000422418; ENSG00000164120 [P15428-3]
    ENST00000541923; ENSP00000438017; ENSG00000164120 [P15428-3]
    ENST00000542498; ENSP00000443644; ENSG00000164120 [P15428-4]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		3248

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:3248

    UCSC genome browser

    More...    UCSCi    		uc003itu.3 human [P15428-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		L76465 mRNA Translation: AAA89175.1
    J05594 mRNA Translation: AAA89174.1
    X82460 mRNA Translation: CAA57843.1
    U63296 mRNA Translation: AAB53034.1
    AK296642 mRNA Translation: BAH12408.1
    AK300125 mRNA Translation: BAG61916.1
    AK300524 mRNA Translation: BAG62236.1
    AK300940 mRNA Translation: BAG62569.1
    AK314624 mRNA Translation: BAG37190.1
    DQ903072 Genomic DNA Translation: ABI75347.1
    AC096751 Genomic DNA No translation available.
    CH471056 Genomic DNA Translation: EAX04734.1
    CH471056 Genomic DNA Translation: EAX04735.1
    CH471056 Genomic DNA Translation: EAX04736.1
    CH471056 Genomic DNA Translation: EAX04737.1
    BC018986 mRNA Translation: AAH18986.1
    CCDSiCCDS3821.1 [P15428-1]
    CCDS54821.1 [P15428-2]
    CCDS58933.1 [P15428-3]
    CCDS58934.1 [P15428-5]
    CCDS58935.1 [P15428-4]
    PIRiA35802
    RefSeqiNP_000851.2, NM_000860.5 [P15428-1]
    NP_001139288.1, NM_001145816.2 [P15428-2]
    NP_001243230.1, NM_001256301.1 [P15428-3]
    NP_001243234.1, NM_001256305.1 [P15428-4]
    NP_001243235.1, NM_001256306.1 [P15428-5]
    NP_001243236.1, NM_001256307.1 [P15428-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2GDZX-ray1.65A3-256[»]
    SMRiP15428
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi109485, 1 interactor
    IntActiP15428, 1 interactor
    STRINGi9606.ENSP00000296522

    Chemistry databases

    BindingDBiP15428
    ChEMBLiCHEMBL1293255
    DrugBankiDB00157 NADH
    GuidetoPHARMACOLOGYi1384
    SwissLipidsiSLP:000000732

    PTM databases

    iPTMnetiP15428
    PhosphoSitePlusiP15428

    Polymorphism and mutation databases

    BioMutaiHPGD
    DMDMi129889

    2D gel databases

    SWISS-2DPAGEiP15428

    Proteomic databases

    EPDiP15428
    jPOSTiP15428
    MassIVEiP15428
    MaxQBiP15428
    PaxDbiP15428
    PeptideAtlasiP15428
    PRIDEiP15428
    ProteomicsDBi18546
    48016
    5156
    53141 [P15428-1]
    53142 [P15428-2]

    Genome annotation databases

    EnsembliENST00000296521; ENSP00000296521; ENSG00000164120 [P15428-2]
    ENST00000296522; ENSP00000296522; ENSG00000164120 [P15428-1]
    ENST00000422112; ENSP00000398720; ENSG00000164120 [P15428-5]
    ENST00000510901; ENSP00000422418; ENSG00000164120 [P15428-3]
    ENST00000541923; ENSP00000438017; ENSG00000164120 [P15428-3]
    ENST00000542498; ENSP00000443644; ENSG00000164120 [P15428-4]
    GeneIDi3248
    KEGGihsa:3248
    UCSCiuc003itu.3 human [P15428-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		3248
    DisGeNETi3248

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		HPGD
    HGNCiHGNC:5154 HPGD
    HPAiHPA004919
    HPA005679
    MalaCardsiHPGD
    MIMi119900 phenotype
    259100 phenotype
    601688 gene
    neXtProtiNX_P15428
    OpenTargetsiENSG00000164120
    Orphaneti1525 Cranio-osteoarthropathy
    217059 Isolated congenital digital clubbing
    2796 Pachydermoperiostosis
    PharmGKBiPA29424

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG4169 Eukaryota
    COG1028 LUCA
    GeneTreeiENSGT00940000154593
    HOGENOMiHOG000070121
    InParanoidiP15428
    KOiK00069
    OMAiPLEMKPQ
    OrthoDBi896005at2759
    PhylomeDBiP15428
    TreeFamiTF324093

    Enzyme and pathway databases

    BRENDAi1.1.1.141 2681
    ReactomeiR-HSA-2142700 Synthesis of Lipoxins (LX)
    R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    R-HSA-9018676 Biosynthesis of D-series resolvins
    R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins
    SABIO-RKiP15428
    SIGNORiP15428

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		HPGD human
    EvolutionaryTraceiP15428

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		HPGD

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		3248
    PharosiP15428

    Protein Ontology

    More...    PROi    		PR:P15428

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000164120 Expressed in 175 organ(s), highest expression level in metanephros
    ExpressionAtlasiP15428 baseline and differential
    GenevisibleiP15428 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam
    PfamiView protein in Pfam
    PF00106 adh_short, 1 hit
    PRINTSiPR00081 GDHRDH
    PR00080 SDRFAMILY
    SUPFAMiSSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGDH_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15428
    Secondary accession number(s): B4DTA4
    , B4DU74, B4DV57, D3DP43, E7EV11, O00749, Q06F08, Q12998
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 16, 2019
    This is version 197 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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