Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycophorin-E

Gene

GYPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Keywordsi

LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-E
Gene namesi
Name:GYPE
Synonyms:GPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000197465.13
HGNCiHGNC:4705 GYPE
MIMi138590 gene
neXtProtiNX_P15421

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 52ExtracellularSequence analysisAdd BLAST33
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 78CytoplasmicSequence analysis5

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2996
OpenTargetsiENSG00000197465
PharmGKBiPA29083

Polymorphism and mutation databases

BioMutaiGYPE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001213820 – 78Glycophorin-EAdd BLAST59

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP15421
PeptideAtlasiP15421
PRIDEiP15421
ProteomicsDBi53140

Expressioni

Tissue specificityi

Erythrocytes.

Gene expression databases

BgeeiENSG00000197465 Expressed in 104 organ(s), highest expression level in liver
CleanExiHS_GYPE
ExpressionAtlasiP15421 baseline and differential
GenevisibleiP15421 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351430

Structurei

3D structure databases

ProteinModelPortaliP15421
SMRiP15421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000142578
HOGENOMiHOG000089933
HOVERGENiHBG005850
InParanoidiP15421
OMAiWWAMARV
OrthoDBiEOG093719HS
PhylomeDBiP15421
TreeFamiTF341456

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
PANTHERiPTHR13813 PTHR13813, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P15421-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGKIIFVLL LSGIVSISAS STTGVAMHTS TSSSVTKSYI SSQTNGITLI
60 70
NWWAMARVIF EVMLVVVGMI ILISYCIR
Length:78
Mass (Da):8,463
Last modified:May 27, 2002 - v2
Checksum:iF1F5B6EE5CFB3EB3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCN6E9PCN6_HUMAN
Glycophorin-E
GYPE
59Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06200613G → E2 PublicationsCorresponds to variant dbSNP:rs1132785Ensembl.1
Natural variantiVAR_05311178R → P. Corresponds to variant dbSNP:rs17018900Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57233 Genomic DNA Translation: AAA63179.1
M29605, M29609, M29608 Genomic DNA Translation: AAA52766.1
M29610 mRNA Translation: AAA52575.1
X53010 Genomic DNA Translation: CAA37191.1
X53004, X53005, X53008 Genomic DNA Translation: CAA37189.1
CH471056 Genomic DNA Translation: EAX05065.1
CH471056 Genomic DNA Translation: EAX05066.1
CH471056 Genomic DNA Translation: EAX05067.1
BC017864 mRNA Translation: AAH17864.1
M57234 Genomic DNA No translation available.
M57232 Genomic DNA Translation: AAA35923.1
L31863 Genomic DNA Translation: AAC41697.1
CCDSiCCDS47138.1
PIRiA34931
RefSeqiNP_002093.2, NM_002102.3
NP_941391.2, NM_198682.2
XP_016863628.1, XM_017008139.1
XP_016863629.1, XM_017008140.1
UniGeneiHs.654368
Hs.728753

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465
ENST00000437468; ENSP00000400698; ENSG00000197465
GeneIDi2996
KEGGihsa:2996
UCSCiuc003ijj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57233 Genomic DNA Translation: AAA63179.1
M29605, M29609, M29608 Genomic DNA Translation: AAA52766.1
M29610 mRNA Translation: AAA52575.1
X53010 Genomic DNA Translation: CAA37191.1
X53004, X53005, X53008 Genomic DNA Translation: CAA37189.1
CH471056 Genomic DNA Translation: EAX05065.1
CH471056 Genomic DNA Translation: EAX05066.1
CH471056 Genomic DNA Translation: EAX05067.1
BC017864 mRNA Translation: AAH17864.1
M57234 Genomic DNA No translation available.
M57232 Genomic DNA Translation: AAA35923.1
L31863 Genomic DNA Translation: AAC41697.1
CCDSiCCDS47138.1
PIRiA34931
RefSeqiNP_002093.2, NM_002102.3
NP_941391.2, NM_198682.2
XP_016863628.1, XM_017008139.1
XP_016863629.1, XM_017008140.1
UniGeneiHs.654368
Hs.728753

3D structure databases

ProteinModelPortaliP15421
SMRiP15421
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351430

Polymorphism and mutation databases

BioMutaiGYPE

Proteomic databases

PaxDbiP15421
PeptideAtlasiP15421
PRIDEiP15421
ProteomicsDBi53140

Protocols and materials databases

DNASUi2996
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358615; ENSP00000351430; ENSG00000197465
ENST00000437468; ENSP00000400698; ENSG00000197465
GeneIDi2996
KEGGihsa:2996
UCSCiuc003ijj.4 human

Organism-specific databases

CTDi2996
DisGeNETi2996
EuPathDBiHostDB:ENSG00000197465.13
GeneCardsiGYPE
HGNCiHGNC:4705 GYPE
MIMi138590 gene
neXtProtiNX_P15421
OpenTargetsiENSG00000197465
PharmGKBiPA29083
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00900000142578
HOGENOMiHOG000089933
HOVERGENiHBG005850
InParanoidiP15421
OMAiWWAMARV
OrthoDBiEOG093719HS
PhylomeDBiP15421
TreeFamiTF341456

Miscellaneous databases

GeneWikiiGYPE
GenomeRNAii2996
PROiPR:P15421
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197465 Expressed in 104 organ(s), highest expression level in liver
CleanExiHS_GYPE
ExpressionAtlasiP15421 baseline and differential
GenevisibleiP15421 HS

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
PANTHERiPTHR13813 PTHR13813, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPE_HUMAN
AccessioniPrimary (citable) accession number: P15421
Secondary accession number(s): D3DNZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 27, 2002
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again