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Protein

Fos-related antigen 2

Gene

FOSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell death Source: ProtInc
  • keratinocyte development Source: Ensembl
  • positive regulation of fibroblast proliferation Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 2
Short name:
FRA-2
Gene namesi
Name:FOSL2
Synonyms:FRA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000075426.11
HGNCiHGNC:3798 FOSL2
MIMi601575 gene
neXtProtiNX_P15408

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2355
OpenTargetsiENSG00000075426
PharmGKBiPA28215

Polymorphism and mutation databases

BioMutaiFOSL2
DMDMi120487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764831 – 326Fos-related antigen 2Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei104N6-acetyllysine; alternateBy similarity1
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei120PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei230PhosphoserineCombined sources1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei308PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP15408
PaxDbiP15408
PeptideAtlasiP15408
PRIDEiP15408
ProteomicsDBi53137
53138 [P15408-2]
53139 [P15408-3]

PTM databases

iPTMnetiP15408
PhosphoSitePlusiP15408

Expressioni

Gene expression databases

BgeeiENSG00000075426
CleanExiHS_FOSL2
ExpressionAtlasiP15408 baseline and differential
GenevisibleiP15408 HS

Organism-specific databases

HPAiCAB013460
HPA004817
HPA061417

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108638, 61 interactors
DIPiDIP-48788N
IntActiP15408, 42 interactors
MINTiP15408
STRINGi9606.ENSP00000264716

Structurei

3D structure databases

ProteinModelPortaliP15408
SMRiP15408
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 187bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 128Basic motifPROSITE-ProRule annotation3
Regioni129 – 136Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP15408
KOiK09030
OMAiLVFTYPN
OrthoDBiEOG091G0GGW
PhylomeDBiP15408
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029814 Fra2
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF25 PTHR23351:SF25, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT
60 70 80 90 100
INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP
110 120 130 140 150
GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE
160 170 180 190 200
KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS
210 220 230 240 250
PPAPGLQPMR SGGGSVGAVV VKQEPLEEDS PSSSSAGLDK AQRSVIKPIS
260 270 280 290 300
IAGGFYGEEP LHTPIVVTST PAVTPGTSNL VFTYPSVLEQ ESPASPSESC
310 320
SKAHRRSSSS GDQSSDSLNS PTLLAL
Length:326
Mass (Da):35,193
Last modified:April 1, 1990 - v1
Checksum:iF61738BE23C5026F
GO
Isoform 2 (identifier: P15408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     26-34: YSSGGGGQQ → MVQGWRIKS
     154-154: A → AIGPWQVAVPHIPLFPWQ

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):34,795
Checksum:iC17D7E59D9DABCB4
GO
Isoform 3 (identifier: P15408-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):31,095
Checksum:iF198987B0A81B778
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89A → V in BX647822 (PubMed:17974005).Curated1
Sequence conflicti111G → D in BAG51539 (PubMed:14702039).Curated1
Sequence conflicti298E → G in BAG37805 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0420831 – 39Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0391271 – 25Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_03912826 – 34YSSGGGGQQ → MVQGWRIKS in isoform 2. 1 Publication9
Alternative sequenceiVSP_039129154A → AIGPWQVAVPHIPLFPWQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16706 mRNA Translation: CAA34678.1
AK055579 mRNA Translation: BAG51539.1
AK302622 mRNA Translation: BAG63866.1
AK315415 mRNA Translation: BAG37805.1
BX647822 mRNA No translation available.
CR542262 mRNA Translation: CAG47058.1
AC104695 Genomic DNA Translation: AAY14908.1
CH471053 Genomic DNA Translation: EAX00538.1
CH471053 Genomic DNA Translation: EAX00539.1
BC022791 mRNA Translation: AAH22791.1
CCDSiCCDS1766.1 [P15408-1]
PIRiS15749
RefSeqiNP_005244.1, NM_005253.3 [P15408-1]
XP_016859226.1, XM_017003737.1 [P15408-3]
UniGeneiHs.220971
Hs.596972

Genome annotation databases

EnsembliENST00000264716; ENSP00000264716; ENSG00000075426 [P15408-1]
ENST00000379619; ENSP00000368939; ENSG00000075426 [P15408-2]
GeneIDi2355
KEGGihsa:2355
UCSCiuc002rma.4 human [P15408-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOSL2_HUMAN
AccessioniPrimary (citable) accession number: P15408
Secondary accession number(s): B2RD58
, B3KP27, B4DYV4, Q6FG46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 18, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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