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Protein

Fos-related antigen 1

Gene

FOSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

SIGNORiP15407

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:FOSL1
Synonyms:FRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175592.8
HGNCiHGNC:13718 FOSL1
MIMi136515 gene
neXtProtiNX_P15407

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8061
OpenTargetsiENSG00000175592
PharmGKBiPA28214

Polymorphism and mutation databases

BioMutaiFOSL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764791 – 271Fos-related antigen 1Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15407
MaxQBiP15407
PaxDbiP15407
PeptideAtlasiP15407
PRIDEiP15407
ProteomicsDBi53136

PTM databases

iPTMnetiP15407
PhosphoSitePlusiP15407

Expressioni

Gene expression databases

BgeeiENSG00000175592
CleanExiHS_FOSL1
ExpressionAtlasiP15407 baseline and differential
GenevisibleiP15407 HS

Organism-specific databases

HPAiCAB004396
HPA066901

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113742, 42 interactors
DIPiDIP-660N
IntActiP15407, 20 interactors
MINTiP15407
STRINGi9606.ENSP00000310170

Structurei

3D structure databases

ProteinModelPortaliP15407
SMRiP15407
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 168bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 127Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni133 – 161Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 106Poly-Glu4
Compositional biasi251 – 255Poly-Ser5

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP15407
KOiK04502
OMAiPCEQISP
OrthoDBiEOG091G0GGW
PhylomeDBiP15407
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029815 Fra1
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF6 PTHR23351:SF6, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL
60 70 80 90 100
QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
110 120 130 140 150
SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE
160 170 180 190 200
IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP
210 220 230 240 250
CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK
260 270
SSSSSGDPSS DPLGSPTLLA L
Length:271
Mass (Da):29,413
Last modified:April 1, 1990 - v1
Checksum:i1B6492D709E66570
GO
Isoform 2 (identifier: P15407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-135: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):17,560
Checksum:i71375CD7300A1169
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05556634 – 135Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16707 mRNA Translation: CAA34679.1
AJ297411, AJ297412, AJ297413 Genomic DNA Translation: CAC50237.1
AK299050 mRNA Translation: BAG61123.1
CR542257 mRNA Translation: CAG47053.1
CR542278 mRNA Translation: CAG47074.1
AP006287 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74469.1
BC016648 mRNA Translation: AAH16648.1
CCDSiCCDS76436.1 [P15407-2]
CCDS8121.1 [P15407-1]
PIRiS15750
RefSeqiNP_001287773.1, NM_001300844.1
NP_001287784.1, NM_001300855.1
NP_001287785.1, NM_001300856.1
NP_001287786.1, NM_001300857.1 [P15407-2]
NP_005429.1, NM_005438.4 [P15407-1]
UniGeneiHs.283565

Genome annotation databases

EnsembliENST00000312562; ENSP00000310170; ENSG00000175592 [P15407-1]
ENST00000448083; ENSP00000393302; ENSG00000175592 [P15407-2]
GeneIDi8061
KEGGihsa:8061
UCSCiuc001ogg.2 human [P15407-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFOSL1_HUMAN
AccessioniPrimary (citable) accession number: P15407
Secondary accession number(s): B4DR11, Q6FG51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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