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Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Anthranilate synthase

Gene

trpE(G)

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate. This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei607Nucleophile; for GATase activityPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei611GlutamineBy similarity1
Active sitei697For GATase activityPROSITE-ProRule annotation1
Active sitei699For GATase activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00035;UER00040

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C26.955

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anthranilate synthase (EC:4.1.3.27)
Including the following 1 domains:
Glutamine amidotransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trpE(G)
Ordered Locus Names:R02387
ORF Names:SMc02725
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri266834 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001976 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000568681 – 729Anthranilate synthaseAdd BLAST729

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
266834.SMc02725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15395

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini530 – 726Glutamine amidotransferase type-1PROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni580 – 582Glutamine bindingBy similarity3
Regioni658 – 659Glutamine bindingBy similarity2

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0147, Bacteria
COG0512, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006493_3_0_5

Identification of Orthologs from Complete Genome Data

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OMAi
AYRSFMN

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01743, GATase1_Anthranilate_Synthase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.880, 1 hit
3.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005801, ADC_synthase
IPR006805, Anth_synth_I_N
IPR015890, Chorismate_C
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR010112, TrpE-G
IPR006221, TrpG/PapA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04715, Anth_synt_I_N, 1 hit
PF00425, Chorismate_bind, 1 hit
PF00117, GATase, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF036934, TrpE-G, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52317, SSF52317, 1 hit
SSF56322, SSF56322, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01815, TrpE-clade3, 1 hit
TIGR00566, trpG_papA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVILEDGA ESYTTKGGIV VTRRRREASY SDAIAGYVDR LDERRGAVFS
60 70 80 90 100
SNYEYPGRYT RWDTAVVDPP LAISSFGRSL WIEAYNERGE VLLALIAEDL
110 120 130 140 150
KSVADITLGS LAARRLDLTI NEPDRVFTEE ERSKMPTVFT VLRAVTNLFH
160 170 180 190 200
SEEDSNLGLY GAFGYDLAFQ FDAIELKLSR PDDQRDMVLF LPDEILVVDH
210 220 230 240 250
YAAKAWIDRY DFARENLSTE GKAADIAPEP FRSVDSIPPH GDHRPGEYAE
260 270 280 290 300
LVVKAKESFR RGDLFEVVPG QKFYERCESR PSEISNRLKA INPSPYSFFI
310 320 330 340 350
NLGNQEYLVG ASPEMFVRVS GRRIETCPIS GTIKRGDDPI ADSEQILKLL
360 370 380 390 400
NSKKDESELT MCSDVDRNDK SRVCVPGSVK VIGRRQIEMY SRLIHTVDHI
410 420 430 440 450
EGRLRDDMDA FDGFLSHAWA VTVTGAPKLW AMRFIESHEK SPRAWYGGAI
460 470 480 490 500
GMVGFNGDMN TGLTLRTIRI KDGIAEVRAG ATLLYDSNPE EEEAETELKA
510 520 530 540 550
SAMIAAIRDA KSANSAKSAR DVAAVGAGVS ILLVDHEDSF VHTLANYFRQ
560 570 580 590 600
TGASVTTVRT PVAEEIFDRV KPDLVVLSPG PGTPKDFDCK ATIKKARARD
610 620 630 640 650
LPIFGVCLGL QALAEAYGGD LRQLAIPMHG KPSRIRVLEP GIVFSGLGKE
660 670 680 690 700
VTVGRYHSIF ADPSNLPREF VITAESEDGT IMGIEHSKEP VAAVQFHPES
710 720
IMTLGGDAGM RMIENVVAHL AKRAKTKAA
Length:729
Mass (Da):80,505
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF16F10A90E3846E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22983 Genomic DNA Translation: AAA26370.1
AL591688 Genomic DNA Translation: CAC46966.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B44515, A30904

NCBI Reference Sequences

More...
RefSeqi
NP_386493.1, NC_003047.1
WP_010969900.1, NC_003047.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAC46966; CAC46966; SMc02725

Database of genes from NCBI RefSeq genomes

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GeneIDi
61603846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sme:SMc02725

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|266834.11.peg.3871

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22983 Genomic DNA Translation: AAA26370.1
AL591688 Genomic DNA Translation: CAC46966.1
PIRiB44515, A30904
RefSeqiNP_386493.1, NC_003047.1
WP_010969900.1, NC_003047.1

3D structure databases

SMRiP15395
ModBaseiSearch...

Protein-protein interaction databases

STRINGi266834.SMc02725

Protein family/group databases

MEROPSiC26.955

Genome annotation databases

EnsemblBacteriaiCAC46966; CAC46966; SMc02725
GeneIDi61603846
KEGGisme:SMc02725
PATRICifig|266834.11.peg.3871

Phylogenomic databases

eggNOGiCOG0147, Bacteria
COG0512, Bacteria
HOGENOMiCLU_006493_3_0_5
OMAiAYRSFMN

Enzyme and pathway databases

UniPathwayiUPA00035;UER00040

Family and domain databases

CDDicd01743, GATase1_Anthranilate_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801, ADC_synthase
IPR006805, Anth_synth_I_N
IPR015890, Chorismate_C
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR010112, TrpE-G
IPR006221, TrpG/PapA_dom
PfamiView protein in Pfam
PF04715, Anth_synt_I_N, 1 hit
PF00425, Chorismate_bind, 1 hit
PF00117, GATase, 1 hit
PIRSFiPIRSF036934, TrpE-G, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
SSF56322, SSF56322, 1 hit
TIGRFAMsiTIGR01815, TrpE-clade3, 1 hit
TIGR00566, trpG_papA, 1 hit
PROSITEiView protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPE_RHIME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15395
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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