UniProtKB - P15391 (CD19_HUMAN)

BLAST

>sp|P15391|CD19_HUMAN B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP
FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGE
LFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSL
NQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMW
VMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYL
IFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSG
LGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF
YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLS
PHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGP
DPAWGGGGRMGTWSTR

Align

Format
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History
Entry version 197 (07 Nov 2018)
Sequence version 6 (13 Nov 2007)
Previous versions | rss
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Protein

B-lymphocyte antigen CD19

Gene

CD19

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functionⁱ

phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 1714482
cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 1373518
positive regulation of protein kinase B signaling Source: Reactome
positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
regulation of complement activation Source: Reactome
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1257604 PIP3 activates AKT signaling R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	P15391
SIGNORⁱ	P15391

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B-lymphocyte antigen CD19 Alternative name(s): B-lymphocyte surface antigen B4 Differentiation antigen CD19 T-cell surface antigen Leu-12 CD_antigen: CD19
Gene namesⁱ	Name:CD19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177455.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1633 CD19
MIMⁱ	107265 gene
neXtProtⁱ	NX_P15391

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 291	ExtracellularSequence analysisAdd BLAST	272
Transmembraneⁱ	292 – 313	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	314 – 556	CytoplasmicSequence analysisAdd BLAST	243

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency, common variable, 3 (CVID3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	930
GeneReviewsⁱ	CD19
MalaCards human disease database More...MalaCardsⁱ	CD19
MIMⁱ	613493 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000177455
Orphanetⁱ	1572 Common variable immunodeficiency
PharmGKBⁱ	PA26192

Chemistry databases

ChEMBLⁱ	CHEMBL3390821
Drug and drug target database More...DrugBankⁱ	DB09052 Blinatumomab
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2764

Polymorphism and mutation databases

BioMutaⁱ	CD19
DMDMⁱ	160332376

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000014648	20 – 556	B-lymphocyte antigen CD19Add BLAST		537

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	38 ↔ 97	PROSITE-ProRule annotation
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	181	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	200 ↔ 261	PROSITE-ProRule annotation
Modified residueⁱ	227	PhosphoserineBy similarity	1
Glycosylationⁱ	265	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	348	Phosphotyrosine1 Publication	1
Modified residueⁱ	378	Phosphotyrosine1 Publication	1
Modified residueⁱ	409	Phosphotyrosine1 Publication	1
Modified residueⁱ	439	Phosphotyrosine1 Publication	1
Modified residueⁱ	500	PhosphotyrosineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.3 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P15391
PeptideAtlas More...PeptideAtlasⁱ	P15391
PRIDEⁱ	P15391
ProteomicsDBⁱ	53135

PTM databases

iPTMnetⁱ	P15391
PhosphoSitePlusⁱ	P15391

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177455 Expressed in 96 organ(s), highest expression level in spleen
CleanExⁱ	HS_CD19
Genevisibleⁱ	P15391 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016110

HPAⁱ

CAB016110

Interactionⁱ

Subunit structureⁱ

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IGHM	P01871	2	EBI-79902,EBI-953797

With

Entry

#Exp.

IntAct

Notes

IGHM

P01871

EBI-79902,EBI-953797

Protein-protein interaction databases

BioGridⁱ	107368, 16 interactors
CORUMⁱ	P15391
ELMⁱ	P15391
IntActⁱ	P15391, 8 interactors
Molecular INTeraction database More...MINTⁱ	P15391
STRINGⁱ	9606.ENSP00000437940

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 29	Combined sources	6
Beta strandⁱ	34 – 36	Combined sources	3
Beta strandⁱ	50 – 55	Combined sources	6
Beta strandⁱ	61 – 75	Combined sources	15
Beta strandⁱ	80 – 84	Combined sources	5
Beta strandⁱ	93 – 100	Combined sources	8
Beta strandⁱ	108 – 115	Combined sources	8
Beta strandⁱ	119 – 125	Combined sources	7
Beta strandⁱ	155 – 160	Combined sources	6
Beta strandⁱ	163 – 166	Combined sources	4
Beta strandⁱ	187 – 190	Combined sources	4
Beta strandⁱ	196 – 198	Combined sources	3
Helixⁱ	203 – 205	Combined sources	3
Beta strandⁱ	208 – 218	Combined sources	11
Beta strandⁱ	221 – 230	Combined sources	10
Beta strandⁱ	239 – 242	Combined sources	4
Beta strandⁱ	245 – 250	Combined sources	6
Helixⁱ	253 – 255	Combined sources	3
Beta strandⁱ	257 – 262	Combined sources	6
Beta strandⁱ	267 – 275	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P15391
SMRⁱ	P15391
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 113	Ig-like C2-type 1Add BLAST		94
Domainⁱ	176 – 277	Ig-like C2-type 2Add BLAST		102

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJ3V Eukaryota ENOG41115SQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014991
HOGENOMⁱ	HOG000111478
HOVERGENⁱ	HBG003388
InParanoidⁱ	P15391
KEGG Orthology (KO) More...KOⁱ	K06465
OMAⁱ	GAQNQYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08D8
PhylomeDBⁱ	P15391
TreeFamⁱ	TF338293

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P15391-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL 
        60         70         80         90        100
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG 
       110        120        130        140        150
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK 
       160        170        180        190        200
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC 
       210        220        230        240        250
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR 
       260        270        280        290        300
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 
       310        320        330        340        350
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN 
       360        370        380        390        400
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG 
       410        420        430        440        450
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE 
       460        470        480        490        500
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY 
       510        520        530        540        550
EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM 

GTWSTR

Length:556

Mass (Da):61,128

Last modified:November 13, 2007 - v6

Checksum:ⁱA0E08DD628B69E51

Isoform 2 (identifier: P15391-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
495-495: L → LA

« Hide

        10         20         30         40         50
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL 
        60         70         80         90        100
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG 
       110        120        130        140        150
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK 
       160        170        180        190        200
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC 
       210        220        230        240        250
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR 
       260        270        280        290        300
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 
       310        320        330        340        350
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN 
       360        370        380        390        400
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG 
       410        420        430        440        450
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE 
       460        470        480        490        500
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLAGSQS 
       510        520        530        540        550
YEDMRGILYA APQLRSIRGQ PGPNHEEDAD SYENMDNPDG PDPAWGGGGR 

MGTWSTR

Note: No experimental confirmation available.

Show »

Length:557

Mass (Da):61,200

Checksum:ⁱ49A39D679F6C6C9A

Sequence cautionⁱ

The sequence AAA35533 differs from that shown. Reason: Frameshift at position 396.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	29	E → EG in AAB60697 (PubMed:1370948).Curated	1
Sequence conflictⁱ	80	I → S in AAA68490 (PubMed:2472450).Curated	1
Sequence conflictⁱ	80	I → S in AAA69966 (PubMed:1375324).Curated	1
Sequence conflictⁱ	80	I → S in AAB60697 (PubMed:1370948).Curated	1
Sequence conflictⁱ	80	I → S in BAB60954 (PubMed:12215898).Curated	1
Sequence conflictⁱ	186	Q → QAFLVLSLPVP in AAA69966 (PubMed:1375324).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026963	174	L → V8 PublicationsCorresponds to variant dbSNP:rs2904880EnsemblClinVar.		1
Natural variantⁱVAR_036987	514	R → H2 PublicationsCorresponds to variant dbSNP:rs34763945EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047194	495	L → LA in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21097 mRNA Translation: AAA35533.1 Frameshift. M28170 mRNA Translation: AAA68490.1 M84371 Genomic DNA Translation: AAA69966.1 M62550 M62549 Genomic DNA Translation: AAB60697.1 AB052799 Genomic DNA Translation: BAB60954.1 AK313577 mRNA No translation available. EF064757 Genomic DNA Translation: ABK41940.1 AC109460 Genomic DNA No translation available. CH471267 Genomic DNA Translation: EAW52012.1 BC006338 mRNA Translation: AAH06338.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10644.1 [P15391-1] CCDS53998.1 [P15391-2]
PIRⁱ	A44441
NCBI Reference Sequences More...RefSeqⁱ	NP_001171569.1, NM_001178098.1 [P15391-2] NP_001761.3, NM_001770.5 [P15391-1]
UniGeneⁱ	Hs.652262

Genome annotation databases

Ensemblⁱ	ENST00000324662; ENSP00000313419; ENSG00000177455 [P15391-1] ENST00000538922; ENSP00000437940; ENSG00000177455 [P15391-2] ENST00000567541; ENSP00000456201; ENSG00000177455 [P15391-2]
GeneIDⁱ	930
KEGGⁱ	hsa:930
UCSC genome browser More...UCSCⁱ	uc002drs.4 human [P15391-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15391	Uncharacterized protein		MACNE		583	UniRef90_P15391
Uncharacterized protein		COLAP		558
CD19 isoform 1		PONAB		558
Uncharacterized protein		NOMLE		558
Uncharacterized protein		PAPAN		558
+32

Protein	Similar proteins		Species	Score	Length	Source
P15391	B-lymphocyte antigen CD19		CALJA		558	UniRef50_P15391
B-lymphocyte antigen CD19 (Fragment)		CAVPO		430
B-lymphocyte antigen CD19		MOUSE		547
Uncharacterized protein		MACNE		583
Uncharacterized protein		COLAP		558
+213

Cross-referencesⁱ

Web resourcesⁱ

CD19base

CD19 mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21097 mRNA Translation: AAA35533.1 Frameshift. M28170 mRNA Translation: AAA68490.1 M84371 Genomic DNA Translation: AAA69966.1 M62550 M62549 Genomic DNA Translation: AAB60697.1 AB052799 Genomic DNA Translation: BAB60954.1 AK313577 mRNA No translation available. EF064757 Genomic DNA Translation: ABK41940.1 AC109460 Genomic DNA No translation available. CH471267 Genomic DNA Translation: EAW52012.1 BC006338 mRNA Translation: AAH06338.1
CCDSⁱ	CCDS10644.1 [P15391-1] CCDS53998.1 [P15391-2]
PIRⁱ	A44441
RefSeqⁱ	NP_001171569.1, NM_001178098.1 [P15391-2] NP_001761.3, NM_001770.5 [P15391-1]
UniGeneⁱ	Hs.652262

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6AL5	X-ray	3.00	A	21-277	[»]
ProteinModelPortalⁱ	P15391
SMRⁱ	P15391
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107368, 16 interactors
CORUMⁱ	P15391
ELMⁱ	P15391
IntActⁱ	P15391, 8 interactors
MINTⁱ	P15391
STRINGⁱ	9606.ENSP00000437940

Chemistry databases

ChEMBLⁱ	CHEMBL3390821
DrugBankⁱ	DB09052 Blinatumomab
GuidetoPHARMACOLOGYⁱ	2764

PTM databases

iPTMnetⁱ	P15391
PhosphoSitePlusⁱ	P15391

Polymorphism and mutation databases

BioMutaⁱ	CD19
DMDMⁱ	160332376

Proteomic databases

PaxDbⁱ	P15391
PeptideAtlasⁱ	P15391
PRIDEⁱ	P15391
ProteomicsDBⁱ	53135

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	930
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000324662; ENSP00000313419; ENSG00000177455 [P15391-1] ENST00000538922; ENSP00000437940; ENSG00000177455 [P15391-2] ENST00000567541; ENSP00000456201; ENSG00000177455 [P15391-2]
GeneIDⁱ	930
KEGGⁱ	hsa:930
UCSCⁱ	uc002drs.4 human [P15391-1]

Organism-specific databases

CTDⁱ	930
DisGeNETⁱ	930
EuPathDBⁱ	HostDB:ENSG00000177455.11
GeneCardsⁱ	CD19
GeneReviewsⁱ	CD19
HGNCⁱ	HGNC:1633 CD19
HPAⁱ	CAB016110
MalaCardsⁱ	CD19
MIMⁱ	107265 gene 613493 phenotype
neXtProtⁱ	NX_P15391
OpenTargetsⁱ	ENSG00000177455
Orphanetⁱ	1572 Common variable immunodeficiency
PharmGKBⁱ	PA26192
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ3V Eukaryota ENOG41115SQ LUCA
GeneTreeⁱ	ENSGT00390000014991
HOGENOMⁱ	HOG000111478
HOVERGENⁱ	HBG003388
InParanoidⁱ	P15391
KOⁱ	K06465
OMAⁱ	GAQNQYG
OrthoDBⁱ	EOG091G08D8
PhylomeDBⁱ	P15391
TreeFamⁱ	TF338293

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1257604 PIP3 activates AKT signaling R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	P15391
SIGNORⁱ	P15391

Miscellaneous databases

GeneWikiⁱ	CD19
GenomeRNAiⁱ	930
Protein Ontology More...PROⁱ	PR:P15391
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177455 Expressed in 96 organ(s), highest expression level in spleen
CleanExⁱ	HS_CD19
Genevisibleⁱ	P15391 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD19_HUMAN
Accessionⁱ	P15391Primary (citable) accession number: P15391 Secondary accession number(s): A0N0P9 , F5H635, Q96S68, Q9BRD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 6 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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Supporting data

UniProtKB - P15391 (CD19_HUMAN)

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B-lymphocyte antigen CD19

CD19

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ