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Protein

B-lymphocyte antigen CD19

Gene

CD19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP15391
SIGNORiP15391

Names & Taxonomyi

Protein namesi
Recommended name:
B-lymphocyte antigen CD19
Alternative name(s):
B-lymphocyte surface antigen B4
Differentiation antigen CD19
T-cell surface antigen Leu-12
CD_antigen: CD19
Gene namesi
Name:CD19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000177455.11
HGNCiHGNC:1633 CD19
MIMi107265 gene
neXtProtiNX_P15391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 291ExtracellularSequence analysisAdd BLAST272
Transmembranei292 – 313HelicalSequence analysisAdd BLAST22
Topological domaini314 – 556CytoplasmicSequence analysisAdd BLAST243

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, common variable, 3 (CVID3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
See also OMIM:613493

Organism-specific databases

DisGeNETi930
GeneReviewsiCD19
MalaCardsiCD19
MIMi613493 phenotype
OpenTargetsiENSG00000177455
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA26192

Chemistry databases

ChEMBLiCHEMBL3390821
DrugBankiDB09052 Blinatumomab
GuidetoPHARMACOLOGYi2764

Polymorphism and mutation databases

BioMutaiCD19
DMDMi160332376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001464820 – 556B-lymphocyte antigen CD19Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 97PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 261PROSITE-ProRule annotation
Modified residuei227PhosphoserineBy similarity1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei348Phosphotyrosine1 Publication1
Modified residuei378Phosphotyrosine1 Publication1
Modified residuei409Phosphotyrosine1 Publication1
Modified residuei439Phosphotyrosine1 Publication1
Modified residuei500PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15391
PeptideAtlasiP15391
PRIDEiP15391
ProteomicsDBi53135

PTM databases

iPTMnetiP15391
PhosphoSitePlusiP15391

Expressioni

Gene expression databases

BgeeiENSG00000177455
CleanExiHS_CD19
GenevisibleiP15391 HS

Organism-specific databases

HPAiCAB016110

Interactioni

Subunit structurei

Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGHMP018712EBI-79902,EBI-953797

Protein-protein interaction databases

BioGridi107368, 16 interactors
CORUMiP15391
ELMiP15391
IntActiP15391, 8 interactors
MINTiP15391
STRINGi9606.ENSP00000437940

Structurei

Secondary structure

1556
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi34 – 36Combined sources3
Beta strandi50 – 55Combined sources6
Beta strandi61 – 75Combined sources15
Beta strandi80 – 84Combined sources5
Beta strandi93 – 100Combined sources8
Beta strandi108 – 115Combined sources8
Beta strandi119 – 125Combined sources7
Beta strandi155 – 160Combined sources6
Beta strandi163 – 166Combined sources4
Beta strandi187 – 190Combined sources4
Beta strandi196 – 198Combined sources3
Helixi203 – 205Combined sources3
Beta strandi208 – 218Combined sources11
Beta strandi221 – 230Combined sources10
Beta strandi239 – 242Combined sources4
Beta strandi245 – 250Combined sources6
Helixi253 – 255Combined sources3
Beta strandi257 – 262Combined sources6
Beta strandi267 – 275Combined sources9

3D structure databases

ProteinModelPortaliP15391
SMRiP15391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 113Ig-like C2-type 1Add BLAST94
Domaini176 – 277Ig-like C2-type 2Add BLAST102

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3V Eukaryota
ENOG41115SQ LUCA
GeneTreeiENSGT00390000014991
HOGENOMiHOG000111478
HOVERGENiHBG003388
InParanoidiP15391
KOiK06465
OMAiLYVWAKD
OrthoDBiEOG091G08D8
PhylomeDBiP15391
TreeFamiTF338293

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15391-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL
60 70 80 90 100
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG
110 120 130 140 150
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK
160 170 180 190 200
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC
210 220 230 240 250
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR
260 270 280 290 300
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL
310 320 330 340 350
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN
360 370 380 390 400
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG
410 420 430 440 450
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE
460 470 480 490 500
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY
510 520 530 540 550
EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM

GTWSTR
Length:556
Mass (Da):61,128
Last modified:November 13, 2007 - v6
Checksum:iA0E08DD628B69E51
GO
Isoform 2 (identifier: P15391-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-495: L → LA

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):61,200
Checksum:i49A39D679F6C6C9A
GO

Sequence cautioni

The sequence AAA35533 differs from that shown. Reason: Frameshift at position 396.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → EG in AAB60697 (PubMed:1370948).Curated1
Sequence conflicti80I → S in AAA68490 (PubMed:2472450).Curated1
Sequence conflicti80I → S in AAA69966 (PubMed:1375324).Curated1
Sequence conflicti80I → S in AAB60697 (PubMed:1370948).Curated1
Sequence conflicti80I → S in BAB60954 (PubMed:12215898).Curated1
Sequence conflicti186Q → QAFLVLSLPVP in AAA69966 (PubMed:1375324).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026963174L → V8 PublicationsCorresponds to variant dbSNP:rs2904880EnsemblClinVar.1
Natural variantiVAR_036987514R → H2 PublicationsCorresponds to variant dbSNP:rs34763945EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047194495L → LA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21097 mRNA Translation: AAA35533.1 Frameshift.
M28170 mRNA Translation: AAA68490.1
M84371 Genomic DNA Translation: AAA69966.1
M62550
, M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA Translation: AAB60697.1
AB052799 Genomic DNA Translation: BAB60954.1
AK313577 mRNA No translation available.
EF064757 Genomic DNA Translation: ABK41940.1
AC109460 Genomic DNA No translation available.
CH471267 Genomic DNA Translation: EAW52012.1
BC006338 mRNA Translation: AAH06338.1
CCDSiCCDS10644.1 [P15391-1]
CCDS53998.1 [P15391-2]
PIRiA44441
RefSeqiNP_001171569.1, NM_001178098.1 [P15391-2]
NP_001761.3, NM_001770.5 [P15391-1]
UniGeneiHs.652262

Genome annotation databases

EnsembliENST00000324662; ENSP00000313419; ENSG00000177455 [P15391-1]
ENST00000538922; ENSP00000437940; ENSG00000177455 [P15391-2]
ENST00000567541; ENSP00000456201; ENSG00000177455 [P15391-2]
GeneIDi930
KEGGihsa:930
UCSCiuc002drs.4 human [P15391-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD19_HUMAN
AccessioniPrimary (citable) accession number: P15391
Secondary accession number(s): A0N0P9
, F5H635, Q96S68, Q9BRD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 195 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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