UniProtKB - P15391 (CD19_HUMAN)
B-lymphocyte antigen CD19
CD19
Functioni
GO - Biological processi
- antigen receptor-mediated signaling pathway Source: UniProtKB
- B-1 B cell differentiation Source: Ensembl
- B cell proliferation involved in immune response Source: UniProtKB
- B cell receptor signaling pathway Source: UniProtKB
- immunoglobulin mediated immune response Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
- regulation of B cell activation Source: UniProtKB
- regulation of B cell receptor signaling pathway Source: UniProtKB
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P15391 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P15391 |
SIGNORi | P15391 |
Names & Taxonomyi
Protein namesi | Recommended name: B-lymphocyte antigen CD19Alternative name(s): B-lymphocyte surface antigen B4 Differentiation antigen CD19 T-cell surface antigen Leu-12 CD_antigen: CD19 |
Gene namesi | Name:CD19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1633, CD19 |
MIMi | 107265, gene |
neXtProti | NX_P15391 |
VEuPathDBi | HostDB:ENSG00000177455.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 7 Publications; Single-pass type I membrane protein Curated
Other locations
- Membrane raft By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- membrane raft Source: UniProtKB-SubCell
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 291 | ExtracellularSequence analysisAdd BLAST | 272 | |
Transmembranei | 292 – 313 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 314 – 556 | CytoplasmicSequence analysisAdd BLAST | 243 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency, common variable, 3 (CVID3)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 309 – 556 | Missing : Abolishes the ability to activate signaling pathways that mediate mobilization of cytoplasmic Ca(2+). Abolishes the ability to restore normal B cell functions and responses to antigenic stimuli. 1 PublicationAdd BLAST | 248 | |
Mutagenesisi | 348 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-378. 1 Publication | 1 | |
Mutagenesisi | 378 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-348. 1 Publication | 1 | |
Mutagenesisi | 409 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-439. 1 Publication | 1 | |
Mutagenesisi | 421 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-461. 1 Publication | 1 | |
Mutagenesisi | 439 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-409. 1 Publication | 1 | |
Mutagenesisi | 461 | Y → F: No effect on the ability to complement impaired B cell development and functions; when associated with F-421. 1 Publication | 1 | |
Mutagenesisi | 500 | Y → F: Strongly reduced tyrosine phosphorylation; when associated with F-531. Abolishes activation of signaling pathways that mediate mobilization of cytoplasmic Ca(2+); when associated with F-531. Abolishes the ability to complement impaired B cell development and functions; when associated with F-531. 3 Publications | 1 | |
Mutagenesisi | 531 | Y → F: Strongly reduced tyrosine phosphorylation; when associated with F-500. Abolishes activation of signaling pathways that mediate mobilization of cytoplasmic Ca(2+); when associated with F-500. Abolishes the ability to complement impaired B cell development and functions; when associated with F-500. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 930 |
MalaCardsi | CD19 |
MIMi | 613493, phenotype |
OpenTargetsi | ENSG00000177455 |
Orphaneti | 1572, Common variable immunodeficiency |
PharmGKBi | PA26192 |
Miscellaneous databases
Pharosi | P15391, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3390821 |
DrugBanki | DB13915, Axicabtagene ciloleucel DB09052, Blinatumomab DB06342, Coltuximab ravtansine DB12530, Inebilizumab DB13881, Tisagenlecleucel |
DrugCentrali | P15391 |
GuidetoPHARMACOLOGYi | 2764 |
Genetic variation databases
BioMutai | CD19 |
DMDMi | 160332376 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014648 | 20 – 556 | B-lymphocyte antigen CD19Add BLAST | 537 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 261 | Combined sources1 Publication | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 97 ↔ 200 | Combined sources1 Publication | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 134 ↔ 173 | Combined sources1 Publication | ||
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 181 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 227 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 348 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 378 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 409 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 439 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 500 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 531 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P15391 |
PaxDbi | P15391 |
PeptideAtlasi | P15391 |
PRIDEi | P15391 |
ProteomicsDBi | 27066 53135 [P15391-1] |
PTM databases
GlyGeni | P15391, 5 sites |
iPTMneti | P15391 |
PhosphoSitePlusi | P15391 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000177455, Expressed in tonsil and 123 other tissues |
Genevisiblei | P15391, HS |
Organism-specific databases
HPAi | ENSG00000177455, Group enriched (blood, intestine, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with CR2/CD21 (PubMed:1702139).
Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells (PubMed:1383329).
Interacts directly with CD81 (via the second extracellular domain); this interaction is initiated early during biosynthesis in the ER/pre-Golgi compartments and is essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells (PubMed:16449649).
Interacts with VAV (PubMed:10706702).
Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378.
Interacts with PLCG2 when phosphorylated on Tyr-409 (PubMed:10706702).
Interacts with LYN (PubMed:7687428).
Interacts (when tyrosine phosphorylated) with the regulatory p85 subunit of phosphatidylinositol 3-kinase (PIK3R1 or PIK3R2) (PubMed:7684160).
6 PublicationsBinary interactionsi
P15391
With | #Exp. | IntAct |
---|---|---|
IGHM [P01871] | 2 | EBI-79902,EBI-953797 |
Protein-protein interaction databases
BioGRIDi | 107368, 20 interactors |
CORUMi | P15391 |
ELMi | P15391 |
IntActi | P15391, 12 interactors |
MINTi | P15391 |
STRINGi | 9606.ENSP00000437940 |
Miscellaneous databases
RNActi | P15391, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P15391 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 113 | Ig-like C2-type 1Add BLAST | 94 | |
Domaini | 176 – 277 | Ig-like C2-type 2Add BLAST | 102 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502STG8, Eukaryota |
GeneTreei | ENSGT00390000014991 |
HOGENOMi | CLU_038774_0_0_1 |
InParanoidi | P15391 |
OMAi | LWLPCGV |
OrthoDBi | 521520at2759 |
PhylomeDBi | P15391 |
TreeFami | TF338293 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR042341, CD19 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
PANTHERi | PTHR16674, PTHR16674, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL
60 70 80 90 100
TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG
110 120 130 140 150
PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK
160 170 180 190 200
LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC
210 220 230 240 250
GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR
260 270 280 290 300
ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL
310 320 330 340 350
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN
360 370 380 390 400
VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG
410 420 430 440 450
PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE
460 470 480 490 500
DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY
510 520 530 540 550
EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM
GTWSTR
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | E → EG in AAB60697 (PubMed:1370948).Curated | 1 | |
Sequence conflicti | 80 | I → S in AAA68490 (PubMed:2472450).Curated | 1 | |
Sequence conflicti | 80 | I → S in AAA69966 (PubMed:1375324).Curated | 1 | |
Sequence conflicti | 80 | I → S in AAB60697 (PubMed:1370948).Curated | 1 | |
Sequence conflicti | 80 | I → S in BAB60954 (PubMed:12215898).Curated | 1 | |
Sequence conflicti | 186 | Q → QAFLVLSLPVP in AAA69966 (PubMed:1375324).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026963 | 174 | L → V8 PublicationsCorresponds to variant dbSNP:rs2904880EnsemblClinVar. | 1 | |
Natural variantiVAR_036987 | 514 | R → H2 PublicationsCorresponds to variant dbSNP:rs34763945EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047194 | 495 | L → LA in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21097 mRNA Translation: AAA35533.1 Frameshift. M28170 mRNA Translation: AAA68490.1 M84371 Genomic DNA Translation: AAA69966.1 M62550 , M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA Translation: AAB60697.1 AB052799 Genomic DNA Translation: BAB60954.1 AK313577 mRNA No translation available. EF064757 Genomic DNA Translation: ABK41940.1 AC109460 Genomic DNA No translation available. CH471267 Genomic DNA Translation: EAW52012.1 BC006338 mRNA Translation: AAH06338.1 |
CCDSi | CCDS10644.1 [P15391-1] CCDS53998.1 [P15391-2] |
PIRi | A44441 |
RefSeqi | NP_001171569.1, NM_001178098.1 [P15391-2] NP_001761.3, NM_001770.5 [P15391-1] |
Genome annotation databases
Ensembli | ENST00000324662; ENSP00000313419; ENSG00000177455 [P15391-2] ENST00000538922; ENSP00000437940; ENSG00000177455 [P15391-1] |
GeneIDi | 930 |
KEGGi | hsa:930 |
UCSCi | uc002drs.4, human [P15391-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
CD19base CD19 mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21097 mRNA Translation: AAA35533.1 Frameshift. M28170 mRNA Translation: AAA68490.1 M84371 Genomic DNA Translation: AAA69966.1 M62550 , M62544, M62545, M62546, M62547, M62548, M62549 Genomic DNA Translation: AAB60697.1 AB052799 Genomic DNA Translation: BAB60954.1 AK313577 mRNA No translation available. EF064757 Genomic DNA Translation: ABK41940.1 AC109460 Genomic DNA No translation available. CH471267 Genomic DNA Translation: EAW52012.1 BC006338 mRNA Translation: AAH06338.1 |
CCDSi | CCDS10644.1 [P15391-1] CCDS53998.1 [P15391-2] |
PIRi | A44441 |
RefSeqi | NP_001171569.1, NM_001178098.1 [P15391-2] NP_001761.3, NM_001770.5 [P15391-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AL5 | X-ray | 3.00 | A | 21-277 | [»] | |
SMRi | P15391 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107368, 20 interactors |
CORUMi | P15391 |
ELMi | P15391 |
IntActi | P15391, 12 interactors |
MINTi | P15391 |
STRINGi | 9606.ENSP00000437940 |
Chemistry databases
ChEMBLi | CHEMBL3390821 |
DrugBanki | DB13915, Axicabtagene ciloleucel DB09052, Blinatumomab DB06342, Coltuximab ravtansine DB12530, Inebilizumab DB13881, Tisagenlecleucel |
DrugCentrali | P15391 |
GuidetoPHARMACOLOGYi | 2764 |
PTM databases
GlyGeni | P15391, 5 sites |
iPTMneti | P15391 |
PhosphoSitePlusi | P15391 |
Genetic variation databases
BioMutai | CD19 |
DMDMi | 160332376 |
Proteomic databases
MassIVEi | P15391 |
PaxDbi | P15391 |
PeptideAtlasi | P15391 |
PRIDEi | P15391 |
ProteomicsDBi | 27066 53135 [P15391-1] |
Protocols and materials databases
ABCDi | P15391, 71 sequenced antibodies |
Antibodypediai | 4237, 4262 antibodies |
DNASUi | 930 |
Genome annotation databases
Ensembli | ENST00000324662; ENSP00000313419; ENSG00000177455 [P15391-2] ENST00000538922; ENSP00000437940; ENSG00000177455 [P15391-1] |
GeneIDi | 930 |
KEGGi | hsa:930 |
UCSCi | uc002drs.4, human [P15391-1] |
Organism-specific databases
CTDi | 930 |
DisGeNETi | 930 |
GeneCardsi | CD19 |
HGNCi | HGNC:1633, CD19 |
HPAi | ENSG00000177455, Group enriched (blood, intestine, lymphoid tissue) |
MalaCardsi | CD19 |
MIMi | 107265, gene 613493, phenotype |
neXtProti | NX_P15391 |
OpenTargetsi | ENSG00000177455 |
Orphaneti | 1572, Common variable immunodeficiency |
PharmGKBi | PA26192 |
VEuPathDBi | HostDB:ENSG00000177455.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502STG8, Eukaryota |
GeneTreei | ENSGT00390000014991 |
HOGENOMi | CLU_038774_0_0_1 |
InParanoidi | P15391 |
OMAi | LWLPCGV |
OrthoDBi | 521520at2759 |
PhylomeDBi | P15391 |
TreeFami | TF338293 |
Enzyme and pathway databases
PathwayCommonsi | P15391 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P15391 |
SIGNORi | P15391 |
Miscellaneous databases
BioGRID-ORCSi | 930, 15 hits in 875 CRISPR screens |
ChiTaRSi | CD19, human |
GeneWikii | CD19 |
GenomeRNAii | 930 |
Pharosi | P15391, Tclin |
PROi | PR:P15391 |
RNActi | P15391, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177455, Expressed in tonsil and 123 other tissues |
Genevisiblei | P15391, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR042341, CD19 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
PANTHERi | PTHR16674, PTHR16674, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD19_HUMAN | |
Accessioni | P15391Primary (citable) accession number: P15391 Secondary accession number(s): A0N0P9 Q9BRD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 216 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references