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Protein

CD44 antigen

Gene

Cd44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43Hyaluronan1 Publication1
Binding sitei80Hyaluronan1 Publication1
Binding sitei81Hyaluronan1 Publication1
Binding sitei107Hyaluronan1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI
  • hyaluronic acid binding Source: MGI
  • phosphoprotein binding Source: MGI
  • protein kinase binding Source: MGI
  • transmembrane signaling receptor activity Source: GO_Central
  • type II transforming growth factor beta receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Hermes antigen
Hyaluronate receptor
Lymphocyte antigen 24
Short name:
Ly-24
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd44
Synonyms:Ly-24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88338 Cd44

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 685ExtracellularSequence analysisAdd BLAST663
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei686 – 706HelicalSequence analysisAdd BLAST21
Topological domaini707 – 778CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi715 – 717KKK → QIN: Loss of interaction with EZR, MSN and RDX and co-localization to microvilli with EZR, MSN and RDX. 1 Publication3

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3232693

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002668923 – 778CD44 antigenAdd BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi55 ↔ 121PROSITE-ProRule annotation1 Publication
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 99PROSITE-ProRule annotation1 Publication
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei410SulfotyrosineBy similarity1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei708Phosphoserine; by PKCBy similarity1
Modified residuei726PhosphothreonineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated.By similarity
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15379

PeptideAtlas

More...
PeptideAtlasi
P15379

PRoteomics IDEntifications database

More...
PRIDEi
P15379

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15379

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15379

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15379

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_CD44

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (By similarity). Interacts with PKN2 (PubMed:17403031). Interacts with TIAM1 and TIAM2 (PubMed:19893486). Interacts with UNC119. Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (By similarity). Interacts with RDX, EZR and MSN (PubMed:9472040).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P15379

Database of interacting proteins

More...
DIPi
DIP-29095N

Protein interaction database and analysis system

More...
IntActi
P15379, 13 interactors

Molecular INTeraction database

More...
MINTi
P15379

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000005218

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15379

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1778
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15379

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15379

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15379

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 123LinkPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni227 – 685StemAdd BLAST459
Regioni709 – 727Required for interaction with EZR, MSN and RDX and for the co-localization to microvilli1 PublicationAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi153 – 161Arg/Lys-rich (basic)9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZCP Eukaryota
ENOG4111S6T LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003850

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15379

KEGG Orthology (KO)

More...
KOi
K06256

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10225:SF6 PTHR10225:SF6, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00193 Xlink, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00658 CD44
PR01265 LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00445 LINK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15379-14) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKFWWHTAW GLCLLQLSLA HQQIDLNVTC RYAGVFHVEK NGRYSISRTE
60 70 80 90 100
AADLCQAFNS TLPTMDQMKL ALSKGFETCR YGFIEGNVVI PRIHPNAICA
110 120 130 140 150
ANHTGVYILV TSNTSHYDTY CFNASAPPEE DCTSVTDLPN SFDGPVTITI
160 170 180 190 200
VNRDGTRYSK KGEYRTHQED IDASNIIDDD VSSGSTIEKS TPEGYILHTY
210 220 230 240 250
LPTEQPTGDQ DDSFFIRSTL ATIASTVHSK SHAAAQKQNN WIWSWFGNSQ
260 270 280 290 300
STTQTQEPTT SATTALMTTP ETPPKRQEAQ NWFSWLFQPS ESKSHLHTTT
310 320 330 340 350
KMPGTESNTN PTGWEPNEEN EDETDTYPSF SGSGIDDDED FISSTIATTP
360 370 380 390 400
RVSARTEDNQ DWTQWKPNHS NPEVLLQTTT RMADIDRIST SAHGENWTPE
410 420 430 440 450
PQPPFNNHEY QDEEETPHAT STTPNSTAEA AATQQETWFQ NGWQGKNPPT
460 470 480 490 500
PSEDSHVTEG TTASAHNNHP SQRITTQSQE DVSWTDFFDP ISHPMGQGHQ
510 520 530 540 550
TESKDTDSSH STTLQPTAAP NTHLVEDLNR TGPLSVTTPQ SHSQNFSTLH
560 570 580 590 600
GEPEEDENYP TTSILPSSTK SSAKDARRGG SLPTDTTTSV EGYTFQYPDT
610 620 630 640 650
MENGTLFPVT PAKTEVFGET EVTLATDSNV NVDGSLPGDR DSSKDSRGSS
660 670 680 690 700
RTVTHGSELA GHSSANQDSG VTTTSGPMRR PQIPEWLIIL ASLLALALIL
710 720 730 740 750
AVCIAVNSRR RCGQKKKLVI NGGNGTVEDR KPSELNGEAS KSQEMVHLVN
760 770
KEPSETPDQC MTADETRNLQ SVDMKIGV
Length:778
Mass (Da):85,617
Last modified:April 30, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD2C073250F6C956
GO
Isoform 2 (identifier: P15379-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-264: Missing.

Show »
Length:736
Mass (Da):81,015
Checksum:iA4697E905F8DCDA5
GO
Isoform 3 (identifier: P15379-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.

Show »
Length:697
Mass (Da):76,463
Checksum:i796CC452E28B8BC5
GO
Isoform 4 (identifier: P15379-4) [UniParc]FASTAAdd to basket
Also known as: M2

The sequence of this isoform differs from the canonical sequence as follows:
     223-346: Missing.

Show »
Length:654
Mass (Da):71,780
Checksum:i6211C96F93F72A16
GO
Isoform 5 (identifier: P15379-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.

Show »
Length:617
Mass (Da):67,517
Checksum:i2CA109453C5D8A90
GO
Isoform 6 (identifier: P15379-5) [UniParc]FASTAAdd to basket
Also known as: M3

The sequence of this isoform differs from the canonical sequence as follows:
     223-424: Missing.

Show »
Length:576
Mass (Da):62,858
Checksum:iE7052A0A1690F9DB
GO
Isoform 7 (identifier: P15379-6) [UniParc]FASTAAdd to basket
Also known as: M4

The sequence of this isoform differs from the canonical sequence as follows:
     223-504: Missing.

Show »
Length:496
Mass (Da):54,055
Checksum:i8CF72BC7AD2C2490
GO
Isoform 8 (identifier: P15379-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-303: Missing.
     424-504: Missing.

Show »
Length:616
Mass (Da):67,563
Checksum:iF945E31D9E1AB63D
GO
Isoform 9 (identifier: P15379-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-383: Missing.
     463-504: Missing.

Show »
Length:575
Mass (Da):62,800
Checksum:i771039FF04C95470
GO
Isoform 10 (identifier: P15379-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-580: TKSSAKDARRGG → VCLVVVADFSAL
     581-778: Missing.

Show »
Length:580
Mass (Da):64,443
Checksum:iF6CB36489A1C9885
GO
Isoform 11 (identifier: P15379-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-592: TKSSAKDARRGGSLPTDTTTSVEG → VRIIKSNWLLSRNQDVMGVSGGGC
     593-778: Missing.

Show »
Length:592
Mass (Da):65,797
Checksum:i60BAF55CBB1308C0
GO
Isoform 12 (identifier: P15379-3) [UniParc]FASTAAdd to basket
Also known as: M1

The sequence of this isoform differs from the canonical sequence as follows:
     223-539: Missing.

Show »
Length:461
Mass (Da):50,398
Checksum:i031244225F1D8AFE
GO
Isoform 13 (identifier: P15379-2) [UniParc]FASTAAdd to basket
Also known as: M0

The sequence of this isoform differs from the canonical sequence as follows:
     223-637: Missing.
     638-638: G → R

Show »
Length:363
Mass (Da):39,999
Checksum:i80031C90F26F8880
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2APM2A2APM2_MOUSE
CD44 antigen
Cd44
780Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APM3A2APM3_MOUSE
CD44 antigen
Cd44
464Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APM4A2APM4_MOUSE
CD44 antigen
Cd44
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APM1A2APM1_MOUSE
CD44 antigen
Cd44
657Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80X37Q80X37_MOUSE
CD44 antigen
Cd44
580Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2APM5A2APM5_MOUSE
CD44 antigen
Cd44
434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3U8S1Q3U8S1_MOUSE
CD44 antigen
Cd44
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QKM8E9QKM8_MOUSE
CD44 antigen
Cd44
577Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326T → K (PubMed:10859330).Curated1
Sequence conflicti326T → K (PubMed:8509359).Curated1
Sequence conflicti348T → S (PubMed:8509359).Curated1
Sequence conflicti559Y → H (PubMed:10859330).Curated1
Sequence conflicti559Y → H (PubMed:8464707).Curated1
Sequence conflicti559Y → H (PubMed:8509359).Curated1
Sequence conflicti572S → G (PubMed:10859330).Curated1
Sequence conflicti572S → G (PubMed:8464707).Curated1
Sequence conflicti572S → G (PubMed:8509359).Curated1
Sequence conflicti639D → RD (PubMed:2403559).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti21H → HPH in Ly-24.2. 1 Publication1
Natural varianti194G → S in Ly-24.2. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005329223 – 637Missing in isoform 13. 5 PublicationsAdd BLAST415
Alternative sequenceiVSP_005328223 – 539Missing in isoform 12. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_005327223 – 504Missing in isoform 7. 2 PublicationsAdd BLAST282
Alternative sequenceiVSP_005326223 – 424Missing in isoform 6. 2 PublicationsAdd BLAST202
Alternative sequenceiVSP_007332223 – 383Missing in isoform 5 and isoform 9. 2 PublicationsAdd BLAST161
Alternative sequenceiVSP_007331223 – 346Missing in isoform 4. 2 PublicationsAdd BLAST124
Alternative sequenceiVSP_007330223 – 303Missing in isoform 3 and isoform 8. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_007329223 – 264Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_007334424 – 504Missing in isoform 8. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_007335463 – 504Missing in isoform 9. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_007338569 – 592TKSSA…TSVEG → VRIIKSNWLLSRNQDVMGVS GGGC in isoform 11. CuratedAdd BLAST24
Alternative sequenceiVSP_007336569 – 580TKSSA…ARRGG → VCLVVVADFSAL in isoform 10. CuratedAdd BLAST12
Alternative sequenceiVSP_007337581 – 778Missing in isoform 10. CuratedAdd BLAST198
Alternative sequenceiVSP_007339593 – 778Missing in isoform 11. CuratedAdd BLAST186
Alternative sequenceiVSP_007333638G → R in isoform 13. 5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X66084 mRNA Translation: CAA46883.1
X66083 mRNA Translation: CAA46882.1
X66082 mRNA Translation: CAA46881.1
X66081 mRNA Translation: CAA46880.1
M30655 mRNA Translation: AAA39922.1
M27129 mRNA Translation: AAA37406.1
M27130 mRNA Translation: AAA37407.1
AJ251594 mRNA Translation: CAB61888.1
BC005676 mRNA Translation: AAH05676.1
AK045226 mRNA Translation: BAC32269.1
J05163 mRNA Translation: AAA39923.1
X69724 mRNA Translation: CAA49380.1
L13611 mRNA Translation: AAA37145.1
U57610 mRNA Translation: AAC52804.1
U57611 mRNA Translation: AAB08756.1
U57612 Genomic DNA Translation: AAC52805.1
U57612 Genomic DNA Translation: AAC52806.1

Protein sequence database of the Protein Information Resource

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PIRi
A34424
A37009
B44355
D44355
S30397

NCBI Reference Sequences

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RefSeqi
NP_001034240.1, NM_001039151.1
NP_001171256.1, NM_001177785.1
NP_001171257.1, NM_001177786.1
NP_001171258.1, NM_001177787.1
NP_033981.2, NM_009851.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.423621

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
12505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12505

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66084 mRNA Translation: CAA46883.1
X66083 mRNA Translation: CAA46882.1
X66082 mRNA Translation: CAA46881.1
X66081 mRNA Translation: CAA46880.1
M30655 mRNA Translation: AAA39922.1
M27129 mRNA Translation: AAA37406.1
M27130 mRNA Translation: AAA37407.1
AJ251594 mRNA Translation: CAB61888.1
BC005676 mRNA Translation: AAH05676.1
AK045226 mRNA Translation: BAC32269.1
J05163 mRNA Translation: AAA39923.1
X69724 mRNA Translation: CAA49380.1
L13611 mRNA Translation: AAA37145.1
U57610 mRNA Translation: AAC52804.1
U57611 mRNA Translation: AAB08756.1
U57612 Genomic DNA Translation: AAC52805.1
U57612 Genomic DNA Translation: AAC52806.1
PIRiA34424
A37009
B44355
D44355
S30397
RefSeqiNP_001034240.1, NM_001039151.1
NP_001171256.1, NM_001177785.1
NP_001171257.1, NM_001177786.1
NP_001171258.1, NM_001177787.1
NP_033981.2, NM_009851.2
UniGeneiMm.423621

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JCPX-ray1.30A23-174[»]
2JCQX-ray1.25A23-174[»]
2JCRX-ray2.00A23-174[»]
2ZPYX-ray2.10B708-727[»]
4MRDX-ray2.55A23-171[»]
4MREX-ray1.58A23-171[»]
4MRFX-ray1.55A23-171[»]
4MRGX-ray1.69A23-171[»]
4MRHX-ray1.12A23-171[»]
4NP2X-ray1.75A23-171[»]
4NP3X-ray1.61A23-171[»]
5BZCX-ray1.95A22-171[»]
5BZEX-ray1.31A23-171[»]
5BZFX-ray2.77A21-171[»]
5BZGX-ray2.19A21-171[»]
5BZHX-ray1.95A21-171[»]
5BZIX-ray1.32A21-171[»]
5BZJX-ray1.40A21-171[»]
5BZKX-ray1.40A21-171[»]
5BZLX-ray1.23A21-171[»]
5BZMX-ray1.25A21-171[»]
5BZNX-ray1.23A21-171[»]
5BZOX-ray1.22A21-171[»]
5BZPX-ray1.23A21-171[»]
5BZQX-ray1.20A21-171[»]
5BZRX-ray1.15A21-171[»]
5BZSX-ray1.50A21-171[»]
5BZTX-ray1.25A21-171[»]
ProteinModelPortaliP15379
SMRiP15379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP15379
DIPiDIP-29095N
IntActiP15379, 13 interactors
MINTiP15379
STRINGi10090.ENSMUSP00000005218

Chemistry databases

BindingDBiP15379
ChEMBLiCHEMBL3232693

PTM databases

iPTMnetiP15379
PhosphoSitePlusiP15379
SwissPalmiP15379

Proteomic databases

PaxDbiP15379
PeptideAtlasiP15379
PRIDEiP15379

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12505
KEGGimmu:12505

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
960
MGIiMGI:88338 Cd44

Phylogenomic databases

eggNOGiENOG410IZCP Eukaryota
ENOG4111S6T LUCA
HOVERGENiHBG003850
InParanoidiP15379
KOiK06256

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cd44 mouse
EvolutionaryTraceiP15379

Protein Ontology

More...
PROi
PR:P15379

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_CD44

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom
PANTHERiPTHR10225:SF6 PTHR10225:SF6, 2 hits
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
PRINTSiPR00658 CD44
PR01265 LINKMODULE
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD44_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15379
Secondary accession number(s): Q05732
, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 30, 2003
Last modified: November 7, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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