Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myogenic factor 6

Gene

Myf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Herculin
Muscle-specific regulatory factor 4
Gene namesi
Name:Myf6
Synonyms:Mrf4, Myf-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97253 Myf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273521 – 242Myogenic factor 6Add BLAST242

Proteomic databases

PaxDbiP15375
PRIDEiP15375

PTM databases

iPTMnetiP15375
PhosphoSitePlusiP15375

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000035923 Expressed in 90 organ(s), highest expression level in diaphragm
CleanExiMM_MYF6
ExpressionAtlasiP15375 baseline and differential
GenevisibleiP15375 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with CSRP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP15375, 1 interactor
MINTiP15375
STRINGi10090.ENSMUSP00000047529

Structurei

3D structure databases

ProteinModelPortaliP15375
SMRiP15375
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 144bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234799
HOVERGENiHBG006429
InParanoidiP15375
KOiK18485
OMAiDQQDKMQ
OrthoDBiEOG091G0GKD
PhylomeDBiP15375
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P15375-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAISY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGANVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Length:242
Mass (Da):26,987
Last modified:April 1, 1990 - v1
Checksum:iDF5FF9A3FA5BBFD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA Translation: AAA37802.1
X59060 mRNA Translation: CAA41785.1
AK029370 mRNA Translation: BAC26423.1
CCDSiCCDS24162.1
PIRiA34872
RefSeqiNP_032683.1, NM_008657.2
UniGeneiMm.11

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923
GeneIDi17878
KEGGimmu:17878
UCSCiuc007gza.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30499 Genomic DNA Translation: AAA37802.1
X59060 mRNA Translation: CAA41785.1
AK029370 mRNA Translation: BAC26423.1
CCDSiCCDS24162.1
PIRiA34872
RefSeqiNP_032683.1, NM_008657.2
UniGeneiMm.11

3D structure databases

ProteinModelPortaliP15375
SMRiP15375
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15375, 1 interactor
MINTiP15375
STRINGi10090.ENSMUSP00000047529

PTM databases

iPTMnetiP15375
PhosphoSitePlusiP15375

Proteomic databases

PaxDbiP15375
PRIDEiP15375

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044210; ENSMUSP00000047529; ENSMUSG00000035923
GeneIDi17878
KEGGimmu:17878
UCSCiuc007gza.1 mouse

Organism-specific databases

CTDi4618
MGIiMGI:97253 Myf6

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234799
HOVERGENiHBG006429
InParanoidiP15375
KOiK18485
OMAiDQQDKMQ
OrthoDBiEOG091G0GKD
PhylomeDBiP15375
TreeFamiTF316344

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Miscellaneous databases

PROiPR:P15375
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035923 Expressed in 90 organ(s), highest expression level in diaphragm
CleanExiMM_MYF6
ExpressionAtlasiP15375 baseline and differential
GenevisibleiP15375 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYF6_MOUSE
AccessioniPrimary (citable) accession number: P15375
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again