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UniProtKB - P15330 (DORS_DROME)

Entry version 223 (07 Oct 2020)
Sequence version 2 (01 Jun 2001)
Previous versions | rss
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Protein

Embryonic polarity protein dorsal

Gene

dl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Embryonic developmental protein (PubMed:2598266, PubMed:10072776). The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage (PubMed:2598266). A morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'-GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in larvae (PubMed:10072776). Part of a signaling pathway involving NF-kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-1169091, Activation of NF-kappaB in B cells
R-DME-1810476, RIP-mediated NFkB activation via ZBP1
R-DME-202424, Downstream TCR signaling
R-DME-209400, Transcriptional activtion by phosphorylated DL/DIF dimer
R-DME-209406, Degradation of NF-kappa-B inhibitor, CACT
R-DME-209560, NF-kB is activated and signals survival
R-DME-214842, DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844, DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214869, Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510, SUMOylation of immune response proteins
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5621575, CD209 (DC-SIGN) signaling
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-6798695, Neutrophil degranulation
R-DME-9020702, Interleukin-1 signaling
R-DME-933542, TRAF6 mediated NF-kB activation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P15330

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Embryonic polarity protein dorsal
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dl
ORF Names:CG6667
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0260632, dl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051641 – 999Embryonic polarity protein dorsalAdd BLAST999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei312Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15330

PRoteomics IDEntifications database

More...PRIDEi		P15330

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P15330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In unchallenged larvae, expression of both isoforms is seen in fat body and gut (isoform A is more abundant). After immune challenge levels of both isoforms are enhanced.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform A is expressed maternally and both isoforms are expressed zygotically from 6-9 hours embryos through to adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0260632, Expressed in crop (Drosophila) and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P15330, differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P15330, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tamo via the nuclear localization signal (PubMed:12653959).

Interacts with emb, a component of the nuclear export complex (PubMed:14638854, PubMed:17032737).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		61043, 74 interactors

Database of interacting proteins

More...DIPi		DIP-17423N

Protein interaction database and analysis system

More...IntActi		P15330, 7 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0080560

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15330

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 342RHDPROSITE-ProRule annotationAdd BLAST296

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi668 – 677Nuclear export signal1 Publication10
Motifi756 – 773Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi395 – 464Gln-richAdd BLAST70
Compositional biasi635 – 705Pro-richAdd BLAST71

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQS6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000171058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016080_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15330

KEGG Orthology (KO)

More...KOi		K09254

Identification of Orthologs from Complete Genome Data

More...OMAi		EGHFNVQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15330

Family and domain databases

Conserved Domains Database

More...CDDi		cd01177, IPT_NFkappaB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24169, PTHR24169, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00057, NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: P15330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPNQNNGAA PGQGPAVDGQ QSLNYNGLPA QQQQQLAQST KNVRKKPYVK 
        60         70         80         90        100
ITEQPAGKAL RFRYECEGRS AGSIPGVNST PENKTYPTIE IVGYKGRAVV 
       110        120        130        140        150
VVSCVTKDTP YRPHPHNLVG KEGCKKGVCT LEINSETMRA VFSNLGIQCV 
       160        170        180        190        200
KKKDIEAALK AREEIRVDPF KTGFSHRFQP SSIDLNSVRL CFQVFMESEQ 
       210        220        230        240        250
KGRFTSPLPP VVSEPIFDKK AMSDLVICRL CSCSATVFGN TQIILLCEKV 
       260        270        280        290        300
AKEDISVRFF EEKNGQSVWE AFGDFQHTDV HKQTAITFKT PRYHTLDITE 
       310        320        330        340        350
PAKVFIQLRR PSDGVTSEAL PFEYVPMDSG KHTFWNLHRH LKRKPDEDLF 
       360        370        380        390        400
QQILRLDAKR EVQPPTIEVI DLDTPKIDVQ REIPSEMEFN HEESQQSEPA 
       410        420        430        440        450
LEQEQSVQQE QYTQEQSLQQ EQYTQEQSLQ QEQYLQQLEQ QQSFQLEEPM 
       460        470        480        490        500
QQDQELPAQQ SFDQAIDHLP DHTSDHIPED MEAADAHAEA EAHRLRSEQE 
       510        520        530        540        550
KEIDTIIDEK VRELEQLDLG QQLEPRPLTA NDKITEWMKS SEIEQQVHEP 
       560        570        580        590        600
SPTAEADVLD SALEISKADK TLDELLETVA ELDEIYTDFK VQRDTYKNTI 
       610        620        630        640        650
QNELAGLQGR APLQVEDSFD DAATYTSLQI AFKNPVLIPM DDIMPPTPPM 
       660        670        680        690        700
SQCAPEDAHQ HYDPVEVNSQ ARKPETPMRP VPPVPPAILT IQYPPEEDKL 
       710        720        730        740        750
PPLPPKRIRK QDSNAENRSI EANTVQTKPS TGESPLNKRL PPAPKNPNFN 
       760        770        780        790        800
TLPRQKKPGF FSKLFSRRKS KPDLAQGQEN SSILDSKANS REPSIGHFNM 
       810        820        830        840        850
QDPMRASLRS SKSAAPFISN PAPAKSSPVK AKKPGSKLTK PVGRSVSSVS 
       860        870        880        890        900
GKRPAYLNAD VVHIPLKGDS VNSLPQQQRT EGYSQSSTIS VGAGLDRRTA 
       910        920        930        940        950
SALQLADIPI SEGGMELVAI ADRQSLHNLV SSIEGHFNVQ LDPNLDLTEA 
       960        970        980        990 
EHFALYTSIP PLAAASEFDE TSAYYAPVDA GEILTPDEVA KRLAAANGI
Length:999
Mass (Da):111,551
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE29C6594AC07D662
GO
Isoform A (identifier: P15330-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     330-677: GKHTFWNLHR...NSQARKPETP → DPAHLRRKRQ...LQISNLSIST
     678-999: Missing.

Note: Nuclear localization signal at positions 335-340.Curated
Show »
Length:677
Mass (Da):75,347
Checksum:i10FEFCEB1D3A5789
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JHK3E1JHK3_DROME
Dorsal, isoform D
dl anon-EST:GressD7, d, DL, Dl, dL
677Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C7LA93C7LA93_DROME
Dorsal, isoform F
dl anon-EST:GressD7, d, DL, Dl, dL
999Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236T → S in AAT94434 (Ref. 6) Curated1
Sequence conflicti391H → Q in AAC35296 (PubMed:10072776).Curated1
Sequence conflicti401L → F in AAC35296 (PubMed:10072776).Curated1
Sequence conflicti407V → SQQEQYTQEQSL in AAC35296 (PubMed:10072776).Curated1
Sequence conflicti698 – 699DK → EQ in AAC35296 (PubMed:10072776).Curated2
Sequence conflicti965 – 999ASEFD…AANGI → PVNLTRPPPTMLPWMLARF in AAC35296 (PubMed:10072776).CuratedAdd BLAST35
Isoform A (identifier: P15330-2)
Sequence conflicti506Q → QQ in AAA28479 (PubMed:3118464).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005581330 – 677GKHTF…KPETP → DPAHLRRKRQKTGGDPMHLL LQQQQKQQLQNDHQDGRQTN MNCWNTQNIPPIKTEPRDTS PQPFGLSYRAPPELTPSPQP LSPSSNYNHNSTPSPYNMAS AVTPTNGQQQLMSPNHPQQQ QQQQQYGATDLGSNYNPFAQ QVLAQQQQHQQQQQQHQHQH QQQHQQQQQQQQQQQQQSLQ FHANPFGNPGGNSWESKFSA AAVAAAAATATGAAPANGNS NNLSNLNNPFTMHNLLTSGG GPGNANNLQWNLTTNHLHNQ HTLHQQQQLQQQQQQQYDNT APTNNNANLNNNNNNNNTAG NQADNNGPTLSNLLSFDSGQ LVHINSEDQQILRLNSEDLQ ISNLSIST in isoform A. 3 PublicationsAdd BLAST348
Alternative sequenceiVSP_005582678 – 999Missing in isoform A. 3 PublicationsAdd BLAST322

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M23702 mRNA Translation: AAA28479.1
AF053614 mRNA Translation: AAC35296.1
AE014134 Genomic DNA Translation: AAF53611.1
AE014134 Genomic DNA Translation: AAF53612.1
BT015205 mRNA Translation: AAT94434.1

Protein sequence database of the Protein Information Resource

More...PIRi		A30350

NCBI Reference Sequences

More...RefSeqi		NP_001163000.1, NM_001169529.1 [P15330-2]
NP_001163001.1, NM_001169530.1 [P15330-2]
NP_001286014.1, NM_001299085.1 [P15330-1]
NP_724052.1, NM_165217.3 [P15330-2]
NP_724053.1, NM_165218.3 [P15330-2]
NP_724054.1, NM_165219.2 [P15330-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0081005; FBpp0080558; FBgn0260632 [P15330-2]
FBtr0081006; FBpp0080559; FBgn0260632 [P15330-2]
FBtr0081007; FBpp0080560; FBgn0260632 [P15330-1]
FBtr0301383; FBpp0290597; FBgn0260632 [P15330-2]
FBtr0301384; FBpp0290598; FBgn0260632 [P15330-2]
FBtr0340250; FBpp0309222; FBgn0260632 [P15330-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG6667

UCSC genome browser

More...UCSCi		CG6667-RA, d. melanogaster [P15330-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23702 mRNA Translation: AAA28479.1
AF053614 mRNA Translation: AAC35296.1
AE014134 Genomic DNA Translation: AAF53611.1
AE014134 Genomic DNA Translation: AAF53612.1
BT015205 mRNA Translation: AAT94434.1
PIRiA30350
RefSeqiNP_001163000.1, NM_001169529.1 [P15330-2]
NP_001163001.1, NM_001169530.1 [P15330-2]
NP_001286014.1, NM_001299085.1 [P15330-1]
NP_724052.1, NM_165217.3 [P15330-2]
NP_724053.1, NM_165218.3 [P15330-2]
NP_724054.1, NM_165219.2 [P15330-1]

3D structure databases

SMRiP15330
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61043, 74 interactors
DIPiDIP-17423N
IntActiP15330, 7 interactors
STRINGi7227.FBpp0080560

PTM databases

iPTMnetiP15330

Proteomic databases

PaxDbiP15330
PRIDEiP15330

Genome annotation databases

EnsemblMetazoaiFBtr0081005; FBpp0080558; FBgn0260632 [P15330-2]
FBtr0081006; FBpp0080559; FBgn0260632 [P15330-2]
FBtr0081007; FBpp0080560; FBgn0260632 [P15330-1]
FBtr0301383; FBpp0290597; FBgn0260632 [P15330-2]
FBtr0301384; FBpp0290598; FBgn0260632 [P15330-2]
FBtr0340250; FBpp0309222; FBgn0260632 [P15330-1]
GeneIDi35047
KEGGidme:Dmel_CG6667
UCSCiCG6667-RA, d. melanogaster [P15330-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35047
FlyBaseiFBgn0260632, dl

Phylogenomic databases

eggNOGiENOG502QQS6, Eukaryota
GeneTreeiENSGT00940000171058
HOGENOMiCLU_016080_0_0_1
InParanoidiP15330
KOiK09254
OMAiEGHFNVQ
PhylomeDBiP15330

Enzyme and pathway databases

ReactomeiR-DME-1169091, Activation of NF-kappaB in B cells
R-DME-1810476, RIP-mediated NFkB activation via ZBP1
R-DME-202424, Downstream TCR signaling
R-DME-209400, Transcriptional activtion by phosphorylated DL/DIF dimer
R-DME-209406, Degradation of NF-kappa-B inhibitor, CACT
R-DME-209560, NF-kB is activated and signals survival
R-DME-214842, DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'
R-DME-214844, DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'
R-DME-214869, Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'
R-DME-2871837, FCERI mediated NF-kB activation
R-DME-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-DME-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DME-4755510, SUMOylation of immune response proteins
R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764, CLEC7A (Dectin-1) signaling
R-DME-5621575, CD209 (DC-SIGN) signaling
R-DME-5676590, NIK-->noncanonical NF-kB signaling
R-DME-6798695, Neutrophil degranulation
R-DME-9020702, Interleukin-1 signaling
R-DME-933542, TRAF6 mediated NF-kB activation
SignaLinkiP15330

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Dl, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35047

Protein Ontology

More...PROi		PR:P15330

Gene expression databases

BgeeiFBgn0260632, Expressed in crop (Drosophila) and 37 other tissues
ExpressionAtlasiP15330, differential
GenevisibleiP15330, DM

Family and domain databases

CDDicd01177, IPT_NFkappaB, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR24169, PTHR24169, 1 hit
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR00057, NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDORS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15330
Secondary accession number(s): O77088
, Q0E8P9, Q6AWP3, Q9VJD9, Q9VJE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 223 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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