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Protein

Folate receptor alpha

Gene

FOLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei103Folate1 Publication1
Binding sitei107Folate1 Publication1
Binding sitei196Folate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug binding Source: BHF-UCL
  • folic acid binding Source: UniProtKB
  • folic acid receptor activity Source: UniProtKB
  • methotrexate binding Source: BHF-UCL
  • signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6807878 COPI-mediated anterograde transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.92.1.1 the folate receptor (fr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folate receptor alpha
Short name:
FR-alpha
Alternative name(s):
Adult folate-binding protein
Short name:
FBP
Folate receptor 1
Folate receptor, adult
KB cells FBP
Ovarian tumor-associated antigen MOv18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOLR1
Synonyms:FOLR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110195.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3791 FOLR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136430 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodegeneration due to cerebral folate transport deficiency (NCFTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy.
See also OMIM:613068

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi82Y → A: Slightly reduced affinity for folate. 1 Publication1
Mutagenesisi103D → A: Strongly reduced affinity for folate. 1 Publication1
Mutagenesisi107Y → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi124W → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi125R → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi128R → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi157H → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi162W → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi196S → A: Moderately reduced affinity for folate. 1 Publication1

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
2348

MalaCards human disease database

More...
MalaCardsi
FOLR1
MIMi613068 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000110195

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
217382 Neurodegenerative syndrome due to cerebral folate transport deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28207

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2121

Drug and drug target database

More...
DrugBanki
DB05168 EC145
DB05595 Farletuzumab
DB00563 Methotrexate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOLR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
544337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000880225 – 234Folate receptor alphaAdd BLAST210
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000008803235 – 257Removed in mature formAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 65Combined sources2 Publications
Disulfide bondi57 ↔ 105Combined sources2 Publications
Disulfide bondi66 ↔ 109Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi89 ↔ 175Combined sources2 Publications
Disulfide bondi96 ↔ 146Combined sources2 Publications
Disulfide bondi135 ↔ 209Combined sources2 Publications
Disulfide bondi139 ↔ 189Combined sources2 Publications
Disulfide bondi152 ↔ 169Combined sources2 Publications
Glycosylationi161N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi201N-linked (GlcNAc...) asparagine3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi234GPI-anchor amidated serine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P15328

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15328

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15328

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15328

PeptideAtlas

More...
PeptideAtlasi
P15328

PRoteomics IDEntifications database

More...
PRIDEi
P15328

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53130

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1248

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110195 Expressed in 139 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

More...
CleanExi
HS_FOLR1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15328 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15328 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA077030

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108631, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P15328, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308137

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15328

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KM6X-ray1.55A30-234[»]
4KM7X-ray1.80A/B28-234[»]
4KMXX-ray2.20A28-234[»]
4LRHX-ray2.80A/B/C/D/E/F/G/H23-235[»]
5IZQX-ray3.60A/B/C/D/E/F/G/H1-235[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P15328

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15328

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 128Folate binding1 Publication5
Regioni157 – 162Folate binding1 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFFP Eukaryota
ENOG4111IU4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153758

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006539

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG039612

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15328

KEGG Orthology (KO)

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KOi
K13649

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNWTSGF

Database of Orthologous Groups

More...
OrthoDBi
1224404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15328

TreeFam database of animal gene trees

More...
TreeFami
TF328532

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032935 FOLR1

The PANTHER Classification System

More...
PANTHERi
PTHR10517 PTHR10517, 1 hit
PTHR10517:SF15 PTHR10517:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03024 Folate_rec, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE
60 70 80 90 100
DKLHEQCRPW RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF
110 120 130 140 150
IQDTCLYECS PNLGPWIQQV DQSWRKERVL NVPLCKEDCE QWWEDCRTSY
160 170 180 190 200
TCKSNWHKGW NWTSGFNKCA VGAACQPFHF YFPTPTVLCN EIWTHSYKVS
210 220 230 240 250
NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA AWPFLLSLAL

MLLWLLS
Length:257
Mass (Da):29,819
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD458D8BB047C96A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180F → L in BAD97247 (Ref. 9) Curated1
Sequence conflicti184T → S in AAA74896 (PubMed:2538429).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05928428W → R. Corresponds to variant dbSNP:rs7928649Ensembl.1
Natural variantiVAR_011963160W → C. Corresponds to variant dbSNP:rs1801932Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05013 mRNA Translation: AAA35823.1
M28099 mRNA Translation: AAA35822.1
X62753 mRNA Translation: CAA44610.1
U20391 Genomic DNA Translation: AAB05827.1
U78793 mRNA Translation: AAB39751.1
U78794 mRNA Translation: AAB39752.1
BT007158 mRNA Translation: AAP35822.1
CR542019 mRNA Translation: CAG46816.1
AK223527 mRNA Translation: BAD97247.1
CH471076 Genomic DNA Translation: EAW74848.1
BC002947 mRNA Translation: AAH02947.1
M25317 mRNA Translation: AAA74896.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8211.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44904 A45753

NCBI Reference Sequences

More...
RefSeqi
NP_000793.1, NM_000802.3
NP_057936.1, NM_016724.2
NP_057937.1, NM_016725.2
NP_057941.1, NM_016729.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.73769

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312293; ENSP00000308137; ENSG00000110195
ENST00000393676; ENSP00000377281; ENSG00000110195
ENST00000393679; ENSP00000377284; ENSG00000110195
ENST00000393681; ENSP00000377286; ENSG00000110195

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2348

UCSC genome browser

More...
UCSCi
uc001orz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05013 mRNA Translation: AAA35823.1
M28099 mRNA Translation: AAA35822.1
X62753 mRNA Translation: CAA44610.1
U20391 Genomic DNA Translation: AAB05827.1
U78793 mRNA Translation: AAB39751.1
U78794 mRNA Translation: AAB39752.1
BT007158 mRNA Translation: AAP35822.1
CR542019 mRNA Translation: CAG46816.1
AK223527 mRNA Translation: BAD97247.1
CH471076 Genomic DNA Translation: EAW74848.1
BC002947 mRNA Translation: AAH02947.1
M25317 mRNA Translation: AAA74896.1
CCDSiCCDS8211.1
PIRiA44904 A45753
RefSeqiNP_000793.1, NM_000802.3
NP_057936.1, NM_016724.2
NP_057937.1, NM_016725.2
NP_057941.1, NM_016729.2
UniGeneiHs.73769

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KM6X-ray1.55A30-234[»]
4KM7X-ray1.80A/B28-234[»]
4KMXX-ray2.20A28-234[»]
4LRHX-ray2.80A/B/C/D/E/F/G/H23-235[»]
5IZQX-ray3.60A/B/C/D/E/F/G/H1-235[»]
ProteinModelPortaliP15328
SMRiP15328
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108631, 13 interactors
IntActiP15328, 13 interactors
STRINGi9606.ENSP00000308137

Chemistry databases

BindingDBiP15328
ChEMBLiCHEMBL2121
DrugBankiDB05168 EC145
DB05595 Farletuzumab
DB00563 Methotrexate

Protein family/group databases

TCDBi9.B.92.1.1 the folate receptor (fr) family

PTM databases

GlyConnecti1248
iPTMnetiP15328

Polymorphism and mutation databases

BioMutaiFOLR1
DMDMi544337

Proteomic databases

EPDiP15328
jPOSTiP15328
MaxQBiP15328
PaxDbiP15328
PeptideAtlasiP15328
PRIDEiP15328
ProteomicsDBi53130

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2348
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312293; ENSP00000308137; ENSG00000110195
ENST00000393676; ENSP00000377281; ENSG00000110195
ENST00000393679; ENSP00000377284; ENSG00000110195
ENST00000393681; ENSP00000377286; ENSG00000110195
GeneIDi2348
KEGGihsa:2348
UCSCiuc001orz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2348
DisGeNETi2348
EuPathDBiHostDB:ENSG00000110195.11

GeneCards: human genes, protein and diseases

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GeneCardsi
FOLR1
HGNCiHGNC:3791 FOLR1
HPAiHPA077030
MalaCardsiFOLR1
MIMi136430 gene
613068 phenotype
neXtProtiNX_P15328
OpenTargetsiENSG00000110195
Orphaneti217382 Neurodegenerative syndrome due to cerebral folate transport deficiency
PharmGKBiPA28207

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00940000153758
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP15328
KOiK13649
OMAiWNWTSGF
OrthoDBi1224404at2759
PhylomeDBiP15328
TreeFamiTF328532

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Folate_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2348

Protein Ontology

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PROi
PR:P15328

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110195 Expressed in 139 organ(s), highest expression level in right uterine tube
CleanExiHS_FOLR1
ExpressionAtlasiP15328 baseline and differential
GenevisibleiP15328 HS

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032935 FOLR1
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF15 PTHR10517:SF15, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOLR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15328
Secondary accession number(s): Q53EW2
, Q6FGT8, Q6LC90, Q9UCT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: January 16, 2019
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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