Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 185 (12 Aug 2020)
Sequence version 3 (01 Jun 1994)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Folate receptor alpha

Gene

FOLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei103Folate1 Publication1
Binding sitei107Folate1 Publication1
Binding sitei196Folate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P15328

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6807878, COPI-mediated anterograde transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.92.1.1, the folate receptor (fr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Folate receptor alpha
Short name:
FR-alpha
Alternative name(s):
Adult folate-binding protein
Short name:
FBP
Folate receptor 1
Folate receptor, adult
KB cells FBP
Ovarian tumor-associated antigen MOv18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOLR1
Synonyms:FOLR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110195.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3791, FOLR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
136430, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodegeneration due to cerebral folate transport deficiency (NCFTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi82Y → A: Slightly reduced affinity for folate. 1 Publication1
Mutagenesisi103D → A: Strongly reduced affinity for folate. 1 Publication1
Mutagenesisi107Y → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi124W → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi125R → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi128R → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi157H → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi162W → A: Moderately reduced affinity for folate. 1 Publication1
Mutagenesisi196S → A: Moderately reduced affinity for folate. 1 Publication1

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
2348

MalaCards human disease database

More...
MalaCardsi
FOLR1
MIMi613068, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000110195

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
217382, Neurodegenerative syndrome due to cerebral folate transport deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28207

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P15328, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2121

Drug and drug target database

More...
DrugBanki
DB05595, Farletuzumab
DB00158, Folic acid
DB00563, Methotrexate
DB05168, Vintafolide

DrugCentral

More...
DrugCentrali
P15328

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOLR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
544337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000880225 – 234Folate receptor alphaAdd BLAST210
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000008803235 – 257Removed in mature formAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 65Combined sources2 Publications
Disulfide bondi57 ↔ 105Combined sources2 Publications
Disulfide bondi66 ↔ 109Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi89 ↔ 175Combined sources2 Publications
Disulfide bondi96 ↔ 146Combined sources2 Publications
Disulfide bondi135 ↔ 209Combined sources2 Publications
Disulfide bondi139 ↔ 189Combined sources2 Publications
Disulfide bondi152 ↔ 169Combined sources2 Publications
Glycosylationi161N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi201N-linked (GlcNAc...) asparagine3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi234GPI-anchor amidated serine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P15328

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P15328

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P15328

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15328

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15328

PeptideAtlas

More...
PeptideAtlasi
P15328

PRoteomics IDEntifications database

More...
PRIDEi
P15328

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53130

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1248, 23 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P15328, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15328

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110195, Expressed in lung and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15328, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15328, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110195, Tissue enhanced (brain, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108631, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P15328, 14 interactors

Molecular INTeraction database

More...
MINTi
P15328

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377284

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15328

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P15328, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15328

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 128Folate binding1 Publication5
Regioni157 – 162Folate binding1 Publication6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183144

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_070826_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15328

KEGG Orthology (KO)

More...
KOi
K13649

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCEEIWS

Database of Orthologous Groups

More...
OrthoDBi
1224404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15328

TreeFam database of animal gene trees

More...
TreeFami
TF328532

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004269, Folate_rcpt
IPR018143, Folate_rcpt-like
IPR032935, FOLR1

The PANTHER Classification System

More...
PANTHERi
PTHR10517, PTHR10517, 1 hit
PTHR10517:SF15, PTHR10517:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03024, Folate_rec, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE
60 70 80 90 100
DKLHEQCRPW RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF
110 120 130 140 150
IQDTCLYECS PNLGPWIQQV DQSWRKERVL NVPLCKEDCE QWWEDCRTSY
160 170 180 190 200
TCKSNWHKGW NWTSGFNKCA VGAACQPFHF YFPTPTVLCN EIWTHSYKVS
210 220 230 240 250
NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA AWPFLLSLAL

MLLWLLS
Length:257
Mass (Da):29,819
Last modified:June 1, 1994 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD458D8BB047C96A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180F → L in BAD97247 (Ref. 9) Curated1
Sequence conflicti184T → S in AAA74896 (PubMed:2538429).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05928428W → R. Corresponds to variant dbSNP:rs7928649Ensembl.1
Natural variantiVAR_011963160W → C. Corresponds to variant dbSNP:rs1801932Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05013 mRNA Translation: AAA35823.1
M28099 mRNA Translation: AAA35822.1
X62753 mRNA Translation: CAA44610.1
U20391 Genomic DNA Translation: AAB05827.1
U78793 mRNA Translation: AAB39751.1
U78794 mRNA Translation: AAB39752.1
BT007158 mRNA Translation: AAP35822.1
CR542019 mRNA Translation: CAG46816.1
AK223527 mRNA Translation: BAD97247.1
CH471076 Genomic DNA Translation: EAW74848.1
BC002947 mRNA Translation: AAH02947.1
M25317 mRNA Translation: AAA74896.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8211.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44904, A45753

NCBI Reference Sequences

More...
RefSeqi
NP_000793.1, NM_000802.3
NP_057936.1, NM_016724.2
NP_057937.1, NM_016725.2
NP_057941.1, NM_016729.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312293; ENSP00000308137; ENSG00000110195
ENST00000393676; ENSP00000377281; ENSG00000110195
ENST00000393679; ENSP00000377284; ENSG00000110195
ENST00000393681; ENSP00000377286; ENSG00000110195

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2348

UCSC genome browser

More...
UCSCi
uc001orz.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05013 mRNA Translation: AAA35823.1
M28099 mRNA Translation: AAA35822.1
X62753 mRNA Translation: CAA44610.1
U20391 Genomic DNA Translation: AAB05827.1
U78793 mRNA Translation: AAB39751.1
U78794 mRNA Translation: AAB39752.1
BT007158 mRNA Translation: AAP35822.1
CR542019 mRNA Translation: CAG46816.1
AK223527 mRNA Translation: BAD97247.1
CH471076 Genomic DNA Translation: EAW74848.1
BC002947 mRNA Translation: AAH02947.1
M25317 mRNA Translation: AAA74896.1
CCDSiCCDS8211.1
PIRiA44904, A45753
RefSeqiNP_000793.1, NM_000802.3
NP_057936.1, NM_016724.2
NP_057937.1, NM_016725.2
NP_057941.1, NM_016729.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KM6X-ray1.55A30-234[»]
4KM7X-ray1.80A/B28-234[»]
4KMXX-ray2.20A28-234[»]
4LRHX-ray2.80A/B/C/D/E/F/G/H23-235[»]
5IZQX-ray3.60A/B/C/D/E/F/G/H1-235[»]
SMRiP15328
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108631, 13 interactors
IntActiP15328, 14 interactors
MINTiP15328
STRINGi9606.ENSP00000377284

Chemistry databases

BindingDBiP15328
ChEMBLiCHEMBL2121
DrugBankiDB05595, Farletuzumab
DB00158, Folic acid
DB00563, Methotrexate
DB05168, Vintafolide
DrugCentraliP15328

Protein family/group databases

TCDBi9.B.92.1.1, the folate receptor (fr) family

PTM databases

GlyConnecti1248, 23 N-Linked glycans (3 sites)
GlyGeniP15328, 3 sites
iPTMnetiP15328
SwissPalmiP15328

Polymorphism and mutation databases

BioMutaiFOLR1
DMDMi544337

Proteomic databases

EPDiP15328
jPOSTiP15328
MassIVEiP15328
MaxQBiP15328
PaxDbiP15328
PeptideAtlasiP15328
PRIDEiP15328
ProteomicsDBi53130

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P15328, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16919, 451 antibodies

The DNASU plasmid repository

More...
DNASUi
2348

Genome annotation databases

EnsembliENST00000312293; ENSP00000308137; ENSG00000110195
ENST00000393676; ENSP00000377281; ENSG00000110195
ENST00000393679; ENSP00000377284; ENSG00000110195
ENST00000393681; ENSP00000377286; ENSG00000110195
GeneIDi2348
KEGGihsa:2348
UCSCiuc001orz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2348
DisGeNETi2348
EuPathDBiHostDB:ENSG00000110195.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FOLR1
HGNCiHGNC:3791, FOLR1
HPAiENSG00000110195, Tissue enhanced (brain, salivary gland)
MalaCardsiFOLR1
MIMi136430, gene
613068, phenotype
neXtProtiNX_P15328
OpenTargetsiENSG00000110195
Orphaneti217382, Neurodegenerative syndrome due to cerebral folate transport deficiency
PharmGKBiPA28207

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00950000183144
HOGENOMiCLU_070826_1_1_1
InParanoidiP15328
KOiK13649
OMAiLCEEIWS
OrthoDBi1224404at2759
PhylomeDBiP15328
TreeFamiTF328532

Enzyme and pathway databases

PathwayCommonsiP15328
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-5694530, Cargo concentration in the ER
R-HSA-6807878, COPI-mediated anterograde transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2348, 3 hits in 870 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Folate_receptor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2348
PharosiP15328, Tchem

Protein Ontology

More...
PROi
PR:P15328
RNActiP15328, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110195, Expressed in lung and 160 other tissues
ExpressionAtlasiP15328, baseline and differential
GenevisibleiP15328, HS

Family and domain databases

InterProiView protein in InterPro
IPR004269, Folate_rcpt
IPR018143, Folate_rcpt-like
IPR032935, FOLR1
PANTHERiPTHR10517, PTHR10517, 1 hit
PTHR10517:SF15, PTHR10517:SF15, 1 hit
PfamiView protein in Pfam
PF03024, Folate_rec, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOLR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15328
Secondary accession number(s): Q53EW2
, Q6FGT8, Q6LC90, Q9UCT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again