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UniProtKB - P15313 (VATB1_HUMAN)

Entry version 218 (23 Feb 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

V-type proton ATPase subunit B, kidney isoform

Gene

ATP6V1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747).

V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).

Essential for the proper assembly and activity of V-ATPase (PubMed:16769747).

In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747).

Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity).

1 PublicationBy similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei394ATP; non-catalytic siteBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P15313

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-9639288, Amino acids regulate mTORC1
R-HSA-983712, Ion channel transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P15313

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase subunit B, kidney isoform
Short name:
V-ATPase subunit B 1
Alternative name(s):
Endomembrane proton pump 58 kDa subunit
Vacuolar proton pump subunit B 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP6V1B1
Synonyms:ATP6B1, VATB, VPP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:853, ATP6V1B1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		192132, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P15313

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116039

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal tubular acidosis, distal, 2, with progressive sensorineural hearing loss (DRTA2)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by the association of renal distal tubular acidosis with sensorineural hearing loss. Distal renal tubular acidosis is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08574031 – 513Missing in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs121964879Add BLAST483
Natural variantiVAR_00786681L → P in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 4 PublicationsCorresponds to variant dbSNP:rs121964880EnsemblClinVar.1
Natural variantiVAR_021012123G → V in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs1343871627Ensembl.1
Natural variantiVAR_007867124R → W in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 PublicationsCorresponds to variant dbSNP:rs727505222EnsemblClinVar.1
Natural variantiVAR_021013157R → C in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs782500780EnsemblClinVar.1
Natural variantiVAR_007868174M → R in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 Publications1
Natural variantiVAR_007869275T → P in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 3 PublicationsCorresponds to variant dbSNP:rs1161604514Ensembl.1
Natural variantiVAR_007870316G → E in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 PublicationsCorresponds to variant dbSNP:rs1553420413Ensembl.1
Natural variantiVAR_007871346P → R in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 4 PublicationsCorresponds to variant dbSNP:rs781838938EnsemblClinVar.1
Natural variantiVAR_007872364G → S in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi513L → G: Loss of interactions with SLC9A3R1 and SCL4A7. 1 Publication1

Keywords - Diseasei

Deafness, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		525

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ATP6V1B1

MalaCards human disease database

More...MalaCardsi		ATP6V1B1
MIMi267300, phenotype

Open Targets

More...OpenTargetsi		ENSG00000116039

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		402041, Autosomal recessive distal renal tubular acidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P15313, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3217

Drug and drug target database

More...DrugBanki		DB01133, Tiludronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP6V1B1

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001446241 – 513V-type proton ATPase subunit B, kidney isoformAdd BLAST513

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P15313

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P15313

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P15313

MaxQB - The MaxQuant DataBase

More...MaxQBi		P15313

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15313

PeptideAtlas

More...PeptideAtlasi		P15313

PRoteomics IDEntifications database

More...PRIDEi		P15313

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53129

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P15313

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P15313

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P15313

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276, PubMed:16769747). Expressed in the cochlea and endolymphatic sac (PubMed:9916796).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116039, Expressed in adult mammalian kidney and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P15313, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P15313, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116039, Group enriched (kidney, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

Forms a complex with SLC9A3R1 and SCL4A7 (PubMed:12444018).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107008, 111 interactors

Protein interaction database and analysis system

More...IntActi		P15313, 37 interactors

Molecular INTeraction database

More...MINTi		P15313

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000234396

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P15313

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P15313, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15313

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi510 – 513PDZ-binding1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1351, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161413

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022916_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15313

Identification of Orthologs from Complete Genome Data

More...OMAi		DYHEDNF

Database of Orthologous Groups

More...OrthoDBi		541116at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15313

TreeFam database of animal gene trees

More...TreeFami		TF300313

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00310, ATP_synth_B_arch, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723, ATPase_V1-cplx_bsu
IPR027417, P-loop_NTPase
IPR022879, V-ATPase_su_B/beta

The PANTHER Classification System

More...PANTHERi		PTHR43389, PTHR43389, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF039114, V-ATPsynth_beta/V-ATPase_B, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01040, V-ATPase_V1_B, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P15313-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMEIDSRPG GLPGSSCNLG AAREHMQAVT RNYITHPRVT YRTVCSVNGP 
        60         70         80         90        100
LVVLDRVKFA QYAEIVHFTL PDGTQRSGQV LEVAGTKAIV QVFEGTSGID 
       110        120        130        140        150
ARKTTCEFTG DILRTPVSED MLGRVFNGSG KPIDKGPVVM AEDFLDINGQ 
       160        170        180        190        200
PINPHSRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI 
       210        220        230        240        250
CRQAGLVKKS KAVLDYHDDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN 
       260        270        280        290        300
VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA 
       310        320        330        340        350
LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM 
       360        370        380        390        400
PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QIYPPINVLP SLSRLMKSAI 
       410        420        430        440        450
GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ 
       460        470        480        490        500
KFEKNFINQG PYENRSVFES LDLGWKLLRI FPKEMLKRIP QAVIDEFYSR 
       510 
EGALQDLAPD TAL
Length:513
Mass (Da):56,833
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5399E2849F3B99AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JL73C9JL73_HUMAN
Vacuolar proton pump subunit B
ATP6V1B1
496Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNS9C9JNS9_HUMAN
V-type proton ATPase subunit B, kid...
ATP6V1B1
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ02C9JZ02_HUMAN
V-type proton ATPase subunit B, kid...
ATP6V1B1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36498 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti467V → M in AAA36498 (PubMed:2527371).Curated1
Sequence conflicti474G → S in AAA36498 (PubMed:2527371).Curated1
Sequence conflicti503A → R in AAA36498 (PubMed:2527371).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02101130T → I2 PublicationsCorresponds to variant dbSNP:rs17720303EnsemblClinVar.1
Natural variantiVAR_08574031 – 513Missing in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs121964879Add BLAST483
Natural variantiVAR_00786681L → P in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 4 PublicationsCorresponds to variant dbSNP:rs121964880EnsemblClinVar.1
Natural variantiVAR_021012123G → V in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs1343871627Ensembl.1
Natural variantiVAR_007867124R → W in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 PublicationsCorresponds to variant dbSNP:rs727505222EnsemblClinVar.1
Natural variantiVAR_021013157R → C in DRTA2. 1 PublicationCorresponds to variant dbSNP:rs782500780EnsemblClinVar.1
Natural variantiVAR_021014161E → K1 PublicationCorresponds to variant dbSNP:rs114234874EnsemblClinVar.1
Natural variantiVAR_007868174M → R in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 Publications1
Natural variantiVAR_007869275T → P in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 3 PublicationsCorresponds to variant dbSNP:rs1161604514Ensembl.1
Natural variantiVAR_007870316G → E in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 PublicationsCorresponds to variant dbSNP:rs1553420413Ensembl.1
Natural variantiVAR_007871346P → R in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 4 PublicationsCorresponds to variant dbSNP:rs781838938EnsemblClinVar.1
Natural variantiVAR_007872364G → S in DRTA2; disruption of V-ATPase assembly resulting in loss of enzyme activity; impaired trafficking of V-ATPase to apical cell membrane; impaired renal proton secretion. 2 Publications1
Natural variantiVAR_021015465R → H2 PublicationsCorresponds to variant dbSNP:rs142905621EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M25809 mRNA Translation: AAA36498.1 Different initiation.
AK291121 mRNA Translation: BAF83810.1
AK313194 mRNA Translation: BAG36011.1
AK223151 mRNA Translation: BAD96871.1
CH471053 Genomic DNA Translation: EAW99790.1
BC063411 mRNA Translation: AAH63411.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1912.1

Protein sequence database of the Protein Information Resource

More...PIRi		A33281

NCBI Reference Sequences

More...RefSeqi		NP_001683.2, NM_001692.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000234396; ENSP00000234396; ENSG00000116039

Database of genes from NCBI RefSeq genomes

More...GeneIDi		525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:525

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000234396.10; ENSP00000234396.4; NM_001692.4; NP_001683.2

UCSC genome browser

More...UCSCi		uc002shj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25809 mRNA Translation: AAA36498.1 Different initiation.
AK291121 mRNA Translation: BAF83810.1
AK313194 mRNA Translation: BAG36011.1
AK223151 mRNA Translation: BAD96871.1
CH471053 Genomic DNA Translation: EAW99790.1
BC063411 mRNA Translation: AAH63411.1
CCDSiCCDS1912.1
PIRiA33281
RefSeqiNP_001683.2, NM_001692.3

3D structure databases

SMRiP15313
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107008, 111 interactors
IntActiP15313, 37 interactors
MINTiP15313
STRINGi9606.ENSP00000234396

Chemistry databases

BindingDBiP15313
ChEMBLiCHEMBL3217
DrugBankiDB01133, Tiludronic acid

Protein family/group databases

TCDBi3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiP15313
MetOSiteiP15313
PhosphoSitePlusiP15313

Genetic variation databases

BioMutaiATP6V1B1
DMDMi215274116

Proteomic databases

EPDiP15313
jPOSTiP15313
MassIVEiP15313
MaxQBiP15313
PaxDbiP15313
PeptideAtlasiP15313
PRIDEiP15313
ProteomicsDBi53129

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4020, 369 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		525

Genome annotation databases

EnsembliENST00000234396; ENSP00000234396; ENSG00000116039
GeneIDi525
KEGGihsa:525
MANE-SelectiENST00000234396.10; ENSP00000234396.4; NM_001692.4; NP_001683.2
UCSCiuc002shj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		525
DisGeNETi525

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP6V1B1
GeneReviewsiATP6V1B1
HGNCiHGNC:853, ATP6V1B1
HPAiENSG00000116039, Group enriched (kidney, salivary gland)
MalaCardsiATP6V1B1
MIMi192132, gene
267300, phenotype
neXtProtiNX_P15313
OpenTargetsiENSG00000116039
Orphaneti402041, Autosomal recessive distal renal tubular acidosis
PharmGKBiPA25154
VEuPathDBiHostDB:ENSG00000116039

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1351, Eukaryota
GeneTreeiENSGT00940000161413
HOGENOMiCLU_022916_3_0_1
InParanoidiP15313
OMAiDYHEDNF
OrthoDBi541116at2759
PhylomeDBiP15313
TreeFamiTF300313

Enzyme and pathway databases

PathwayCommonsiP15313
ReactomeiR-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-9639288, Amino acids regulate mTORC1
R-HSA-983712, Ion channel transport
SignaLinkiP15313

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		525, 5 hits in 1032 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP6V1B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		525
PharosiP15313, Tchem

Protein Ontology

More...PROi		PR:P15313
RNActiP15313, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116039, Expressed in adult mammalian kidney and 124 other tissues
ExpressionAtlasiP15313, baseline and differential
GenevisibleiP15313, HS

Family and domain databases

HAMAPiMF_00310, ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723, ATPase_V1-cplx_bsu
IPR027417, P-loop_NTPase
IPR022879, V-ATPase_su_B/beta
PANTHERiPTHR43389, PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114, V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01040, V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVATB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15313
Secondary accession number(s): Q53FY0, Q6P4H6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: February 23, 2022
This is version 218 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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