ACPP

Functionⁱ

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Miscellaneous

Used as a diagnostic tool for staging metastatic prostatic cancer.

Catalytic activityⁱ

A phosphate monoester + H₂O = an alcohol + phosphate.1 Publication

A 5'-ribonucleotide + H₂O = a ribonucleoside + phosphate.1 Publication

Activity regulationⁱ

Phosphatase activity inhibited by L⁺-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	43	Substrate	1
Active siteⁱ	44	Nucleophile1 Publication	1
Binding siteⁱ	47	Substrate	1
Siteⁱ	49	Important for substrate specificity	1
Binding siteⁱ	111	Substrate	1
Siteⁱ	138	Required for homodimerizationBy similarity	1
Siteⁱ	144	Required for homodimerizationBy similarity	1
Siteⁱ	206	Required for structural stability	1
Binding siteⁱ	289	Substrate	1
Active siteⁱ	290	Proton donor1 Publication	1

GO - Molecular functionⁱ

5'-nucleotidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18940592
acid phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8132635
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18083097
- 24657436
lysophosphatidic acid phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15280042
phosphatase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18940592
- 22389722
protein homodimerization activity
Source: CAFA
Inferred from direct assayⁱ
- 10639192
thiamine phosphate phosphatase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenosine metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18940592
dephosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8132635
neutrophil degranulation Source: Reactome
nucleotide metabolic process Source: Ensembl
positive regulation of adenosine receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18940592
- 22389722
protein homotetramerization
Source: CAFA
Inferred from direct assayⁱ
- 10639192
purine nucleobase metabolic process Source: Ensembl
regulation of sensory perception of pain
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18940592
- 22389722
thiamine metabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.2 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation
SABIO-RKⁱ	P15309

Chemistry databases

SwissLipidsⁱ	SLP:000001295 [P15309-1]

SwissLipidsⁱ

SLP:000001295 [P15309-1]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostatic acid phosphatase (EC:3.1.3.2) Short name: PAP Alternative name(s): 5'-nucleotidase (EC:3.1.3.5) Short name: 5'-NT Ecto-5'-nucleotidase Thiamine monophosphatase Short name: TMPase Cleaved into the following chain: PAPf39
Gene namesⁱ	Name:ACPP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000014257.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:125 ACPP
MIMⁱ	171790 gene
neXtProtⁱ	NX_P15309

Keywords - Cellular componentⁱ

Amyloid, Cell membrane, Lysosome, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	206	W → F: Greatly reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication		1
Mutagenesisⁱ	206	W → L: Reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55
Open Targets More...OpenTargetsⁱ	ENSG00000014257
PharmGKBⁱ	PA24449

Chemistry databases

ChEMBLⁱ	CHEMBL2633
Drug and drug target database More...DrugBankⁱ	DB03577 Alpha-Benzyl-Aminobenzyl-Phosphonic Acid DB03390 N-Propyl-Tartramic Acid DB06688 Sipuleucel-T

Polymorphism and mutation databases

BioMutaⁱ	ACPP
DMDMⁱ	130730

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 32	Add BLAST	32
ChainⁱPRO_0000023963	33 – 386	Prostatic acid phosphataseAdd BLAST	354
PeptideⁱPRO_0000411250	248 – 286	PAPf39Add BLAST	39

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	94	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	161 ↔ 372
Disulfide bondⁱ	215 ↔ 313
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	333	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	347 ↔ 351

Post-translational modificationⁱ

N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.2 Publications

Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P15309
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15309
PaxDbⁱ	P15309
PeptideAtlas More...PeptideAtlasⁱ	P15309
PRIDEⁱ	P15309
ProteomicsDBⁱ	53126 53127 [P15309-2]

PTM databases

DEPODⁱ	P15309
iPTMnetⁱ	P15309
PhosphoSitePlusⁱ	P15309

Miscellaneous databases

PMAP-CutDBⁱ	P15309

PMAP-CutDBⁱ

P15309

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000014257 Expressed in 140 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_ACPP
ExpressionAtlasⁱ	P15309 baseline and differential
Genevisibleⁱ	P15309 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000071 HPA004335 HPA063916

HPAⁱ

CAB000071
HPA004335
HPA063916

Interactionⁱ

Subunit structureⁱ

Homodimer; dimer formation is required for phosphatase activity.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-1222012,EBI-1222012
ERBB2	P04626	2	EBI-1222012,EBI-641062

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18083097
- 24657436
protein homodimerization activity
Source: CAFA
Inferred from direct assayⁱ
- 10639192

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106571, 27 interactors
ComplexPortalⁱ	CPX-120 Prostatic acid phosphatase complex
IntActⁱ	P15309, 2 interactors
Molecular INTeraction database More...MINTⁱ	P15309
STRINGⁱ	9606.ENSP00000323036

Chemistry databases

BindingDBⁱ

P15309

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 43	Combined sources	10
Helixⁱ	60 – 62	Combined sources	3
Helixⁱ	72 – 88	Combined sources	17
Turnⁱ	89 – 93	Combined sources	5
Helixⁱ	99 – 101	Combined sources	3
Beta strandⁱ	102 – 108	Combined sources	7
Helixⁱ	110 – 123	Combined sources	14
Helixⁱ	128 – 130	Combined sources	3
Beta strandⁱ	134 – 136	Combined sources	3
Beta strandⁱ	144 – 146	Combined sources	3
Helixⁱ	148 – 150	Combined sources	3
Beta strandⁱ	152 – 155	Combined sources	4
Helixⁱ	162 – 173	Combined sources	12
Helixⁱ	175 – 181	Combined sources	7
Helixⁱ	182 – 184	Combined sources	3
Helixⁱ	185 – 195	Combined sources	11
Helixⁱ	202 – 208	Combined sources	7
Helixⁱ	210 – 218	Combined sources	9
Helixⁱ	229 – 247	Combined sources	19
Beta strandⁱ	248 – 251	Combined sources	4
Helixⁱ	252 – 258	Combined sources	7
Helixⁱ	261 – 276	Combined sources	16
Beta strandⁱ	277 – 279	Combined sources	3
Beta strandⁱ	282 – 288	Combined sources	7
Helixⁱ	290 – 299	Combined sources	10
Beta strandⁱ	313 – 321	Combined sources	9
Beta strandⁱ	324 – 332	Combined sources	9
Beta strandⁱ	335 – 337	Combined sources	3
Beta strandⁱ	340 – 342	Combined sources	3
Beta strandⁱ	349 – 352	Combined sources	4
Helixⁱ	353 – 360	Combined sources	8
Helixⁱ	361 – 363	Combined sources	3
Helixⁱ	368 – 371	Combined sources	4

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00628
ProteinModelPortalⁱ	P15309
SMRⁱ	P15309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P15309

EvolutionaryTraceⁱ

P15309

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3720 Eukaryota ENOG410ZVBQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062956
HOGENOMⁱ	HOG000231439
HOVERGENⁱ	HBG002203
InParanoidⁱ	P15309
KEGG Orthology (KO) More...KOⁱ	K19283
OMAⁱ	YKDFIAT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09FA
PhylomeDBⁱ	P15309
TreeFamⁱ	TF312893

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07061 HP_HAP_like, 1 hit
Gene3Dⁱ	3.40.50.1240, 1 hit
InterProⁱ	View protein in InterPro IPR033379 Acid_Pase_AS IPR000560 His_Pase_clade-2 IPR029033 His_PPase_superfam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00328 His_Phos_2, 1 hit
SUPFAMⁱ	SSF53254 SSF53254, 1 hit
PROSITEⁱ	View protein in PROSITE PS00616 HIS_ACID_PHOSPHAT_1, 1 hit PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P15309-1) [UniParc]FASTA Add to basket

Also known as: Secreted PAP, sPAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI 
        60         70         80         90        100
DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE 
       110        120        130        140        150
QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE 
       160        170        180        190        200
DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ 
       210        220        230        240        250
DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH 
       260        270        280        290        300
KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL 
       310        320        330        340        350
DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS 
       360        370        380 
CPLERFAELV GPVIPQDWST ECMTTNSHQG TEDSTD

Length:386

Mass (Da):44,566

Last modified:March 1, 1992 - v3

Checksum:ⁱEF81E11DFAECADEA

GO

Isoform 2 (identifier: P15309-2) [UniParc]FASTA Add to basket

Also known as: TMPase, TM-PAP, cellular PAP, cPAP

The sequence of this isoform differs from the canonical sequence as follows:
380-386: GTEDSTD → VLKVIFAVAFCLISAVLMVLLFIHIRRGLCWQRESYGNI

« Hide

        10         20         30         40         50
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI 
        60         70         80         90        100
DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE 
       110        120        130        140        150
QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE 
       160        170        180        190        200
DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ 
       210        220        230        240        250
DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH 
       260        270        280        290        300
KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL 
       310        320        330        340        350
DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS 
       360        370        380        390        400
CPLERFAELV GPVIPQDWST ECMTTNSHQV LKVIFAVAFC LISAVLMVLL 
       410 
FIHIRRGLCW QRESYGNI

Show »

Length:418

Mass (Da):48,336

Checksum:ⁱ68E1131197595362

GO

Isoform 3 (identifier: P15309-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
153-185: Missing.

« Hide

        10         20         30         40         50
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI 
        60         70         80         90        100
DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE 
       110        120        130        140        150
QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE 
       160        170        180        190        200
DQDFIATLGK LSGLHGQDLF GIWSKVYDPL YCESVHNFTL PSWATEDTMT 
       210        220        230        240        250
KLRELSELSL LSLYGIHKQK EKSRLQGGVL VNEILNHMKR ATQIPSYKKL 
       260        270        280        290        300
IMYSAHDTTV SGLQMALDVY NGLLPPYASC HLTELYFEKG EYFVEMYYRN 
       310        320        330        340        350
ETQHEPYPLM LPGCSPSCPL ERFAELVGPV IPQDWSTECM TTNSHQGTED 

STD

Show »

Length:353

Mass (Da):40,443

Checksum:ⁱC3E376122B63DA82

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PFE6	E9PFE6_HUMAN	Prostatic acid phosphatase Prostatic acid phosphatase	ACPP	165	Annotation score:
H0Y8T3	H0Y8T3_HUMAN	Prostatic acid phosphatase Prostatic acid phosphatase	ACPP	99	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15 – 24	SLGFLFLLFF → AFASCFCFFC in CAA37673 (PubMed:2395659).Curated	10
Sequence conflictⁱ	15 – 24	SLGFLFLLFF → ALASCFCFFC in AAA60022 (PubMed:2712834).Curated	10
Sequence conflictⁱ	15 – 24	SLGFLFLLFF → ALASCFCFFC in CAA36422 (PubMed:2842184).Curated	10
Sequence conflictⁱ	46	D → H in CAA37673 (PubMed:2395659).Curated	1
Sequence conflictⁱ	66 – 73	GFGQLTQL → RIWPTHPA in CAA37673 (PubMed:2395659).Curated	8
Sequence conflictⁱ	66 – 73	GFGQLTQL → WIWPTHPA in CAA36422 (PubMed:2842184).Curated	8
Sequence conflictⁱ	95	E → D in AAA60022 (PubMed:2712834).Curated	1
Sequence conflictⁱ	116	A → R in AAA60022 (PubMed:2712834).Curated	1
Sequence conflictⁱ	139	Q → E in CAA37673 (PubMed:2395659).Curated	1
Sequence conflictⁱ	157	P → R in CAA37673 (PubMed:2395659).Curated	1
Sequence conflictⁱ	212	P → A in CAA36422 (PubMed:2842184).Curated	1
Sequence conflictⁱ	215	C → S in AAA60022 (PubMed:2712834).Curated	1
Sequence conflictⁱ	294	S → T in AAA60022 (PubMed:2712834).Curated	1
Sequence conflictⁱ	372	C → V in AAA60022 (PubMed:2712834).Curated	1
Sequence conflictⁱ	383	D → N in CAA37673 (PubMed:2395659).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047960	15	S → N1 PublicationCorresponds to variant dbSNP:rs17850347Ensembl.	1
Natural variantⁱVAR_047961	124	F → V1 PublicationCorresponds to variant dbSNP:rs17856254Ensembl.	1
Natural variantⁱVAR_047962	226	W → R1 PublicationCorresponds to variant dbSNP:rs17856253Ensembl.	1
Natural variantⁱVAR_047963	330	Y → H1 PublicationCorresponds to variant dbSNP:rs17851392Ensembl.	1
Natural variantⁱVAR_047964	360	V → A1 PublicationCorresponds to variant dbSNP:rs17850198Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053360	153 – 185	Missing in isoform 3. 2 PublicationsAdd BLAST		33
Alternative sequenceⁱVSP_036023	380 – 386	GTEDSTD → VLKVIFAVAFCLISAVLMVL LFIHIRRGLCWQRESYGNI in isoform 2. 1 Publication		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97589 M97588 Genomic DNA Translation: AAA60021.1 M34840 mRNA Translation: AAA69694.1 M24902 mRNA Translation: AAA60022.1 X52174 mRNA Translation: CAA36422.1 X53605 mRNA Translation: CAA37673.1 U07097 U07095 Genomic DNA Translation: AAB60640.1 AB102888 mRNA Translation: BAD89417.1 AK300540 mRNA Translation: BAG62248.1 AC020633 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79203.1 CH471052 Genomic DNA Translation: EAW79205.1 BC007460 mRNA Translation: AAH07460.1 BC008493 mRNA Translation: AAH08493.1 BC016344 mRNA Translation: AAH16344.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3073.1 [P15309-1] CCDS46916.1 [P15309-2] CCDS77818.1 [P15309-3]
PIRⁱ	JH0610
NCBI Reference Sequences More...RefSeqⁱ	NP_001090.2, NM_001099.4 [P15309-1] NP_001127666.1, NM_001134194.1 [P15309-2] NP_001278966.1, NM_001292037.1 [P15309-3]
UniGeneⁱ	Hs.433060

Genome annotation databases

Ensemblⁱ	ENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1] ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2] ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3]
GeneIDⁱ	55
KEGGⁱ	hsa:55
UCSC genome browser More...UCSCⁱ	uc003eon.4 human [P15309-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15309	ACPP isoform 2 (Fragment)		PONAB		387	UniRef90_P15309
Prostatic acid phosphatase isoform PAP		CALJA		386
ACPP isoform 1		PANTR		386
Prostatic acid phosphatase (Fragment)		MACMU		354
UPI0000112794		HUMAN		354
+3
P15309-2	Acid phosphatase, prostate		PONAB		421	UniRef90_P15309-2
Prostatic acid phosphatase (Fragment)		SYMSY		31
ACPP (Fragment)		PONPY		40
Acid phosphatase, prostate		MACFA		418
Acid phosphatase, prostate		SAIBB		418
+23
P15309-3	ACPP isoform 4 (Fragment)		PONAB		354	UniRef90_P15309-3
Acid phosphatase, prostate		SAIBB		353
Uncharacterized protein		PANPA		353
Uncharacterized protein		CERAT		353
Uncharacterized protein		RHIRO		353
+14

Protein	Similar proteins		Species	Score	Length	Source
P15309	Prostatic acid phosphatase		MOUSE		381	UniRef50_P15309
Prostatic acid phosphatase	)	RAT		381
Prostatic acid phosphatase		BOVIN		387
ACPP isoform 2 (Fragment)		PONAB		387
ACPP isoform 1		PANTR		386
+252

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M97589 M97588 Genomic DNA Translation: AAA60021.1 M34840 mRNA Translation: AAA69694.1 M24902 mRNA Translation: AAA60022.1 X52174 mRNA Translation: CAA36422.1 X53605 mRNA Translation: CAA37673.1 U07097 U07095 Genomic DNA Translation: AAB60640.1 AB102888 mRNA Translation: BAD89417.1 AK300540 mRNA Translation: BAG62248.1 AC020633 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79203.1 CH471052 Genomic DNA Translation: EAW79205.1 BC007460 mRNA Translation: AAH07460.1 BC008493 mRNA Translation: AAH08493.1 BC016344 mRNA Translation: AAH16344.1
CCDSⁱ	CCDS3073.1 [P15309-1] CCDS46916.1 [P15309-2] CCDS77818.1 [P15309-3]
PIRⁱ	JH0610
RefSeqⁱ	NP_001090.2, NM_001099.4 [P15309-1] NP_001127666.1, NM_001134194.1 [P15309-2] NP_001278966.1, NM_001292037.1 [P15309-3]
UniGeneⁱ	Hs.433060

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CVI	X-ray	3.20	A/B/C/D	33-374	[»]
	1ND5	X-ray	2.90	A/B/C/D	33-386	[»]
	1ND6	X-ray	2.40	A/B/C/D	33-386	[»]
	2HPA	X-ray	2.90	A/B/C/D	33-374	[»]
	2L3H	NMR	-	A	248-286	[»]
	2L77	NMR	-	A	248-286	[»]
	2L79	NMR	-	A	248-286	[»]
	2MG0	NMR	-	A	262-270	[»]
	3PPD	X-ray	1.50	A	260-265	[»]
DisProtⁱ	DP00628
ProteinModelPortalⁱ	P15309
SMRⁱ	P15309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106571, 27 interactors
ComplexPortalⁱ	CPX-120 Prostatic acid phosphatase complex
IntActⁱ	P15309, 2 interactors
MINTⁱ	P15309
STRINGⁱ	9606.ENSP00000323036

Chemistry databases

BindingDBⁱ	P15309
ChEMBLⁱ	CHEMBL2633
DrugBankⁱ	DB03577 Alpha-Benzyl-Aminobenzyl-Phosphonic Acid DB03390 N-Propyl-Tartramic Acid DB06688 Sipuleucel-T
SwissLipidsⁱ	SLP:000001295 [P15309-1]

PTM databases

DEPODⁱ	P15309
iPTMnetⁱ	P15309
PhosphoSitePlusⁱ	P15309

Polymorphism and mutation databases

BioMutaⁱ	ACPP
DMDMⁱ	130730

Proteomic databases

EPDⁱ	P15309
MaxQBⁱ	P15309
PaxDbⁱ	P15309
PeptideAtlasⁱ	P15309
PRIDEⁱ	P15309
ProteomicsDBⁱ	53126 53127 [P15309-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1] ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2] ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3]
GeneIDⁱ	55
KEGGⁱ	hsa:55
UCSCⁱ	uc003eon.4 human [P15309-1]

Organism-specific databases

CTDⁱ	55
DisGeNETⁱ	55
EuPathDBⁱ	HostDB:ENSG00000014257.15
GeneCardsⁱ	ACPP
HGNCⁱ	HGNC:125 ACPP
HPAⁱ	CAB000071 HPA004335 HPA063916
MIMⁱ	171790 gene
neXtProtⁱ	NX_P15309
OpenTargetsⁱ	ENSG00000014257
PharmGKBⁱ	PA24449
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3720 Eukaryota ENOG410ZVBQ LUCA
GeneTreeⁱ	ENSGT00530000062956
HOGENOMⁱ	HOG000231439
HOVERGENⁱ	HBG002203
InParanoidⁱ	P15309
KOⁱ	K19283
OMAⁱ	YKDFIAT
OrthoDBⁱ	EOG091G09FA
PhylomeDBⁱ	P15309
TreeFamⁱ	TF312893

Enzyme and pathway databases

BRENDAⁱ	3.1.3.2 2681
Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation
SABIO-RKⁱ	P15309

Miscellaneous databases

ChiTaRSⁱ	ACPP human
EvolutionaryTraceⁱ	P15309
GeneWikiⁱ	Prostatic_acid_phosphatase
GenomeRNAiⁱ	55
PMAP-CutDBⁱ	P15309
Protein Ontology More...PROⁱ	PR:P15309
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000014257 Expressed in 140 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_ACPP
ExpressionAtlasⁱ	P15309 baseline and differential
Genevisibleⁱ	P15309 HS

Family and domain databases

CDDⁱ	cd07061 HP_HAP_like, 1 hit
Gene3Dⁱ	3.40.50.1240, 1 hit
InterProⁱ	View protein in InterPro IPR033379 Acid_Pase_AS IPR000560 His_Pase_clade-2 IPR029033 His_PPase_superfam
Pfamⁱ	View protein in Pfam PF00328 His_Phos_2, 1 hit
SUPFAMⁱ	SSF53254 SSF53254, 1 hit
PROSITEⁱ	View protein in PROSITE PS00616 HIS_ACID_PHOSPHAT_1, 1 hit PS00778 HIS_ACID_PHOSPHAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPAP_HUMAN
Accessionⁱ	P15309Primary (citable) accession number: P15309 Secondary accession number(s): D3DNC6 , Q5FBY0, Q96KY0, Q96QK9, Q96QM0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P15309 (PPAP_HUMAN)

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Prostatic acid phosphatase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Organism-specific databases

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

PTM databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

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Experimental Info

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Keywords - Coding sequence diversityi

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Sequence databases

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Chemistry databases

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Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ