UniProtKB - P15309 (PPAP_HUMAN)
Protein
Prostatic acid phosphatase
Gene
ACP3
Organism
Homo sapiens (Human)
Status
Functioni
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042).4 Publications
Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling (PubMed:20498373). In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity).By similarity1 Publication
(Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection (PubMed:18083097, PubMed:19451623, PubMed:19897482). SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea (PubMed:19451623). Target cell attachment and enhancement of HIV infection is inhibited by surfen (PubMed:19897482). Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection (PubMed:19403677).4 Publications
Miscellaneous
Has been used as a diagnostic tool for staging metastatic prostatic cancer.
Catalytic activityi
- EC:3.1.3.23 Publications
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- EC:3.1.3.5By similarity
- EC:3.1.3.481 Publication
Activity regulationi
Phosphatase activity inhibited by L+-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | Substrate1 Publication | 1 | |
Active sitei | 44 | Nucleophile1 Publication | 1 | |
Binding sitei | 47 | Substrate1 Publication | 1 | |
Sitei | 49 | Important for substrate specificity | 1 | |
Binding sitei | 111 | Substrate1 Publication | 1 | |
Sitei | 138 | Required for homodimerizationBy similarity | 1 | |
Sitei | 144 | Required for homodimerizationBy similarity | 1 | |
Sitei | 206 | Required for structural stability1 Publication | 1 | |
Binding sitei | 289 | Substrate1 Publication | 1 | |
Active sitei | 290 | Proton donor1 Publication | 1 |
GO - Molecular functioni
- 5'-nucleotidase activity Source: UniProtKB
- acid phosphatase activity Source: UniProtKB
- identical protein binding Source: IntAct
- lysophosphatidic acid phosphatase activity Source: UniProtKB
- phosphatase activity Source: UniProtKB
- protein homodimerization activity Source: CAFA
- thiamine phosphate phosphatase activity Source: UniProtKB
GO - Biological processi
- adenosine metabolic process Source: UniProtKB
- dephosphorylation Source: UniProtKB
- lysosome organization Source: GO_Central
- neutrophil degranulation Source: Reactome
- nucleotide metabolic process Source: Ensembl
- positive regulation of adenosine receptor signaling pathway Source: UniProtKB
- purine nucleobase metabolic process Source: Ensembl
- regulation of sensory perception of pain Source: UniProtKB
- thiamine metabolic process Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.2, 2681 |
PathwayCommonsi | P15309 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P15309 |
Chemistry databases
SwissLipidsi | SLP:000001295 [P15309-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Prostatic acid phosphataseCurated (EC:3.1.3.23 Publications)Short name: PAP Alternative name(s): Acid phosphatase 3Imported Ecto-5'-nucleotidase Protein tyrosine phosphatase ACP31 Publication (EC:3.1.3.481 Publication) Thiamine monophosphatase Short name: TMPase Cleaved into the following chain: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:125, ACP3 |
MIMi | 171790, gene |
neXtProti | NX_P15309 |
VEuPathDBi | HostDB:ENSG00000014257.15 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Nucleus
- Nucleus 1 Publication
Lysosome
- Lysosome membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Cytosol
- cytosol 1 Publication
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein Sequence analysis
Note: Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319).2 Publications
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Lysosome
- azurophil granule membrane Source: Reactome
- lysosomal membrane Source: UniProtKB
- lysosome Source: GO_Central
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- filopodium Source: Ensembl
- integral component of membrane Source: Ensembl
- vesicle membrane Source: UniProtKB
Keywords - Cellular componenti
Amyloid, Cell membrane, Cytoplasm, Lysosome, Membrane, Nucleus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 206 | W → F: Greatly reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication | 1 | |
Mutagenesisi | 206 | W → L: Reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55 |
OpenTargetsi | ENSG00000014257 |
PharmGKBi | PA24449 |
Miscellaneous databases
Pharosi | P15309, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2633 |
DrugBanki | DB03390, (2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid DB03577, Alpha-Benzyl-Aminobenzyl-Phosphonic Acid DB06688, Sipuleucel-T |
DrugCentrali | P15309 |
Genetic variation databases
BioMutai | ACPP |
DMDMi | 130730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | 1 PublicationAdd BLAST | 32 | |
ChainiPRO_0000023963 | 33 – 386 | Prostatic acid phosphataseAdd BLAST | 354 | |
PeptideiPRO_0000411250 | 248 – 286 | PAPf391 PublicationAdd BLAST | 39 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 94 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 161 ↔ 372 | 2 Publications | ||
Disulfide bondi | 215 ↔ 313 | 1 Publication | ||
Glycosylationi | 220 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 347 ↔ 351 | 2 Publications |
Post-translational modificationi
N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.2 Publications
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P15309 |
jPOSTi | P15309 |
MassIVEi | P15309 |
MaxQBi | P15309 |
PaxDbi | P15309 |
PeptideAtlasi | P15309 |
PRIDEi | P15309 |
ProteomicsDBi | 53126 [P15309-1] 53127 [P15309-2] 62789 |
PTM databases
DEPODi | ACPP |
GlyConnecti | 2001, 6 N-Linked glycans (2 sites) |
GlyGeni | P15309, 3 sites, 14 N-linked glycans (2 sites) |
iPTMneti | P15309 |
PhosphoSitePlusi | P15309 |
Expressioni
Tissue specificityi
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues.2 Publications
Widely expressed. Expressed in the sarcolemma of skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000014257, Expressed in prostate gland and 163 other tissues |
ExpressionAtlasi | P15309, baseline and differential |
Genevisiblei | P15309, HS |
Organism-specific databases
HPAi | ENSG00000014257, Tissue enriched (prostate) |
Interactioni
Subunit structurei
Homodimer; dimer formation is required for phosphatase activity.
By similarityBinary interactionsi
Hide detailsP15309
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-1222012,EBI-1222012 |
ERBB2 [P04626] | 2 | EBI-1222012,EBI-641062 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: CAFA
Protein-protein interaction databases
BioGRIDi | 106571, 80 interactors |
ComplexPortali | CPX-120, Prostatic acid phosphatase complex |
IntActi | P15309, 22 interactors |
MINTi | P15309 |
STRINGi | 9606.ENSP00000323036 |
Chemistry databases
BindingDBi | P15309 |
Miscellaneous databases
RNActi | P15309, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P15309 |
SMRi | P15309 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15309 |
Family & Domainsi
Sequence similaritiesi
Belongs to the histidine acid phosphatase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3720, Eukaryota |
GeneTreei | ENSGT00940000160450 |
HOGENOMi | CLU_030431_1_1_1 |
InParanoidi | P15309 |
OMAi | CEGVHNF |
OrthoDBi | 1221585at2759 |
PhylomeDBi | P15309 |
TreeFami | TF312893 |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
DisProti | DP00628 |
Gene3Di | 3.40.50.1240, 1 hit |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR029033, His_PPase_superfam |
Pfami | View protein in Pfam PF00328, His_Phos_2, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit PS00778, HIS_ACID_PHOSPHAT_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P15309-1) [UniParc]FASTAAdd to basket
Also known as: Secreted PAP, sPAP
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI
60 70 80 90 100
DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE
110 120 130 140 150
QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE
160 170 180 190 200
DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ
210 220 230 240 250
DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH
260 270 280 290 300
KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL
310 320 330 340 350
DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS
360 370 380
CPLERFAELV GPVIPQDWST ECMTTNSHQG TEDSTD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PFE6 | E9PFE6_HUMAN | Prostatic acid phosphatase | ACP3 | 165 | Annotation score: | ||
H0Y8T3 | H0Y8T3_HUMAN | Prostatic acid phosphatase | ACP3 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 – 24 | SLGFLFLLFF → AFASCFCFFC in CAA37673 (PubMed:2395659).Curated | 10 | |
Sequence conflicti | 15 – 24 | SLGFLFLLFF → ALASCFCFFC in AAA60022 (PubMed:2712834).Curated | 10 | |
Sequence conflicti | 15 – 24 | SLGFLFLLFF → ALASCFCFFC in CAA36422 (PubMed:2842184).Curated | 10 | |
Sequence conflicti | 46 | D → H in CAA37673 (PubMed:2395659).Curated | 1 | |
Sequence conflicti | 66 – 73 | GFGQLTQL → RIWPTHPA in CAA37673 (PubMed:2395659).Curated | 8 | |
Sequence conflicti | 66 – 73 | GFGQLTQL → WIWPTHPA in CAA36422 (PubMed:2842184).Curated | 8 | |
Sequence conflicti | 95 | E → D in AAA60022 (PubMed:2712834).Curated | 1 | |
Sequence conflicti | 116 | A → R in AAA60022 (PubMed:2712834).Curated | 1 | |
Sequence conflicti | 139 | Q → E in CAA37673 (PubMed:2395659).Curated | 1 | |
Sequence conflicti | 157 | P → R in CAA37673 (PubMed:2395659).Curated | 1 | |
Sequence conflicti | 212 | P → A in CAA36422 (PubMed:2842184).Curated | 1 | |
Sequence conflicti | 215 | C → S in AAA60022 (PubMed:2712834).Curated | 1 | |
Sequence conflicti | 294 | S → T in AAA60022 (PubMed:2712834).Curated | 1 | |
Sequence conflicti | 372 | C → V in AAA60022 (PubMed:2712834).Curated | 1 | |
Sequence conflicti | 383 | D → N in CAA37673 (PubMed:2395659).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047960 | 15 | S → N1 PublicationCorresponds to variant dbSNP:rs17850347Ensembl. | 1 | |
Natural variantiVAR_047961 | 124 | F → V1 PublicationCorresponds to variant dbSNP:rs17856254Ensembl. | 1 | |
Natural variantiVAR_047962 | 226 | W → R1 PublicationCorresponds to variant dbSNP:rs17856253Ensembl. | 1 | |
Natural variantiVAR_047963 | 330 | Y → H1 PublicationCorresponds to variant dbSNP:rs17851392Ensembl. | 1 | |
Natural variantiVAR_047964 | 360 | V → A1 PublicationCorresponds to variant dbSNP:rs17850198Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053360 | 153 – 185 | Missing in isoform 3. 2 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_036023 | 380 – 386 | GTEDSTD → VLKVIFAVAFCLISAVLMVL LFIHIRRGLCWQRESYGNI in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97589 , M97580, M97581, M97582, M97583, M97584, M97585, M97586, M97587, M97588 Genomic DNA Translation: AAA60021.1 M34840 mRNA Translation: AAA69694.1 M24902 mRNA Translation: AAA60022.1 X52174 mRNA Translation: CAA36422.1 X53605 mRNA Translation: CAA37673.1 U07097 , U07083, U07085, U07086, U07088, U07091, U07092, U07093, U07095 Genomic DNA Translation: AAB60640.1 AB102888 mRNA Translation: BAD89417.1 AK300540 mRNA Translation: BAG62248.1 AC020633 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79203.1 CH471052 Genomic DNA Translation: EAW79205.1 BC007460 mRNA Translation: AAH07460.1 BC008493 mRNA Translation: AAH08493.1 BC016344 mRNA Translation: AAH16344.1 |
CCDSi | CCDS3073.1 [P15309-1] CCDS46916.1 [P15309-2] CCDS77818.1 [P15309-3] |
PIRi | JH0610 |
RefSeqi | NP_001090.2, NM_001099.4 [P15309-1] NP_001127666.1, NM_001134194.1 [P15309-2] NP_001278966.1, NM_001292037.1 [P15309-3] |
Genome annotation databases
Ensembli | ENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1] ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2] ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3] |
GeneIDi | 55 |
KEGGi | hsa:55 |
UCSCi | uc003eon.4, human [P15309-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M97589 , M97580, M97581, M97582, M97583, M97584, M97585, M97586, M97587, M97588 Genomic DNA Translation: AAA60021.1 M34840 mRNA Translation: AAA69694.1 M24902 mRNA Translation: AAA60022.1 X52174 mRNA Translation: CAA36422.1 X53605 mRNA Translation: CAA37673.1 U07097 , U07083, U07085, U07086, U07088, U07091, U07092, U07093, U07095 Genomic DNA Translation: AAB60640.1 AB102888 mRNA Translation: BAD89417.1 AK300540 mRNA Translation: BAG62248.1 AC020633 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79203.1 CH471052 Genomic DNA Translation: EAW79205.1 BC007460 mRNA Translation: AAH07460.1 BC008493 mRNA Translation: AAH08493.1 BC016344 mRNA Translation: AAH16344.1 |
CCDSi | CCDS3073.1 [P15309-1] CCDS46916.1 [P15309-2] CCDS77818.1 [P15309-3] |
PIRi | JH0610 |
RefSeqi | NP_001090.2, NM_001099.4 [P15309-1] NP_001127666.1, NM_001134194.1 [P15309-2] NP_001278966.1, NM_001292037.1 [P15309-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CVI | X-ray | 3.20 | A/B/C/D | 33-374 | [»] | |
1ND5 | X-ray | 2.90 | A/B/C/D | 33-386 | [»] | |
1ND6 | X-ray | 2.40 | A/B/C/D | 33-386 | [»] | |
2HPA | X-ray | 2.90 | A/B/C/D | 33-374 | [»] | |
2L3H | NMR | - | A | 248-286 | [»] | |
2L77 | NMR | - | A | 248-286 | [»] | |
2L79 | NMR | - | A | 248-286 | [»] | |
2MG0 | NMR | - | A | 262-270 | [»] | |
3PPD | X-ray | 1.50 | A | 260-265 | [»] | |
BMRBi | P15309 | |||||
SMRi | P15309 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106571, 80 interactors |
ComplexPortali | CPX-120, Prostatic acid phosphatase complex |
IntActi | P15309, 22 interactors |
MINTi | P15309 |
STRINGi | 9606.ENSP00000323036 |
Chemistry databases
BindingDBi | P15309 |
ChEMBLi | CHEMBL2633 |
DrugBanki | DB03390, (2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid DB03577, Alpha-Benzyl-Aminobenzyl-Phosphonic Acid DB06688, Sipuleucel-T |
DrugCentrali | P15309 |
SwissLipidsi | SLP:000001295 [P15309-1] |
PTM databases
DEPODi | ACPP |
GlyConnecti | 2001, 6 N-Linked glycans (2 sites) |
GlyGeni | P15309, 3 sites, 14 N-linked glycans (2 sites) |
iPTMneti | P15309 |
PhosphoSitePlusi | P15309 |
Genetic variation databases
BioMutai | ACPP |
DMDMi | 130730 |
Proteomic databases
EPDi | P15309 |
jPOSTi | P15309 |
MassIVEi | P15309 |
MaxQBi | P15309 |
PaxDbi | P15309 |
PeptideAtlasi | P15309 |
PRIDEi | P15309 |
ProteomicsDBi | 53126 [P15309-1] 53127 [P15309-2] 62789 |
Protocols and materials databases
Antibodypediai | 1343, 922 antibodies |
DNASUi | 55 |
Genome annotation databases
Ensembli | ENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1] ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2] ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3] |
GeneIDi | 55 |
KEGGi | hsa:55 |
UCSCi | uc003eon.4, human [P15309-1] |
Organism-specific databases
CTDi | 55 |
DisGeNETi | 55 |
GeneCardsi | ACP3 |
HGNCi | HGNC:125, ACP3 |
HPAi | ENSG00000014257, Tissue enriched (prostate) |
MIMi | 171790, gene |
neXtProti | NX_P15309 |
OpenTargetsi | ENSG00000014257 |
PharmGKBi | PA24449 |
VEuPathDBi | HostDB:ENSG00000014257.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3720, Eukaryota |
GeneTreei | ENSGT00940000160450 |
HOGENOMi | CLU_030431_1_1_1 |
InParanoidi | P15309 |
OMAi | CEGVHNF |
OrthoDBi | 1221585at2759 |
PhylomeDBi | P15309 |
TreeFami | TF312893 |
Enzyme and pathway databases
BRENDAi | 3.1.3.2, 2681 |
PathwayCommonsi | P15309 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SABIO-RKi | P15309 |
Miscellaneous databases
BioGRID-ORCSi | 55, 4 hits in 868 CRISPR screens |
ChiTaRSi | ACPP, human |
EvolutionaryTracei | P15309 |
GeneWikii | Prostatic_acid_phosphatase |
GenomeRNAii | 55 |
Pharosi | P15309, Tchem |
PROi | PR:P15309 |
RNActi | P15309, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000014257, Expressed in prostate gland and 163 other tissues |
ExpressionAtlasi | P15309, baseline and differential |
Genevisiblei | P15309, HS |
Family and domain databases
CDDi | cd07061, HP_HAP_like, 1 hit |
DisProti | DP00628 |
Gene3Di | 3.40.50.1240, 1 hit |
InterProi | View protein in InterPro IPR033379, Acid_Pase_AS IPR000560, His_Pase_clade-2 IPR029033, His_PPase_superfam |
Pfami | View protein in Pfam PF00328, His_Phos_2, 1 hit |
SUPFAMi | SSF53254, SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616, HIS_ACID_PHOSPHAT_1, 1 hit PS00778, HIS_ACID_PHOSPHAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPAP_HUMAN | |
Accessioni | P15309Primary (citable) accession number: P15309 Secondary accession number(s): D3DNC6 Q96QM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants