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Protein

Prostatic acid phosphatase

Gene

ACPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Miscellaneous

Used as a diagnostic tool for staging metastatic prostatic cancer.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Phosphatase activity inhibited by L+-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei44Nucleophile1 Publication1
Binding sitei47Substrate1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei49Important for substrate specificity1
Binding sitei111Substrate1
Sitei138Required for homodimerizationBy similarity1
Sitei144Required for homodimerizationBy similarity1
Sitei206Required for structural stability1
Binding sitei289Substrate1
Active sitei290Proton donor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5'-nucleotidase activity Source: UniProtKB
  • acid phosphatase activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • lysophosphatidic acid phosphatase activity Source: UniProtKB
  • phosphatase activity Source: UniProtKB
  • protein homodimerization activity Source: CAFA
  • thiamine phosphate phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P15309

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001295 [P15309-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostatic acid phosphatase (EC:3.1.3.2)
Short name:
PAP
Alternative name(s):
5'-nucleotidase (EC:3.1.3.5)
Short name:
5'-NT
Ecto-5'-nucleotidase
Thiamine monophosphatase
Short name:
TMPase
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000014257.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:125 ACPP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
171790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15309

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membrane, Lysosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi206W → F: Greatly reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication1
Mutagenesisi206W → L: Reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55

Open Targets

More...
OpenTargetsi
ENSG00000014257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24449

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2633

Drug and drug target database

More...
DrugBanki
DB03577 Alpha-Benzyl-Aminobenzyl-Phosphonic Acid
DB03390 N-Propyl-Tartramic Acid
DB06688 Sipuleucel-T

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACPP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
130730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Add BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002396333 – 386Prostatic acid phosphataseAdd BLAST354
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_0000411250248 – 286PAPf39Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi161 ↔ 372
Disulfide bondi215 ↔ 313
Glycosylationi220N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi333N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi347 ↔ 351

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.2 Publications
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P15309

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15309

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15309

PeptideAtlas

More...
PeptideAtlasi
P15309

PRoteomics IDEntifications database

More...
PRIDEi
P15309

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53126
53127 [P15309-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P15309

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15309

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15309

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P15309

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000014257 Expressed in 140 organ(s), highest expression level in prostate gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACPP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15309 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15309 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000071
HPA004335
HPA063916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; dimer formation is required for phosphatase activity.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106571, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-120 Prostatic acid phosphatase complex

Protein interaction database and analysis system

More...
IntActi
P15309, 2 interactors

Molecular INTeraction database

More...
MINTi
P15309

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000323036

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P15309

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00628

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15309

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15309

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15309

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3720 Eukaryota
ENOG410ZVBQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160450

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231439

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002203

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15309

KEGG Orthology (KO)

More...
KOi
K19283

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKDFIAT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G09FA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15309

TreeFam database of animal gene trees

More...
TreeFami
TF312893

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07061 HP_HAP_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1240, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00328 His_Phos_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53254 SSF53254, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15309-1) [UniParc]FASTAAdd to basket
Also known as: Secreted PAP, sPAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAAPLLLAR AASLSLGFLF LLFFWLDRSV LAKELKFVTL VFRHGDRSPI
60 70 80 90 100
DTFPTDPIKE SSWPQGFGQL TQLGMEQHYE LGEYIRKRYR KFLNESYKHE
110 120 130 140 150
QVYIRSTDVD RTLMSAMTNL AALFPPEGVS IWNPILLWQP IPVHTVPLSE
160 170 180 190 200
DQLLYLPFRN CPRFQELESE TLKSEEFQKR LHPYKDFIAT LGKLSGLHGQ
210 220 230 240 250
DLFGIWSKVY DPLYCESVHN FTLPSWATED TMTKLRELSE LSLLSLYGIH
260 270 280 290 300
KQKEKSRLQG GVLVNEILNH MKRATQIPSY KKLIMYSAHD TTVSGLQMAL
310 320 330 340 350
DVYNGLLPPY ASCHLTELYF EKGEYFVEMY YRNETQHEPY PLMLPGCSPS
360 370 380
CPLERFAELV GPVIPQDWST ECMTTNSHQG TEDSTD
Length:386
Mass (Da):44,566
Last modified:March 1, 1992 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF81E11DFAECADEA
GO
Isoform 2 (identifier: P15309-2) [UniParc]FASTAAdd to basket
Also known as: TMPase, TM-PAP, cellular PAP, cPAP

The sequence of this isoform differs from the canonical sequence as follows:
     380-386: GTEDSTD → VLKVIFAVAFCLISAVLMVLLFIHIRRGLCWQRESYGNI

Show »
Length:418
Mass (Da):48,336
Checksum:i68E1131197595362
GO
Isoform 3 (identifier: P15309-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-185: Missing.

Show »
Length:353
Mass (Da):40,443
Checksum:iC3E376122B63DA82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFE6E9PFE6_HUMAN
Prostatic acid phosphatase
ACPP
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8T3H0Y8T3_HUMAN
Prostatic acid phosphatase
ACPP
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15 – 24SLGFLFLLFF → AFASCFCFFC in CAA37673 (PubMed:2395659).Curated10
Sequence conflicti15 – 24SLGFLFLLFF → ALASCFCFFC in AAA60022 (PubMed:2712834).Curated10
Sequence conflicti15 – 24SLGFLFLLFF → ALASCFCFFC in CAA36422 (PubMed:2842184).Curated10
Sequence conflicti46D → H in CAA37673 (PubMed:2395659).Curated1
Sequence conflicti66 – 73GFGQLTQL → RIWPTHPA in CAA37673 (PubMed:2395659).Curated8
Sequence conflicti66 – 73GFGQLTQL → WIWPTHPA in CAA36422 (PubMed:2842184).Curated8
Sequence conflicti95E → D in AAA60022 (PubMed:2712834).Curated1
Sequence conflicti116A → R in AAA60022 (PubMed:2712834).Curated1
Sequence conflicti139Q → E in CAA37673 (PubMed:2395659).Curated1
Sequence conflicti157P → R in CAA37673 (PubMed:2395659).Curated1
Sequence conflicti212P → A in CAA36422 (PubMed:2842184).Curated1
Sequence conflicti215C → S in AAA60022 (PubMed:2712834).Curated1
Sequence conflicti294S → T in AAA60022 (PubMed:2712834).Curated1
Sequence conflicti372C → V in AAA60022 (PubMed:2712834).Curated1
Sequence conflicti383D → N in CAA37673 (PubMed:2395659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04796015S → N1 PublicationCorresponds to variant dbSNP:rs17850347Ensembl.1
Natural variantiVAR_047961124F → V1 PublicationCorresponds to variant dbSNP:rs17856254Ensembl.1
Natural variantiVAR_047962226W → R1 PublicationCorresponds to variant dbSNP:rs17856253Ensembl.1
Natural variantiVAR_047963330Y → H1 PublicationCorresponds to variant dbSNP:rs17851392Ensembl.1
Natural variantiVAR_047964360V → A1 PublicationCorresponds to variant dbSNP:rs17850198Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053360153 – 185Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_036023380 – 386GTEDSTD → VLKVIFAVAFCLISAVLMVL LFIHIRRGLCWQRESYGNI in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M97589
, M97580, M97581, M97582, M97583, M97584, M97585, M97586, M97587, M97588 Genomic DNA Translation: AAA60021.1
M34840 mRNA Translation: AAA69694.1
M24902 mRNA Translation: AAA60022.1
X52174 mRNA Translation: CAA36422.1
X53605 mRNA Translation: CAA37673.1
U07097
, U07083, U07085, U07086, U07088, U07091, U07092, U07093, U07095 Genomic DNA Translation: AAB60640.1
AB102888 mRNA Translation: BAD89417.1
AK300540 mRNA Translation: BAG62248.1
AC020633 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79203.1
CH471052 Genomic DNA Translation: EAW79205.1
BC007460 mRNA Translation: AAH07460.1
BC008493 mRNA Translation: AAH08493.1
BC016344 mRNA Translation: AAH16344.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3073.1 [P15309-1]
CCDS46916.1 [P15309-2]
CCDS77818.1 [P15309-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JH0610

NCBI Reference Sequences

More...
RefSeqi
NP_001090.2, NM_001099.4 [P15309-1]
NP_001127666.1, NM_001134194.1 [P15309-2]
NP_001278966.1, NM_001292037.1 [P15309-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.433060

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1]
ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2]
ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55

UCSC genome browser

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UCSCi
uc003eon.4 human [P15309-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97589
, M97580, M97581, M97582, M97583, M97584, M97585, M97586, M97587, M97588 Genomic DNA Translation: AAA60021.1
M34840 mRNA Translation: AAA69694.1
M24902 mRNA Translation: AAA60022.1
X52174 mRNA Translation: CAA36422.1
X53605 mRNA Translation: CAA37673.1
U07097
, U07083, U07085, U07086, U07088, U07091, U07092, U07093, U07095 Genomic DNA Translation: AAB60640.1
AB102888 mRNA Translation: BAD89417.1
AK300540 mRNA Translation: BAG62248.1
AC020633 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79203.1
CH471052 Genomic DNA Translation: EAW79205.1
BC007460 mRNA Translation: AAH07460.1
BC008493 mRNA Translation: AAH08493.1
BC016344 mRNA Translation: AAH16344.1
CCDSiCCDS3073.1 [P15309-1]
CCDS46916.1 [P15309-2]
CCDS77818.1 [P15309-3]
PIRiJH0610
RefSeqiNP_001090.2, NM_001099.4 [P15309-1]
NP_001127666.1, NM_001134194.1 [P15309-2]
NP_001278966.1, NM_001292037.1 [P15309-3]
UniGeneiHs.433060

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CVIX-ray3.20A/B/C/D33-374[»]
1ND5X-ray2.90A/B/C/D33-386[»]
1ND6X-ray2.40A/B/C/D33-386[»]
2HPAX-ray2.90A/B/C/D33-374[»]
2L3HNMR-A248-286[»]
2L77NMR-A248-286[»]
2L79NMR-A248-286[»]
2MG0NMR-A262-270[»]
3PPDX-ray1.50A260-265[»]
DisProtiDP00628
ProteinModelPortaliP15309
SMRiP15309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106571, 27 interactors
ComplexPortaliCPX-120 Prostatic acid phosphatase complex
IntActiP15309, 2 interactors
MINTiP15309
STRINGi9606.ENSP00000323036

Chemistry databases

BindingDBiP15309
ChEMBLiCHEMBL2633
DrugBankiDB03577 Alpha-Benzyl-Aminobenzyl-Phosphonic Acid
DB03390 N-Propyl-Tartramic Acid
DB06688 Sipuleucel-T
SwissLipidsiSLP:000001295 [P15309-1]

PTM databases

DEPODiP15309
iPTMnetiP15309
PhosphoSitePlusiP15309

Polymorphism and mutation databases

BioMutaiACPP
DMDMi130730

Proteomic databases

EPDiP15309
MaxQBiP15309
PaxDbiP15309
PeptideAtlasiP15309
PRIDEiP15309
ProteomicsDBi53126
53127 [P15309-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336375; ENSP00000337471; ENSG00000014257 [P15309-1]
ENST00000351273; ENSP00000323036; ENSG00000014257 [P15309-2]
ENST00000475741; ENSP00000417744; ENSG00000014257 [P15309-3]
GeneIDi55
KEGGihsa:55
UCSCiuc003eon.4 human [P15309-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55
DisGeNETi55
EuPathDBiHostDB:ENSG00000014257.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACPP
HGNCiHGNC:125 ACPP
HPAiCAB000071
HPA004335
HPA063916
MIMi171790 gene
neXtProtiNX_P15309
OpenTargetsiENSG00000014257
PharmGKBiPA24449

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00940000160450
HOGENOMiHOG000231439
HOVERGENiHBG002203
InParanoidiP15309
KOiK19283
OMAiYKDFIAT
OrthoDBiEOG091G09FA
PhylomeDBiP15309
TreeFamiTF312893

Enzyme and pathway databases

BRENDAi3.1.3.2 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
SABIO-RKiP15309

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACPP human
EvolutionaryTraceiP15309

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Prostatic_acid_phosphatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55
PMAP-CutDBiP15309

Protein Ontology

More...
PROi
PR:P15309

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000014257 Expressed in 140 organ(s), highest expression level in prostate gland
CleanExiHS_ACPP
ExpressionAtlasiP15309 baseline and differential
GenevisibleiP15309 HS

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15309
Secondary accession number(s): D3DNC6
, Q5FBY0, Q96KY0, Q96QK9, Q96QM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: March 1, 1992
Last modified: December 5, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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