Thbd

Functionⁱ

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
transmembrane signaling receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation
Source: MGI
Traceable author statementⁱ
- 7846065
female pregnancy
Source: MGI
Inferred from mutant phenotypeⁱ
- 7846065
negative regulation of blood coagulation Source: InterPro
negative regulation of coagulation
Source: MGI
Traceable author statementⁱ
- 7846065
response to cAMP Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to X-ray Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Blood coagulation, Hemostasis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140875 Common Pathway of Fibrin Clot Formation R-MMU-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thrombomodulin Short name: TM Alternative name(s): Fetomodulin CD_antigen: CD141
Gene namesⁱ	Name:Thbd
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:98736 Thbd

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	17 – 517	ExtracellularSequence analysisAdd BLAST	501
Transmembraneⁱ	518 – 541	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	542 – 577	CytoplasmicSequence analysisAdd BLAST	36

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 16	Sequence analysisAdd BLAST		16
ChainⁱPRO_0000007772	17 – 577	ThrombomodulinAdd BLAST		561

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	135 ↔ 156	By similarity
Glycosylationⁱ	243	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	244 ↔ 255	By similarity
Disulfide bondⁱ	251 ↔ 264	By similarity
Glycosylationⁱ	256	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	266 ↔ 279	By similarity
Disulfide bondⁱ	287 ↔ 295	By similarity
Disulfide bondⁱ	291 ↔ 307	By similarity
Disulfide bondⁱ	309 ↔ 322	By similarity
Disulfide bondⁱ	328 ↔ 339	By similarity
Disulfide bondⁱ	335 ↔ 348	By similarity
Disulfide bondⁱ	350 ↔ 361	By similarity
Disulfide bondⁱ	368 ↔ 377	By similarity
Disulfide bondⁱ	373 ↔ 387	By similarity
Disulfide bondⁱ	389 ↔ 403	By similarity
Disulfide bondⁱ	407 ↔ 416	By similarity
Glycosylationⁱ	408	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	412 ↔ 424	By similarity
Disulfide bondⁱ	426 ↔ 438	By similarity
Disulfide bondⁱ	444 ↔ 454	By similarity
Disulfide bondⁱ	449 ↔ 463	By similarity
Disulfide bondⁱ	465 ↔ 479	By similarity
Glycosylationⁱ	494	O-linked (Xyl...) (glycosaminoglycan) serineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbⁱ	P15306
PeptideAtlas More...PeptideAtlasⁱ	P15306
PRIDEⁱ	P15306

PTM databases

iPTMnetⁱ	P15306
PhosphoSitePlusⁱ	P15306

Expressionⁱ

Tissue specificityⁱ

Endothelial cells are unique in synthesizing thrombomodulin.

Gene expression databases

Bgeeⁱ	ENSMUSG00000074743 Expressed in 275 organ(s), highest expression level in lung
CleanExⁱ	MM_THBD
ExpressionAtlasⁱ	P15306 baseline and differential
Genevisibleⁱ	P15306 MM

Interactionⁱ

Subunit structureⁱ

Interacts with ITGAL, ITGAM and ITGB2.By similarity

Protein-protein interaction databases

IntActⁱ	P15306, 2 interactors
Molecular INTeraction database More...MINTⁱ	P15306
STRINGⁱ	10090.ENSMUSP00000096877

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P15306
SMRⁱ	P15306
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	31 – 167	C-type lectinPROSITE-ProRule annotationAdd BLAST	137
Domainⁱ	240 – 280	EGF-like 1PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	283 – 323	EGF-like 2PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	324 – 362	EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	364 – 404	EGF-like 4PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	403 – 439	EGF-like 5PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	440 – 480	EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST	41

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IF0T Eukaryota ENOG410Y5JS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150853
HOGENOMⁱ	HOG000114624
HOVERGENⁱ	HBG000291
InParanoidⁱ	P15306
KEGG Orthology (KO) More...KOⁱ	K03907
OMAⁱ	LCGPLCV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06M1
PhylomeDBⁱ	P15306
TreeFamⁱ	TF330714

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016316 CD141 IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR015149 Tme5_EGF-like
PANTHERⁱ	PTHR24036:SF5 PTHR24036:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07645 EGF_CA, 2 hits PF00059 Lectin_C, 1 hit PF09064 Tme5_EGF_like, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit SM00181 EGF, 6 hits SM00179 EGF_CA, 4 hits
SUPFAMⁱ	SSF56436 SSF56436, 1 hit SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS01187 EGF_CA, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P15306-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGIFFLGVL APASLGLSAL AKLQPTGSQC VEHECFALFQ GPATFLDASQ 
        60         70         80         90        100
ACQRLQGHLM TVRSSVAADV ISLLLSQSSM DLGPWIGLQL PQGCDDPVHL 
       110        120        130        140        150
GPLRGFQWVT GDNHTSYSRW ARPNDQTAPL CGPLCVTVST ATEAAPGEPA 
       160        170        180        190        200
WEEKPCETET QGFLCEFYFT ASCRPLTVNT RDPEAAHISS TYNTPFGVSG 
       210        220        230        240        250
ADFQTLPVGS SAAVEPLGLE LVCRAPPGTS EGHWAWEATG AWNCSVENGG 
       260        270        280        290        300
CEYLCNRSTN EPRCLCPRDM DLQADGRSCA RPVVQSCNEL CEHFCVSNAE 
       310        320        330        340        350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCV NTKGGFECFC 
       360        370        380        390        400
YDGYELVDGE CVELLDPCFG SNCEFQCQPV SPTDYRCICA PGFAPKPDEP 
       410        420        430        440        450
HKCEMFCNET SCPADCDPNS PTVCECPEGF ILDEGSVCTD IDECSQGECF 
       460        470        480        490        500
TSECRNFPGS YECICGPDTA LAGQISKDCD PIPVREDTKE EEGSGEPPVS 
       510        520        530        540        550
PTPGSPTGPP SARPVHSGVL IGISIASLSL VVALLALLCH LRKKQGAARA 
       560        570 
ELEYKCASSA KEVVLQHVRT DRTLQKF

Length:577

Mass (Da):61,868

Last modified:April 1, 1990 - v1

Checksum:ⁱB20E50B0FE745014

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14432 mRNA Translation: CAA32597.1 BC019154 mRNA Translation: AAH19154.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16838.1
PIRⁱ	S08488 A60501
NCBI Reference Sequences More...RefSeqⁱ	NP_033404.1, NM_009378.3
UniGeneⁱ	Mm.24096

Genome annotation databases

Ensemblⁱ	ENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743
GeneIDⁱ	21824
KEGGⁱ	mmu:21824
UCSC genome browser More...UCSCⁱ	uc008mtd.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15306	Thbd protein		MOUSE		577	UniRef100_P15306
Uncharacterized protein (Fragment)		MOUSE		491

Protein	Similar proteins		Species	Score	Length	Source
P15306	Thbd protein		MOUSE		577	UniRef90_P15306
UPI000A30D135		MUSPA		579
UPI000A3187F8		MUSCR		578
Uncharacterized protein (Fragment)		MOUSE		491

Protein	Similar proteins		Species	Score	Length	Source
P15306	Thrombomodulin	)	HUMAN		575	UniRef50_P07204
Thrombomodulin		SAISC		575
Thrombomodulin		CANLF		578
Thrombomodulin		PANTR		631
Uncharacterized protein		PANPA		631
+117

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

Thrombomodulin

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14432 mRNA Translation: CAA32597.1 BC019154 mRNA Translation: AAH19154.1
CCDSⁱ	CCDS16838.1
PIRⁱ	S08488 A60501
RefSeqⁱ	NP_033404.1, NM_009378.3
UniGeneⁱ	Mm.24096

3D structure databases

ProteinModelPortalⁱ	P15306
SMRⁱ	P15306
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P15306, 2 interactors
MINTⁱ	P15306
STRINGⁱ	10090.ENSMUSP00000096877

PTM databases

iPTMnetⁱ	P15306
PhosphoSitePlusⁱ	P15306

Proteomic databases

PaxDbⁱ	P15306
PeptideAtlasⁱ	P15306
PRIDEⁱ	P15306

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743
GeneIDⁱ	21824
KEGGⁱ	mmu:21824
UCSCⁱ	uc008mtd.2 mouse

Organism-specific databases

CTDⁱ	7056
MGIⁱ	MGI:98736 Thbd

Phylogenomic databases

eggNOGⁱ	ENOG410IF0T Eukaryota ENOG410Y5JS LUCA
GeneTreeⁱ	ENSGT00930000150853
HOGENOMⁱ	HOG000114624
HOVERGENⁱ	HBG000291
InParanoidⁱ	P15306
KOⁱ	K03907
OMAⁱ	LCGPLCV
OrthoDBⁱ	EOG091G06M1
PhylomeDBⁱ	P15306
TreeFamⁱ	TF330714

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140875 Common Pathway of Fibrin Clot Formation R-MMU-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P15306
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000074743 Expressed in 275 organ(s), highest expression level in lung
CleanExⁱ	MM_THBD
ExpressionAtlasⁱ	P15306 baseline and differential
Genevisibleⁱ	P15306 MM

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016316 CD141 IPR016187 CTDL_fold IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR015149 Tme5_EGF-like
PANTHERⁱ	PTHR24036:SF5 PTHR24036:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF07645 EGF_CA, 2 hits PF00059 Lectin_C, 1 hit PF09064 Tme5_EGF_like, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit SM00181 EGF, 6 hits SM00179 EGF_CA, 4 hits
SUPFAMⁱ	SSF56436 SSF56436, 1 hit SSF57184 SSF57184, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 3 hits PS50026 EGF_3, 3 hits PS01187 EGF_CA, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRBM_MOUSE
Accessionⁱ	P15306Primary (citable) accession number: P15306
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P15306 (TRBM_MOUSE)

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Thrombomodulin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ