Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thrombomodulin

Gene

Thbd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: MGI
  • female pregnancy Source: MGI
  • negative regulation of blood coagulation Source: InterPro
  • negative regulation of coagulation Source: MGI
  • response to cAMP Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • response to X-ray Source: Ensembl

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombomodulin
Short name:
TM
Alternative name(s):
Fetomodulin
CD_antigen: CD141
Gene namesi
Name:Thbd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98736 Thbd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 517ExtracellularSequence analysisAdd BLAST501
Transmembranei518 – 541HelicalSequence analysisAdd BLAST24
Topological domaini542 – 577CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000777217 – 577ThrombomodulinAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi135 ↔ 156By similarity
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 255By similarity
Disulfide bondi251 ↔ 264By similarity
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 279By similarity
Disulfide bondi287 ↔ 295By similarity
Disulfide bondi291 ↔ 307By similarity
Disulfide bondi309 ↔ 322By similarity
Disulfide bondi328 ↔ 339By similarity
Disulfide bondi335 ↔ 348By similarity
Disulfide bondi350 ↔ 361By similarity
Disulfide bondi368 ↔ 377By similarity
Disulfide bondi373 ↔ 387By similarity
Disulfide bondi389 ↔ 403By similarity
Disulfide bondi407 ↔ 416By similarity
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi412 ↔ 424By similarity
Disulfide bondi426 ↔ 438By similarity
Disulfide bondi444 ↔ 454By similarity
Disulfide bondi449 ↔ 463By similarity
Disulfide bondi465 ↔ 479By similarity
Glycosylationi494O-linked (Xyl...) (glycosaminoglycan) serineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP15306
PeptideAtlasiP15306
PRIDEiP15306

PTM databases

iPTMnetiP15306
PhosphoSitePlusiP15306

Expressioni

Tissue specificityi

Endothelial cells are unique in synthesizing thrombomodulin.

Gene expression databases

BgeeiENSMUSG00000074743 Expressed in 275 organ(s), highest expression level in lung
CleanExiMM_THBD
ExpressionAtlasiP15306 baseline and differential
GenevisibleiP15306 MM

Interactioni

Subunit structurei

Interacts with ITGAL, ITGAM and ITGB2.By similarity

Protein-protein interaction databases

IntActiP15306, 2 interactors
MINTiP15306
STRINGi10090.ENSMUSP00000096877

Structurei

3D structure databases

ProteinModelPortaliP15306
SMRiP15306
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 167C-type lectinPROSITE-ProRule annotationAdd BLAST137
Domaini240 – 280EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini283 – 323EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini324 – 362EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini364 – 404EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini403 – 439EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini440 – 480EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0T Eukaryota
ENOG410Y5JS LUCA
GeneTreeiENSGT00930000150853
HOGENOMiHOG000114624
HOVERGENiHBG000291
InParanoidiP15306
KOiK03907
OMAiLCGPLCV
OrthoDBiEOG091G06M1
PhylomeDBiP15306
TreeFamiTF330714

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016316 CD141
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR015149 Tme5_EGF-like
PANTHERiPTHR24036:SF5 PTHR24036:SF5, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
PF09064 Tme5_EGF_like, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGIFFLGVL APASLGLSAL AKLQPTGSQC VEHECFALFQ GPATFLDASQ
60 70 80 90 100
ACQRLQGHLM TVRSSVAADV ISLLLSQSSM DLGPWIGLQL PQGCDDPVHL
110 120 130 140 150
GPLRGFQWVT GDNHTSYSRW ARPNDQTAPL CGPLCVTVST ATEAAPGEPA
160 170 180 190 200
WEEKPCETET QGFLCEFYFT ASCRPLTVNT RDPEAAHISS TYNTPFGVSG
210 220 230 240 250
ADFQTLPVGS SAAVEPLGLE LVCRAPPGTS EGHWAWEATG AWNCSVENGG
260 270 280 290 300
CEYLCNRSTN EPRCLCPRDM DLQADGRSCA RPVVQSCNEL CEHFCVSNAE
310 320 330 340 350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCV NTKGGFECFC
360 370 380 390 400
YDGYELVDGE CVELLDPCFG SNCEFQCQPV SPTDYRCICA PGFAPKPDEP
410 420 430 440 450
HKCEMFCNET SCPADCDPNS PTVCECPEGF ILDEGSVCTD IDECSQGECF
460 470 480 490 500
TSECRNFPGS YECICGPDTA LAGQISKDCD PIPVREDTKE EEGSGEPPVS
510 520 530 540 550
PTPGSPTGPP SARPVHSGVL IGISIASLSL VVALLALLCH LRKKQGAARA
560 570
ELEYKCASSA KEVVLQHVRT DRTLQKF
Length:577
Mass (Da):61,868
Last modified:April 1, 1990 - v1
Checksum:iB20E50B0FE745014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14432 mRNA Translation: CAA32597.1
BC019154 mRNA Translation: AAH19154.1
CCDSiCCDS16838.1
PIRiS08488 A60501
RefSeqiNP_033404.1, NM_009378.3
UniGeneiMm.24096

Genome annotation databases

EnsembliENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743
GeneIDi21824
KEGGimmu:21824
UCSCiuc008mtd.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Thrombomodulin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14432 mRNA Translation: CAA32597.1
BC019154 mRNA Translation: AAH19154.1
CCDSiCCDS16838.1
PIRiS08488 A60501
RefSeqiNP_033404.1, NM_009378.3
UniGeneiMm.24096

3D structure databases

ProteinModelPortaliP15306
SMRiP15306
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15306, 2 interactors
MINTiP15306
STRINGi10090.ENSMUSP00000096877

PTM databases

iPTMnetiP15306
PhosphoSitePlusiP15306

Proteomic databases

PaxDbiP15306
PeptideAtlasiP15306
PRIDEiP15306

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743
GeneIDi21824
KEGGimmu:21824
UCSCiuc008mtd.2 mouse

Organism-specific databases

CTDi7056
MGIiMGI:98736 Thbd

Phylogenomic databases

eggNOGiENOG410IF0T Eukaryota
ENOG410Y5JS LUCA
GeneTreeiENSGT00930000150853
HOGENOMiHOG000114624
HOVERGENiHBG000291
InParanoidiP15306
KOiK03907
OMAiLCGPLCV
OrthoDBiEOG091G06M1
PhylomeDBiP15306
TreeFamiTF330714

Enzyme and pathway databases

ReactomeiR-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

PROiPR:P15306
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074743 Expressed in 275 organ(s), highest expression level in lung
CleanExiMM_THBD
ExpressionAtlasiP15306 baseline and differential
GenevisibleiP15306 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016316 CD141
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR015149 Tme5_EGF-like
PANTHERiPTHR24036:SF5 PTHR24036:SF5, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
PF09064 Tme5_EGF_like, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTRBM_MOUSE
AccessioniPrimary (citable) accession number: P15306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again