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UniProtKB - P15306 (TRBM_MOUSE)
Protein
Thrombomodulin
Gene
Thbd
Organism
Mus musculus (Mouse)
Status
Functioni
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- blood coagulation Source: MGI
- female pregnancy Source: MGI
- negative regulation of blood coagulation Source: InterPro
- negative regulation of coagulation Source: MGI
- response to cAMP Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to X-ray Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Blood coagulation, Hemostasis |
Enzyme and pathway databases
Reactomei | R-MMU-140875, Common Pathway of Fibrin Clot Formation R-MMU-202733, Cell surface interactions at the vascular wall |
Names & Taxonomyi
Protein namesi | Recommended name: ThrombomodulinShort name: TM Alternative name(s): Fetomodulin CD_antigen: CD141 |
Gene namesi | Name:Thbd |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98736, Thbd |
VEuPathDBi | HostDB:ENSMUSG00000074743 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- apicolateral plasma membrane Source: MGI
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- serine-type endopeptidase complex Source: MGI
- vacuolar membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 517 | ExtracellularSequence analysisAdd BLAST | 501 | |
Transmembranei | 518 – 541 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 542 – 577 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000007772 | 17 – 577 | ThrombomodulinAdd BLAST | 561 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 135 ↔ 156 | By similarity | ||
Glycosylationi | 243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 244 ↔ 255 | By similarity | ||
Disulfide bondi | 251 ↔ 264 | By similarity | ||
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 266 ↔ 279 | By similarity | ||
Disulfide bondi | 287 ↔ 295 | By similarity | ||
Disulfide bondi | 291 ↔ 307 | By similarity | ||
Disulfide bondi | 309 ↔ 322 | By similarity | ||
Disulfide bondi | 328 ↔ 339 | By similarity | ||
Disulfide bondi | 335 ↔ 348 | By similarity | ||
Disulfide bondi | 350 ↔ 361 | By similarity | ||
Disulfide bondi | 368 ↔ 377 | By similarity | ||
Disulfide bondi | 373 ↔ 387 | By similarity | ||
Disulfide bondi | 389 ↔ 403 | By similarity | ||
Disulfide bondi | 407 ↔ 416 | By similarity | ||
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 412 ↔ 424 | By similarity | ||
Disulfide bondi | 426 ↔ 438 | By similarity | ||
Disulfide bondi | 444 ↔ 454 | By similarity | ||
Disulfide bondi | 449 ↔ 463 | By similarity | ||
Disulfide bondi | 465 ↔ 479 | By similarity | ||
Glycosylationi | 494 | O-linked (Xyl...) (glycosaminoglycan) serineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
PaxDbi | P15306 |
PeptideAtlasi | P15306 |
PRIDEi | P15306 |
ProteomicsDBi | 298287 |
PTM databases
GlyGeni | P15306, 5 sites |
iPTMneti | P15306 |
PhosphoSitePlusi | P15306 |
Expressioni
Tissue specificityi
Endothelial cells are unique in synthesizing thrombomodulin.
Gene expression databases
Bgeei | ENSMUSG00000074743, Expressed in lung and 303 other tissues |
ExpressionAtlasi | P15306, baseline and differential |
Genevisiblei | P15306, MM |
Interactioni
Subunit structurei
Interacts with ITGAL, ITGAM and ITGB2.
By similarityProtein-protein interaction databases
BioGRIDi | 204174, 2 interactors |
IntActi | P15306, 1 interactor |
MINTi | P15306 |
STRINGi | 10090.ENSMUSP00000096877 |
Miscellaneous databases
RNActi | P15306, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 167 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 137 | |
Domaini | 240 – 280 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 283 – 323 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 324 – 362 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 364 – 404 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 403 – 439 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 440 – 480 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 476 – 513 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 480 – 494 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R1T7, Eukaryota |
GeneTreei | ENSGT00940000163276 |
HOGENOMi | CLU_027075_2_1_1 |
InParanoidi | P15306 |
OMAi | HRCQMFC |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P15306 |
TreeFami | TF330714 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016316, CD141 IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR015149, Tme5_EGF-like |
PANTHERi | PTHR24036:SF5, PTHR24036:SF5, 1 hit |
Pfami | View protein in Pfam PF07645, EGF_CA, 2 hits PF00059, Lectin_C, 1 hit PF09064, Tme5_EGF_like, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00181, EGF, 6 hits SM00179, EGF_CA, 4 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS50041, C_TYPE_LECTIN_2, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS01187, EGF_CA, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15306-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGIFFLGVL APASLGLSAL AKLQPTGSQC VEHECFALFQ GPATFLDASQ
60 70 80 90 100
ACQRLQGHLM TVRSSVAADV ISLLLSQSSM DLGPWIGLQL PQGCDDPVHL
110 120 130 140 150
GPLRGFQWVT GDNHTSYSRW ARPNDQTAPL CGPLCVTVST ATEAAPGEPA
160 170 180 190 200
WEEKPCETET QGFLCEFYFT ASCRPLTVNT RDPEAAHISS TYNTPFGVSG
210 220 230 240 250
ADFQTLPVGS SAAVEPLGLE LVCRAPPGTS EGHWAWEATG AWNCSVENGG
260 270 280 290 300
CEYLCNRSTN EPRCLCPRDM DLQADGRSCA RPVVQSCNEL CEHFCVSNAE
310 320 330 340 350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCV NTKGGFECFC
360 370 380 390 400
YDGYELVDGE CVELLDPCFG SNCEFQCQPV SPTDYRCICA PGFAPKPDEP
410 420 430 440 450
HKCEMFCNET SCPADCDPNS PTVCECPEGF ILDEGSVCTD IDECSQGECF
460 470 480 490 500
TSECRNFPGS YECICGPDTA LAGQISKDCD PIPVREDTKE EEGSGEPPVS
510 520 530 540 550
PTPGSPTGPP SARPVHSGVL IGISIASLSL VVALLALLCH LRKKQGAARA
560 570
ELEYKCASSA KEVVLQHVRT DRTLQKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14432 mRNA Translation: CAA32597.1 BC019154 mRNA Translation: AAH19154.1 |
CCDSi | CCDS16838.1 |
PIRi | S08488, A60501 |
RefSeqi | NP_033404.1, NM_009378.3 |
Genome annotation databases
Ensembli | ENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743 |
GeneIDi | 21824 |
KEGGi | mmu:21824 |
UCSCi | uc008mtd.2, mouse |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Thrombomodulin |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14432 mRNA Translation: CAA32597.1 BC019154 mRNA Translation: AAH19154.1 |
CCDSi | CCDS16838.1 |
PIRi | S08488, A60501 |
RefSeqi | NP_033404.1, NM_009378.3 |
3D structure databases
AlphaFoldDBi | P15306 |
SMRi | P15306 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204174, 2 interactors |
IntActi | P15306, 1 interactor |
MINTi | P15306 |
STRINGi | 10090.ENSMUSP00000096877 |
PTM databases
GlyGeni | P15306, 5 sites |
iPTMneti | P15306 |
PhosphoSitePlusi | P15306 |
Proteomic databases
PaxDbi | P15306 |
PeptideAtlasi | P15306 |
PRIDEi | P15306 |
ProteomicsDBi | 298287 |
Protocols and materials databases
Antibodypediai | 792, 1004 antibodies from 44 providers |
DNASUi | 21824 |
Genome annotation databases
Ensembli | ENSMUST00000099270; ENSMUSP00000096877; ENSMUSG00000074743 |
GeneIDi | 21824 |
KEGGi | mmu:21824 |
UCSCi | uc008mtd.2, mouse |
Organism-specific databases
CTDi | 7056 |
MGIi | MGI:98736, Thbd |
VEuPathDBi | HostDB:ENSMUSG00000074743 |
Phylogenomic databases
eggNOGi | ENOG502R1T7, Eukaryota |
GeneTreei | ENSGT00940000163276 |
HOGENOMi | CLU_027075_2_1_1 |
InParanoidi | P15306 |
OMAi | HRCQMFC |
OrthoDBi | 1174178at2759 |
PhylomeDBi | P15306 |
TreeFami | TF330714 |
Enzyme and pathway databases
Reactomei | R-MMU-140875, Common Pathway of Fibrin Clot Formation R-MMU-202733, Cell surface interactions at the vascular wall |
Miscellaneous databases
BioGRID-ORCSi | 21824, 3 hits in 72 CRISPR screens |
PROi | PR:P15306 |
RNActi | P15306, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074743, Expressed in lung and 303 other tissues |
ExpressionAtlasi | P15306, baseline and differential |
Genevisiblei | P15306, MM |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016316, CD141 IPR016187, CTDL_fold IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR015149, Tme5_EGF-like |
PANTHERi | PTHR24036:SF5, PTHR24036:SF5, 1 hit |
Pfami | View protein in Pfam PF07645, EGF_CA, 2 hits PF00059, Lectin_C, 1 hit PF09064, Tme5_EGF_like, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit SM00181, EGF, 6 hits SM00179, EGF_CA, 4 hits |
SUPFAMi | SSF56436, SSF56436, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 2 hits PS50041, C_TYPE_LECTIN_2, 1 hit PS01186, EGF_2, 3 hits PS50026, EGF_3, 3 hits PS01187, EGF_CA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TRBM_MOUSE | |
Accessioni | P15306Primary (citable) accession number: P15306 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot