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Entry version 117 (03 Jul 2019)
Sequence version 1 (01 Apr 1990)
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Protein

PII-type proteinase

Gene

prt

Organism
Lactococcus lactis subsp. cremoris (Streptococcus cremoris)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease which breaks down milk proteins during the growth of the bacteria on milk.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endopeptidase activity with very broad specificity, although some subsite preference have been noted, e.g. large hydrophobic residues in the P1 and P4 positions, and Pro in the P2 position. Best known for its action on caseins, although it has been shown to hydrolyze hemoglobin and oxidized insulin B-chain. EC:3.4.21.96

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei217Charge relay systemPROSITE-ProRule annotation1
Active sitei281Charge relay systemPROSITE-ProRule annotation1
Active sitei620Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PII-type proteinase (EC:3.4.21.96)
Alternative name(s):
Cell wall-associated serine proteinase
LP151
Lactocepin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pLP7630 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLactococcus lactis subsp. cremoris (Streptococcus cremoris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002708934 – 187Sequence analysisAdd BLAST154
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027090188 – 1870PII-type proteinaseAdd BLAST1683
PropeptideiPRO_00000270911871 – 1902Removed by sortasePROSITE-ProRule annotationAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1870Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor, Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P15293

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 697Peptidase S8PROSITE-ProRule annotationAdd BLAST507

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1867 – 1871LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07475 Peptidases_S8_C5a_Peptidase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034216 C5a_Peptidase
IPR010435 Fn3_5
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR003137 PA_domain
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06280 fn3_5, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF02225 PA, 1 hit
PF00082 Peptidase_S8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P15293-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRKKKGLSI LLAGTVALGA LAVLPVGEIQ AKAAISQQTK GSSLANTVTA
60 70 80 90 100
ATAKQAATDT TAATTNQAIA TQLAAKGIDY NKLNKVQQQD IYVDVIVQMS
110 120 130 140 150
AAPASENGTL RTDYSSTAEI QQETNKVIAA QASVKAAVEQ VTQQTAGESY
160 170 180 190 200
GYVVNGFSTK VRVVDIPKLK QIAGVKTVTL AKVYYPTDAK ANSMANVQAV
210 220 230 240 250
WSNYKYKGEG TVVSVIDSGI DPTHKDMRLS DDKDVKLTKS DVEKFTDTAK
260 270 280 290 300
HGRYFNSKVP YGFNYADNND TITDDTVDEQ HGMHVAGIIG ANGTGDDPAK
310 320 330 340 350
SVVGVAPEAQ LLAMKVFTNS DTSATTGSAT LVSAIEDSAK IGADVLNMSL
360 370 380 390 400
GSDSGNQTLE DPELAAVQNA NESGTAAVIS AGNSGTSGSA TEGVNKDYYG
410 420 430 440 450
LQDNEMVGTP GTSRGATTVA SAENTDVITQ AVTITDGTGL QLGPETIQLS
460 470 480 490 500
SNDFTGSFDQ KKFYVVKDAS GNLSKGKVAD YTADAKGKIA IVKRGELTFA
510 520 530 540 550
DKQKYAQAAG AAGLIIVNND GTATPVTSMA LTTTFPTFGL SSVTGQKLVD
560 570 580 590 600
WVAAHPDDSL GVKIALTLVP NQKYTEDKMS DFTSYGPVSN LSFKPDITAP
610 620 630 640 650
GGNIWSTQNN NGYTNMSGTS MASPFIAGSQ ALLKQALNNK NNPFYAYYKQ
660 670 680 690 700
LKGTALTDFL KTVEMNTAQP INDINYNNVI VSPRRQGAGL VDVKAAIDAL
710 720 730 740 750
EKNPSTVVAE NGYPAVELKD FTSTDKTFKL TFTNRTTHEL TYQMDSNTDT
760 770 780 790 800
NAVYTSATDP NSGVLYDKKI DGAAIKAGSN ITVPAGKTAQ IEFTLSLPKS
810 820 830 840 850
FDQQQFVEGF LNFKGSDGSR LNLPYMGFFG DWNDGKIVDS LNGITYSPAG
860 870 880 890 900
GNFGTVPLLT NKNTGTQYYG GMVTDADGNQ TVDDQAIAFS SDKNALYNDI
910 920 930 940 950
SMKYYLLRNI SNVQVDILDG QGNKVTTLSS STNRKKTYYN AHSQQYIYYH
960 970 980 990 1000
APAWDGTYYD QRDGNIKTAD DGSYTYRISG VPEGGDKRQV FDVPFKLDSK
1010 1020 1030 1040 1050
APTVRHVALS AKTENGKTQY YLTAEAKDDL SGLDATKSVK TAINEVTNLD
1060 1070 1080 1090 1100
ATFTDAGTTA DGYTKIETPL SDEQAQALGN GDNSAELYLT DNASNATDQD
1110 1120 1130 1140 1150
ASVQKPGSTS FDLIVNGGGI PDKISSTTTG YEANTQGGGT YTFSGTYPAA
1160 1170 1180 1190 1200
VDGTYTDAQG KKHDLNTTYD AATNSFTASM PVTNADYAAQ VDLYADKAHT
1210 1220 1230 1240 1250
QLLKHFDTKV RLTAPTFTDL KFNNGSDQTS EATIKVTGTV SADTKTVNVG
1260 1270 1280 1290 1300
DTVAALDAQH HFSVDVPVNY GDNTIKVTAT DEDGNTTTEQ KTITSSYDPD
1310 1320 1330 1340 1350
MLKNSVTFDQ GVTFGANEFN ATSAKFYDPK TGIATITGKV KHPTTTLQVD
1360 1370 1380 1390 1400
GKQIPIKDDL TFSFTLDLGT LGQKPFGVVV GDTTQNKTFQ EALTFILDAV
1410 1420 1430 1440 1450
APTLSLDSST DAPVYTNNPN FQITGTATDN AQYLSLSING SSVASQYVDI
1460 1470 1480 1490 1500
NINSGKPGHM AIDQPVKLLE GKNVLTVAVT DSEDNTTTKN ITVYYEPKKT
1510 1520 1530 1540 1550
LAAPTVTPST TEPAKTVTLT ANSAATGETV QYSADGGKTY QDVPAAGVTV
1560 1570 1580 1590 1600
TANGTFKFKS TDLYGNESPA VDYVVTNIKA DDPAQLQAAK QELTNLIASA
1610 1620 1630 1640 1650
KTLSASGKYD DATTTALAAA TQKAQTALDQ TNASVDSLTG ANRDLQTAIN
1660 1670 1680 1690 1700
QLAAKLPADK KTSLLNQLQS VKAALETDLG NQTDSSTGKT FTAALDDLVA
1710 1720 1730 1740 1750
QAQAGTQTDD QLQATLAKVL DAVLAKLAEG IKAATPAEVG NAKDAATGKT
1760 1770 1780 1790 1800
WYADIADTLT SGQASADASD KLAHLQALQS LKTKVAAAVE AAKTVGKGDG
1810 1820 1830 1840 1850
TTGTSDKGGG QGTPAPTPGD IGKDKGDEGS QPSSGGNIPT NPATTTSTST
1860 1870 1880 1890 1900
DDTTDRNGQL TSGKGALPKT GETTERPAFG FLGVIVVSLM GVLGLKRKQR

EE
Length:1,902
Mass (Da):200,140
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B8D8B844D88CDF7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14130 Genomic DNA Translation: CAA32350.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S06997

NCBI Reference Sequences

More...
RefSeqi
WP_063284091.1, NZ_LITG01000051.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14130 Genomic DNA Translation: CAA32350.1
PIRiS06997
RefSeqiWP_063284091.1, NZ_LITG01000051.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP15293

Family and domain databases

CDDicd07475 Peptidases_S8_C5a_Peptidase, 1 hit
Gene3Di2.60.40.10, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR034216 C5a_Peptidase
IPR010435 Fn3_5
IPR019948 Gram-positive_anchor
IPR013783 Ig-like_fold
IPR019931 LPXTG_anchor
IPR003137 PA_domain
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
PfamiView protein in Pfam
PF06280 fn3_5, 1 hit
PF00746 Gram_pos_anchor, 1 hit
PF02225 PA, 1 hit
PF00082 Peptidase_S8, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS51892 SUBTILASE, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2P_LACLC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15293
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 3, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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