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UniProtKB - P15278 (FAS3_DROME)
Protein
Fasciclin-3
Gene
Fas3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Mediates cell adhesion in a Ca2+-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system.
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
GO - Biological processi
- axonal fasciculation Source: FlyBase
- axon guidance Source: FlyBase
- cell-cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
- synaptic target recognition Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Fasciclin-3Alternative name(s): Fasciclin III Short name: FAS III |
Gene namesi | Name:Fas3 ORF Names:CG5803 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000636, Fas3 |
VEuPathDBi | VectorBase:FBgn0000636 |
Subcellular locationi
Other locations
Endosome
- recycling endosome Source: FlyBase
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell-cell junction Source: GO_Central
- neuromuscular junction Source: FlyBase
- smooth septate junction Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 346 | ExtracellularSequence analysisAdd BLAST | 326 | |
Transmembranei | 347 – 370 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 371 – 508 | CytoplasmicSequence analysisAdd BLAST | 138 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000014760 | 21 – 508 | Fasciclin-3Add BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 150 ↔ 211 | PROSITE-ProRule annotation | ||
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 257 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 300 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 382 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 459 | PhosphoserineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acidProteomic databases
PaxDbi | P15278 |
PTM databases
GlyGeni | P15278, 3 sites |
SwissPalmi | P15278 |
Expressioni
Tissue specificityi
Expressed on different subsets of axon bundles (fascicles) in insect embryos.
Gene expression databases
Bgeei | FBgn0000636, Expressed in wing disc (Drosophila) and 56 other tissues |
ExpressionAtlasi | P15278, baseline and differential |
Genevisiblei | P15278, DM |
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 61092, 13 interactors |
DIPi | DIP-21336N |
STRINGi | 7227.FBpp0111717 |
Structurei
3D structure databases
AlphaFoldDBi | P15278 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 106 | Ig-like V-typeAdd BLAST | 63 | |
Domaini | 126 – 223 | Ig-like C2-type 1Add BLAST | 98 | |
Domaini | 236 – 310 | Ig-like C2-type 2Add BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 381 – 439 | DisorderedSequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 383 – 412 | Polar residuesSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000169499 |
InParanoidi | P15278 |
PhylomeDBi | P15278 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: P15278-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRIVFICLA AILTDALTWA QVNVEPNTAL LNEGDRTELL CRYGRSINYC
60 70 80 90 100
RIEIPGEQKV LNLSPEWSKT PGFTYFGAGL TAGQCGVSIE RVKASNNGQV
110 120 130 140 150
KCSLGVEGEE LSGTIDLVVA LRPQQPIIEL LSRPNREGYF NEGTEFRARC
160 170 180 190 200
SVRDGRPPAN ISWYIDNMPA NKRTTPLEVM SSTNDNVELS TSVQEIQWHL
210 220 230 240 250
SPEDSNRKLV CRSHHQTDRE SVPPQEAAYI INVRYAPVHQ PDAAVYGLYL
260 270 280 290 300
EHTAIVNITI RASPQPKIEW TIDGAIVGQG RTDGRYSAYE PQYLGNDEYN
310 320 330 340 350
VTLAIAGLTL EDTTKIYNLR ASNELGLTDY QVRISSSSKP PSSSLDVAAI
360 370 380 390 400
VGIVVAVAVL VLVVLLIVFA RATGRWCFGG KSIKTPTNET SDTESADIKA
410 420 430 440 450
TSTATATTTM GGVGVSAEEE ETVNEQESPQ EQQQQQQKKA KRLPAFAAAI
460 470 480 490 500
LRRFNEKDSR KYKDNQESLN IVEGSVQEIP ATNNAIDGND NEPKAIVWQS
TSPVWTFK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8DZ14 | A8DZ14_DROME | FI17828p1 | Fas3 Dmel\CG5803, Fas, FAS III, Fas III, fas III | 577 | Annotation score: | ||
X2JAT7 | X2JAT7_DROME | Fasciclin 3, isoform G | Fas3 Dmel\CG5803, Fas, FAS III, Fas III, fas III | 557 | Annotation score: | ||
Q8INX7 | Q8INX7_DROME | Fasciclin 3, isoform C | Fas3 Dmel\CG5803, Fas, FAS III, Fas III, fas III | 475 | Annotation score: | ||
X2J6N7 | X2J6N7_DROME | Fasciclin 3, isoform F | Fas3 Dmel\CG5803, Fas, FAS III, Fas III, fas III | 401 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007949 | 391 – 401 | SDTESADIKAT → KTNNSSMLNLY in isoform B. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_007950 | 402 – 508 | Missing in isoform B. 1 PublicationAdd BLAST | 107 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27813 mRNA Translation: AAA28532.1 AE014134 Genomic DNA Translation: AAF53665.2 AE014134 Genomic DNA Translation: AAN11002.1 AY075516 mRNA Translation: AAL68324.1 |
PIRi | A33378 |
RefSeqi | NP_001286039.1, NM_001299110.1 [P15278-2] NP_724106.1, NM_165249.4 [P15278-2] NP_724107.1, NM_165250.4 [P15278-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0081051; FBpp0080604; FBgn0000636 [P15278-1] FBtr0081052; FBpp0080605; FBgn0000636 [P15278-2] FBtr0340580; FBpp0309467; FBgn0000636 [P15278-2] |
GeneIDi | 35097 |
KEGGi | dme:Dmel_CG5803 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27813 mRNA Translation: AAA28532.1 AE014134 Genomic DNA Translation: AAF53665.2 AE014134 Genomic DNA Translation: AAN11002.1 AY075516 mRNA Translation: AAL68324.1 |
PIRi | A33378 |
RefSeqi | NP_001286039.1, NM_001299110.1 [P15278-2] NP_724106.1, NM_165249.4 [P15278-2] NP_724107.1, NM_165250.4 [P15278-1] |
3D structure databases
AlphaFoldDBi | P15278 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 61092, 13 interactors |
DIPi | DIP-21336N |
STRINGi | 7227.FBpp0111717 |
PTM databases
GlyGeni | P15278, 3 sites |
SwissPalmi | P15278 |
Proteomic databases
PaxDbi | P15278 |
Protocols and materials databases
DNASUi | 35097 |
Genome annotation databases
EnsemblMetazoai | FBtr0081051; FBpp0080604; FBgn0000636 [P15278-1] FBtr0081052; FBpp0080605; FBgn0000636 [P15278-2] FBtr0340580; FBpp0309467; FBgn0000636 [P15278-2] |
GeneIDi | 35097 |
KEGGi | dme:Dmel_CG5803 |
Organism-specific databases
CTDi | 35097 |
FlyBasei | FBgn0000636, Fas3 |
VEuPathDBi | VectorBase:FBgn0000636 |
Phylogenomic databases
eggNOGi | ENOG502QWSY, Eukaryota |
GeneTreei | ENSGT00940000169499 |
InParanoidi | P15278 |
PhylomeDBi | P15278 |
Miscellaneous databases
BioGRID-ORCSi | 35097, 0 hits in 1 CRISPR screen |
ChiTaRSi | Fas3, fly |
GenomeRNAii | 35097 |
PROi | PR:P15278 |
Gene expression databases
Bgeei | FBgn0000636, Expressed in wing disc (Drosophila) and 56 other tissues |
ExpressionAtlasi | P15278, baseline and differential |
Genevisiblei | P15278, DM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FAS3_DROME | |
Accessioni | P15278Primary (citable) accession number: P15278 Secondary accession number(s): Q8SXX9, Q9VJ89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase