UniProtKB - P15266 (NDK_MYXXA)
Protein
Nucleoside diphosphate kinase
Gene
ndk
Organism
Myxococcus xanthus
Status
Functioni
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation
Catalytic activityi
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADPUniRule annotationEC:2.7.4.6UniRule annotation
- EC:2.7.4.6UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 11 | ATPUniRule annotation | 1 | |
Binding sitei | 59 | ATPUniRule annotation | 1 | |
Binding sitei | 87 | ATPUniRule annotation | 1 | |
Binding sitei | 93 | ATPUniRule annotation | 1 | |
Binding sitei | 104 | ATPUniRule annotation | 1 | |
Binding sitei | 114 | ATPUniRule annotation | 1 | |
Active sitei | 117 | Pros-phosphohistidine intermediateUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
- nucleoside diphosphate kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- CTP biosynthetic process Source: UniProtKB-UniRule
- GTP biosynthetic process Source: UniProtKB-UniRule
- UTP biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Nucleotide metabolism |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)Short name: NDKUniRule annotation Short name: NDP kinaseUniRule annotation Alternative name(s): Nucleoside-2-P kinaseUniRule annotation |
Gene namesi | Name:ndkUniRule annotation |
Organismi | Myxococcus xanthus |
Taxonomic identifieri | 34 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000137011 | 2 – 145 | Nucleoside diphosphate kinaseAdd BLAST | 144 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
Homotetramer.
UniRule annotation1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P15266 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15266 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
HAMAPi | MF_00451, NDP_kinase, 1 hit |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR001564, Nucleoside_diP_kinase IPR023005, Nucleoside_diP_kinase_AS |
Pfami | View protein in Pfam PF00334, NDK, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
PROSITEi | View protein in PROSITE PS00469, NDP_KINASES, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15266-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIERTLSII KPDGLEKGVI GKIISRFEEK GLKPVAIRLQ HLSQAQAEGF
60 70 80 90 100
YAVHKARPFF KDLVQFMISG PVVLMVLEGE NAVLANRDIM GATNPAQAAE
110 120 130 140
GTIRKDFATS IDKNTVHGSD SLENAKIEIA YFFRETEIHS YPYQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05207 Genomic DNA Translation: AAA25400.1 |
PIRi | A35539 |
RefSeqi | WP_011553572.1, NZ_JABFNT010000005.1 |
Genome annotation databases
GeneIDi | 41360888 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05207 Genomic DNA Translation: AAA25400.1 |
PIRi | A35539 |
RefSeqi | WP_011553572.1, NZ_JABFNT010000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NHK | X-ray | 1.90 | L/R | 2-145 | [»] | |
1NLK | X-ray | 2.00 | L/R | 2-145 | [»] | |
2NCK | X-ray | 2.00 | L/R | 2-145 | [»] | |
SMRi | P15266 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 41360888 |
Miscellaneous databases
EvolutionaryTracei | P15266 |
Family and domain databases
Gene3Di | 3.30.70.141, 1 hit |
HAMAPi | MF_00451, NDP_kinase, 1 hit |
InterProi | View protein in InterPro IPR034907, NDK-like_dom IPR036850, NDK-like_dom_sf IPR001564, Nucleoside_diP_kinase IPR023005, Nucleoside_diP_kinase_AS |
Pfami | View protein in Pfam PF00334, NDK, 1 hit |
PRINTSi | PR01243, NUCDPKINASE |
SMARTi | View protein in SMART SM00562, NDK, 1 hit |
SUPFAMi | SSF54919, SSF54919, 1 hit |
PROSITEi | View protein in PROSITE PS00469, NDP_KINASES, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDK_MYXXA | |
Accessioni | P15266Primary (citable) accession number: P15266 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families