Hepatocyte nuclear factor 1-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: Ensembl
• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein."
    Mendel D.B., Khavari P.A., Conley P.B., Graves M.K., Hansen L.P., Admon A., Crabtree G.R.
    Science 254:1762-1767(1991) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCLInferred from direct assayⁱ
  • "Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression."
    Wang Z., Burke P.A.
    FEBS J. 277:4066-4075(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein."
    Mendel D.B., Khavari P.A., Conley P.B., Graves M.K., Hansen L.P., Admon A., Crabtree G.R.
    Science 254:1762-1767(1991) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: RGDInferred from direct assayⁱ
  • "Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP."
    Whalen R., Voss S.H., Boyer T.D.
    Biochem. J. 377:763-768(2004) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding."
    Ihara T., Tsujikawa T., Fujiyama Y., Bamba T.
    J. Gastroenterol. Hepatol. 18:705-711(2003) [PubMed] [Europe PMC] [Abstract]
  • "Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP."
    Whalen R., Voss S.H., Boyer T.D.
    Biochem. J. 377:763-768(2004) [PubMed] [Europe PMC] [Abstract]
• transcription cofactor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes."
    Dohda T., Kaneoka H., Inayoshi Y., Kamihira M., Miyake K., Iijima S.
    J. Biochem. 136:313-319(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes."
    Dohda T., Kaneoka H., Inayoshi Y., Kamihira M., Miyake K., Iijima S.
    J. Biochem. 136:313-319(2004) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processⁱ

• bile acid and bile salt transport Source: Ensembl
• bile acid biosynthetic process Source: Ensembl
• blastocyst development Source: Ensembl
• bone resorption Source: Ensembl
• cholesterol metabolic process Source: Ensembl
• chromatin remodeling Source: Ensembl
• embryonic limb morphogenesis Source: Ensembl
• endocrine pancreas development Source: Ensembl
• fatty acid biosynthetic process Source: Ensembl
• fatty acid transport Source: Ensembl
• glucose homeostasis Source: Ensembl
• glucose import Source: Ensembl
• heme biosynthetic process Source: Ensembl
• histone acetylation Source: Ensembl
• insulin secretion Source: Ensembl
• liver development Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • Ref.3

    "LFB1/HNF1 acts as a repressor of its own transcription."
    Piaggio G., Tomei L., Toniatti C., De Francesco R., Gerstner J., Cortese R.
    Nucleic Acids Res. 22:4284-4290(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-12.
• paraxial mesoderm formation Source: Ensembl
• placenta development Source: Ensembl
• positive regulation of transcription, DNA-templated Source: MGIInferred from physical interactionⁱ
  • "Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein."
    Mendel D.B., Khavari P.A., Conley P.B., Graves M.K., Hansen L.P., Admon A., Crabtree G.R.
    Science 254:1762-1767(1991) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression."
    Wang Z., Burke P.A.
    FEBS J. 277:4066-4075(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of hormone secretion Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of Wnt signaling pathway Source: Ensembl
• renal glucose absorption Source: Ensembl
• response to glucose Source: Ensembl
• response to oxidative stress Source: Ensembl
• reverse cholesterol transport Source: Ensembl
• SMAD protein signal transduction Source: Ensembl
• transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • "Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP."
    Whalen R., Voss S.H., Boyer T.D.
    Biochem. J. 377:763-768(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• transcription cofactor binding Source: RGDInferred from physical interactionⁱ
  • "Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes."
    Dohda T., Kaneoka H., Inayoshi Y., Kamihira M., Miyake K., Iijima S.
    J. Biochem. 136:313-319(2004) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes."
    Dohda T., Kaneoka H., Inayoshi Y., Kamihira M., Miyake K., Iijima S.
    J. Biochem. 136:313-319(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG DGPLDKGESC 
        60         70         80         90        100
GGTRGDLTEL PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ 
       110        120        130        140        150
KAVVESLLQE DPWRVAKMVK SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK 
       160        170        180        190        200
GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA GQGGLIEEPT GDELPTKKGR 
       210        220        230        240        250
RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE CIQRGVSPSQ 
       260        270        280        290        300
AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP 
       310        320        330        340        350
AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ 
       360        370        380        390        400
VSPTGLEPSS LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ 
       410        420        430        440        450
NLIMASLPGV MTIGPGEPAS LGPTFTNTGA STLVIGLAST QAQSVPVINS 
       460        470        480        490        500
MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ SHVAQSPFMA TMAQLQSPHA 
       510        520        530        540        550
LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV FTSDTEASSE 
       560        570        580        590        600
PGLHEPSSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD 
       610        620 
SNGHSHLLPS NHGVIETFIS TQMASSSQ                         

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references