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Entry version 176 (08 May 2019)
Sequence version 3 (04 Dec 2007)
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Protein

Phosphoribosylformylglycinamidine synthase

Gene

purL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=64 µM for glutamine (at pH 7.25 and 37 degrees Celsius)1 Publication
  2. KM=51 µM for ATP (at pH 7.25 and 37 degrees Celsius)1 Publication
  3. KM=30 µM for FGAR (formylglycinamide ribonucleotide at pH 7.25 and 37 degrees Celsius)1 Publication

    pH dependencei

    Optimum pH is 7.2 with only 50% of this activity retains at pH 6.2 or 8.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Phosphoribosylformylglycinamidine synthase (purL)
    2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
    This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei678ATP; via carbonyl oxygenUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi718MagnesiumUniRule annotation1
    Metal bindingi722MagnesiumUniRule annotation1
    Metal bindingi884MagnesiumUniRule annotation1
    Binding sitei886ATPUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1135NucleophileUniRule annotation1
    Active sitei1260UniRule annotation1
    Active sitei1262UniRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi307 – 318ATPUniRule annotationAdd BLAST12

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase
    Biological processPurine biosynthesis
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:FGAMSYN-MONOMER
    ECOL316407:JW2541-MONOMER
    MetaCyc:FGAMSYN-MONOMER

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00074;UER00128

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C56.972

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine synthaseUniRule annotation (EC:6.3.5.3UniRule annotation)
    Short name:
    FGAM synthaseUniRule annotation
    Short name:
    FGAMSUniRule annotation
    Alternative name(s):
    Formylglycinamide ribonucleotide amidotransferaseUniRule annotation
    Short name:
    FGAR amidotransferaseUniRule annotation
    Short name:
    FGAR-ATUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:purLUniRule annotation
    Synonyms:purI
    Ordered Locus Names:b2557, JW2541
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG10797 purL

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001004061 – 1295Phosphoribosylformylglycinamidine synthaseAdd BLAST1295

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Both N-terminus methionine truncation and retention have been observed for this protein.1 Publication

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P15254

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P15254

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P15254

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    UniRule annotation1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4259206, 75 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-10614N

    Protein interaction database and analysis system

    More...
    IntActi
    P15254, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b2557

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P15254

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1042 – 1295Glutamine amidotransferase type-1UniRule annotationAdd BLAST254

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the N-terminal section; belongs to the FGAMS family.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4107QIK Bacteria
    COG0046 LUCA
    COG0047 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000261359

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P15254

    KEGG Orthology (KO)

    More...
    KOi
    K01952

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P15254

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1330.10, 2 hits
    3.40.50.880, 1 hit
    3.90.650.10, 2 hits

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00419 PurL_1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR040707 FGAR-AT_N
    IPR017926 GATASE
    IPR010073 PurL_large
    IPR041609 PurL_linker
    IPR010918 PurM-like_C_dom
    IPR036676 PurM-like_C_sf
    IPR036921 PurM-like_N_sf
    IPR036604 PurS-like_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02769 AIRS_C, 2 hits
    PF18072 FGAR-AT_linker, 1 hit
    PF18076 FGAR-AT_N, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52317 SSF52317, 1 hit
    SSF55326 SSF55326, 2 hits
    SSF56042 SSF56042, 2 hits
    SSF82697 SSF82697, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01735 FGAM_synt, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51273 GATASE_TYPE_1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P15254-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MMEILRGSPA LSAFRINKLL ARFQAARLPV HNIYAEYVHF ADLNAPLNDD
    60 70 80 90 100
    EHAQLERLLK YGPALASHAP QGKLLLVTPR PGTISPWSSK ATDIAHNCGL
    110 120 130 140 150
    QQVNRLERGV AYYIEAGTLT NEQWQQVTAE LHDRMMETVF FALDDAEQLF
    160 170 180 190 200
    AHHQPTPVTS VDLLGQGRQA LIDANLRLGL ALAEDEIDYL QDAFTKLGRN
    210 220 230 240 250
    PNDIELYMFA QANSEHCRHK IFNADWVIDG EQQPKSLFKM IKNTFETTPD
    260 270 280 290 300
    HVLSAYKDNA AVMEGSEVGR YFADHETGRY DFHQEPAHIL MKVETHNHPT
    310 320 330 340 350
    AISPWPGAAT GSGGEIRDEG ATGRGAKPKA GLVGFSVSNL RIPGFEQPWE
    360 370 380 390 400
    EDFGKPERIV TALDIMTEGP LGGAAFNNEF GRPALNGYFR TYEEKVNSHN
    410 420 430 440 450
    GEELRGYHKP IMLAGGIGNI RADHVQKGEI NVGAKLVVLG GPAMNIGLGG
    460 470 480 490 500
    GAASSMASGQ SDADLDFASV QRDNPEMERR CQEVIDRCWQ LGDANPILFI
    510 520 530 540 550
    HDVGAGGLSN AMPELVSDGG RGGKFELREI LSDEPGMSPL EIWCNESQER
    560 570 580 590 600
    YVLAVAADQL PLFDELCKRE RAPYAVIGEA TEELHLSLHD RHFDNQPIDL
    610 620 630 640 650
    PLDVLLGKTP KMTRDVQTLK AKGDALAREG ITIADAVKRV LHLPTVAEKT
    660 670 680 690 700
    FLVTIGDRSV TGMVARDQMV GPWQVPVANC AVTTASLDSY YGEAMAIGER
    710 720 730 740 750
    APVALLDFAA SARLAVGEAL TNIAATQIGD IKRIKLSANW MAAAGHPGED
    760 770 780 790 800
    AGLYEAVKAV GEELCPALGL TIPVGKDSMS MKTRWQEGNE EREMTSPLSL
    810 820 830 840 850
    VISAFARVED VRHTITPQLS TEDNALLLID LGKGNNALGA TALAQVYRQL
    860 870 880 890 900
    GDKPADVRDV AQLKGFYDAI QALVAQRKLL AYHDRSDGGL LVTLAEMAFA
    910 920 930 940 950
    GHCGIDADIA TLGDDRLAAL FNEELGAVIQ VRAADREAVE SVLAQHGLAD
    960 970 980 990 1000
    CVHYVGQAVS GDRFVITANG QTVFSESRTT LRVWWAETTW QMQRLRDNPE
    1010 1020 1030 1040 1050
    CADQEHQAKS NDADPGLNVK LSFDINEDVA APYIATGARP KVAVLREQGV
    1060 1070 1080 1090 1100
    NSHVEMAAAF HRAGFDAIDV HMSDLLTGRT GLEDFHALVA CGGFSYGDVL
    1110 1120 1130 1140 1150
    GAGEGWAKSI LFNDRVRDEF ATFFHRPQTL ALGVCNGCQM MSNLRELIPG
    1160 1170 1180 1190 1200
    SELWPRFVRN TSDRFEARFS LVEVTQSPSL LLQGMVGSQM PIAVSHGEGR
    1210 1220 1230 1240 1250
    VEVRDAAHLA ALESKGLVAL RYVDNFGKVT ETYPANPNGS PNGITAVTTE
    1260 1270 1280 1290
    SGRVTIMMPH PERVFRTVSN SWHPENWGED GPWMRIFRNA RKQLG
    Length:1,295
    Mass (Da):141,403
    Last modified:December 4, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30943AA218D758FE
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M19501 Genomic DNA Translation: AAA24456.1
    U36841 Genomic DNA Translation: AAA79819.1
    U00096 Genomic DNA Translation: AAT48143.1
    AP009048 Genomic DNA Translation: BAE76733.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    D65033 SYECPG

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_000970102.1, NZ_LN832404.1
    YP_026170.1, NC_000913.3

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAT48143; AAT48143; b2557
    BAE76733; BAE76733; BAE76733

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    947032

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW2541
    eco:b2557

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.4177

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M19501 Genomic DNA Translation: AAA24456.1
    U36841 Genomic DNA Translation: AAA79819.1
    U00096 Genomic DNA Translation: AAT48143.1
    AP009048 Genomic DNA Translation: BAE76733.1
    PIRiD65033 SYECPG
    RefSeqiWP_000970102.1, NZ_LN832404.1
    YP_026170.1, NC_000913.3

    3D structure databases

    SMRiP15254
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi4259206, 75 interactors
    DIPiDIP-10614N
    IntActiP15254, 14 interactors
    STRINGi511145.b2557

    Protein family/group databases

    MEROPSiC56.972

    Proteomic databases

    jPOSTiP15254
    PaxDbiP15254
    PRIDEiP15254

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAT48143; AAT48143; b2557
    BAE76733; BAE76733; BAE76733
    GeneIDi947032
    KEGGiecj:JW2541
    eco:b2557
    PATRICifig|1411691.4.peg.4177

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0790
    EcoGeneiEG10797 purL

    Phylogenomic databases

    eggNOGiENOG4107QIK Bacteria
    COG0046 LUCA
    COG0047 LUCA
    HOGENOMiHOG000261359
    InParanoidiP15254
    KOiK01952
    PhylomeDBiP15254

    Enzyme and pathway databases

    UniPathwayiUPA00074;UER00128
    BioCyciEcoCyc:FGAMSYN-MONOMER
    ECOL316407:JW2541-MONOMER
    MetaCyc:FGAMSYN-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P15254

    Family and domain databases

    Gene3Di3.30.1330.10, 2 hits
    3.40.50.880, 1 hit
    3.90.650.10, 2 hits
    HAMAPiMF_00419 PurL_1, 1 hit
    InterProiView protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR040707 FGAR-AT_N
    IPR017926 GATASE
    IPR010073 PurL_large
    IPR041609 PurL_linker
    IPR010918 PurM-like_C_dom
    IPR036676 PurM-like_C_sf
    IPR036921 PurM-like_N_sf
    IPR036604 PurS-like_sf
    PfamiView protein in Pfam
    PF02769 AIRS_C, 2 hits
    PF18072 FGAR-AT_linker, 1 hit
    PF18076 FGAR-AT_N, 1 hit
    SUPFAMiSSF52317 SSF52317, 1 hit
    SSF55326 SSF55326, 2 hits
    SSF56042 SSF56042, 2 hits
    SSF82697 SSF82697, 1 hit
    TIGRFAMsiTIGR01735 FGAM_synt, 1 hit
    PROSITEiView protein in PROSITE
    PS51273 GATASE_TYPE_1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUR4_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15254
    Secondary accession number(s): P78097, Q2MAH3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: December 4, 2007
    Last modified: May 8, 2019
    This is version 176 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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