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Protein

Interleukin-9

Gene

IL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-8985947 Interleukin-9 signaling
SignaLinkiP15248
SIGNORiP15248

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:IL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145839.1
HGNCiHGNC:6029 IL9
MIMi146931 gene
neXtProtiNX_P15248

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3578
OpenTargetsiENSG00000145839
PharmGKBiPA29845

Chemistry databases

ChEMBLiCHEMBL3712932

Polymorphism and mutation databases

BioMutaiIL9
DMDMi124362

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001562719 – 144Interleukin-9Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP15248
PRIDEiP15248
ProteomicsDBi53120

PTM databases

iPTMnetiP15248
PhosphoSitePlusiP15248

Expressioni

Gene expression databases

BgeeiENSG00000145839 Expressed in 29 organ(s), highest expression level in tibial nerve
CleanExiHS_IL9
GenevisibleiP15248 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109792, 1 interactor
DIPiDIP-3155N
STRINGi9606.ENSP00000274520

Structurei

3D structure databases

ProteinModelPortaliP15248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYR9 Eukaryota
ENOG41114M6 LUCA
GeneTreeiENSGT00390000015384
HOGENOMiHOG000113052
HOVERGENiHBG003933
InParanoidiP15248
KOiK05432
OMAiFSCEQPC
OrthoDBiEOG091G0U4U
PhylomeDBiP15248
TreeFamiTF336367

Family and domain databases

InterProiView protein in InterPro
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR020447 IL-9
PANTHERiPTHR16926 PTHR16926, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PRINTSiPR01926 INTERLEUKIN9
ProDomiView protein in ProDom or Entries sharing at least one domain
PD033324 PD033324, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15248-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN
60 70 80 90 100
VTSCLCLGIP SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK
110 120 130 140
NNKCPYFSCE QPCNQTTAGN ALTFLKSLLE IFQKEKMRGM RGKI
Length:144
Mass (Da):15,909
Last modified:April 1, 1990 - v1
Checksum:i2EAA08690558ECAB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013079117T → M1 PublicationCorresponds to variant dbSNP:rs2069885Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30134 mRNA Translation: AAA36400.1
X17543 mRNA Translation: CAA35581.1
S63356 mRNA Translation: AAB19823.1
M30135 Genomic DNA Translation: AAA35887.1
M86593 Genomic DNA Translation: AAA59161.1
AF361105 Genomic DNA Translation: AAK26666.1
AC002428 Genomic DNA Translation: AAB66904.1
AC004763 Genomic DNA Translation: AAC17735.1
BC066283 mRNA Translation: AAH66283.1
BC066285 mRNA Translation: AAH66285.1
BC066286 mRNA Translation: AAH66286.1
CCDSiCCDS4189.1
PIRiA60480
RefSeqiNP_000581.1, NM_000590.1
UniGeneiHs.960

Genome annotation databases

EnsembliENST00000274520; ENSP00000274520; ENSG00000145839
GeneIDi3578
KEGGihsa:3578
UCSCiuc003lbb.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-9 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30134 mRNA Translation: AAA36400.1
X17543 mRNA Translation: CAA35581.1
S63356 mRNA Translation: AAB19823.1
M30135 Genomic DNA Translation: AAA35887.1
M86593 Genomic DNA Translation: AAA59161.1
AF361105 Genomic DNA Translation: AAK26666.1
AC002428 Genomic DNA Translation: AAB66904.1
AC004763 Genomic DNA Translation: AAC17735.1
BC066283 mRNA Translation: AAH66283.1
BC066285 mRNA Translation: AAH66285.1
BC066286 mRNA Translation: AAH66286.1
CCDSiCCDS4189.1
PIRiA60480
RefSeqiNP_000581.1, NM_000590.1
UniGeneiHs.960

3D structure databases

ProteinModelPortaliP15248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109792, 1 interactor
DIPiDIP-3155N
STRINGi9606.ENSP00000274520

Chemistry databases

ChEMBLiCHEMBL3712932

PTM databases

iPTMnetiP15248
PhosphoSitePlusiP15248

Polymorphism and mutation databases

BioMutaiIL9
DMDMi124362

Proteomic databases

PaxDbiP15248
PRIDEiP15248
ProteomicsDBi53120

Protocols and materials databases

DNASUi3578
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274520; ENSP00000274520; ENSG00000145839
GeneIDi3578
KEGGihsa:3578
UCSCiuc003lbb.1 human

Organism-specific databases

CTDi3578
DisGeNETi3578
EuPathDBiHostDB:ENSG00000145839.1
GeneCardsiIL9
HGNCiHGNC:6029 IL9
MIMi146931 gene
neXtProtiNX_P15248
OpenTargetsiENSG00000145839
PharmGKBiPA29845
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYR9 Eukaryota
ENOG41114M6 LUCA
GeneTreeiENSGT00390000015384
HOGENOMiHOG000113052
HOVERGENiHBG003933
InParanoidiP15248
KOiK05432
OMAiFSCEQPC
OrthoDBiEOG091G0U4U
PhylomeDBiP15248
TreeFamiTF336367

Enzyme and pathway databases

ReactomeiR-HSA-8985947 Interleukin-9 signaling
SignaLinkiP15248
SIGNORiP15248

Miscellaneous databases

GeneWikiiInterleukin_9
GenomeRNAii3578
PROiPR:P15248
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145839 Expressed in 29 organ(s), highest expression level in tibial nerve
CleanExiHS_IL9
GenevisibleiP15248 HS

Family and domain databases

InterProiView protein in InterPro
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR020447 IL-9
PANTHERiPTHR16926 PTHR16926, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PRINTSiPR01926 INTERLEUKIN9
ProDomiView protein in ProDom or Entries sharing at least one domain
PD033324 PD033324, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL9_HUMAN
AccessioniPrimary (citable) accession number: P15248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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