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Protein

Interleukin-9

Gene

Il9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of cell growth Source: MGI
  • positive regulation of interleukin-5 biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-8985947 Interleukin-9 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:Il9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96563 Il9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001562819 – 144Interleukin-9Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Glycosylationi50N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi78N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi114N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP15247
PRIDEiP15247

PTM databases

iPTMnetiP15247
PhosphoSitePlusiP15247

Expressioni

Gene expression databases

BgeeiENSMUSG00000021538
CleanExiMM_IL9
GenevisibleiP15247 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022019

Structurei

3D structure databases

ProteinModelPortaliP15247
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYR9 Eukaryota
ENOG41114M6 LUCA
GeneTreeiENSGT00390000015384
HOGENOMiHOG000113052
HOVERGENiHBG003933
InParanoidiP15247
KOiK05432
OMAiFSCEQPC
OrthoDBiEOG091G0U4U
PhylomeDBiP15247
TreeFamiTF336367

Family and domain databases

InterProiView protein in InterPro
IPR018049 IL-7/IL-9_CS
IPR000226 IL-7/IL-9_fam
IPR020447 IL-9
PANTHERiPTHR16926 PTHR16926, 1 hit
PfamiView protein in Pfam
PF01415 IL7, 1 hit
PRINTSiPR01926 INTERLEUKIN9
ProDomiView protein in ProDom or Entries sharing at least one domain
PD033324 PD033324, 1 hit
PROSITEiView protein in PROSITE
PS00255 INTERLEUKIN_7_9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN
60 70 80 90 100
VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK
110 120 130 140
NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP
Length:144
Mass (Da):16,075
Last modified:April 1, 1990 - v1
Checksum:iECD944632CE837C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14045 mRNA Translation: CAA32203.1
M30136 Genomic DNA Translation: AAA39874.1
CCDSiCCDS26562.1
PIRiJL0089
RefSeqiNP_032399.1, NM_008373.1
UniGeneiMm.3006

Genome annotation databases

EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538
GeneIDi16198
KEGGimmu:16198
UCSCiuc007qso.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL9_MOUSE
AccessioniPrimary (citable) accession number: P15247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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