The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P15247 (IL9_MOUSE)
Protein
Interleukin-9
Gene
Il9
Organism
Mus musculus (Mouse)
Status
Functioni
Supports IL-2 independent and IL-4 independent growth of helper T-cells.
GO - Molecular functioni
- cytokine activity Source: MGI
- growth factor activity Source: UniProtKB-KW
- interleukin-9 receptor binding Source: MGI
GO - Biological processi
- B cell differentiation Source: MGI
- B cell proliferation Source: MGI
- immunoglobulin mediated immune response Source: MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: MGI
- positive regulation of cell growth Source: MGI
- positive regulation of interleukin-5 production Source: UniProtKB
- regulation of peptidyl-tyrosine phosphorylation Source: MGI
- regulation of receptor signaling pathway via JAK-STAT Source: MGI
Keywordsi
Molecular function | Cytokine, Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-8985947, Interleukin-9 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-9Short name: IL-9 Alternative name(s): Cytokine P40 T-cell growth factor P40 |
Gene namesi | Name:Il9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96563, Il9 |
VEuPathDBi | HostDB:ENSMUSG00000021538 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000015628 | 19 – 144 | Interleukin-9Add BLAST | 126 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Glycosylationi | 50 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 78 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 114 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
PaxDbi | P15247 |
PRIDEi | P15247 |
PTM databases
GlyGeni | P15247, 4 sites |
iPTMneti | P15247 |
PhosphoSitePlusi | P15247 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000021538, Expressed in muscle tissue and 35 other tissues |
Genevisiblei | P15247, MM |
Interactioni
GO - Molecular functioni
- cytokine activity Source: MGI
- growth factor activity Source: UniProtKB-KW
- interleukin-9 receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022019 |
Miscellaneous databases
RNActi | P15247, protein |
Structurei
3D structure databases
AlphaFoldDBi | P15247 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-7/IL-9 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TDE1, Eukaryota |
GeneTreei | ENSGT00390000015384 |
HOGENOMi | CLU_150120_0_0_1 |
InParanoidi | P15247 |
OMAi | CPFFSCE |
OrthoDBi | 1444257at2759 |
PhylomeDBi | P15247 |
TreeFami | TF336367 |
Family and domain databases
InterProi | View protein in InterPro IPR018049, IL-7/IL-9_CS IPR020447, IL-9 |
PANTHERi | PTHR16926, PTHR16926, 1 hit |
PRINTSi | PR01926, INTERLEUKIN9 |
PROSITEi | View protein in PROSITE PS00255, INTERLEUKIN_7_9, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15247-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN
60 70 80 90 100
VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK
110 120 130 140
NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14045 mRNA Translation: CAA32203.1 M30136 Genomic DNA Translation: AAA39874.1 |
CCDSi | CCDS26562.1 |
PIRi | JL0089 |
RefSeqi | NP_032399.1, NM_008373.1 |
Genome annotation databases
Ensembli | ENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538 |
GeneIDi | 16198 |
KEGGi | mmu:16198 |
UCSCi | uc007qso.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14045 mRNA Translation: CAA32203.1 M30136 Genomic DNA Translation: AAA39874.1 |
CCDSi | CCDS26562.1 |
PIRi | JL0089 |
RefSeqi | NP_032399.1, NM_008373.1 |
3D structure databases
AlphaFoldDBi | P15247 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022019 |
PTM databases
GlyGeni | P15247, 4 sites |
iPTMneti | P15247 |
PhosphoSitePlusi | P15247 |
Proteomic databases
PaxDbi | P15247 |
PRIDEi | P15247 |
Protocols and materials databases
Antibodypediai | 14762, 657 antibodies from 39 providers |
DNASUi | 16198 |
Genome annotation databases
Ensembli | ENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538 |
GeneIDi | 16198 |
KEGGi | mmu:16198 |
UCSCi | uc007qso.1, mouse |
Organism-specific databases
CTDi | 3578 |
MGIi | MGI:96563, Il9 |
VEuPathDBi | HostDB:ENSMUSG00000021538 |
Phylogenomic databases
eggNOGi | ENOG502TDE1, Eukaryota |
GeneTreei | ENSGT00390000015384 |
HOGENOMi | CLU_150120_0_0_1 |
InParanoidi | P15247 |
OMAi | CPFFSCE |
OrthoDBi | 1444257at2759 |
PhylomeDBi | P15247 |
TreeFami | TF336367 |
Enzyme and pathway databases
Reactomei | R-MMU-8985947, Interleukin-9 signaling |
Miscellaneous databases
BioGRID-ORCSi | 16198, 2 hits in 71 CRISPR screens |
PROi | PR:P15247 |
RNActi | P15247, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021538, Expressed in muscle tissue and 35 other tissues |
Genevisiblei | P15247, MM |
Family and domain databases
InterProi | View protein in InterPro IPR018049, IL-7/IL-9_CS IPR020447, IL-9 |
PANTHERi | PTHR16926, PTHR16926, 1 hit |
PRINTSi | PR01926, INTERLEUKIN9 |
PROSITEi | View protein in PROSITE PS00255, INTERLEUKIN_7_9, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL9_MOUSE | |
Accessioni | P15247Primary (citable) accession number: P15247 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families