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Protein

Peroxidase C1C

Gene

PRXC1C

Organism
Armoracia rusticana (Horseradish) (Armoracia laphatifolia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 2 calcium ions per subunit.
  • heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47Transition state stabilizerPROSITE-ProRule annotation1
Active sitei51Proton acceptorPROSITE-ProRule annotation1
Metal bindingi52Calcium 1PROSITE-ProRule annotation1
Metal bindingi55Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi57Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi59Calcium 1PROSITE-ProRule annotation1
Metal bindingi61Calcium 1PROSITE-ProRule annotation1
Binding sitei148Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi179Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi180Calcium 2PROSITE-ProRule annotation1
Metal bindingi231Calcium 2PROSITE-ProRule annotation1
Metal bindingi234Calcium 2PROSITE-ProRule annotation1
Metal bindingi239Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKiP15233

Protein family/group databases

PeroxiBasei88 AruPrx01-3

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase C1C (EC:1.11.1.7)
Gene namesi
Name:PRXC1C
Synonyms:HRPC3
OrganismiArmoracia rusticana (Horseradish) (Armoracia laphatifolia)
Taxonomic identifieri3704 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCardamineaeArmoracia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 9›9
ChainiPRO_000002374210 – 332Peroxidase C1CAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Pyrrolidone carboxylic acidPROSITE-ProRule annotationBy similarity1
Disulfide bondi20 ↔ 100PROSITE-ProRule annotation
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 58PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 310PROSITE-ProRule annotation
Disulfide bondi186 ↔ 218PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Structurei

3D structure databases

ProteinModelPortaliP15233
SMRiP15233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15233-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHASFSNAQ LTPTFYDNSC PNVSNIVRDI IINELRSDPS IAASILRLHF
60 70 80 90 100
HDCFVNGCDA SILLDNTTSF RTEKDAFGNA NSARGFPVVD RIKAAVERAC
110 120 130 140 150
PRTVSCADVL TIAAQQSVNL AGGPSWRVPL GRRDSRQAFL DLANANLPAP
160 170 180 190 200
SFTLPELKAA FANVGLNRPS DLVALSGGHT FGKNQCRFIM DRLYNFSNTG
210 220 230 240 250
LPDPTLNTTY LQTLRQQCPR NGNQSVLVDF DLRTPTVFDN KYYVNLKEQK
260 270 280 290 300
GLIQSDQELF SSPNATDTIP LVRSYADGTQ TFFNAFVEAM NRMGNITPLT
310 320 330
GTQGEIRLNC RVVNSNSLLH DIVEVVDFVS SM
Length:332
Mass (Da):36,548
Last modified:April 1, 1990 - v1
Checksum:i1938A450D595DFBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60729 Genomic DNA Translation: AAA33379.1
PIRiS00627

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60729 Genomic DNA Translation: AAA33379.1
PIRiS00627

3D structure databases

ProteinModelPortaliP15233
SMRiP15233
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei88 AruPrx01-3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKiP15233

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER1C_ARMRU
AccessioniPrimary (citable) accession number: P15233
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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