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Entry version 188 (17 Jun 2020)
Sequence version 2 (01 Nov 1997)
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Protein

Laminin subunit gamma-1

Gene

LanB2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3000157 Laminin interactions
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-1
Alternative name(s):
Laminin B2 chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LanB2
Synonyms:LAMC1, LAMG1
ORF Names:CG3322
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0267348 LanB2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001708134 – 1639Laminin subunit gamma-1Add BLAST1606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi301 ↔ 322PROSITE-ProRule annotation
Disulfide bondi324 ↔ 333PROSITE-ProRule annotation
Disulfide bondi336 ↔ 356PROSITE-ProRule annotation
Disulfide bondi359 ↔ 368PROSITE-ProRule annotation
Disulfide bondi361 ↔ 384PROSITE-ProRule annotation
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi387 ↔ 396PROSITE-ProRule annotation
Disulfide bondi399 ↔ 411PROSITE-ProRule annotation
Disulfide bondi414 ↔ 426PROSITE-ProRule annotation
Disulfide bondi416 ↔ 432PROSITE-ProRule annotation
Disulfide bondi434 ↔ 443PROSITE-ProRule annotation
Disulfide bondi446 ↔ 458PROSITE-ProRule annotation
Disulfide bondi461 ↔ 475PROSITE-ProRule annotation
Disulfide bondi463 ↔ 482PROSITE-ProRule annotation
Disulfide bondi484 ↔ 493PROSITE-ProRule annotation
Disulfide bondi496 ↔ 511PROSITE-ProRule annotation
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi712 ↔ 721PROSITE-ProRule annotation
Disulfide bondi724 ↔ 741PROSITE-ProRule annotation
Disulfide bondi744 ↔ 753PROSITE-ProRule annotation
Disulfide bondi746 ↔ 760PROSITE-ProRule annotation
Disulfide bondi762 ↔ 771PROSITE-ProRule annotation
Disulfide bondi774 ↔ 790PROSITE-ProRule annotation
Disulfide bondi793 ↔ 801PROSITE-ProRule annotation
Disulfide bondi795 ↔ 811PROSITE-ProRule annotation
Disulfide bondi814 ↔ 823PROSITE-ProRule annotation
Disulfide bondi826 ↔ 844PROSITE-ProRule annotation
Disulfide bondi847 ↔ 861PROSITE-ProRule annotation
Disulfide bondi849 ↔ 868PROSITE-ProRule annotation
Glycosylationi862N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi871 ↔ 880PROSITE-ProRule annotation
Disulfide bondi883 ↔ 899PROSITE-ProRule annotation
Disulfide bondi902 ↔ 919PROSITE-ProRule annotation
Disulfide bondi904 ↔ 926PROSITE-ProRule annotation
Disulfide bondi928 ↔ 937PROSITE-ProRule annotation
Disulfide bondi940 ↔ 953PROSITE-ProRule annotation
Disulfide bondi956 ↔ 968PROSITE-ProRule annotation
Disulfide bondi958 ↔ 975PROSITE-ProRule annotation
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi977 ↔ 986PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1016PROSITE-ProRule annotation
Disulfide bondi1006 ↔ 1022PROSITE-ProRule annotation
Disulfide bondi1024 ↔ 1033PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1047PROSITE-ProRule annotation
Disulfide bondi1050InterchainCurated
Disulfide bondi1053InterchainCurated
Glycosylationi1070N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1584N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1631InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15215

PRoteomics IDEntifications database

More...
PRIDEi
P15215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0267348 Expressed in embryonic/larval hemocyte (Drosophila) and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15215 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15215 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
64509, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-21994N

Protein interaction database and analysis system

More...
IntActi
P15215, 12 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0076111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15215

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 298Laminin N-terminalPROSITE-ProRule annotationAdd BLAST236
Domaini299 – 358Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini359 – 413Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST55
Domaini414 – 460Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini461 – 513Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST53
Domaini514 – 523Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini533 – 709Laminin IV type APROSITE-ProRule annotationAdd BLAST177
Domaini710 – 743Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST34
Domaini744 – 792Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST49
Domaini793 – 846Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST54
Domaini847 – 901Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST55
Domaini902 – 955Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST54
Domaini956 – 1003Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini1004 – 1049Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1050 – 1609Domain II and IAdd BLAST560

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1087 – 1109Sequence analysisAdd BLAST23
Coiled coili1144 – 1247Sequence analysisAdd BLAST104
Coiled coili1306 – 1627Sequence analysisAdd BLAST322

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002471_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15215

KEGG Orthology (KO)

More...
KOi
K05635

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCNCNGY

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15215

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 11 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P15215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRSRWSHSG SSTARLLLIG VLFASCSTAI LGAQRPPINS AGGHELRGTT
60 70 80 90 100
FMPALECYDP YGRPQKCLPE FINAAYQLQI ESTNTCGEQN DNHFCIQTMN
110 120 130 140 150
QNHKNCEFCK YNDHNPSFLT DLHDPQSPTW WQSETMFEGI QHPNYVNLTL
160 170 180 190 200
HLGKSYDITY VRILFRSPRP ESFTIYKRTS ESGPWIPYQF YSATCRDTYS
210 220 230 240 250
LPDSRAIRKG EGEAHALCTS EYSDISPLRD GEIAFSTLEG RPSGINFERS
260 270 280 290 300
GELQEWVTAT DIRITLDRLN TFGDELFGDS QVLKSYFYAI SDIAVGARCK
310 320 330 340 350
CNGHASKCVP STGMHGERTL VCECRHNTDG PDCDRCLPLY NDLKWKRSTS
360 370 380 390 400
TEVNECKACN CNGLADKCFF DANLFNRTGH GGHCLDCREN RDGPNCERCK
410 420 430 440 450
ENFYMRDDGY CVNCACDPVG SRSLQCNSHG KCQCKPGVTG DKCDRCDNNY
460 470 480 490 500
YQFGPHGCQQ CGCDSGGSHQ NTPACDTETG ICFCKENVEG RRCNECKPGF
510 520 530 540 550
FNLDKNNRFG CTPCFCYGHT SECMTAPGYS IVSVTSNFNK FKERWTAADL
560 570 580 590 600
NQREVDIKYN QYSRSIGTTA QGNEHVYFQA PDRFLGDQRA SYNRDLKFKL
610 620 630 640 650
QLVGQVANTG VSDVILEGAG SRISLPIFAQ GNGIPDQGVK EYTFRLHEHH
660 670 680 690 700
DYQWQPSQSA RGFLSILSNL TAIKIRATYS VQGEAILDDV ELQTAHRGAA
710 720 730 740 750
GHPATWIEQC TCPEGYLGQF CESCAPGYRH SPARGGPFMP CIPCDCHGHA
760 770 780 790 800
DICDSETGRC ICQHNTHGDN CDQCAKGFYG NALGGTPNDC KRCPCPNDGA
810 820 830 840 850
CLQINEDTVI CTECPKGYFG SRCEQCSDGF FGDPTGLLGE VQTCKSCDCN
860 870 880 890 900
GNVDPNAVGN CNRTTGECLK CIHNTAGEHC DQCLSGHFGD PLALPHGRCD
910 920 930 940 950
RCSCYEAGTE QDEQSITRCD QVTGQCQCKP NVIGRDCGEC QPGYFNIRSG
960 970 980 990 1000
NGCENCLCDP VGSYNSTCDR YSGQCHCRPG VMGQRCDQCE NYFYGFSSEG
1010 1020 1030 1040 1050
CKPCECDESG SKGFQCDQNG QCPCNDNVEG RRCDRCKENK YDRHRGCIDC
1060 1070 1080 1090 1100
PDCYNLVQDA ADLHRAKLFN LSQTLDEIAR TPVTNDDEFE AKLKAVQEKV
1110 1120 1130 1140 1150
AVLAQDARDN SGDGGQTYAE VIDDLHKHLD SVREHLVSAD KFQADANGEI
1160 1170 1180 1190 1200
DRARQNYTIL DQITENAKKE LQQALDLLND EGAQALARAK EKSVEFGQQS
1210 1220 1230 1240 1250
EQISDISREA RALADKLESE AQFDLKNAKD AKDAVEKAHQ LAKSAIDLQL
1260 1270 1280 1290 1300
KIGTELRSEV GLELSHVKQS LGTVVQTSKE ALRKANEVYD TALTLLNDVN
1310 1320 1330 1340 1350
RQTQPEIDIS QLKKDAVAAN ERADELLKQI TELSNSNGEL FADFETEQEL
1360 1370 1380 1390 1400
TEALLKRAEQ QQLEDIELLE RAKAAHDKAT KAVEQGDNTL KEANNTYEKL
1410 1420 1430 1440 1450
AGFQSDVQRS SESAEKALQT VPNIEKEIQN AESLISQAEE ALDGANKNAN
1460 1470 1480 1490 1500
EAKKNAQEAQ LKYAEQASKD AELIRRKANE TKVAARNLRE EADQLNHRVK
1510 1520 1530 1540 1550
LTEMDIFKLE ESSTKDDNLV DDAKRKVGQA KADTQEAQKQ IEKANADLTA
1560 1570 1580 1590 1600
IKDELENLKD INTGDLDRLE NRLATVEGEI NRVNLTGRIE KYREQRTIQK
1610 1620 1630
NLIDKYDAEL RELKDEVQNI GLISKALPDS CFSRNRLEP
Length:1,639
Mass (Da):182,339
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F510AC6933A52BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JAW6X2JAW6_DROME
Laminin B2, isoform B
LanB2 anon-EST:fe2H3, CT11145, Dmel\CG3322, DROLAMB2A, gamma
1,639Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1026 – 1027DN → EY (PubMed:2912972).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti831F → Y. 1
Natural varianti892L → P in strain: Oregon-R. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M58417 Genomic DNA Translation: AAA28665.1
M25063 mRNA Translation: AAA28664.1
AE014296 Genomic DNA Translation: AAF50238.1
BT021394 mRNA Translation: AAX33542.1

Protein sequence database of the Protein Information Resource

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PIRi
A31483 MMFFB2

NCBI Reference Sequences

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RefSeqi
NP_001287009.1, NM_001300080.1
NP_524006.1, NM_079282.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0076382; FBpp0076111; FBgn0267348
FBtr0345031; FBpp0311281; FBgn0267348

Database of genes from NCBI RefSeq genomes

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GeneIDi
39118

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3322

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58417 Genomic DNA Translation: AAA28665.1
M25063 mRNA Translation: AAA28664.1
AE014296 Genomic DNA Translation: AAF50238.1
BT021394 mRNA Translation: AAX33542.1
PIRiA31483 MMFFB2
RefSeqiNP_001287009.1, NM_001300080.1
NP_524006.1, NM_079282.2

3D structure databases

SMRiP15215
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi64509, 14 interactors
DIPiDIP-21994N
IntActiP15215, 12 interactors
STRINGi7227.FBpp0076111

Proteomic databases

PaxDbiP15215
PRIDEiP15215

Genome annotation databases

EnsemblMetazoaiFBtr0076382; FBpp0076111; FBgn0267348
FBtr0345031; FBpp0311281; FBgn0267348
GeneIDi39118
KEGGidme:Dmel_CG3322

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
39118
FlyBaseiFBgn0267348 LanB2

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
HOGENOMiCLU_002471_1_0_1
InParanoidiP15215
KOiK05635
OMAiPCNCNGY
OrthoDBi156553at2759
PhylomeDBiP15215

Enzyme and pathway databases

ReactomeiR-DME-3000157 Laminin interactions
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275 Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
39118 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
39118

Protein Ontology

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PROi
PR:P15215

Gene expression databases

BgeeiFBgn0267348 Expressed in embryonic/larval hemocyte (Drosophila) and 34 other tissues
ExpressionAtlasiP15215 differential
GenevisibleiP15215 DM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 11 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 11 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 1 hit
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 11 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15215
Secondary accession number(s): Q24373, Q5BI30, Q9VT18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: June 17, 2020
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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