UniProtKB - P15209 (NTRK2_MOUSE)
BDNF/NT-3 growth factors receptor
Ntrk2
Functioni
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
10 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation1 PublicationEC:2.7.10.1PROSITE-ProRule annotation1 Publication
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 571 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 675 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 543 – 551 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- brain-derived neurotrophic factor-activated receptor activity Source: UniProtKB
- brain-derived neurotrophic factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- neurotrophin receptor activity Source: MGI
- protease binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- receptor tyrosine kinase binding Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: MGI
GO - Biological processi
- brain-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- cellular response to amino acid stimulus Source: MGI
- cellular response to brain-derived neurotrophic factor stimulus Source: GO_Central
- cellular response to nerve growth factor stimulus Source: GO_Central
- central nervous system neuron development Source: UniProtKB
- cerebral cortex development Source: UniProtKB
- circadian rhythm Source: UniProtKB
- feeding behavior Source: MGI
- glutamate secretion Source: MGI
- learning Source: UniProtKB
- long-term memory Source: MGI
- long-term synaptic potentiation Source: UniProtKB
- mechanoreceptor differentiation Source: MGI
- myelination in peripheral nervous system Source: MGI
- negative regulation of amyloid-beta formation Source: MGI
- negative regulation of anoikis Source: UniProtKB
- negative regulation of neuron apoptotic process Source: UniProtKB
- neuronal action potential propagation Source: MGI
- neuron differentiation Source: UniProtKB
- neuron migration Source: UniProtKB
- oligodendrocyte differentiation Source: UniProtKB
- peripheral nervous system neuron development Source: UniProtKB
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glucocorticoid receptor signaling pathway Source: MGI
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of synapse assembly Source: MGI
- positive regulation of synaptic transmission, glutamatergic Source: MGI
- protein autophosphorylation Source: UniProtKB
- regulation of dendrite development Source: MGI
- regulation of GTPase activity Source: UniProtKB
- regulation of MAPK cascade Source: MGI
- regulation of metabolic process Source: MGI
- regulation of neurotransmitter secretion Source: MGI
- regulation of protein kinase B signaling Source: UniProtKB
- retina development in camera-type eye Source: MGI
- retinal rod cell development Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- trans-synaptic signaling by BDNF, modulating synaptic transmission Source: SynGO
- trans-synaptic signaling by neuropeptide, modulating synaptic transmission Source: SynGO
- vasculogenesis Source: MGI
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Differentiation, Neurogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-MMU-9032759, NTRK2 activates RAC1 |
Names & Taxonomyi
Protein namesi | Recommended name: BDNF/NT-3 growth factors receptor (EC:2.7.10.11 Publication)Alternative name(s): GP145-TrkB/GP95-TrkB Short name: Trk-B Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97384, Ntrk2 |
VEuPathDBi | HostDB:ENSMUSG00000055254 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
- Early endosome membrane 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- axon By similarity
- dendrite By similarity
- perinuclear region By similarity
- postsynaptic density 1 Publication
Note: Internalized to endosomes upon ligand-binding.1 Publication
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- rough endoplasmic reticulum Source: MGI
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- axon Source: MGI
- axon terminus Source: MGI
- cell surface Source: MGI
- cytoplasm Source: MGI
- dendrite Source: UniProtKB
- dendritic spine Source: MGI
- excitatory synapse Source: MGI
- glutamatergic synapse Source: MGI
- growth cone Source: MGI
- neuronal cell body Source: MGI
- perikaryon Source: MGI
- perinuclear region of cytoplasm Source: UniProtKB
- postsynapse Source: MGI
- postsynaptic density Source: ARUK-UCL
- presynaptic active zone Source: MGI
- receptor complex Source: MGI
- terminal bouton Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 429 | ExtracellularSequence analysisAdd BLAST | 398 | |
Transmembranei | 430 – 453 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 454 – 821 | CytoplasmicSequence analysisAdd BLAST | 368 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane, SynapsePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 515 | Y → F: Loss of interaction with SHC1. 1 Publication | 1 | |
Mutagenesisi | 816 | Y → F: Loss of interaction with PLCG1. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL4523190 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Add BLAST | 31 | |
ChainiPRO_0000016728 | 32 – 821 | BDNF/NT-3 growth factors receptorAdd BLAST | 790 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 38 | PROSITE-ProRule annotation | ||
Disulfide bondi | 36 ↔ 45 | PROSITE-ProRule annotation | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 152 ↔ 176 | PROSITE-ProRule annotation | ||
Disulfide bondi | 154 ↔ 194 | PROSITE-ProRule annotation | ||
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 218 ↔ 266 | PROSITE-ProRule annotation | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 302 ↔ 345 | PROSITE-ProRule annotation | ||
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 338 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 515 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 701 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 705 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 706 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 816 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P15209 |
PaxDbi | P15209 |
PeptideAtlasi | P15209 |
PRIDEi | P15209 |
ProteomicsDBi | 287834 [P15209-1] 287835 [P15209-2] 287836 [P15209-3] 287837 [P15209-4] |
PTM databases
GlyConnecti | 2148, 26 N-Linked glycans (8 sites) |
GlyGeni | P15209, 12 sites, 25 N-linked glycans (8 sites) |
iPTMneti | P15209 |
PhosphoSitePlusi | P15209 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000055254, Expressed in median eminence of neurohypophysis and 309 other tissues |
Genevisiblei | P15209, MM |
Interactioni
Subunit structurei
Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation.
Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation.
Interacts with SH2B1 and SH2B2.
Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity).
Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (PubMed:27457814).
Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2.
Interacts with SQSTM1 and KIDINS220 (By similarity).
Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (By similarity).
Interacts with APPL1 (PubMed:21849472).
Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).
Interacts with SORL1; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (PubMed:23977241).
By similarity3 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 515 | Interaction with SHC1 | 1 | |
Sitei | 705 | Interaction with SH2D1ABy similarity | 1 | |
Sitei | 816 | Interaction with PLCG1 | 1 |
Binary interactionsi
P15209
With | #Exp. | IntAct |
---|---|---|
Dlg4 [Q62108] | 4 | EBI-309647,EBI-300895 |
Hgs [Q99LI8] | 2 | EBI-309647,EBI-2119135 |
Pirb [Q8K4V6] | 4 | EBI-309647,EBI-8602514 |
Ptpn11 [P35235] | 2 | EBI-309647,EBI-397236 |
Sort1 [Q6PHU5] | 3 | EBI-309647,EBI-6985663 |
GO - Molecular functioni
- brain-derived neurotrophic factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- protease binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- receptor tyrosine kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201869, 15 interactors |
DIPi | DIP-5722N |
IntActi | P15209, 14 interactors |
MINTi | P15209 |
STRINGi | 10090.ENSMUSP00000078757 |
Miscellaneous databases
RNActi | P15209, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 61 | LRRNTAdd BLAST | 30 | |
Repeati | 92 – 113 | LRR 1Add BLAST | 22 | |
Repeati | 116 – 137 | LRR 2Add BLAST | 22 | |
Domaini | 148 – 196 | LRRCTAdd BLAST | 49 | |
Domaini | 197 – 282 | Ig-like C2-type 1Add BLAST | 86 | |
Domaini | 301 – 365 | Ig-like C2-type 2Add BLAST | 65 | |
Domaini | 537 – 806 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 270 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 454 – 465 | Interaction with MAPK8IP3/JIP3By similarityAdd BLAST | 12 | |
Regioni | 474 – 497 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 474 – 495 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155181 |
HOGENOMi | CLU_030959_1_0_1 |
InParanoidi | P15209 |
OMAi | TCSCEIM |
OrthoDBi | 295510at2759 |
PhylomeDBi | P15209 |
TreeFami | TF106465 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR000372, LRRNT IPR020777, NTRK IPR020455, NTRK2 IPR031635, NTRK_LRRCT IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 1 hit PF16920, LRRCT_2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01939, NTKRECEPTOR PR01941, NTKRECEPTOR2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP
60 70 80 90 100
GIVAFPRLEP NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD
110 120 130 140 150
SGLKFVAYKA FLKNSNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF
160 170 180 190 200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNMPLANLQ IPNCGLPSAR
210 220 230 240 250
LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW
410 420 430 440 450
TTPTDIGDTT NKSNEIPSTD VADQSNREHL SVYAVVVIAS VVGFCLLVML
460 470 480 490 500
LLLKLARHSK FGMKGPASVI SNDDDSASPL HHISNGSNTP SSSEGGPDAV
510 520 530 540 550
IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK RELGEGAFGK
560 570 580 590 600
VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV
610 620 630 640 650
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS
660 670 680 690 700
QMLHIAQQIA AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV
710 720 730 740 750
YSTDYYRVGG HTMLPIRWMP PESIMYRKFT TESDVWSLGV VLWEIFTYGK
760 770 780 790 800
QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHTRKNIK
810 820
SIHTLLQNLA KASPVYLDIL G
The sequence of this isoform differs from the canonical sequence as follows:
466-476: PASVISNDDDS → FVLFHKIPLDG
477-821: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
72-120: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
71-71: I → M
72-143: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YDA3 | A0A286YDA3_MOUSE | BDNF/NT-3 growth factors receptor | Ntrk2 | 492 | Annotation score: | ||
A0A286YCV8 | A0A286YCV8_MOUSE | BDNF/NT-3 growth factors receptor | Ntrk2 | 489 | Annotation score: | ||
A0A286YDA0 | A0A286YDA0_MOUSE | BDNF/NT-3 growth factors receptor | Ntrk2 | 466 | Annotation score: | ||
A0A286YCB7 | A0A286YCB7_MOUSE | BDNF/NT-3 growth factors receptor | Ntrk2 | 51 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002905 | 71 | I → M in isoform L10. Curated | 1 | |
Alternative sequenceiVSP_002906 | 72 – 143 | Missing in isoform L10. CuratedAdd BLAST | 72 | |
Alternative sequenceiVSP_002907 | 72 – 120 | Missing in isoform L1. CuratedAdd BLAST | 49 | |
Alternative sequenceiVSP_002908 | 466 – 476 | PASVISNDDDS → FVLFHKIPLDG in isoform GP95-TRKB. 3 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_002909 | 477 – 821 | Missing in isoform GP95-TRKB. 3 PublicationsAdd BLAST | 345 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33385 mRNA Translation: AAA40482.1 X17647 mRNA Translation: CAA35636.1 AK018789 mRNA Translation: BAB31412.1 AK147391 mRNA Translation: BAE27880.1 AK160789 mRNA Translation: BAE36012.1 BC052014 mRNA Translation: AAH52014.2 |
CCDSi | CCDS26573.1 [P15209-1] CCDS36685.1 [P15209-2] |
PIRi | A35104 S06943 |
RefSeqi | NP_001020245.1, NM_001025074.2 [P15209-1] NP_001269890.1, NM_001282961.1 [P15209-1] NP_032771.1, NM_008745.3 [P15209-2] XP_006517212.1, XM_006517149.3 [P15209-1] XP_006517215.1, XM_006517152.3 [P15209-2] XP_017170908.1, XM_017315419.1 XP_017170909.1, XM_017315420.1 |
Genome annotation databases
Ensembli | ENSMUST00000079828; ENSMUSP00000078757; ENSMUSG00000055254 [P15209-1] ENSMUST00000109838; ENSMUSP00000105464; ENSMUSG00000055254 [P15209-2] ENSMUST00000224259; ENSMUSP00000153270; ENSMUSG00000055254 [P15209-2] ENSMUST00000225488; ENSMUSP00000153553; ENSMUSG00000055254 [P15209-1] |
GeneIDi | 18212 |
KEGGi | mmu:18212 |
UCSCi | uc007qui.2, mouse [P15209-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33385 mRNA Translation: AAA40482.1 X17647 mRNA Translation: CAA35636.1 AK018789 mRNA Translation: BAB31412.1 AK147391 mRNA Translation: BAE27880.1 AK160789 mRNA Translation: BAE36012.1 BC052014 mRNA Translation: AAH52014.2 |
CCDSi | CCDS26573.1 [P15209-1] CCDS36685.1 [P15209-2] |
PIRi | A35104 S06943 |
RefSeqi | NP_001020245.1, NM_001025074.2 [P15209-1] NP_001269890.1, NM_001282961.1 [P15209-1] NP_032771.1, NM_008745.3 [P15209-2] XP_006517212.1, XM_006517149.3 [P15209-1] XP_006517215.1, XM_006517152.3 [P15209-2] XP_017170908.1, XM_017315419.1 XP_017170909.1, XM_017315420.1 |
3D structure databases
AlphaFoldDBi | P15209 |
SMRi | P15209 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201869, 15 interactors |
DIPi | DIP-5722N |
IntActi | P15209, 14 interactors |
MINTi | P15209 |
STRINGi | 10090.ENSMUSP00000078757 |
Chemistry databases
ChEMBLi | CHEMBL4523190 |
PTM databases
GlyConnecti | 2148, 26 N-Linked glycans (8 sites) |
GlyGeni | P15209, 12 sites, 25 N-linked glycans (8 sites) |
iPTMneti | P15209 |
PhosphoSitePlusi | P15209 |
Proteomic databases
MaxQBi | P15209 |
PaxDbi | P15209 |
PeptideAtlasi | P15209 |
PRIDEi | P15209 |
ProteomicsDBi | 287834 [P15209-1] 287835 [P15209-2] 287836 [P15209-3] 287837 [P15209-4] |
Protocols and materials databases
Antibodypediai | 2081, 1442 antibodies from 48 providers |
DNASUi | 18212 |
Genome annotation databases
Ensembli | ENSMUST00000079828; ENSMUSP00000078757; ENSMUSG00000055254 [P15209-1] ENSMUST00000109838; ENSMUSP00000105464; ENSMUSG00000055254 [P15209-2] ENSMUST00000224259; ENSMUSP00000153270; ENSMUSG00000055254 [P15209-2] ENSMUST00000225488; ENSMUSP00000153553; ENSMUSG00000055254 [P15209-1] |
GeneIDi | 18212 |
KEGGi | mmu:18212 |
UCSCi | uc007qui.2, mouse [P15209-1] |
Organism-specific databases
CTDi | 4915 |
MGIi | MGI:97384, Ntrk2 |
VEuPathDBi | HostDB:ENSMUSG00000055254 |
Phylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155181 |
HOGENOMi | CLU_030959_1_0_1 |
InParanoidi | P15209 |
OMAi | TCSCEIM |
OrthoDBi | 295510at2759 |
PhylomeDBi | P15209 |
TreeFami | TF106465 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-9026527, Activated NTRK2 signals through PLCG1 R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-MMU-9032759, NTRK2 activates RAC1 |
Miscellaneous databases
BioGRID-ORCSi | 18212, 2 hits in 75 CRISPR screens |
ChiTaRSi | Ntrk2, mouse |
PROi | PR:P15209 |
RNActi | P15209, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055254, Expressed in median eminence of neurohypophysis and 309 other tissues |
Genevisiblei | P15209, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR000372, LRRNT IPR020777, NTRK IPR020455, NTRK2 IPR031635, NTRK_LRRCT IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF13855, LRR_8, 1 hit PF16920, LRRCT_2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01939, NTKRECEPTOR PR01941, NTKRECEPTOR2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NTRK2_MOUSE | |
Accessioni | P15209Primary (citable) accession number: P15209 Secondary accession number(s): Q3TUF9, Q80WU0, Q91XJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 230 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families