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UniProtKB - P15209 (NTRK2_MOUSE)

Protein

BDNF/NT-3 growth factors receptor

Gene

Ntrk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.9 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Activity regulationi

The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity). The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades.By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei571ATPPROSITE-ProRule annotation1
Active sitei675Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi543 – 551ATPPROSITE-ProRule annotation9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
BDNF/NT-3 growth factors receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkB/GP95-TrkB
Short name:
Trk-B
Neurotrophic tyrosine kinase receptor type 2
TrkB tyrosine kinase
Gene namesi
Name:Ntrk2Imported
Synonyms:Trkb1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97384 Ntrk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 429ExtracellularSequence analysisAdd BLAST398
Transmembranei430 – 453HelicalSequence analysisAdd BLAST24
Topological domaini454 – 821CytoplasmicSequence analysisAdd BLAST368

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking isoform GP145-TRKB, the catalytic isoform, do not display feeding activity and die at P1. This is associated neuronal deficiencies in the central and the peripheral nervous systems.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi515Y → F: Loss of interaction with SHC1. 1 Publication1
Mutagenesisi816Y → F: Loss of interaction with PLCG1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Add BLAST31
ChainiPRO_000001672832 – 821BDNF/NT-3 growth factors receptorAdd BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 38PROSITE-ProRule annotation
Disulfide bondi36 ↔ 45PROSITE-ProRule annotation
Glycosylationi67N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi95N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi121N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi152 ↔ 176PROSITE-ProRule annotation
Disulfide bondi154 ↔ 194PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi205N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi218 ↔ 266PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi254N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi280N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi302 ↔ 345PROSITE-ProRule annotation
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi411N-linked (GlcNAc...) asparagineBy similarity1
Modified residuei515PhosphotyrosineCombined sources1
Modified residuei701Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei705Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei706Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei816Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Some isoforms are not phosphorylated (By similarity).By similarity
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP15209
PaxDbiP15209
PeptideAtlasiP15209
PRIDEiP15209

PTM databases

iPTMnetiP15209
PhosphoSitePlusiP15209

Expressioni

Tissue specificityi

Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is specifically expressed in glial cells.

Inductioni

Expression oscillates in a circadian manner in the liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000055254 Expressed in 286 organ(s), highest expression level in median eminence of neurohypophysis
CleanExiMM_NTRK2
ExpressionAtlasiP15209 baseline and differential
GenevisibleiP15209 MM

Interactioni

Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (By similarity). Interacts with APPL1 (PubMed:21849472). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei515Interaction with SHC11
Sitei705Interaction with SH2D1ABy similarity1
Sitei816Interaction with PLCG11

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201869, 6 interactors
DIPiDIP-5722N
IntActiP15209, 14 interactors
MINTiP15209
STRINGi10090.ENSMUSP00000078757

Structurei

3D structure databases

ProteinModelPortaliP15209
SMRiP15209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 61LRRNTAdd BLAST30
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Domaini148 – 196LRRCTAdd BLAST49
Domaini197 – 282Ig-like C2-type 1Add BLAST86
Domaini301 – 365Ig-like C2-type 2Add BLAST65
Domaini537 – 806Protein kinasePROSITE-ProRule annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni454 – 465Interaction with MAPK8IP3/JIP3By similarityAdd BLAST12

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000264255
HOVERGENiHBG056735
InParanoidiP15209
KOiK04360
OMAiCSCEIMW
OrthoDBiEOG091G01JY
PhylomeDBiP15209
TreeFamiTF106465

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform GP145-TRKB (identifier: P15209-1) [UniParc]FASTAAdd to basket
Also known as: L3, TrkBTK+, TRKB-FL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP 
        60         70         80         90        100
GIVAFPRLEP NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD 
       110        120        130        140        150
SGLKFVAYKA FLKNSNLRHI NFTRNKLTSL SRRHFRHLDL SDLILTGNPF 
       160        170        180        190        200
TCSCDIMWLK TLQETKSSPD TQDLYCLNES SKNMPLANLQ IPNCGLPSAR 
       210        220        230        240        250
LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM NETSHTQGSL 
       260        270        280        290        300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
       310        320        330        340        350
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN 
       360        370        380        390        400
PTHMNNGDYT LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW 
       410        420        430        440        450
TTPTDIGDTT NKSNEIPSTD VADQSNREHL SVYAVVVIAS VVGFCLLVML 
       460        470        480        490        500
LLLKLARHSK FGMKGPASVI SNDDDSASPL HHISNGSNTP SSSEGGPDAV 
       510        520        530        540        550
IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK RELGEGAFGK 
       560        570        580        590        600
VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV 
       610        620        630        640        650
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS 
       660        670        680        690        700
QMLHIAQQIA AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV 
       710        720        730        740        750
YSTDYYRVGG HTMLPIRWMP PESIMYRKFT TESDVWSLGV VLWEIFTYGK 
       760        770        780        790        800
QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHTRKNIK 
       810        820 
SIHTLLQNLA KASPVYLDIL G
Length:821
Mass (Da):92,133
Last modified:April 1, 1990 - v1
Checksum:i50E08D5FF86D8F30
GO
Isoform GP95-TRKB (identifier: P15209-2) [UniParc]FASTAAdd to basket
Also known as: TRKB-T1, TrkBTK-

The sequence of this isoform differs from the canonical sequence as follows:
     466-476: PASVISNDDDS → FVLFHKIPLDG
     477-821: Missing.

Note: Non-catalytic isoform.
Show »
Length:476
Mass (Da):53,186
Checksum:i20A8B375ED397ACE
GO
Isoform L1 (identifier: P15209-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-120: Missing.

Show »
Length:772
Mass (Da):86,535
Checksum:iE3E800582F9D3FB6
GO
Isoform L10 (identifier: P15209-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-71: I → M
     72-143: Missing.

Show »
Length:749
Mass (Da):83,744
Checksum:i791E6861C97AA53F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDA3A0A286YDA3_MOUSE
BDNF/NT-3 growth factors receptor
Ntrk2
492Annotation score:
A0A286YDA0A0A286YDA0_MOUSE
BDNF/NT-3 growth factors receptor
Ntrk2
466Annotation score:
A0A286YCV8A0A286YCV8_MOUSE
BDNF/NT-3 growth factors receptor
Ntrk2
489Annotation score:
A0A286YCB7A0A286YCB7_MOUSE
BDNF/NT-3 growth factors receptor
Ntrk2
51Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00290571I → M in isoform L10. Curated1
Alternative sequenceiVSP_00290672 – 143Missing in isoform L10. CuratedAdd BLAST72
Alternative sequenceiVSP_00290772 – 120Missing in isoform L1. CuratedAdd BLAST49
Alternative sequenceiVSP_002908466 – 476PASVISNDDDS → FVLFHKIPLDG in isoform GP95-TRKB. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_002909477 – 821Missing in isoform GP95-TRKB. 3 PublicationsAdd BLAST345

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33385 mRNA Translation: AAA40482.1
X17647 mRNA Translation: CAA35636.1
AK018789 mRNA Translation: BAB31412.1
AK147391 mRNA Translation: BAE27880.1
AK160789 mRNA Translation: BAE36012.1
BC052014 mRNA Translation: AAH52014.2
CCDSiCCDS26573.1 [P15209-1]
CCDS36685.1 [P15209-2]
PIRiA35104
S06943
RefSeqiNP_001020245.1, NM_001025074.2 [P15209-1]
NP_001269890.1, NM_001282961.1 [P15209-1]
NP_032771.1, NM_008745.3 [P15209-2]
XP_006517212.1, XM_006517149.3 [P15209-1]
XP_006517215.1, XM_006517152.3 [P15209-2]
XP_017170908.1, XM_017315419.1 [P15209-1]
XP_017170909.1, XM_017315420.1 [P15209-2]
UniGeneiMm.130054

Genome annotation databases

EnsembliENSMUST00000079828; ENSMUSP00000078757; ENSMUSG00000055254 [P15209-1]
ENSMUST00000109838; ENSMUSP00000105464; ENSMUSG00000055254 [P15209-2]
ENSMUST00000224259; ENSMUSP00000153270; ENSMUSG00000055254 [P15209-2]
ENSMUST00000225488; ENSMUSP00000153553; ENSMUSG00000055254 [P15209-1]
GeneIDi18212
KEGGimmu:18212
UCSCiuc007qui.2 mouse [P15209-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33385 mRNA Translation: AAA40482.1
X17647 mRNA Translation: CAA35636.1
AK018789 mRNA Translation: BAB31412.1
AK147391 mRNA Translation: BAE27880.1
AK160789 mRNA Translation: BAE36012.1
BC052014 mRNA Translation: AAH52014.2
CCDSiCCDS26573.1 [P15209-1]
CCDS36685.1 [P15209-2]
PIRiA35104
S06943
RefSeqiNP_001020245.1, NM_001025074.2 [P15209-1]
NP_001269890.1, NM_001282961.1 [P15209-1]
NP_032771.1, NM_008745.3 [P15209-2]
XP_006517212.1, XM_006517149.3 [P15209-1]
XP_006517215.1, XM_006517152.3 [P15209-2]
XP_017170908.1, XM_017315419.1 [P15209-1]
XP_017170909.1, XM_017315420.1 [P15209-2]
UniGeneiMm.130054

3D structure databases

ProteinModelPortaliP15209
SMRiP15209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201869, 6 interactors
DIPiDIP-5722N
IntActiP15209, 14 interactors
MINTiP15209
STRINGi10090.ENSMUSP00000078757

PTM databases

iPTMnetiP15209
PhosphoSitePlusiP15209

Proteomic databases

MaxQBiP15209
PaxDbiP15209
PeptideAtlasiP15209
PRIDEiP15209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079828; ENSMUSP00000078757; ENSMUSG00000055254 [P15209-1]
ENSMUST00000109838; ENSMUSP00000105464; ENSMUSG00000055254 [P15209-2]
ENSMUST00000224259; ENSMUSP00000153270; ENSMUSG00000055254 [P15209-2]
ENSMUST00000225488; ENSMUSP00000153553; ENSMUSG00000055254 [P15209-1]
GeneIDi18212
KEGGimmu:18212
UCSCiuc007qui.2 mouse [P15209-1]

Organism-specific databases

CTDi4915
MGIiMGI:97384 Ntrk2

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000264255
HOVERGENiHBG056735
InParanoidiP15209
KOiK04360
OMAiCSCEIMW
OrthoDBiEOG091G01JY
PhylomeDBiP15209
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Miscellaneous databases

ChiTaRSiNtrk2 mouse
PROiPR:P15209
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055254 Expressed in 286 organ(s), highest expression level in median eminence of neurohypophysis
CleanExiMM_NTRK2
ExpressionAtlasiP15209 baseline and differential
GenevisibleiP15209 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTRK2_MOUSE
AccessioniPrimary (citable) accession number: P15209
Secondary accession number(s): Q3TUF9, Q80WU0, Q91XJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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