Androgen receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• androgen binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• androgen receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription."
    Moilanen A.-M., Poukka H., Karvonen U., Hakli M., Janne O.A., Palvimo J.J.
    Mol. Cell. Biol. 18:5128-5139(1998) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from sequence orthologyⁱ
  • "Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription."
    Rouleau N., Domans'kyi A., Reeben M., Moilanen A.-M., Havas K., Kang Z., Owen-Hughes T., Palvimo J.J., Jaenne O.A.
    Mol. Biol. Cell 13:2106-2119(2002) [PubMed] [Europe PMC] [Abstract]
• beta-catenin binding Source: UniProtKB
• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations."
    Tsai Y.H.
    J. Androl. 8:299-306(1987) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat."
    DonCarlos L.L., Garcia-Ovejero D., Sarkey S., Garcia-Segura L.M., Azcoitia I.
    Endocrinology 144:3632-3638(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1."
    Ou X.-M., Chen K., Shih J.C.
    J. Biol. Chem. 281:21512-21525(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: UniProtKB
• enzyme binding Source: RGDInferred from sequence orthologyⁱ
  • "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression."
    Wissmann M., Yin N., Muller J.M., Greschik H., Fodor B.D., Jenuwein T., Vogler C., Schneider R., Gunther T., Buettner R., Metzger E., Schule R.
    Nat. Cell Biol. 9:347-353(2007) [PubMed] [Europe PMC] [Abstract]
  • "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor."
    Meyer R., Wolf S.S., Obendorf M.
    J. Steroid Biochem. Mol. Biol. 107:1-14(2007) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: RGDInferred from direct assayⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• POU domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct."
    Gonzalez M.I., Tovaglieri A., Robins D.M.
    Mol. Cell. Endocrinol. 190:39-49(2002) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• ribonucleotide binding Source: RGDInferred from direct assayⁱ
  • "DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates."
    Mulder E., Vrij A.A., Brinkmann A.O.
    Biochem. Biophys. Res. Commun. 114:1147-1153(1983) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1."
    Ou X.-M., Chen K., Shih J.C.
    J. Biol. Chem. 281:21512-21525(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II general transcription initiation factor binding Source: RGDInferred from sequence orthologyⁱ
  • "TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains."
    Tavassoli P., Wafa L.A., Cheng H., Zoubeidi A., Fazli L., Gleave M., Snoek R., Rennie P.S.
    Mol. Endocrinol. 24:696-708(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor."
    Chen G., Nomura M., Morinaga H., Matsubara E., Okabe T., Goto K., Yanase T., Zheng H., Lu J., Nawata H.
    J. Biol. Chem. 280:36355-36363(2005) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1."
    Holter E., Kotaja N., Makela S., Strauss L., Kietz S., Janne O.A., Gustafsson J.A., Palvimo J.J., Treuter E.
    Mol. Endocrinol. 16:515-528(2002) [PubMed] [Europe PMC] [Abstract]
• steroid binding Source: UniProtKB-KW
• steroid hormone receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4."
    Amir A.L., Barua M., McKnight N.C., Cheng S., Yuan X., Balk S.P.
    J. Biol. Chem. 278:30828-30834(2003) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization."
    Bowers J.M., Perez-Pouchoulen M., Roby C.R., Ryan T.E., McCarthy M.M.
    Endocrinology 155:4881-4894(2014) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: UniProtKB
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• activation of prostate induction by androgen receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function."
    Simanainen U., Allan C.M., Lim P., McPherson S., Jimenez M., Zajac J.D., Davey R.A., Handelsman D.J.
    Endocrinology 148:2264-2272(2007) [PubMed] [Europe PMC] [Abstract]
• androgen receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• animal organ formation Source: RGDInferred from sequence orthologyⁱ
  • "Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function."
    Simanainen U., Allan C.M., Lim P., McPherson S., Jimenez M., Zajac J.D., Davey R.A., Handelsman D.J.
    Endocrinology 148:2264-2272(2007) [PubMed] [Europe PMC] [Abstract]
• cellular process Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase."
    Lin H.K., Wang L., Hu Y.C., Altuwaijri S., Chang C.
    EMBO J. 21:4037-4048(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to follicle-stimulating hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells."
    Blok L.J., Mackenbach P., Trapman J., Themmen A.P., Brinkmann A.O., Grootegoed J.A.
    Mol. Cell. Endocrinol. 63:267-271(1989) [PubMed] [Europe PMC] [Abstract]
• cellular response to steroid hormone stimulus Source: RGDInferred from expression patternⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• cellular response to testosterone stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Identification and characterization of a novel thymus aging related protein Rwdd1."
    Kang N., Duan L., Tang L., Liu S., Li C., Li Y., Liu Q., Hu Y., Cui L., He W.
    Cell. Mol. Immunol. 5:279-285(2008) [PubMed] [Europe PMC] [Abstract]
• copulation Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors."
    Harding S.M., McGinnis M.Y.
    Physiol. Behav. 81:671-680(2004) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation involved in prostate gland development Source: RGDInferred from sequence orthologyⁱ
  • "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor."
    Wu C.T., Altuwaijri S., Ricke W.A., Huang S.P., Yeh S., Zhang C., Niu Y., Tsai M.Y., Chang C.
    Proc. Natl. Acad. Sci. U.S.A. 104:12679-12684(2007) [PubMed] [Europe PMC] [Abstract]
• epithelial cell morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia."
    Krutskikh A., De Gendt K., Sharp V., Verhoeven G., Poutanen M., Huhtaniemi I.
    Endocrinology 152:689-696(2011) [PubMed] [Europe PMC] [Abstract]
• fertilization Source: RGDInferred from sequence orthologyⁱ
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
• intracellular receptor signaling pathway Source: BHF-UCL
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Targeted disruption of the Insl3 gene causes bilateral cryptorchidism."
    Zimmermann S., Steding G., Emmen J.M., Brinkmann A.O., Nayernia K., Holstein A.F., Engel W., Adham I.M.
    Mol. Endocrinol. 13:681-691(1999) [PubMed] [Europe PMC] [Abstract]
• lateral sprouting involved in mammary gland duct morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• Leydig cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
• male courtship behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors."
    Harding S.M., McGinnis M.Y.
    Physiol. Behav. 81:671-680(2004) [PubMed] [Europe PMC] [Abstract]
• male genitalia morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia."
    Miyagawa S., Satoh Y., Haraguchi R., Suzuki K., Iguchi T., Taketo M.M., Nakagata N., Matsumoto T., Takeyama K., Kato S., Yamada G.
    Mol. Endocrinol. 23:871-880(2009) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: RGDInferred from sequence orthologyⁱ
  • "Targeted disruption of the Insl3 gene causes bilateral cryptorchidism."
    Zimmermann S., Steding G., Emmen J.M., Brinkmann A.O., Nayernia K., Holstein A.F., Engel W., Adham I.M.
    Mol. Endocrinol. 13:681-691(1999) [PubMed] [Europe PMC] [Abstract]
  • "Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function."
    Simanainen U., Allan C.M., Lim P., McPherson S., Jimenez M., Zajac J.D., Davey R.A., Handelsman D.J.
    Endocrinology 148:2264-2272(2007) [PubMed] [Europe PMC] [Abstract]
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
  • "Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia."
    Krutskikh A., De Gendt K., Sharp V., Verhoeven G., Poutanen M., Huhtaniemi I.
    Endocrinology 152:689-696(2011) [PubMed] [Europe PMC] [Abstract]
• male sex differentiation Source: RGDInferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• male somatic sex determination Source: RGDInferred from sequence orthologyⁱ
  • "X-linked gene for testicular feminization in the mouse."
    Lyon M.F., Hawkes S.G.
    Nature 227:1217-1219(1970) [PubMed] [Europe PMC] [Abstract]
• mammary gland alveolus development Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of an epithelial fold Source: RGDInferred from sequence orthologyⁱ
  • "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor."
    Wu C.T., Altuwaijri S., Ricke W.A., Huang S.P., Yeh S., Zhang C., Niu Y., Tsai M.Y., Chang C.
    Proc. Natl. Acad. Sci. U.S.A. 104:12679-12684(2007) [PubMed] [Europe PMC] [Abstract]
• multicellular organism growth Source: RGDInferred from sequence orthologyⁱ
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation."
    Chauhan S., Pandey R., Way J.F., Sroka T.C., Demetriou M.C., Kunz S., Cress A.E., Mount D.W., Miesfeld R.L.
    Biochem. Biophys. Res. Commun. 310:421-432(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor."
    Wu C.T., Altuwaijri S., Ricke W.A., Huang S.P., Yeh S., Zhang C., Niu Y., Tsai M.Y., Chang C.
    Proc. Natl. Acad. Sci. U.S.A. 104:12679-12684(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
• negative regulation of integrin biosynthetic process Source: UniProtKB
• negative regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action."
    Li G., Wang S., Gelehrter T.D.
    J. Biol. Chem. 278:41779-41788(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation."
    Chauhan S., Pandey R., Way J.F., Sroka T.C., Demetriou M.C., Kunz S., Cress A.E., Mount D.W., Miesfeld R.L.
    Biochem. Biophys. Res. Commun. 310:421-432(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of epithelial cell proliferation involved in prostate gland development Source: RGDInferred from sequence orthologyⁱ
  • "Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium."
    Stanbrough M., Leav I., Kwan P.W., Bubley G.J., Balk S.P.
    Proc. Natl. Acad. Sci. U.S.A. 98:10823-10828(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation."
    Chauhan S., Pandey R., Way J.F., Sroka T.C., Demetriou M.C., Kunz S., Cress A.E., Mount D.W., Miesfeld R.L.
    Biochem. Biophys. Res. Commun. 310:421-432(2003) [PubMed] [Europe PMC] [Abstract]
  • "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling."
    Correa R.G., Krajewska M., Ware C.F., Gerlic M., Reed J.C.
    Oncotarget 5:1666-1682(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin-like growth factor receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of integrin biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "The androgen receptor induces integrin alpha6beta1 to promote prostate tumor cell survival via NF-kappaB and Bcl-xL Independently of PI3K signaling."
    Lamb L.E., Zarif J.C., Miranti C.K.
    Cancer Res. 71:2739-2749(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intracellular estrogen receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
• positive regulation of penile erection Source: RGDInferred from mutant phenotypeⁱ
  • "Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats."
    Bialy M., Nikolaev-Diak A., Kalata U., Nikolaev E.
    Physiol. Behav. 103:295-301(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphorylation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• positive regulation of transcription by RNA polymerase III Source: RGDInferred from sequence orthologyⁱ
  • "Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes."
    Dai Y., Ngo D., Jacob J., Forman L.W., Faller D.V.
    Carcinogenesis 29:1725-1733(2008) [PubMed] [Europe PMC] [Abstract]
• prostate gland epithelium morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor."
    Wu C.T., Altuwaijri S., Ricke W.A., Huang S.P., Yeh S., Zhang C., Niu Y., Tsai M.Y., Chang C.
    Proc. Natl. Acad. Sci. U.S.A. 104:12679-12684(2007) [PubMed] [Europe PMC] [Abstract]
• prostate gland growth Source: RGDInferred from expression patternⁱ
  • "Ontogeny of the androgen receptor in rat ventral prostate during sexual development."
    Moeller H., Blank B., Lander K., Mates G.
    Res Exp Med (Berl) 187:287-294(1987) [PubMed] [Europe PMC] [Abstract]
• regulation of developmental growth Source: RGDInferred from sequence orthologyⁱ
  • "Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function."
    Simanainen U., Allan C.M., Lim P., McPherson S., Jimenez M., Zajac J.D., Davey R.A., Handelsman D.J.
    Endocrinology 148:2264-2272(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis."
    O'Shaughnessy P.J., Abel M., Charlton H.M., Hu B., Johnston H., Baker P.J.
    Endocrinology 148:2914-2924(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of prostatic bud formation Source: RGDInferred from sequence orthologyⁱ
  • "FGF-10 plays an essential role in the growth of the fetal prostate."
    Donjacour A.A., Thomson A.A., Cunha G.R.
    Dev. Biol. 261:39-54(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of protein localization to plasma membrane Source: UniProtKB
• regulation of systemic arterial blood pressure Source: RGDInferred from sequence orthologyⁱ
  • "Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome."
    Lyssand J.S., DeFino M.C., Tang X.B., Hertz A.L., Feller D.B., Wacker J.L., Adams M.E., Hague C.
    J. Biol. Chem. 283:18792-18800(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase."
    Lin H.K., Wang L., Hu Y.C., Altuwaijri S., Chang C.
    EMBO J. 21:4037-4048(2002) [PubMed] [Europe PMC] [Abstract]
  • "Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase."
    Jeong B.C., Hong C.Y., Chattopadhyay S., Park J.H., Gong E.Y., Kim H.J., Chun S.Y., Lee K.
    Mol. Endocrinol. 18:13-25(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis."
    O'Shaughnessy P.J., Abel M., Charlton H.M., Hu B., Johnston H., Baker P.J.
    Endocrinology 148:2914-2924(2007) [PubMed] [Europe PMC] [Abstract]
• reproductive behavior Source: RGDInferred from direct assayⁱ
  • "A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats."
    Kudwa A.E., Lopez F.J., McGivern R.F., Handa R.J.
    Endocrinology 151:2659-2668(2010) [PubMed] [Europe PMC] [Abstract]
• reproductive structure development Source: RGDInferred from sequence orthologyⁱ
  • "Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function."
    Simanainen U., Allan C.M., Lim P., McPherson S., Jimenez M., Zajac J.D., Davey R.A., Handelsman D.J.
    Endocrinology 148:2264-2272(2007) [PubMed] [Europe PMC] [Abstract]
• reproductive system development Source: RGDInferred from sequence orthologyⁱ
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity."
    Lynch C.S., Story A.J.
    Physiol. Behav. 69:445-453(2000) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: RGDInferred from expression patternⁱ
  • "Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment."
    Shirai M., Yamanaka M., Shiina H., Igawa M., Ogishima T., Fujime M., Ishii N., Okuyama A., Lue T.F., Dahiya R.
    Urology 64:1244-1249(2004) [PubMed] [Europe PMC] [Abstract]
• response to testosterone Source: RGDInferred from expression patternⁱ
  • "Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity."
    Lynch C.S., Story A.J.
    Physiol. Behav. 69:445-453(2000) [PubMed] [Europe PMC] [Abstract]
• seminiferous tubule development Source: RGDInferred from sequence orthologyⁱ
  • "Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis."
    Lim P., Robson M., Spaliviero J., McTavish K.J., Jimenez M., Zajac J.D., Handelsman D.J., Allan C.M.
    Endocrinology 150:4755-4765(2009) [PubMed] [Europe PMC] [Abstract]
  • "Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia."
    Krutskikh A., De Gendt K., Sharp V., Verhoeven G., Poutanen M., Huhtaniemi I.
    Endocrinology 152:689-696(2011) [PubMed] [Europe PMC] [Abstract]
• single fertilization Source: RGDInferred from sequence orthologyⁱ
  • "Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia."
    Krutskikh A., De Gendt K., Sharp V., Verhoeven G., Poutanen M., Huhtaniemi I.
    Endocrinology 152:689-696(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle hypertrophy Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle."
    Inoue K., Yamasaki S., Fushiki T., Okada Y., Sugimoto E.
    Eur J Appl Physiol Occup Physiol 69:88-91(1994) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "A selective androgen receptor modulator for hormonal male contraception."
    Chen J., Hwang D.J., Bohl C.E., Miller D.D., Dalton J.T.
    J. Pharmacol. Exp. Ther. 312:546-553(2005) [PubMed] [Europe PMC] [Abstract]
• tertiary branching involved in mammary gland duct morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor."
    Yeh S., Hu Y.C., Wang P.H., Xie C., Xu Q., Tsai M.Y., Dong Z., Wang R.S., Lee T.H., Chang C.
    J. Exp. Med. 198:1899-1908(2003) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Sites

GO - Molecular functionⁱ

• androgen receptor binding Source: RGDInferred from physical interactionⁱ
  • "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription."
    Moilanen A.-M., Poukka H., Karvonen U., Hakli M., Janne O.A., Palvimo J.J.
    Mol. Cell. Biol. 18:5128-5139(1998) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from sequence orthologyⁱ
  • "Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription."
    Rouleau N., Domans'kyi A., Reeben M., Moilanen A.-M., Havas K., Kang Z., Owen-Hughes T., Palvimo J.J., Jaenne O.A.
    Mol. Biol. Cell 13:2106-2119(2002) [PubMed] [Europe PMC] [Abstract]
• beta-catenin binding Source: UniProtKB
• enzyme binding Source: RGDInferred from sequence orthologyⁱ
  • "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression."
    Wissmann M., Yin N., Muller J.M., Greschik H., Fodor B.D., Jenuwein T., Vogler C., Schneider R., Gunther T., Buettner R., Metzger E., Schule R.
    Nat. Cell Biol. 9:347-353(2007) [PubMed] [Europe PMC] [Abstract]
  • "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor."
    Meyer R., Wolf S.S., Obendorf M.
    J. Steroid Biochem. Mol. Biol. 107:1-14(2007) [PubMed] [Europe PMC] [Abstract]
• POU domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct."
    Gonzalez M.I., Tovaglieri A., Robins D.M.
    Mol. Cell. Endocrinol. 190:39-49(2002) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II general transcription initiation factor binding Source: RGDInferred from sequence orthologyⁱ
  • "TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains."
    Tavassoli P., Wafa L.A., Cheng H., Zoubeidi A., Fazli L., Gleave M., Snoek R., Rennie P.S.
    Mol. Endocrinol. 24:696-708(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor."
    Chen G., Nomura M., Morinaga H., Matsubara E., Okabe T., Goto K., Yanase T., Zheng H., Lu J., Nawata H.
    J. Biol. Chem. 280:36355-36363(2005) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1."
    Holter E., Kotaja N., Makela S., Strauss L., Kietz S., Janne O.A., Gustafsson J.A., Palvimo J.J., Treuter E.
    Mol. Endocrinol. 16:515-528(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization."
    Bowers J.M., Perez-Pouchoulen M., Roby C.R., Ryan T.E., McCarthy M.M.
    Endocrinology 155:4881-4894(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAASIAPP 
        60         70         80         90        100
GACLQQRQET SPRRRRRQQH PEDGSPQAHI RGTTGYLALE EEQQPSQQQS 
       110        120        130        140        150
ASEGHPESGC LPEPGAATAP GKGLPQQPPA PPDQDDSAAP STLSLLGPTF 
       160        170        180        190        200
PGLSSCSADI KDILSEAGTM QLLQQQQQQQ QQQQQQQQQQ QQQQQEVISE 
       210        220        230        240        250
GSSSVRAREA TGAPSSSKDS YLGGNSTISD SAKELCKAVS VSMGLGVEAL 
       260        270        280        290        300
EHLSPGEQLR GDCMYASLLG GPPAVRPTPC APLAECKGLS LDEGPGKGTE 
       310        320        330        340        350
ETAEYSSFKG GYAKGLEGES LGCSGSSEAG SSGTLEIPSS LSLYKSGAVD 
       360        370        380        390        400
EAAAYQNRDY YNFPLALSGP PHPPPPTHPH ARIKLENPSD YGSAWAAAAA 
       410        420        430        440        450
QCRYGDLASL HGGSVAGPST GSPPATASSS WHTLFTAEEG QLYGPGGGGG 
       460        470        480        490        500
SSSPSDAGPV APYGYTRPPQ GLASQEGDFS ASEVWYPGGV VNRVPYPSPS 
       510        520        530        540        550
CVKSEMGPWM ENYSGPYGDM RLDSTRDHVL PIDYYFPPQK TCLICGDEAS 
       560        570        580        590        600
GCHYGALTCG SCKVFFKRAA EGKQKYLCAS RNDCTIDKFR RKNCPSCRLR 
       610        620        630        640        650
KCYEAGMTLG ARKLKKLGNL KLQEEGENSS AGSPTEDPSQ KMTVSHIEGY 
       660        670        680        690        700
ECQPIFLNVL EAIEPGVVCA GHDNNQPDSF AALLSSLNEL GERQLVHVVK 
       710        720        730        740        750
WAKALPGFRN LHVDDQMAVI QYSWMGLMVF AMGWRSFTNV NSRMLYFAPD 
       760        770        780        790        800
LVFNEYRMHK SRMYSQCVRM RHLSQEFGWL QITPQEFLCM KALLLFSIIP 
       810        820        830        840        850
VDGLKNQKFF DELRMNYIKE LDRIIACKRK NPTSCSRRFY QLTKLLDSVQ 
       860        870        880        890        900
PIARELHQFT FDLLIKSHMV SVDFPEMMAE IISVQVPKIL SGKVKPIYFH 

TQ                                                     

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families