Androgen receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• androgen binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• androgen receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription."
    Moilanen A.-M., Poukka H., Karvonen U., Hakli M., Janne O.A., Palvimo J.J.
    Mol. Cell. Biol. 18:5128-5139(1998) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGD
• beta-catenin binding Source: UniProtKB
• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations."
    Tsai Y.H.
    J Androl 8:299-306(1987) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat."
    DonCarlos L.L., Garcia-Ovejero D., Sarkey S., Garcia-Segura L.M., Azcoitia I.
    Endocrinology 144:3632-3638(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: UniProtKB
• enzyme binding Source: RGD
• nuclear receptor activity Source: RGDInferred from direct assayⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• POU domain binding Source: RGD
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• ribonucleotide binding Source: RGDInferred from direct assayⁱ
  • "DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates."
    Mulder E., Vrij A.A., Brinkmann A.O.
    Biochem Biophys Res Commun 114:1147-1153(1983) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• RNA polymerase II general transcription initiation factor binding Source: RGD
• RNA polymerase II transcription coactivator binding Source: RGD
• RNA polymerase II transcription factor binding Source: RGD
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1."
    Holter E., Kotaja N., Makela S., Strauss L., Kietz S., Janne O.A., Gustafsson J.A., Palvimo J.J., Treuter E.
    Mol Endocrinol 16:515-528(2002) [PubMed] [Europe PMC] [Abstract]
• steroid binding Source: UniProtKB-KW
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization."
    Bowers J.M., Perez-Pouchoulen M., Roby C.R., Ryan T.E., McCarthy M.M.
    Endocrinology 155:4881-4894(2014) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: UniProtKB
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• activation of prostate induction by androgen receptor signaling pathway Source: RGD
• androgen receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• animal organ formation Source: RGD
• cellular process Source: RGD
• cellular response to estrogen stimulus Source: RGD
• cellular response to follicle-stimulating hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells."
    Blok L.J., Mackenbach P., Trapman J., Themmen A.P., Brinkmann A.O., Grootegoed J.A.
    Mol Cell Endocrinol 63:267-271(1989) [PubMed] [Europe PMC] [Abstract]
• cellular response to steroid hormone stimulus Source: RGDInferred from expression patternⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• cellular response to testosterone stimulus Source: RGD
• copulation Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors."
    Harding S.M., McGinnis M.Y.
    Physiol Behav 81:671-680(2004) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation involved in prostate gland development Source: RGD
• epithelial cell morphogenesis Source: RGD
• fertilization Source: RGD
• intracellular estrogen receptor signaling pathway Source: RGD
• intracellular receptor signaling pathway Source: BHF-UCL
• intracellular steroid hormone receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGD
• lateral sprouting involved in mammary gland duct morphogenesis Source: RGD
• Leydig cell differentiation Source: RGD
• male courtship behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors."
    Harding S.M., McGinnis M.Y.
    Physiol Behav 81:671-680(2004) [PubMed] [Europe PMC] [Abstract]
• male genitalia morphogenesis Source: RGD
• male gonad development Source: RGD
• male sex differentiation Source: RGDInferred from mutant phenotypeⁱ
  • Ref.3

    "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat."
    Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M.
    J. Biol. Chem. 265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TFM GLN-735.
• male somatic sex determination Source: RGD
• mammary gland alveolus development Source: RGD
• morphogenesis of an epithelial fold Source: RGD
• multicellular organism growth Source: RGD
• negative regulation of cell population proliferation Source: RGD
• negative regulation of epithelial cell proliferation Source: RGD
• negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
• negative regulation of integrin biosynthetic process Source: UniProtKB
• negative regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of cell differentiation Source: RGD
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of epithelial cell proliferation involved in prostate gland development Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of insulin-like growth factor receptor signaling pathway Source: RGD
• positive regulation of integrin biosynthetic process Source: RGD
• positive regulation of intracellular estrogen receptor signaling pathway Source: RGD
• positive regulation of MAPK cascade Source: RGD
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
• positive regulation of penile erection Source: RGDInferred from mutant phenotypeⁱ
  • "Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats."
    Bialy M., Nikolaev-Diak A., Kalata U., Nikolaev E.
    Physiol Behav 103:295-301(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphorylation Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: RGDInferred from direct assayⁱ
  • "Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain."
    Aarnisalo P., Santti H., Poukka H., Palvimo J.J., Janne O.A.
    Endocrinology 140:3097-3105(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• positive regulation of transcription by RNA polymerase III Source: RGD
• prostate gland epithelium morphogenesis Source: RGD
• prostate gland growth Source: RGDInferred from expression patternⁱ
  • "Ontogeny of the androgen receptor in rat ventral prostate during sexual development."
    Moeller H., Blank B., Lander K., Mates G.
    Res Exp Med (Berl) 187:287-294(1987) [PubMed] [Europe PMC] [Abstract]
• regulation of developmental growth Source: RGD
• regulation of gene expression Source: RGD
• regulation of prostatic bud formation Source: RGD
• regulation of protein localization to plasma membrane Source: UniProtKB
• regulation of systemic arterial blood pressure Source: RGD
• regulation of transcription, DNA-templated Source: RGD
• regulation of transcription by RNA polymerase II Source: RGD
• reproductive behavior Source: RGDInferred from direct assayⁱ
  • "A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats."
    Kudwa A.E., Lopez F.J., McGivern R.F., Handa R.J.
    Endocrinology 151:2659-2668(2010) [PubMed] [Europe PMC] [Abstract]
• reproductive structure development Source: RGD
• reproductive system development Source: RGD
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity."
    Lynch C.S., Story A.J.
    Physiol Behav 69:445-453(2000) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: RGDInferred from expression patternⁱ
  • "Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment."
    Shirai M., Yamanaka M., Shiina H., Igawa M., Ogishima T., Fujime M., Ishii N., Okuyama A., Lue T.F., Dahiya R.
    Urology 64:1244-1249(2004) [PubMed] [Europe PMC] [Abstract]
• response to testosterone Source: RGDInferred from expression patternⁱ
  • "Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity."
    Lynch C.S., Story A.J.
    Physiol Behav 69:445-453(2000) [PubMed] [Europe PMC] [Abstract]
• seminiferous tubule development Source: RGD
• single fertilization Source: RGD
• skeletal muscle hypertrophy Source: RGDInferred from mutant phenotypeⁱ
  • "Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle."
    Inoue K., Yamasaki S., Fushiki T., Okada Y., Sugimoto E.
    Eur J Appl Physiol Occup Physiol 69:88-91(1994) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "A selective androgen receptor modulator for hormonal male contraception."
    Chen J., Hwang D.J., Bohl C.E., Miller D.D., Dalton J.T.
    J Pharmacol Exp Ther 312:546-553(2005) [PubMed] [Europe PMC] [Abstract]
• tertiary branching involved in mammary gland duct morphogenesis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Sites

GO - Molecular functionⁱ

• androgen receptor binding Source: RGDInferred from physical interactionⁱ
  • "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription."
    Moilanen A.-M., Poukka H., Karvonen U., Hakli M., Janne O.A., Palvimo J.J.
    Mol. Cell. Biol. 18:5128-5139(1998) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGD
• beta-catenin binding Source: UniProtKB
• enzyme binding Source: RGD
• POU domain binding Source: RGD
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II general transcription initiation factor binding Source: RGD
• RNA polymerase II transcription coactivator binding Source: RGD
• RNA polymerase II transcription factor binding Source: RGD
• signaling receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1."
    Holter E., Kotaja N., Makela S., Strauss L., Kietz S., Janne O.A., Gustafsson J.A., Palvimo J.J., Treuter E.
    Mol Endocrinol 16:515-528(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization."
    Bowers J.M., Perez-Pouchoulen M., Roby C.R., Ryan T.E., McCarthy M.M.
    Endocrinology 155:4881-4894(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REAIQNPGPR HPEAASIAPP 
        60         70         80         90        100
GACLQQRQET SPRRRRRQQH PEDGSPQAHI RGTTGYLALE EEQQPSQQQS 
       110        120        130        140        150
ASEGHPESGC LPEPGAATAP GKGLPQQPPA PPDQDDSAAP STLSLLGPTF 
       160        170        180        190        200
PGLSSCSADI KDILSEAGTM QLLQQQQQQQ QQQQQQQQQQ QQQQQEVISE 
       210        220        230        240        250
GSSSVRAREA TGAPSSSKDS YLGGNSTISD SAKELCKAVS VSMGLGVEAL 
       260        270        280        290        300
EHLSPGEQLR GDCMYASLLG GPPAVRPTPC APLAECKGLS LDEGPGKGTE 
       310        320        330        340        350
ETAEYSSFKG GYAKGLEGES LGCSGSSEAG SSGTLEIPSS LSLYKSGAVD 
       360        370        380        390        400
EAAAYQNRDY YNFPLALSGP PHPPPPTHPH ARIKLENPSD YGSAWAAAAA 
       410        420        430        440        450
QCRYGDLASL HGGSVAGPST GSPPATASSS WHTLFTAEEG QLYGPGGGGG 
       460        470        480        490        500
SSSPSDAGPV APYGYTRPPQ GLASQEGDFS ASEVWYPGGV VNRVPYPSPS 
       510        520        530        540        550
CVKSEMGPWM ENYSGPYGDM RLDSTRDHVL PIDYYFPPQK TCLICGDEAS 
       560        570        580        590        600
GCHYGALTCG SCKVFFKRAA EGKQKYLCAS RNDCTIDKFR RKNCPSCRLR 
       610        620        630        640        650
KCYEAGMTLG ARKLKKLGNL KLQEEGENSS AGSPTEDPSQ KMTVSHIEGY 
       660        670        680        690        700
ECQPIFLNVL EAIEPGVVCA GHDNNQPDSF AALLSSLNEL GERQLVHVVK 
       710        720        730        740        750
WAKALPGFRN LHVDDQMAVI QYSWMGLMVF AMGWRSFTNV NSRMLYFAPD 
       760        770        780        790        800
LVFNEYRMHK SRMYSQCVRM RHLSQEFGWL QITPQEFLCM KALLLFSIIP 
       810        820        830        840        850
VDGLKNQKFF DELRMNYIKE LDRIIACKRK NPTSCSRRFY QLTKLLDSVQ 
       860        870        880        890        900
PIARELHQFT FDLLIKSHMV SVDFPEMMAE IISVQVPKIL SGKVKPIYFH 

TQ                                                     

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families