UniProtKB - P15203 (TGFB3_PIG)
Transforming growth factor beta-3 proprotein
TGFB3
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: AgBase
- transforming growth factor beta binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
- type I transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- cell-cell junction organization Source: AgBase
- detection of hypoxia Source: AgBase
- face morphogenesis Source: AgBase
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of macrophage cytokine production Source: AgBase
- ossification involved in bone remodeling Source: AgBase
- positive regulation of bone mineralization Source: AgBase
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of collagen biosynthetic process Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: AgBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: AgBase
- regulation of cell population proliferation Source: GO_Central
- response to hypoxia Source: AgBase
- response to progesterone Source: AgBase
- salivary gland morphogenesis Source: AgBase
- secondary palate development Source: UniProtKB
- SMAD protein signal transduction Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: AgBase
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-3 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:TGFB3 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular matrix Source: AgBase
- extracellular space Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000033800 | 22 – 297 | Latency-associated peptideBy similarityAdd BLAST | 276 | |
ChainiPRO_0000033801 | 298 – 409 | Transforming growth factor beta-3By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 304 ↔ 313 | By similarity | ||
Disulfide bondi | 312 ↔ 375 | By similarity | ||
Disulfide bondi | 341 ↔ 406 | By similarity | ||
Disulfide bondi | 345 ↔ 408 | By similarity | ||
Disulfide bondi | 374 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P15203 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000002385, Expressed in longissimus thoracis muscle and 30 other tissues |
Genevisiblei | P15203, SS |
Interactioni
Subunit structurei
Interacts with ASPN (By similarity). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide:
Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide:
Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-3:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: AgBase
- transforming growth factor beta binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
- type I transforming growth factor beta receptor binding Source: AgBase
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000030885 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 259 – 261 | Cell attachment siteBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P15203 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MHLQRALVVL ALLNFATVSL SMSTCTTLDF DHIKRKRVEA IRGQILSKLR
60 70 80 90 100
LTSPPDPSML ANIPTQVLDL YNSTRELLEE VHGERGDDCT QENTESEYYA
110 120 130 140 150
KEIYKFDMIQ GLEEHNDLAV CPKGITSKIF RFNVSSVEKN ETNLFRAEFR
160 170 180 190 200
VLRMPNPSSK RSEQRIELFQ ILQPDEHIAK QRYIDGKNLP TRGAAEWLSF
210 220 230 240 250
DVTDTVREWL LRRESNLGLE ISIHCPCHTF QPNGDILENI QEVMEIKFKG
260 270 280 290 300
VDSEDDPGRG DLGRLKKKKE HSPHLILMMI PPDRLDNPGL GAQRKKRALD
310 320 330 340 350
TNYCFRNLEE NCCVRPLYID FRQDLGWKWV HEPKGYYANF CSGPCPYLRS
360 370 380 390 400
ADTTHSSVLG LYNTLNPEAS ASPCCVPQDL EPLTILYYVG RTAKVEQLSN
MVVKSCKCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14150 mRNA Translation: CAA32363.1 |
PIRi | S01825 |
RefSeqi | NP_999363.1, NM_214198.1 |
Genome annotation databases
Ensembli | ENSSSCT00015109301; ENSSSCP00015046449; ENSSSCG00015080409 |
GeneIDi | 397400 |
KEGGi | ssc:397400 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14150 mRNA Translation: CAA32363.1 |
PIRi | S01825 |
RefSeqi | NP_999363.1, NM_214198.1 |
3D structure databases
BMRBi | P15203 |
SMRi | P15203 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000030885 |
Proteomic databases
PaxDbi | P15203 |
Genome annotation databases
Ensembli | ENSSSCT00015109301; ENSSSCP00015046449; ENSSSCG00015080409 |
GeneIDi | 397400 |
KEGGi | ssc:397400 |
Organism-specific databases
CTDi | 7043 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P15203 |
Gene expression databases
Bgeei | ENSSSCG00000002385, Expressed in longissimus thoracis muscle and 30 other tissues |
Genevisiblei | P15203, SS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB3_PIG | |
Accessioni | P15203Primary (citable) accession number: P15203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families