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Protein

Phosphoprotein

Gene

P

Organism
Rabies virus (strain PM1503/AVO1) (RABV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Microtubular inwards viral transport, Viral immunoevasion, Viral RNA replication, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoprotein
Short name:
Protein P
Alternative name(s):
Protein M1
Gene namesi
Name:P
OrganismiRabies virus (strain PM1503/AVO1) (RABV)
Taxonomic identifieri11293 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]
Proteomesi
  • UP000008617 Componenti: Genome

Subcellular locationi

Isoform P3 :
Isoform P4 :
Isoform P5 :

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228271 – 297PhosphoproteinAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Phosphoserine; by hostBy similarity1
Modified residuei64Phosphoserine; by hostBy similarity1
Modified residuei162Phosphoserine; by host PKCBy similarity1
Modified residuei210Phosphoserine; by host PKCBy similarity1
Modified residuei271Phosphoserine; by host PKCBy similarity1

Post-translational modificationi

Phosphorylated by host PKC and by an unknown kinase.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotrimer when phosphorylated. This trimer is stabilized by binding to the L protein. Binds soluble protein N, and ribonucleocapsid. Interacts with host DYNLL1 and DYNLL2; this interaction may play a role in intracellular microtubule-dependent virus transport of incoming virus. Interacts with host STAT1, STAT2 and PML. Isoform P3 binds host PML (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP15198
SMRiP15198
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 172DYNLL1 and DYNLL2 bindingBy similarityAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 58Nuclear export signalBy similarity10
Motifi211 – 214Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the lyssavirus protein P family.Curated

Phylogenomic databases

OrthoDBiVOG090000H9

Family and domain databases

Gene3Di1.20.120.820, 1 hit
InterProiView protein in InterPro
IPR004259 PP_M1
IPR037199 PP_M1_C
PfamiView protein in Pfam
PF03012 PP_M1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004155 PP_M1, 1 hit
SUPFAMiSSF118173 SSF118173, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform P (identifier: P15198-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKIFVNPSA IRAGLADLEM AEETVDLINR NIEDNDAHLQ GEPIEVDNLP
60 70 80 90 100
EDMKRLHLDD EKSSNLGEMV RVGEGKYRED FQMDEGEDPN LLFQSYLDNV
110 120 130 140 150
GVQIVRQMRS GERFLKIWSQ TVEEIVSYVT VNFPNPPRRS SEDKSTQTTG
160 170 180 190 200
RELKKETTSA FSQRESQPSK ARMVAQVAPG PPALEWSATN EEDDLSVEAE
210 220 230 240 250
IAHQIAESFS KKYKFPSRSS GIFLYNFEQL KMNLDDIVKE AKNVPGVTRL
260 270 280 290
AHDGSKIPLR CVLGWVALAN SKKFQLLVEA DKLSKIMQDD LNRYTSC
Length:297
Mass (Da):33,603
Last modified:April 1, 1990 - v1
Checksum:iE935DEDBFFA3DB06
GO
Isoform P2 (identifier: P15198-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:278
Mass (Da):31,588
Checksum:i4CA2838BA656511C
GO
Isoform P3 (identifier: P15198-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:245
Mass (Da):27,857
Checksum:iC43E30CC191C3F10
GO
Isoform P4 (identifier: P15198-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:229
Mass (Da):26,003
Checksum:i25D7A21F4A4DB726
GO
Isoform P5 (identifier: P15198-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:215
Mass (Da):24,307
Checksum:i48C26245875004D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30R → Q in strain: Isolate PM1503. 1
Natural varianti36D → Q in strain: Isolate PM1503. 1
Natural varianti84D → G in strain: Isolate PM1503. 1
Natural varianti122V → I in strain: Isolate PM1503. 1
Natural varianti179P → S in strain: Isolate PM1503. 1
Natural varianti223F → L in strain: Isolate PM1503. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0268641 – 82Missing in isoform P5. CuratedAdd BLAST82
Alternative sequenceiVSP_0268651 – 68Missing in isoform P4. CuratedAdd BLAST68
Alternative sequenceiVSP_0268661 – 52Missing in isoform P3. CuratedAdd BLAST52
Alternative sequenceiVSP_0268671 – 19Missing in isoform P2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13357 Genomic RNA Translation: CAA31734.1
DQ099525 Genomic RNA Translation: AAZ07892.1
PIRiS07814 MNVNAV

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13357 Genomic RNA Translation: CAA31734.1
DQ099525 Genomic RNA Translation: AAZ07892.1
PIRiS07814 MNVNAV

3D structure databases

ProteinModelPortaliP15198
SMRiP15198
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000H9

Family and domain databases

Gene3Di1.20.120.820, 1 hit
InterProiView protein in InterPro
IPR004259 PP_M1
IPR037199 PP_M1_C
PfamiView protein in Pfam
PF03012 PP_M1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004155 PP_M1, 1 hit
SUPFAMiSSF118173 SSF118173, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOSP_RABVA
AccessioniPrimary (citable) accession number: P15198
Secondary accession number(s): Q4F902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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