UniProtKB - P15180 (SYKC_YEAST)
Protein
Lysine--tRNA ligase, cytoplasmic
Gene
KRS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalytic activityi
- EC:6.1.1.6
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- lysine-tRNA ligase activity Source: SGD
- mRNA binding Source: SGD
- tRNA binding Source: GO_Central
GO - Biological processi
- lysyl-tRNA aminoacylation Source: SGD
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lysine--tRNA ligase, cytoplasmic (EC:6.1.1.6)Alternative name(s): Lysyl-tRNA synthetase Short name: LysRS |
Gene namesi | Name:KRS1 Synonyms:GCD5 Ordered Locus Names:YDR037W ORF Names:YD9673.09 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002444, KRS1 |
VEuPathDBi | FungiDB:YDR037W |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 488 | R → L in GCD5-1; defects in lysine-binding. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000152771 | 2 – 591 | Lysine--tRNA ligase, cytoplasmicAdd BLAST | 590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 | |
Modified residuei | 30 | PhosphoserineCombined sources | 1 | |
Modified residuei | 62 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 308 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Cross-linki | 577 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P15180 |
PaxDbi | P15180 |
PRIDEi | P15180 |
PTM databases
CarbonylDBi | P15180 |
iPTMneti | P15180 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 32092, 163 interactors |
DIPi | DIP-6359N |
IntActi | P15180, 10 interactors |
MINTi | P15180 |
STRINGi | 4932.YDR037W |
Miscellaneous databases
RNActi | P15180, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 61 | Lys-rich (basic)Add BLAST | 29 |
Sequence similaritiesi
Belongs to the class-II aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG1885, Eukaryota |
GeneTreei | ENSGT01020000230546 |
HOGENOMi | CLU_008255_6_0_1 |
InParanoidi | P15180 |
OMAi | EIFGEKC |
Family and domain databases
CDDi | cd00775, LysRS_core, 1 hit cd04322, LysRS_N, 1 hit |
HAMAPi | MF_00252, Lys_tRNA_synth_class2, 1 hit |
InterProi | View protein in InterPro IPR004364, Aa-tRNA-synt_II IPR006195, aa-tRNA-synth_II IPR002313, Lys-tRNA-ligase_II IPR034762, Lys-tRNA-ligase_II_bac/euk IPR044136, Lys-tRNA-ligase_II_N IPR018149, Lys-tRNA-synth_II_C IPR012340, NA-bd_OB-fold IPR004365, NA-bd_OB_tRNA |
Pfami | View protein in Pfam PF00152, tRNA-synt_2, 1 hit PF01336, tRNA_anti-codon, 1 hit |
PIRSFi | PIRSF039101, LysRS2, 1 hit |
PRINTSi | PR00982, TRNASYNTHLYS |
SUPFAMi | SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00499, lysS_bact, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15180-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQQDNVKAA AEGVANLHLD EATGEMVSKS ELKKRIKQRQ VEAKKAAKKA
60 70 80 90 100
AAQPKPASKK KTDLFADLDP SQYFETRSRQ IQELRKTHEP NPYPHKFHVS
110 120 130 140 150
ISNPEFLAKY AHLKKGETLP EEKVSIAGRI HAKRESGSKL KFYVLHGDGV
160 170 180 190 200
EVQLMSQLQD YCDPDSYEKD HDLLKRGDIV GVEGYVGRTQ PKKGGEGEVS
210 220 230 240 250
VFVSRVQLLT PCLHMLPADH FGFKDQETRY RKRYLDLIMN KDARNRFITR
260 270 280 290 300
SEIIRYIRRF LDQRKFIEVE TPMMNVIAGG ATAKPFITHH NDLDMDMYMR
310 320 330 340 350
IAPELFLKQL VVGGLDRVYE IGRQFRNEGI DMTHNPEFTT CEFYQAYADV
360 370 380 390 400
YDLMDMTELM FSEMVKEITG SYIIKYHPDP ADPAKELELN FSRPWKRINM
410 420 430 440 450
IEELEKVFNV KFPSGDQLHT AETGEFLKKI LVDNKLECPP PLTNARMLDK
460 470 480 490 500
LVGELEDTCI NPTFIFGHPQ MMSPLAKYSR DQPGLCERFE VFVATKEICN
510 520 530 540 550
AYTELNDPFD QRARFEEQAR QKDQGDDEAQ LVDETFCNAL EYGLPPTGGW
560 570 580 590
GCGIDRLAMF LTDSNTIREV LLFPTLKPDV LREEVKKEEE N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | A → V in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 51 | A → T in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 111 | A → V in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 162 | C → H in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 165 | D → E in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 259 | R → K in CAA39699 (PubMed:2046655).Curated | 1 | |
Sequence conflicti | 430 – 432 | ILV → VLA in CAA39699 (PubMed:2046655).Curated | 3 | |
Sequence conflicti | 591 | N → H in CAA39699 (PubMed:2046655).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04186 Genomic DNA Translation: AAA66916.1 X56259 Genomic DNA Translation: CAA39699.1 Z68196 Genomic DNA Translation: CAA92376.1 Z74333 Genomic DNA Translation: CAA98863.1 BK006938 Genomic DNA Translation: DAA11885.1 |
PIRi | A92695, SYBYKT |
RefSeqi | NP_010322.1, NM_001180345.1 |
Genome annotation databases
EnsemblFungii | YDR037W_mRNA; YDR037W; YDR037W |
GeneIDi | 851607 |
KEGGi | sce:YDR037W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04186 Genomic DNA Translation: AAA66916.1 X56259 Genomic DNA Translation: CAA39699.1 Z68196 Genomic DNA Translation: CAA92376.1 Z74333 Genomic DNA Translation: CAA98863.1 BK006938 Genomic DNA Translation: DAA11885.1 |
PIRi | A92695, SYBYKT |
RefSeqi | NP_010322.1, NM_001180345.1 |
3D structure databases
SMRi | P15180 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32092, 163 interactors |
DIPi | DIP-6359N |
IntActi | P15180, 10 interactors |
MINTi | P15180 |
STRINGi | 4932.YDR037W |
PTM databases
CarbonylDBi | P15180 |
iPTMneti | P15180 |
Proteomic databases
MaxQBi | P15180 |
PaxDbi | P15180 |
PRIDEi | P15180 |
Genome annotation databases
EnsemblFungii | YDR037W_mRNA; YDR037W; YDR037W |
GeneIDi | 851607 |
KEGGi | sce:YDR037W |
Organism-specific databases
SGDi | S000002444, KRS1 |
VEuPathDBi | FungiDB:YDR037W |
Phylogenomic databases
eggNOGi | KOG1885, Eukaryota |
GeneTreei | ENSGT01020000230546 |
HOGENOMi | CLU_008255_6_0_1 |
InParanoidi | P15180 |
OMAi | EIFGEKC |
Miscellaneous databases
PROi | PR:P15180 |
RNActi | P15180, protein |
Family and domain databases
CDDi | cd00775, LysRS_core, 1 hit cd04322, LysRS_N, 1 hit |
HAMAPi | MF_00252, Lys_tRNA_synth_class2, 1 hit |
InterProi | View protein in InterPro IPR004364, Aa-tRNA-synt_II IPR006195, aa-tRNA-synth_II IPR002313, Lys-tRNA-ligase_II IPR034762, Lys-tRNA-ligase_II_bac/euk IPR044136, Lys-tRNA-ligase_II_N IPR018149, Lys-tRNA-synth_II_C IPR012340, NA-bd_OB-fold IPR004365, NA-bd_OB_tRNA |
Pfami | View protein in Pfam PF00152, tRNA-synt_2, 1 hit PF01336, tRNA_anti-codon, 1 hit |
PIRSFi | PIRSF039101, LysRS2, 1 hit |
PRINTSi | PR00982, TRNASYNTHLYS |
SUPFAMi | SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00499, lysS_bact, 1 hit |
PROSITEi | View protein in PROSITE PS50862, AA_TRNA_LIGASE_II, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYKC_YEAST | |
Accessioni | P15180Primary (citable) accession number: P15180 Secondary accession number(s): D6VS25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families